메뉴 건너뛰기




Volumn 18, Issue 1, 2011, Pages

Clinical significance of estrogen receptor phosphorylation

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; LETROZOLE; TAMOXIFEN;

EID: 79251518293     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1677/ERC-10-0070     Document Type: Review
Times cited : (120)

References (123)
  • 1
    • 33845329220 scopus 로고    scopus 로고
    • An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration
    • doi:10.1158/0008-5472.CAN-06-2676
    • Acconcia F, Manavathi B, Mascarenhas J, Talukder AH, Mills G & Kumar R 2006 An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration. Cancer Research 66 11030-11038. (doi:10.1158/0008-5472.CAN-06-2676)
    • (2006) Cancer Research , vol.66 , pp. 11030-11038
    • Acconcia, F.1    Manavathi, B.2    Mascarenhas, J.3    Talukder, A.H.4    Mills, G.5    Kumar, R.6
  • 2
    • 0036284423 scopus 로고    scopus 로고
    • Activated mitogen-activated protein kinase expression during human breast tumorigenesis and breast cancer progression
    • Adeyinka A, Niu Y, Cherlet T, Snell L, Watson P & Murphy L 2002 Activated mitogen-activated protein kinase expression during human breast tumorigenesis and breast cancer progression. Clinical Cancer Research 8 1747-1753.
    • (2002) Clinical Cancer Research , vol.8 , pp. 1747-1753
    • Adeyinka, A.1    Niu, Y.2    Cherlet, T.3    Snell, L.4    Watson, P.5    Murphy, L.6
  • 3
    • 0027978187 scopus 로고
    • Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor
    • doi:10.1210/me.8.9.1208
    • Arnold S, Obourn J, Jaffe H & Notides A 1994 Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor. Molecular Endocrinology 8 1208-1214. (doi:10.1210/me.8.9.1208)
    • (1994) Molecular Endocrinology , vol.8 , pp. 1208-1214
    • Arnold, S.1    Obourn, J.2    Jaffe, H.3    Notides, A.4
  • 4
    • 0028833473 scopus 로고
    • Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by Src family tyrosines in vitro
    • doi:10.1210/me.9.1.24
    • Arnold S, Obourn J, Jaffe H & Notides A 1995a Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by Src family tyrosines in vitro. Molecular Endocrinology 9 24-33. (doi:10.1210/me.9.1.24)
    • (1995) Molecular Endocrinology , vol.9 , pp. 24-33
    • Arnold, S.1    Obourn, J.2    Jaffe, H.3    Notides, A.4
  • 5
    • 0029563173 scopus 로고
    • Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element
    • doi:10.1074/jbc.270.4.1850
    • Arnold S, Vorojeikina D & Notides A 1995b Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element. Journal of Biological Chemistry 270 30205-30212. (doi:10.1074/jbc.270.4.1850)
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 30205-30212
    • Arnold, S.1    Vorojeikina, D.2    Notides, A.3
  • 6
    • 0031036099 scopus 로고    scopus 로고
    • Estradiol-binding mechanism and binding capacity of the human estrogen receptor is regulated by tyrosine phosphorylation
    • doi:10.1210/me.11.1.48
    • Arnold SF, Melamed M, Vorojeikina DP, Notides AC & Sasson S 1997 Estradiol-binding mechanism and binding capacity of the human estrogen receptor is regulated by tyrosine phosphorylation. Molecular Endocrinology 11 48-53. (doi:10.1210/me.11.1.48)
    • (1997) Molecular Endocrinology , vol.11 , pp. 48-53
    • Arnold, S.F.1    Melamed, M.2    Vorojeikina, D.P.3    Notides, A.C.4    Sasson, S.5
  • 7
    • 36048969501 scopus 로고    scopus 로고
    • Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer
    • doi:10.1136/jcp.2006.041616
    • Assender JW, Gee JM, Lewis I, Ellis IO, Robertson JF & Nicholson RI 2007 Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer. Journal of Clinical Pathology 60 1216-1221. (doi:10.1136/jcp.2006.041616)
    • (2007) Journal of Clinical Pathology , vol.60 , pp. 1216-1221
    • Assender, J.W.1    Gee, J.M.2    Lewis, I.3    Ellis, I.O.4    Robertson, J.F.5    Nicholson, R.I.6
  • 8
    • 63049112424 scopus 로고    scopus 로고
    • Systematic mapping of posttranslational modifications in human estrogen receptor-α with emphasis on novel phosphorylation sites
    • doi:10.1074/mcp.M800282-MCP200
    • Atsriku C, Britton DJ, Held JM, Schilling B, Scott GK, Gibson BW, Benz CC & Baldwin MA 2009 Systematic mapping of posttranslational modifications in human estrogen receptor-α with emphasis on novel phosphorylation sites. Molecular and Cellular Proteomics 8 467-480. (doi:10.1074/mcp.M800282-MCP200)
    • (2009) Molecular and Cellular Proteomics , vol.8 , pp. 467-480
    • Atsriku, C.1    Britton, D.J.2    Held, J.M.3    Schilling, B.4    Scott, G.K.5    Gibson, B.W.6    Benz, C.C.7    Baldwin, M.A.8
  • 9
    • 0037064150 scopus 로고    scopus 로고
    • Coordinate regulation of transcription and splicing by steroid receptor coregulators
    • doi:10.1126/science.1073734
    • Auboeuf D, Hönig A, Berget SM & O'Malley BW 2002 Coordinate regulation of transcription and splicing by steroid receptor coregulators. Science 298 416-419. (doi:10.1126/science.1073734)
    • (2002) Science , vol.298 , pp. 416-419
    • Auboeuf, D.1    Hönig, A.2    Berget, S.M.3    O'Malley, B.W.4
  • 11
    • 0038688478 scopus 로고    scopus 로고
    • Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases
    • doi:10.1200/JCO.2003.09.099
    • Bardou V, Arpino G, Elledge R, Osborne C & Clark G 2003 Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases. Journal of Clinical Oncology 21 1973-1979. (doi:10.1200/JCO.2003.09. 099)
    • (2003) Journal of Clinical Oncology , vol.21 , pp. 1973-1979
    • Bardou, V.1    Arpino, G.2    Elledge, R.3    Osborne, C.4    Clark, G.5
  • 13
    • 57449120081 scopus 로고    scopus 로고
    • Influence of evolution in tumor biobanking on the interpretation of translational research
    • doi:10.1158/1055-9965.EPI-08-0622
    • Barnes RO, Parisien M, Murphy LC & Watson PH 2008 Influence of evolution in tumor biobanking on the interpretation of translational research. Cancer Epidemiology, Biomarkers and Prevention 17 3344-3350. (doi:10.1158/1055-9965.EPI-08-0622)
    • (2008) Cancer Epidemiology, Biomarkers and Prevention , vol.17 , pp. 3344-3350
    • Barnes, R.O.1    Parisien, M.2    Murphy, L.C.3    Watson, P.H.4
  • 14
    • 77951557127 scopus 로고    scopus 로고
    • Phosphorylation of the mutant K303R estrogen receptor a at serine 305 affects aromatase inhibitor sensitivity
    • doi:10.1038/onc.2009.520
    • Barone I, Iacopetta D, Covington KR, Cui Y, Tsimelzon A, Beyer A, Ando S & Fuqua SA 2010 Phosphorylation of the mutant K303R estrogen receptor a at serine 305 affects aromatase inhibitor sensitivity. Oncogene 29 2404-2414. (doi:10.1038/onc.2009.520)
    • (2010) Oncogene , vol.29 , pp. 2404-2414
    • Barone, I.1    Iacopetta, D.2    Covington, K.R.3    Cui, Y.4    Tsimelzon, A.5    Beyer, A.6    Ando, S.7    Fuqua, S.A.8
