Platelet-activating factor receptor plays a role in lung injury and death caused by influenza A in mice

PLoS Pathogens

Volumn 6, Issue 11, 2010, Pages

  Garcia, Cristiana C ^a   Russo, Remo C ^a   Guabiraba, Rodrigo ^a   Fagundes, Caio T ^a   Polidoro, Rafael B ^a   Tavares, Luciana P ^a   Salgado, Ana Paula C ^b   Cassali, Geovanni D ^a   Sousa, Lirlândia P ^a   Machado, Alexandre V ^b   Teixeira, Mauro M ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,4,6 TRIMETHYL 3,5 PYRIDINEDICARBOXYLIC ACID METHYL 2 PHENYLTHIOETHYL ESTER; ACYLTRANSFERASE; AUTACOID; CYTOKINE; LYSO THROMBOCYTE ACTIVATING FACTOR ACETYLTRANSFERASE; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; UNCLASSIFIED DRUG; DIHYDROPYRIDINE DERIVATIVE; FIBRINOGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; TOLL LIKE RECEPTOR;

AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; BLOOD VESSEL PERMEABILITY; CAUSE OF DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFECTION PREVENTION; INFLAMMATION; INFLUENZA A; INFLUENZA A (H1N1); INFLUENZA VIRUS A H1N1; KNOCKOUT MOUSE; LETHALITY; LUNG EDEMA; LUNG INJURY; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PANDEMIC INFLUENZA; PROTEIN SYNTHESIS; RECEPTOR INTRINSIC ACTIVITY; REINFECTION; SYMPTOM; VIRUS LOAD; VIRUS STRAIN; VIRUS TITRATION; ANIMAL; APOPTOSIS; C57BL MOUSE; CHICKEN; DISEASE MODEL; DRUG ANTAGONISM; GENETICS; METABOLISM; MOUSE MUTANT; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE; VIROLOGY; WESTERN BLOTTING;

ANIMALIA; INFLUENZA A VIRUS; MUS;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CHICKENS; DIHYDROPYRIDINES; DISEASE MODELS, ANIMAL; INFLAMMATION MEDIATORS; INFLUENZA A VIRUS, H1N1 SUBTYPE; LUNG INJURY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORTHOMYXOVIRIDAE INFECTIONS; PLATELET ACTIVATING FACTOR; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; TOLL-LIKE RECEPTORS; VIRAL LOAD;

EID: 79251512615     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1001171     Document Type: Article

References (62)

1. Bouvier NM, Palese P (2008) The biology of influenza viruses. Vaccine 26 Suppl 4: D49-53.
2. Michaelis M, Doerr HW, Cinatl J, Jr. (2009) Novel swine-origin influenza A virus in humans: another pandemic knocking at the door. Med Microbiol Immunol 198: 175-183.
3. White NJ, Webster RG, Govorkova EA, Uyeki TM (2009) What is the optimal therapy for patients with H5N1 influenza? PLoS Med 6: e1000091.
4. Ruf BR, Szucs T (2009) Reducing the burden of influenza-associated complications with antiviral therapy. Infection 37: 186-196.
5. Aoki FY, Macleod MD, Paggiaro P, Carewicz O, El Sawy A, et al. (2003) Early administration of oral oseltamivir increases the benefits of influenza treatment. J Antimicrob Chemother 51: 123-129.
6. Kiso M, Mitamura K, Sakai-Tagawa Y, Shiraishi K, Kawakami C, et al. (2004) Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Lancet 364: 759-765.
7. Fedson DS (2009) Confronting the next influenza pandemic with anti-inflammatory and immunomodulatory agents: why they are needed and how they might work. Influenza Other Respi Viruses 3: 129-142.
8. Wang JP, Bowen GN, Padden C, Cerny A, Finberg RW, et al. (2008) Toll-like receptor-mediated activation of neutrophils by influenza A virus. Blood 112: 2028-2034.
9. Opitz B, Rejaibi A, Dauber B, Eckhard J, Vinzing M, et al. (2007) IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein. Cell Microbiol 9: 930-938.
10. Allen IC, Scull MA, Moore CB, Holl EK, McElvania-TeKippe E, et al. (2009) The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 30: 556-565.
11. Thomas PG, Dash P, Aldridge JR, Jr., Ellebedy AH, Reynolds C, et al. (2009) The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 30: 566-575.
12. Le Goffic R, Pothlichet J, Vitour D, Fujita T, Meurs E, et al. (2007) Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-Idependent antiviral responses in human lung epithelial cells. J Immunol 178: 3368-3372.
13. Julkunen I, Melen K, Nyqvist M, Pirhonen J, Sareneva T, et al. (2000) Inflammatory responses in influenza A virus infection. Vaccine 19 Suppl 1: S32-37.
14. Kohlmeier JE, Woodland DL (2009) Immunity to respiratory viruses. Annu Rev Immunol 27: 61-82.
15. Fujisawa H (2008) Neutrophils play an essential role in cooperation with antibody in both protection against and recovery from pulmonary infection with influenza virus in mice. J Virol 82: 2772-2783.
16. Hartshorn KL, Liou LS, White MR, Kazhdan MM, Tauber JL, et al. (1995) Neutrophil deactivation by influenza A virus. Role of hemagglutinin binding to specific sialic acid-bearing cellular proteins. J Immunol 154: 3952-3960.
17. Tuvim MJ, Evans SE, Clement CG, Dickey BF, Gilbert BE (2009) Augmented lung inflammation protects against influenza A pneumonia. PLoS One 4: e4176.
18. Chen XJ, Seth S, Yue G, Kamat P, Compans RW, et al. (2004) Influenza virus inhibits ENaC and lung fluid clearance. Am J Physiol Lung Cell Mol Physiol 287: L366-373.
19. Shindou H, Hishikawa D, Nakanishi H, Harayama T, Ishii S, et al. (2007) A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA: LYSO-PAF acetyltransferase. J Biol Chem 282: 6532-6539.
20. Ishii S, Shimizu T (2000) Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog Lipid Res 39: 41-82.
21. Uhlig S, Goggel R, Engel S (2005) Mechanisms of platelet-activating factor (PAF)-mediated responses in the lung. Pharmacol Rep 57 Suppl: 206-221.
22. Montrucchio G, Alloatti G, Camussi G (2000) Role of platelet-activating factor in cardiovascular pathophysiology. Physiol Rev 80: 1669-1699.
23. Souza DG, Pinho V, Soares AC, Shimizu T, Ishii S, et al. (2003) Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment. Br J Pharmacol 139: 733-740.
24. Bedirli A, Gokahmetoglu S, Sakrak O, Soyuer I, Ince O, et al. (2004) Beneficial effects of recombinant platelet-activating factor acetylhydrolase and BN 52021 on bacterial translocation in cerulein-induced pancreatitis. Eur Surg Res 36: 136-141.
25. Landgraf RG, Nossi DF, Sirois P, Jancar S (2007