  • 15
    • 33646429471 scopus 로고    scopus 로고
    • Activated ERK1/2 and phosphorylated oestrogen receptor α are associated with improved breast cancer survival in women treated with tamoxifen
    • doi:10.1016/j.ejca.2006.01.028
    • Bergqvist J, Elmberger G, Ohd J, Linderholm B, Bjohle J, Hellborg H, Nordgren H, Borg A, Skoog L & Bergh J 2006 Activated ERK1/2 and phosphorylated oestrogen receptor α are associated with improved breast cancer survival in women treated with tamoxifen. European Journal of Cancer 42 1104-1112. (doi:10.1016/j.ejca.2006.01.028)
    • (2006) European Journal of Cancer , vol.42 , pp. 1104-1112
    • Bergqvist, J.1    Elmberger, G.2    Ohd, J.3    Linderholm, B.4    Bjohle, J.5    Hellborg, H.6    Nordgren, H.7    Borg, A.8    Skoog, L.9    Bergh, J.10
  • 16
    • 77649091619 scopus 로고    scopus 로고
    • Estrogen receptor-α phosphorylation at serine 305, nuclear p21-activated kinase 1 expression, and response to tamoxifen in postmenopausal breast cancer
    • doi:10.1158/1078-0432.CCR-09-1733
    • Bostner J, Skoog L, Fornander T, Nordenskjold B & Stal O 2010 Estrogen receptor-α phosphorylation at serine 305, nuclear p21-activated kinase 1 expression, and response to tamoxifen in postmenopausal breast cancer. Clinical Cancer Research 16 1624-1633. (doi:10.1158/1078-0432.CCR-09-1733)
    • (2010) Clinical Cancer Research , vol.16 , pp. 1624-1633
    • Bostner, J.1    Skoog, L.2    Fornander, T.3    Nordenskjold, B.4    Stal, O.5
  • 18
    • 0035971181 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance
    • doi:10.1074/jbc.M010840200
    • Campbell R, Bhat-Nakshatri P, Patel N, Constantinidou D, Ali S & Nakshatri H 2001 Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. Journal of Biological Chemistry 276 9817-9824. (doi:10.1074/jbc.M010840200)
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 9817-9824
    • Campbell, R.1    Bhat-Nakshatri, P.2    Patel, N.3    Constantinidou, D.4    Ali, S.5    Nakshatri, H.6
  • 19
    • 0030884528 scopus 로고    scopus 로고
    • Phosphorylation of serine-167 on the human oestrogen receptor is important for oestrogen response element binding and transcriptional activation
    • Castana E, Vorojeikina D & Notides A 1997 Phosphorylation of serine-167 on the human oestrogen receptor is important for oestrogen response element binding and transcriptional activation. Biochemical Journal 326 149-157.
    • (1997) Biochemical Journal , vol.326 , pp. 149-157
    • Castana, E.1    Vorojeikina, D.2    Notides, A.3
  • 20
    • 0032906876 scopus 로고    scopus 로고
    • Phosphorylation of human estrogen receptor α by protein kinase A regulates dimerization
    • Chen D, Pace P, Coombes R & Ali S 1999 Phosphorylation of human estrogen receptor α by protein kinase A regulates dimerization. Molecular and Cellular Biology 19 1002-1015.
    • (1999) Molecular and Cellular Biology , vol.19 , pp. 1002-1015
    • Chen, D.1    Pace, P.2    Coombes, R.3    Ali, S.4
  • 21
    • 0037173738 scopus 로고    scopus 로고
    • Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera
    • doi:10.1038/sj.onc.1205420
    • Chen D, Washbrook E, Sarwar N, Bates G, Pace P, Thirunuvakkarasu V, Taylor J, Epstein R, Fuller-Pace F, Egly J et al. 2002 Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera. Oncogene 21 4921-4931. (doi:10.1038/sj.onc.1205420)
    • (2002) Oncogene , vol.21 , pp. 4921-4931
    • Chen, D.1    Washbrook, E.2    Sarwar, N.3    Bates, G.4    Pace, P.5    Thirunuvakkarasu, V.6    Taylor, J.7    Epstein, R.8    Fuller-Pace, F.9    Egly, J.10
  • 23
    • 10744230036 scopus 로고    scopus 로고
    • Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling
    • doi:10.1038/sj.onc.1206937
    • Clarke R, Liu M, Bouker K, Gu Z, Lee R, Zhu Y, Skaar T, Gomez B, O'Brien K, Wang Y et al. 2003 Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling. Oncogene 22 7316-7339. (doi:10.1038/sj.onc.1206937)
    • (2003) Oncogene , vol.22 , pp. 7316-7339
    • Clarke, R.1    Liu, M.2    Bouker, K.3    Gu, Z.4    Lee, R.5    Zhu, Y.6    Skaar, T.7    Gomez, B.8    O'Brien, K.9    Wang, Y.10
  • 24
    • 11144231029 scopus 로고    scopus 로고
    • Intermittent hypoxia induces proteasome-dependent down-regulation of estrogen receptor α in human breast carcinoma
    • doi:10.1158/1078-0432.CCR-04-1235
    • Cooper C, Liu G, Niu Y, Santos S, Murphy L & Watson P 2004 Intermittent hypoxia induces proteasome-dependent down-regulation of estrogen receptor α in human breast carcinoma. Clinical Cancer Research 10 8720-8727. (doi:10.1158/1078-0432.CCR-04-1235)
    • (2004) Clinical Cancer Research , vol.10 , pp. 8720-8727
    • Cooper, C.1    Liu, G.2    Niu, Y.3    Santos, S.4    Murphy, L.5    Watson, P.6
  • 25
    • 33645730357 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase in estrogen receptor α-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor a-negative human breast tumors
    • doi:10.1158/0008-5472.CAN-05-4363
    • Creighton CJ, Hilger AM, Murthy S, Rae JM, Chinnaiyan AM & El-Ashry D 2006 Activation of mitogen-activated protein kinase in estrogen receptor α-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor a-negative human breast tumors. Cancer Research 66 3903-3911. (doi:10.1158/0008-5472.CAN-05-4363)
    • (2006) Cancer Research , vol.66 , pp. 3903-3911
    • Creighton, C.J.1    Hilger, A.M.2    Murthy, S.3    Rae, J.M.4    Chinnaiyan, A.M.5    El-Ashry, D.6
  • 26
    • 10844286471 scopus 로고    scopus 로고
    • Phosphorylation of estrogen receptor α blocks its acetylation and regulates estrogen sensitivity
    • doi:10.1158/0008-5472.CAN-04-2126
    • Cui Y, Zhang M, Pestell R, Curran EM, Welshons WV & Fuqua SA 2004 Phosphorylation of estrogen receptor α blocks its acetylation and regulates estrogen sensitivity. Cancer Research 64 9199-9208. (doi:10.1158/0008-5472.CAN-04-2126)
    • (2004) Cancer Research , vol.64 , pp. 9199-9208
    • Cui, Y.1    Zhang, M.2    Pestell, R.3    Curran, E.M.4    Welshons, W.V.5    Fuqua, S.A.6
  • 28
    • 0038648982 scopus 로고    scopus 로고
    • Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: Regulation by phosphorylation sites in the A/B region depends on other receptor domains
    • doi:10.1210/me.2001-0316
    • Dutertre M & Smith C 2003 Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains. Molecular Endocrinology 17 1296-1314. (doi:10.1210/me.2001-0316)
    • (2003) Molecular Endocrinology , vol.17 , pp. 1296-1314
    • Dutertre, M.1    Smith, C.2
  • 29
    • 73549112454 scopus 로고    scopus 로고
    • Is expression or activation of Src kinase associated with cancer-specific survival in ER-, PR- and HER2-negative breast cancer patients?
    • doi:10.2353/ajpath.2009.090273
    • Elsberger B, Tan BA, Mitchell TJ, Brown SB, Mallon EA, Tovey SM, Cooke TG, Brunton VG & Edwards J 2009 Is expression or activation of Src kinase associated with cancer-specific survival in ER-, PR- and HER2-negative breast cancer patients? American Journal of Pathology 175 1389-1397. (doi:10.2353/ajpath.2009.090273)
    • (2009) American Journal of Pathology , vol.175 , pp. 1389-1397
    • Elsberger, B.1    Tan, B.A.2    Mitchell, T.J.3    Brown, S.B.4    Mallon, E.A.5    Tovey, S.M.6    Cooke, T.G.7    Brunton, V.G.8    Edwards, J.9
  • 31
    • 33750316364 scopus 로고    scopus 로고
    • Post-translational modifications of steroid receptors
    • doi:10.1016/j.biopha.2006.07.082
    • Faus H & Haendler B 2006 Post-translational modifications of steroid receptors. Biomedicine and Pharmacotherapy 60 520-528. (doi:10.1016/j.biopha. 2006.07.082)
    • (2006) Biomedicine and Pharmacotherapy , vol.60 , pp. 520-528
    • Faus, H.1    Haendler, B.2
  • 32
    • 0141929385 scopus 로고    scopus 로고
    • Binary switches and modification cassettes in histone biology and beyond
    • DOI 10.1038/nature02017
    • Fischle W, Wang Y & Allis CD 2003 Binary switches and modification cassettes in histone biology and beyond. Nature 425 475-479. (doi:10.1038/nature02017) (Pubitemid 37237036)
    • (2003) Nature , vol.425 , Issue.6957 , pp. 475-479
    • Fischle, W.1    Wang, Y.2    Allis, C.D.3
  • 33
    • 0001392322 scopus 로고    scopus 로고
    • AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor
    • doi:10.1128/MCB.20.14.5041-5047.2000
    • Font de Mora J & Brown M 2000 AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Molecular and Cellular Biology 20 5041-5047. (doi:10.1128/MCB.20.14.5041-5047.2000)
    • (2000) Molecular and Cellular Biology , vol.20 , pp. 5041-5047
    • Font De Mora, J.1    Brown, M.2
  • 34
    • 37449028688 scopus 로고    scopus 로고
    • Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial
    • doi:10.1016/S1470-2045(07)70385-6
    • Forbes JF, Cuzick J, Buzdar A, Howell A, Tobias JS & Baum M 2008 Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncology 9 45-53. (doi:10.1016/S1470-2045(07)70385-6)
    • (2008) Lancet Oncology , vol.9 , pp. 45-53
    • Forbes, J.F.1    Cuzick, J.2    Buzdar, A.3    Howell, A.4    Tobias, J.S.5    Baum, M.6
  • 35
    • 25844468319 scopus 로고    scopus 로고
    • Epidermal growth factor receptor/- HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer
    • doi:10.1677/erc.1.01005
    • Gee J, Robertson J, Gutteridge E, Ellis I, Pinder S, Rubini M & Nicholson R 2005 Epidermal growth factor receptor/- HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer. Endocrine-Related Cancer 12 (Suppl 1) S99-S111. (doi:10.1677/erc.1. 01005)
    • (2005) Endocrine-Related Cancer , vol.12 , Issue.SUPPL. 1
    • Gee, J.1    Robertson, J.2    Gutteridge, E.3    Ellis, I.4    Pinder, S.5    Rubini, M.6    Nicholson, R.7
  • 36
    • 58249084142 scopus 로고    scopus 로고
    • Phosphorylated ERα, HIF-1α, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer
    • doi:10.1200/JCO.2007.13.7083
    • Generali D, Buffa FM, Berruti A, Brizzi MP, Campo L, Bonardi S, Bersiga A, Allevi G, Milani M, Aguggini S et al. 2009 Phosphorylated ERα, HIF-1α, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer. Journal of Clinical Oncology 27 227-234. (doi:10.1200/JCO.2007.13.7083)
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 227-234
    • Generali, D.1    Buffa, F.M.2    Berruti, A.3    Brizzi, M.P.4    Campo, L.5    Bonardi, S.6    Bersiga, A.7    Allevi, G.8    Milani, M.9    Aguggini, S.10
  • 38
    • 34948886577 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 protects estrogen receptor α from proteasomal degradation and is required for full transcriptional activity of the receptor
    • DOI 10.1210/me.2007-0129
    • Grisouard J, Medunjanin S, Hermani A, Shukla A & Mayer D 2007 Glycogen synthase kinase-3 protects estrogen receptor α from proteasomal degradation and is required for full transcriptional activity of the receptor. Molecular Endocrinology 21 2427-2439. (doi:10.1210/me.2007-0129) (Pubitemid 47529356)
    • (2007) Molecular Endocrinology , vol.21 , Issue.10 , pp. 2427-2439
    • Grisouard, J.1    Medunjanin, S.2    Hermani, A.3    Shukla, A.4    Mayer, D.5
  • 40
    • 77950470765 scopus 로고    scopus 로고
    • IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer
    • doi:10.1074/jbc.M109.078212
    • Guo JP, Shu SK, Esposito NN, Coppola D, Koomen JM & Cheng JQ 2010 IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer. Journal of Biological Chemistry 285 3676-3684. (doi:10.1074/jbc.M109.078212)
    • (2010) Journal of Biological Chemistry , vol.285 , pp. 3676-3684
    • Guo, J.P.1    Shu, S.K.2    Esposito, N.N.3    Coppola, D.4    Koomen, J.M.5    Cheng, J.Q.6
  • 41
    • 17844398046 scopus 로고    scopus 로고
    • Molecular changes in tamoxifen-resistant breast cancer: Relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase
    • DOI 10.1200/JCO.2005.01.172
    • Gutierrez MC, Detre S, Johnston S, Mohsin SK, Shou J, Allred DC, Schiff R, Osborne CK & Dowsett M 2005 Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase. Journal of Clinical Oncology 23 2469-2476. (doi:10.1200/JCO.2005.01.172) (Pubitemid 47050837)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.11 , pp. 2469-2476
    • Gutierrez, M.C.1    Detre, S.2    Johnston, S.3    Mohsin, S.K.4    Shou, J.5    Alfred, D.C.6    Schiff, R.7    Osborne, C.K.8    Dowsett, M.9
  • 42
    • 0035813112 scopus 로고    scopus 로고
    • The multifaceted mechanisms of estradiol and estrogen receptor signaling
    • doi:10.1074/jbc.R100029200
    • Hall J, Couse J & Korach K 2001 The multifaceted mechanisms of estradiol and estrogen receptor signaling. Journal of Biological Chemistry 276 36869-36872. (doi:10.1074/jbc.R100029200)
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 36869-36872
    • Hall, J.1    Couse, J.2    Korach, K.3
  • 44
    • 0032896905 scopus 로고    scopus 로고
    • Estrogen receptor status by immunohistochemistry is superior to the ligand binding assay for predicting response to adjuvant endocrine therapy in breast cancer
    • Harvey J, Clark G, Osborne C & Allred D 1999 Estrogen receptor status by immunohistochemistry is superior to the ligand binding assay for predicting response to adjuvant endocrine therapy in breast cancer. Journal of Clinical Oncology 17 1474-1481.
    • (1999) Journal of Clinical Oncology , vol.17 , pp. 1474-1481
    • Harvey, J.1    Clark, G.2    Osborne, C.3    Allred, D.4
  • 45
    • 77951081069 scopus 로고    scopus 로고
    • c-Abl regulates estrogen receptor alpha transcription activity through its stabilization by phosphorylation
    • doi:10.1038/onc.2009.513
    • He X, Zheng Z, Song T, Wei C, Ma H, Ma Q, Zhang Y, Xu Y, Shi W, Ye Q et al. 2010 c-Abl regulates estrogen receptor alpha transcription activity through its stabilization by phosphorylation. Oncogene 29 2238-2251. (doi:10.1038/onc.2009.513)
    • (2010) Oncogene , vol.29 , pp. 2238-2251
    • He, X.1    Zheng, Z.2    Song, T.3    Wei, C.4    Ma, H.5    Ma, Q.6    Zhang, Y.7    Xu, Y.8    Shi, W.9    Ye, Q.10
  • 47
    • 49249129393 scopus 로고    scopus 로고
    • Clinical importance of estrogen receptor-β evaluation in breast cancer patients treated with adjuvant tamoxifen therapy
    • doi:10.1200/JCO.2007.14.2968
    • Honma N, Horii R, Iwase T, Saji S, Younes M, Takubo K, Matsuura M, Ito Y, Akiyama F & Sakamoto G 2008 Clinical importance of estrogen receptor-β evaluation in breast cancer patients treated with adjuvant tamoxifen therapy. Journal of Clinical Oncology 26 3727-3734. (doi:10.1200/JCO.2007.14.2968)
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 3727-3734
    • Honma, N.1    Horii, R.2    Iwase, T.3    Saji, S.4    Younes, M.5    Takubo, K.6    Matsuura, M.7    Ito, Y.8    Akiyama, F.9    Sakamoto, G.10
  • 48
    • 0037501319 scopus 로고    scopus 로고
    • The estrogen receptor: A model for molecular medicine
    • Jensen E & Jordan V 2003 The estrogen receptor: a model for molecular medicine. Clinical Cancer Research 9 1980-1989.
    • (2003) Clinical Cancer Research , vol.9 , pp. 1980-1989
    • Jensen, E.1    Jordan, V.2
  • 49
    • 35348904493 scopus 로고    scopus 로고
    • Phosphorylation of estrogen receptor-α at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients
    • doi:10.1158/1078-0432.CCR-07-0822
    • Jiang J, Sarwar N, Peston D, Kulinskaya E, Shousha S, Coombes R & Ali S 2007 Phosphorylation of estrogen receptor-α at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients. Clinical Cancer Research 13 5769-5776. (doi:10.1158/1078-0432.CCR-07-0822)
    • (2007) Clinical Cancer Research , vol.13 , pp. 5769-5776
    • Jiang, J.1    Sarwar, N.2    Peston, D.3    Kulinskaya, E.4    Shousha, S.5    Coombes, R.6    Ali, S.7
  • 51
    • 0037420201 scopus 로고    scopus 로고
    • Is tamoxifen the Rosetta stone for breast cancer?
    • doi:10.1093/jnci/95.5.338
    • Jordan V 2003 Is tamoxifen the Rosetta stone for breast cancer? Journal of the National Cancer Institute 95 338-340. (doi:10.1093/jnci/95.5.338)
    • (2003) Journal of the National Cancer Institute , vol.95 , pp. 338-340
    • Jordan, V.1
  • 53
    • 26044443105 scopus 로고    scopus 로고
    • AKT activation predicts outcome in breast cancer patients treated with tamoxifen
    • doi:10.1002/path.1829
    • Kirkegaard T, Witton C, McGlynn L, Tovey S, Dunne B, Lyon A & Bartlett J 2005 AKT activation predicts outcome in breast cancer patients treated with tamoxifen. Journal of Pathology 207 139-146. (doi:10.1002/path. 1829)
    • (2005) Journal of Pathology , vol.207 , pp. 139-146
    • Kirkegaard, T.1    Witton, C.2    McGlynn, L.3    Tovey, S.4    Dunne, B.5    Lyon, A.6    Bartlett, J.7
  • 54
    • 0037373326 scopus 로고    scopus 로고
    • Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    • doi:10.1210/en.2002-220620
    • Knowlden J, Hutcheson I, Jones H, Madden T, Gee J, Harper M, Barrow D, Wakeling A & Nicholson R 2003 Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 144 1032-1044. (doi:10.1210/en.2002-220620)
    • (2003) Endocrinology , vol.144 , pp. 1032-1044
    • Knowlden, J.1    Hutcheson, I.2    Jones, H.3    Madden, T.4    Gee, J.5    Harper, M.6    Barrow, D.7    Wakeling, A.8    Nicholson, R.9
  • 56
    • 78651089973 scopus 로고    scopus 로고
    • PKA-induced phosphorylation of ERalpha at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer
    • doi:10.1007/s10549-010-0798-y
    • Kok M, Zwart W, Holm C, Fles R, Hauptmann M, Van't Veer LJ, Wessels LF, Neefjes J, Stal O, Linn SC et al. 2010 PKA-induced phosphorylation of ERalpha at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer. Breast Cancer Research and Treatment 125 1-12. (doi:10.1007/s10549-010-0798-y)
    • (2010) Breast Cancer Research and Treatment , vol.125 , pp. 1-12
    • Kok, M.1    Zwart, W.2    Holm, C.3    Fles, R.4    Hauptmann, M.5    Van't Veer, L.J.6    Wessels, L.F.7    Neefjes, J.8    Stal, O.9    Linn, S.C.10
  • 57
    • 5644271449 scopus 로고    scopus 로고
    • Protein kinase C alpha expression in breast and ovarian cancer
    • doi:10.1159/000080279
    • Lahn M, Kohler G, Sundell K, Su C, Li S, Paterson BM & Bumol TF 2004 Protein kinase C alpha expression in breast and ovarian cancer. Oncology 67 1-10. (doi:10.1159/000080279)
    • (2004) Oncology , vol.67 , pp. 1-10
    • Lahn, M.1    Kohler, G.2    Sundell, K.3    Su, C.4    Li, S.5    Paterson, B.M.6    Bumol, T.F.7
  • 59
    • 0037211754 scopus 로고    scopus 로고
    • Estrogen receptor phosphorylation
    • doi:10.1016/S0039-128X(02)00110-1
    • Lannigan D 2003 Estrogen receptor phosphorylation. Steroids 68 1-9. (doi:10.1016/S0039-128X(02)00110-1)
    • (2003) Steroids , vol.68 , pp. 1-9
    • Lannigan, D.1
  • 60
    • 0036318571 scopus 로고    scopus 로고
    • Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation
    • doi:10.1128/MCB.22.16.5835-5845.2002
    • Lee H & BaiW2002 Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation. Molecular and Cellular Biology 22 5835-5845. (doi:10.1128/MCB.22.16.5835-5845.2002)
    • (2002) Molecular and Cellular Biology , vol.22 , pp. 5835-5845
    • Lee, H.1    Bai, W.2
  • 61
    • 0028111526 scopus 로고
    • Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity
    • Le Goff P, Montano MM, Schodin DJ & Katzenellenbogen BS 1994 Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity. Journal of Biological Chemistry 269 4458-4466.
    • (1994) Journal of Biological Chemistry , vol.269 , pp. 4458-4466
    • Le Goff, P.1    Montano, M.M.2    Schodin, D.J.3    Katzenellenbogen, B.S.4
  • 62
    • 0032145441 scopus 로고    scopus 로고
    • Altered estrogen receptor α and β messenger RNA expression during human breast tumorigenesis
    • Leygue E, Dotzlaw H, Watson P & Murphy L 1998 Altered estrogen receptor α and β mRNAexpression during human breast tumorigenesis. Cancer Research 58 3197-3201. (Pubitemid 28371051)
    • (1998) Cancer Research , vol.58 , Issue.15 , pp. 3197-3201
    • Leygue, E.1    Dotzlaw, H.2    Watson, P.H.3    Murphy, L.C.4
  • 63
    • 33751552134 scopus 로고    scopus 로고
    • Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity
    • doi:10.1210/me.2006-0068
    • Likhite VS, Stossi F, Kim K, Katzenellenbogen BS & Katzenellenbogen JA 2006 Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity. Molecular Endocrinology 20 3120-3132. (doi:10.1210/me.2006-0068)
    • (2006) Molecular Endocrinology , vol.20 , pp. 3120-3132
    • Likhite, V.S.1    Stossi, F.2    Kim, K.3    Katzenellenbogen, B.S.4    Katzenellenbogen, J.A.5
  • 64
    • 37249006717 scopus 로고    scopus 로고
    • The dynamics of estrogen receptor status in breast cancer: Re-shaping the paradigm
    • doi:10.1158/1078-0432.CCR-07-1399
    • Lopez-Tarruella S & Schiff R 2007 The dynamics of estrogen receptor status in breast cancer: re-shaping the paradigm. Clinical Cancer Research 13 6921-6925. (doi:10.1158/1078-0432.CCR-07-1399)
    • (2007) Clinical Cancer Research , vol.13 , pp. 6921-6925
    • Lopez-Tarruella, S.1    Schiff, R.2
  • 66
    • 0033305547 scopus 로고    scopus 로고
    • Nuclear receptor coregulators: Cellular and molecular biology
    • doi:10.1210/er.20.3.321
    • McKenna N, Lanz R & O'Malley B 1999 Nuclear receptor coregulators: cellular and molecular biology. Endocrine Reviews 20 321-344. (doi:10.1210/er.20.3.321)
    • (1999) Endocrine Reviews , vol.20 , pp. 321-344
    • McKenna, N.1    Lanz, R.2    O'Malley, B.3
  • 67
    • 25444468111 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor α and is involved in the regulation of receptor activity
    • doi:10.1074/jbc.M506758200
    • Medunjanin S, Hermani A, Servi BD, Grisouard J, Rincke G & Mayer D 2005 Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor α and is involved in the regulation of receptor activity. Journal of Biological Chemistry 280 33006-33014. (doi:10.1074/jbc.M506758200)
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 33006-33014
    • Medunjanin, S.1    Hermani, A.2    Servi, B.D.3    Grisouard, J.4    Rincke, G.5    Mayer, D.6
  • 68
    • 77951746652 scopus 로고    scopus 로고
    • Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-α
    • doi:10.1091/mbc.E09-08-0724
    • Medunjanin S, Weinert S, Schmeisser A, Mayer D & Braun-Dullaeus RC 2010 Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-α. Molecular Biology of the Cell 21 1620-1628. (doi:10.1091/mbc.E09-08-0724)
    • (2010) Molecular Biology of the Cell , vol.21 , pp. 1620-1628
    • Medunjanin, S.1    Weinert, S.2    Schmeisser, A.3    Mayer, D.4    Braun-Dullaeus, R.C.5
  • 70
    • 0027220462 scopus 로고
    • Tumour cyclic AMP binding proteins: An independent prognostic factor for disease recurrence and survival in breast cancer
    • doi:10.1007/BF00682703
    • Miller WR, Watson DM, Jack W, Chetty U & Elton RA 1993 Tumour cyclic AMP binding proteins: an independent prognostic factor for disease recurrence and survival in breast cancer. Breast Cancer Research and Treatment 26 89-94. (doi:10.1007/BF00682703)
    • (1993) Breast Cancer Research and Treatment , vol.26 , pp. 89-94
    • Miller, W.R.1    Watson, D.M.2    Jack, W.3    Chetty, U.4    Elton, R.A.5
  • 71
    • 11144245919 scopus 로고    scopus 로고
    • Early nuclear alterations and immunohistochemical expression of Ki-67, Erb-B2, vascular endothelial growth factor (VEGF), transforming growth factor (TGF-beta1) and integrine-linked kinase (ILK) two days after tamoxifen in breast carcinoma
    • Morena AM, Oshima CT, Gebrim LH, Egami MI, Silva MR, Segreto RA, Giannotti Filho O, Teixeira VP & Segreto HR 2004 Early nuclear alterations and immunohistochemical expression of Ki-67, Erb-B2, vascular endothelial growth factor (VEGF), transforming growth factor (TGF-beta1) and integrine-linked kinase (ILK) two days after tamoxifen in breast carcinoma. Neoplasma 51 481-486.
    • (2004) Neoplasma , vol.51 , pp. 481-486
    • Morena, A.M.1    Oshima, C.T.2    Gebrim, L.H.3    Egami, M.I.4    Silva, M.R.5    Segreto, R.A.6    Giannotti Filho, O.7    Teixeira, V.P.8    Segreto, H.R.9
  • 72
    • 33745111199 scopus 로고    scopus 로고
    • Is oestrogen receptor-β a predictor of endocrine therapy responsiveness in human breast cancer?
    • doi:10.1677/erc.1.01141
    • Murphy L & Watson P 2006 Is oestrogen receptor-β a predictor of endocrine therapy responsiveness in human breast cancer? Endocrine-Related Cancer 13 327-334. (doi:10.1677/erc.1.01141)
    • (2006) Endocrine-Related Cancer , vol.13 , pp. 327-334
    • Murphy, L.1    Watson, P.2
  • 73
    • 0348107410 scopus 로고    scopus 로고
    • New insights into estogen receptor function in human breast cancer
    • doi:10.1080/07853890310014579
    • Murphy L, Cherlet T, Lewis A, Banu Y & Watson P 2003 New insights into estogen receptor function in human breast cancer. Annals of Medicine 35 614-631. (doi:10.1080/07853890310014579)
    • (2003) Annals of Medicine , vol.35 , pp. 614-631
    • Murphy, L.1    Cherlet, T.2    Lewis, A.3    Banu, Y.4    Watson, P.5
  • 74
    • 4444324186 scopus 로고    scopus 로고
    • Phospho-Serine-118 estrogen receptor-α expression in primary human breast tumors in vivo is associated with better disease outcome in women treated with tamoxifen
    • doi:10.1158/1078-0432.CCR-04-0191
    • Murphy L, Niu Y, Snell L & Watson P 2004a Phospho-Serine-118 estrogen receptor-α expression in primary human breast tumors in vivo is associated with better disease outcome in women treated with tamoxifen. Clinical Cancer Research 10 5902-5906. (doi:10.1158/1078-0432.CCR-04-0191)
    • (2004) Clinical Cancer Research , vol.10 , pp. 5902-5906
    • Murphy, L.1    Niu, Y.2    Snell, L.3    Watson, P.4
  • 75
    • 1642387680 scopus 로고    scopus 로고
    • Phospho-Serine-118 estrogen receptor-α detection in human breast tumors in vivo
    • doi:10.1158/1078-0432.CCR-03-0112
    • Murphy LC, Cherlet T, Adeyinka A, Niu Y, Snell L & Watson P 2004b Phospho-Serine-118 estrogen receptor-α detection in human breast tumors in vivo. Clinical Cancer Research 10 1354-1359. (doi:10.1158/1078-0432.CCR-03- 0112)
    • (2004) Clinical Cancer Research , vol.10 , pp. 1354-1359
    • Murphy, L.C.1    Cherlet, T.2    Adeyinka, A.3    Niu, Y.4    Snell, L.5    Watson, P.6
  • 78
    • 1542297619 scopus 로고    scopus 로고
    • Urban renewal in the nucleus: Is protein turnover by proteasomes absolutely required for nuclear receptor regulated transcription?
    • doi:10.1210/me.2003-0388
    • Nawaz Z & O'Malley B 2004 Urban renewal in the nucleus: is protein turnover by proteasomes absolutely required for nuclear receptor regulated transcription? Molecular Endocrinology 18 493-499. (doi:10.1210/me.2003-0388)
    • (2004) Molecular Endocrinology , vol.18 , pp. 493-499
    • Nawaz, Z.1    O'Malley, B.2
  • 79
    • 0032423729 scopus 로고    scopus 로고
    • Steroid hormone receptors in breast cancer management
    • doi:10.1023/A:1006132427948
    • Osborne C 1998 Steroid hormone receptors in breast cancer management. Breast Cancer Research and Treatment 51 227-238. (doi:10.1023/A:1006132427948)
    • (1998) Breast Cancer Research and Treatment , vol.51 , pp. 227-238
    • Osborne, C.1
  • 81
    • 12144269500 scopus 로고    scopus 로고
    • Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer
    • Osborne C, Shou J, Massarweh S & Schiff R 2005 Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer. Clinical Cancer Research 11 865s-870s.
    • (2005) Clinical Cancer Research , vol.11
    • Osborne, C.1    Shou, J.2    Massarweh, S.3    Schiff, R.4
  • 82
    • 15944379896 scopus 로고    scopus 로고
    • Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation
    • doi:10.1016/j.molcel.2005.03.006
    • Park K, Krishnan V, O'Malley B, Yamamoto Y & Gaynor R 2005 Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. Molecular Cell 18 71-82. (doi:10.1016/j. molcel.2005.03.006)
    • (2005) Molecular Cell , vol.18 , pp. 71-82
    • Park, K.1    Krishnan, V.2    O'Malley, B.3    Yamamoto, Y.4    Gaynor, R.5
  • 84
    • 77955927946 scopus 로고    scopus 로고
    • Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance
    • doi:10.1038/onc.2010.209
    • Plaza-Menacho I, Morandi A, Robertson D, Pancholi S, Drury S, Dowsett M, Martin LA & Isacke CM 2010 Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance. Oncogene 29 4648-4657. (doi:10.1038/onc.2010.209)
    • (2010) Oncogene , vol.29 , pp. 4648-4657
    • Plaza-Menacho, I.1    Morandi, A.2    Robertson, D.3    Pancholi, S.4    Drury, S.5    Dowsett, M.6    Martin, L.A.7    Isacke, C.M.8
  • 85
    • 40449130327 scopus 로고    scopus 로고
    • Oncogene-mediated inhibition of glycogen synthase kinase 3 beta impairs degradation of prolactin receptor
    • doi:10.1158/0008-5472.CAN-07-6094
    • Plotnikov A, Li Y, Tran TH, Tang W, Palazzo JP, Rui H & Fuchs SY 2008 Oncogene-mediated inhibition of glycogen synthase kinase 3 beta impairs degradation of prolactin receptor. Cancer Research 68 1354-1361. (doi:10.1158/0008-5472.CAN-07-6094)
    • (2008) Cancer Research , vol.68 , pp. 1354-1361
    • Plotnikov, A.1    Li, Y.2    Tran, T.H.3    Tang, W.4    Palazzo, J.P.5    Rui, H.6    Fuchs, S.Y.7
  • 86
    • 32944473985 scopus 로고    scopus 로고
    • P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation
    • doi:10.1158/0008-5472.CAN-05-2922
    • Rayala SK, Talukder AH, Balasenthil S, Tharakan R, Barnes CJ, Wang RA, Aldaz CM, Khan S & Kumar R 2006 P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. Cancer Research 66 1694-1701. (doi:10.1158/0008- 5472.CAN-05-2922)
    • (2006) Cancer Research , vol.66 , pp. 1694-1701
    • Rayala, S.K.1    Talukder, A.H.2    Balasenthil, S.3    Tharakan, R.4    Barnes, C.J.5    Wang, R.A.6    Aldaz, C.M.7    Khan, S.8    Kumar, R.9
  • 87
    • 0037351881 scopus 로고    scopus 로고
    • Cyclic, proteasome-mediated turnover of unliganded and liganded ERα on responsive promoters is an integral feature of estrogen signaling
    • doi:10.1016/S1097-2765(03)00090-X
    • Reid G, Hubner M, Metivier R, Brand H, Denger S, Manu D, Beaudouin J, Ellenberg J & Gannon F 2003 Cyclic, proteasome-mediated turnover of unliganded and liganded ERα on responsive promoters is an integral feature of estrogen signaling. Molecular Cell 11 695-707. (doi:10.1016/S1097-2765(03) 00090-X)
    • (2003) Molecular Cell , vol.11 , pp. 695-707
    • Reid, G.1    Hubner, M.2    Metivier, R.3    Brand, H.4    Denger, S.5    Manu, D.6    Beaudouin, J.7    Ellenberg, J.8    Gannon, F.9
  • 88
    • 0030028024 scopus 로고    scopus 로고
    • Oestrogen receptor: A stable phenotype in breast cancer
    • Robertson J 1996 Oestrogen receptor: a stable phenotype in breast cancer. British Journal of Cancer 73 5-12.
    • (1996) British Journal of Cancer , vol.73 , pp. 5-12
    • Robertson, J.1
  • 89
    • 0036194272 scopus 로고    scopus 로고
    • Estrogen receptor downregulators: New antihormonal therapy for advanced breast cancer
    • doi:10.1016/S0149-2918(02)85032-9
    • Robertson J 2002 Estrogen receptor downregulators: new antihormonal therapy for advanced breast cancer. Clinical Therapeutics 24 (Suppl A) A17-A30. (doi:10.1016/S0149-2918(02)85032-9)
    • (2002) Clinical Therapeutics , vol.24 , Issue.SUPPL. A
    • Robertson, J.1
  • 90
    • 0033529557 scopus 로고    scopus 로고
    • Potentiation of human estrogen receptor α transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex
    • doi:10.1074/jbc.274.32.22296
    • Rogatsky I, Trowbridge J & Garabedian M 1999 Potentiation of human estrogen receptor α transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex. Journal of Biological Chemistry 274 22296-22302. (doi:10.1074/jbc.274.32.22296)
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 22296-22302
    • Rogatsky, I.1    Trowbridge, J.2    Garabedian, M.3
  • 92
    • 9144270449 scopus 로고    scopus 로고
    • Adaptive hypersensitivity to estrogen: Mechanism for sequential responses to hormonal therapy in breast cancer
    • doi:10.1158/1078-0432.CCR-031207
    • Santen R, Song R, Zhang Z, Yue W & Kumar R 2004 Adaptive hypersensitivity to estrogen: mechanism for sequential responses to hormonal therapy in breast cancer. Clinical Cancer Research 10 337S-345S. (doi:10.1158/1078-0432.CCR-031207)
    • (2004) Clinical Cancer Research , vol.10
    • Santen, R.1    Song, R.2    Zhang, Z.3    Yue, W.4    Kumar, R.5
  • 93
    • 63649117164 scopus 로고    scopus 로고
    • Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells
    • doi:10.1016/j.steroids.2008.11.020
    • Santen RJ, Fan P, Zhang Z, Bao Y, Song RX & Yue W 2009 Estrogen signals via an extra-nuclear pathway involving IGF-1R and EGFR in tamoxifen-sensitive and -resistant breast cancer cells. Steroids 74 586-594. (doi:10.1016/j.steroids.2008.11.020)
    • (2009) Steroids , vol.74 , pp. 586-594
    • Santen, R.J.1    Fan, P.2    Zhang, Z.3    Bao, Y.4    Song, R.X.5    Yue, W.6
  • 94
    • 33751101625 scopus 로고    scopus 로고
    • Phosphorylation of ERα at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERα phosphorylation in breast cancer progression
    • doi:10.1677/erc.1.01123
    • Sarwar N, Kim J, Jiang J, Peston D, Sinnett H, Madden P, Gee J, Nicholson R, Lykkesfeldt A, Shousha S et al. 2006 Phosphorylation of ERα at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERα phosphorylation in breast cancer progression. Endocrine-Related Cancer 13 851-861. (doi:10.1677/erc.1.01123)
    • (2006) Endocrine-Related Cancer , vol.13 , pp. 851-861
    • Sarwar, N.1    Kim, J.2    Jiang, J.3    Peston, D.4    Sinnett, H.5    Madden, P.6    Gee, J.7    Nicholson, R.8    Lykkesfeldt, A.9    Shousha, S.10
  • 95
    • 9144256614 scopus 로고    scopus 로고
    • Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance
    • doi:10.1158/1078-0432.CCR-031212
    • Schiff R, Massarweh S, Shou J, Bharwani L, Mohsin S & Osborne C 2004 Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance. Clinical Cancer Research 10 331S-336S. (doi:10.1158/1078-0432.CCR-031212)
    • (2004) Clinical Cancer Research , vol.10
    • Schiff, R.1    Massarweh, S.2    Shou, J.3    Bharwani, L.4    Mohsin, S.5    Osborne, C.6
  • 96
    • 14844325297 scopus 로고    scopus 로고
    • The Src kinase pathway promotes tamoxifen agonist action in Ishikawa endometrial cells through phosphorylation-dependent stabilization of estrogen receptor (alpha) promoter interaction and elevated steroid receptor coactivator 1 activity
    • doi:10.1210/me.2004-0298
    • Shah Y & Rowan B 2005 The Src kinase pathway promotes tamoxifen agonist action in Ishikawa endometrial cells through phosphorylation-dependent stabilization of estrogen receptor (alpha) promoter interaction and elevated steroid receptor coactivator 1 activity. Molecular Endocrinology 19 732-748. (doi:10.1210/me.2004-0298)
    • (2005) Molecular Endocrinology , vol.19 , pp. 732-748
    • Shah, Y.1    Rowan, B.2
  • 97
    • 52449132322 scopus 로고    scopus 로고
    • Is there a code embedded in proteins that is based on post-translational modifications? Nature Reviews
    • doi:10.1038/nrm2502
    • Sims RJ III & Reinberg D 2008 Is there a code embedded in proteins that is based on post-translational modifications? Nature Reviews. Molecular Cell Biology 9 815-820. (doi:10.1038/nrm2502)
    • (2008) Molecular Cell Biology , vol.9 , pp. 815-820
    • Sims III, R.J.1    Reinberg, D.2
  • 98
    • 33748305646 scopus 로고    scopus 로고
    • Expression of oestrogen receptor-β in oestrogen receptor-α negative human breast tumours
    • doi:10.1038/sj.bjc.6603295
    • Skliris G, Leygue E, Curtis-Snell L, Watson P&Murphy L 2006 Expression of oestrogen receptor-β in oestrogen receptor-α negative human breast tumours. British Journal ofCancer 95 616-626. (doi:10.1038/sj.bjc. 6603295)
    • (2006) British Journal OfCancer , vol.95 , pp. 616-626
    • Skliris, G.1    Leygue, E.2    Curtis-Snell, L.3    Watson, P.4    Murphy, L.5
  • 99
    • 70449587245 scopus 로고    scopus 로고
    • Immunohistochemical validation of multiple phospho-specific epitopes for estrogen receptor α (ERα) in tissue microarrays of ERα positive human breast carcinomas
    • doi:10.1007/s10549-008-0267-z
    • Skliris GP, Rowan BG, Al-Dhaheri M, Williams C, Troup S, Begic S, Parisien M, Watson PH & Murphy LC 2009 Immunohistochemical validation of multiple phospho-specific epitopes for estrogen receptor α (ERα) in tissue microarrays of ERα positive human breast carcinomas. Breast Cancer Research and Treatment 118 443-453. (doi:10.1007/s10549-008-0267-z)
    • (2009) Breast Cancer Research and Treatment , vol.118 , pp. 443-453
    • Skliris, G.P.1    Rowan, B.G.2    Al-Dhaheri, M.3    Williams, C.4    Troup, S.5    Begic, S.6    Parisien, M.7    Watson, P.H.8    Murphy, L.C.9
  • 100
    • 77956205328 scopus 로고    scopus 로고
    • A phosphorylation code for oestrogen receptor-α predicts clinical outcome to endocrine therapy in breast cancer
    • doi:10.1677/ERC-10-0030
    • Skliris GP, Nugent ZJ, Rowan BG, Penner CR, Watson PH & Murphy LC 2010 A phosphorylation code for oestrogen receptor-α predicts clinical outcome to endocrine therapy in breast cancer. Endocrine-Related Cancer 17 589-597. (doi:10.1677/ERC-10-0030)
    • (2010) Endocrine-Related Cancer , vol.17 , pp. 589-597
    • Skliris, G.P.1    Nugent, Z.J.2    Rowan, B.G.3    Penner, C.R.4    Watson, P.H.5    Murphy, L.C.6
  • 102
    • 54849437262 scopus 로고    scopus 로고
    • Phosphorylation of estrogen receptor alpha, serine residue 305 enhances activity
    • doi:10.1016/j.mce.2008.07.018
    • Tharakan R, Lepont P, Singleton D, Kumar R & Khan S 2008 Phosphorylation of estrogen receptor alpha, serine residue 305 enhances activity. Molecular and Cellular Endocrinology 295 70-78. (doi:10.1016/j.mce. 2008.07.018)
    • (2008) Molecular and Cellular Endocrinology , vol.295 , pp. 70-78
    • Tharakan, R.1    Lepont, P.2    Singleton, D.3    Kumar, R.4    Khan, S.5
  • 103
    • 42549131382 scopus 로고    scopus 로고
    • Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity
    • doi:10.1677/JME-07-0165
    • Thomas RS, Sarwar N, Phoenix F, Coombes RC & Ali S 2008 Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity. Journal of Molecular Endocrinology 40 173-184. (doi:10.1677/JME-07-0165)
    • (2008) Journal of Molecular Endocrinology , vol.40 , pp. 173-184
    • Thomas, R.S.1    Sarwar, N.2    Phoenix, F.3    Coombes, R.C.4    Ali, S.5
  • 104
    • 20844453021 scopus 로고    scopus 로고
    • Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor α N terminus
    • doi:10.1128/MCB.25.13.5417-5428.2005
    • Valley C, Metivier R, Solodin N, Fowler A, Mashek M, Hill L & Alarid E 2005 Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor α N terminus. Molecular and Cellular Biology 25 5417-5428. (doi:10.1128/MCB.25.13.5417-5428.2005)
    • (2005) Molecular and Cellular Biology , vol.25 , pp. 5417-5428
    • Valley, C.1    Metivier, R.2    Solodin, N.3    Fowler, A.4    Mashek, M.5    Hill, L.6    Alarid, E.7
  • 106
    • 0037107380 scopus 로고    scopus 로고
    • P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium
    • doi:10.1093/emboj/cdf543
    • Wang RA, Mazumdar A, Vadlamudi RK & Kumar R 2002 P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium. EMBO Journal 21 5437-5447. (doi:10.1093/emboj/cdf543)
    • (2002) EMBO Journal , vol.21 , pp. 5437-5447
    • Wang, R.A.1    Mazumdar, A.2    Vadlamudi, R.K.3    Kumar, R.4
  • 108
    • 73349085238 scopus 로고    scopus 로고
    • Steroid receptor phosphorylation: Assigning function to site-specific phosphorylation
    • doi:10.1002/biof.66
    • Ward RD & Weigel NL 2009 Steroid receptor phosphorylation: assigning function to site-specific phosphorylation. Biofactors 35 528-536. (doi:10.1002/biof.66)
    • (2009) Biofactors , vol.35 , pp. 528-536
    • Ward, R.D.1    Weigel, N.L.2
  • 109
    • 34948900221 scopus 로고    scopus 로고
    • Steroid receptor phosphorylation: A key modulator of multiple receptor functions
    • doi:10.1210/me.2007-0101
    • Weigel N & Moore N 2007 Steroid receptor phosphorylation: a key modulator of multiple receptor functions. Molecular Endocrinology 21 2311-2319. (doi:10.1210/me.2007-0101)
    • (2007) Molecular Endocrinology , vol.21 , pp. 2311-2319
    • Weigel, N.1    Moore, N.2
  • 110
    • 0030445855 scopus 로고    scopus 로고
    • Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein
    • doi:10.1210/me.10.11.1388
    • Weis K, Ekena K, Thomas J, Lazennec G & Katzenellenbogen B 1996 Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein. Molecular Endocrinology 10 1388-1398. (doi:10.1210/me.10.11.1388)
    • (1996) Molecular Endocrinology , vol.10 , pp. 1388-1398
    • Weis, K.1    Ekena, K.2    Thomas, J.3    Lazennec, G.4    Katzenellenbogen, B.5
  • 111
    • 33750552134 scopus 로고    scopus 로고
    • Estrogen receptor-α phosphorylated at Serine 118 is present at the promoters of estrogen-regulated genes and is not altered due to Her2 over-expression
    • doi:10.1158/0008-5472.CAN-05-4111
    • Weitsman G, Li L, Skliris G, Davie J, Ung K, Curtis-Snell L, Tomes L, Watson P & Murphy L 2006 Estrogen receptor-α phosphorylated at Serine 118 is present at the promoters of estrogen-regulated genes and is not altered due to Her2 over-expression. Cancer Research 66 10162-10170. (doi:10.1158/0008-5472.CAN-05-4111)
    • (2006) Cancer Research , vol.66 , pp. 10162-10170
    • Weitsman, G.1    Li, L.2    Skliris, G.3    Davie, J.4    Ung, K.5    Curtis-Snell, L.6    Tomes, L.7    Watson, P.8    Murphy, L.9
  • 112
    • 77950860642 scopus 로고    scopus 로고
    • S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer
    • doi:10.1038/onc.2009.488
    • West NR & Watson PH 2010 S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer. Oncogene 29 2083-2092. (doi:10.1038/onc.2009.488)
    • (2010) Oncogene , vol.29 , pp. 2083-2092
    • West, N.R.1    Watson, P.H.2
  • 113
    • 62949124364 scopus 로고    scopus 로고
    • Identification of four novel phosphorylation sites in estrogen receptor α: Impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2
    • Toronto, Canada
    • Williams C, Smith CL & Rowan BG 2007 Identification of four novel phosphorylation sites in estrogen receptor α: impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2. In The Endocrine Society's 89th Annual Meeting, pp P2-P258. Toronto, Canada.
    • (2007) The Endocrine Society's 89th Annual Meeting
    • Williams, C.1    Smith, C.L.2    Rowan, B.G.3
  • 114
    • 76149105148 scopus 로고    scopus 로고
    • Identification of four novel phosphorylation sites in estrogen receptor α: Impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2
    • doi:10.1186/1471-2091-10-36
    • Williams CC, Basu A, El-Gharbawy A, Carrier LM, Smith CL & Rowan BG 2009 Identification of four novel phosphorylation sites in estrogen receptor α: impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2. BMC Biochemistry 10 36. (doi:10.1186/1471-2091-10-36)
    • (2009) BMC Biochemistry , vol.10 , pp. 36
    • Williams, C.C.1    Basu, A.2    El-Gharbawy, A.3    Carrier, L.M.4    Smith, C.L.5    Rowan, B.G.6
  • 115
    • 33644873967 scopus 로고    scopus 로고
    • Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer
    • doi:10.1186/bcr1285
    • Yamashita H, Nishio M, Kobayashi S, Ando Y, Sugiura H, Zhang Z, Hamaguchi M, Mita K, Fujii Y & Iwase H 2005 Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer. Breast Cancer Research 7 R753-R764. (doi:10.1186/bcr1285)
    • (2005) Breast Cancer Research , vol.7
    • Yamashita, H.1    Nishio, M.2    Kobayashi, S.3    Ando, Y.4    Sugiura, H.5    Zhang, Z.6    Hamaguchi, M.7    Mita, K.8    Fujii, Y.9    Iwase, H.10
  • 116
    • 50249163362 scopus 로고    scopus 로고
    • Low phosphorylation of estrogen receptor α (ERα) serine 118 and high phosphorylation of ERα serine 167 improve survival in ER-positive breast cancer
    • doi:10.1677/ERC-08-0078
    • Yamashita H, Nishio M, Toyama T, Sugiura H, Kondo N, Kobayashi S, Fuji Y & Iwase H 2008 Low phosphorylation of estrogen receptor α (ERα) serine 118 and high phosphorylation of ERα serine 167 improve survival in ER-positive breast cancer. Endocrine-Related Cancer 15 755-763. (doi:10.1677/ERC-08-0078)
    • (2008) Endocrine-Related Cancer , vol.15 , pp. 755-763
    • Yamashita, H.1    Nishio, M.2    Toyama, T.3    Sugiura, H.4    Kondo, N.5    Kobayashi, S.6    Fuji, Y.7    Iwase, H.8
  • 117
    • 71049159605 scopus 로고    scopus 로고
    • Predictors of response to exemestane as primary endocrine therapy in estrogen receptor-positive breast cancer
    • doi:10.1111/j.1349-7006.2009.01274.x
    • Yamashita H, Takahashi S, Ito Y, Yamashita T, Ando Y, Toyama T, Sugiura H, Yoshimoto N, Kobayashi S, Fujii Y et al. 2009 Predictors of response to exemestane as primary endocrine therapy in estrogen receptor-positive breast cancer. Cancer Science 100 2028-2033. (doi:10.1111/j.1349-7006.2009.01274.x)
    • (2009) Cancer Science , vol.100 , pp. 2028-2033
    • Yamashita, H.1    Takahashi, S.2    Ito, Y.3    Yamashita, T.4    Ando, Y.5    Toyama, T.6    Sugiura, H.7    Yoshimoto, N.8    Kobayashi, S.9    Fujii, Y.10
  • 118
    • 65249190250 scopus 로고    scopus 로고
    • S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation
    • doi:10.1074/jbc.M807532200
    • Yamnik RL, Digilova A, Davis DC, Brodt ZN, Murphy CJ & Holz MK 2009 S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation. Journal of Biological Chemistry 284 6361-6369. (doi:10.1074/jbc.M807532200)
    • (2009) Journal of Biological Chemistry , vol.284 , pp. 6361-6369
    • Yamnik, R.L.1    Digilova, A.2    Davis, D.C.3    Brodt, Z.N.4    Murphy, C.J.5    Holz, M.K.6
  • 119
    • 34247596339 scopus 로고    scopus 로고
    • Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions
    • doi:10.1128/MCB.02411-06
    • Yang C, Xin H, Kelley J, Spencer A, Brautigan D & Paschal B 2007 Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions. Molecular and Cellular Biology 27 3390-3404. (doi:10.1128/MCB.02411-06)
    • (2007) Molecular and Cellular Biology , vol.27 , pp. 3390-3404
    • Yang, C.1    Xin, H.2    Kelley, J.3    Spencer, A.4    Brautigan, D.5    Paschal, B.6
  • 120
    • 77954648696 scopus 로고    scopus 로고
    • Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology
    • doi:10.1073/pnas.1005262107
    • York B, Yu C, Sagen JV, Liu Z, Nikolai BC, Wu RC, Finegold M, Xu J & O'Malley BW 2010 Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology. PNAS 107 11122-11127. (doi:10.1073/pnas. 1005262107)
    • (2010) PNAS , vol.107 , pp. 11122-11127
    • York, B.1    Yu, C.2    Sagen, J.V.3    Liu, Z.4    Nikolai, B.C.5    Wu, R.C.6    Finegold, M.7    Xu, J.8    O'Malley, B.W.9
  • 121
    • 0033607306 scopus 로고    scopus 로고
    • Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation
    • doi:10.1021/bi9911132
    • Yudt M, Vorojeikina D, Zhong L, Kafar D, Sasson S, Gasiewicz T & Notides A 1999 Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation. Biochemistry 38 14146-14156. (doi:10.1021/bi9911132)
    • (1999) Biochemistry , vol.38 , pp. 14146-14156
    • Yudt, M.1    Vorojeikina, D.2    Zhong, L.3    Kafar, D.4    Sasson, S.5    Gasiewicz, T.6    Notides, A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.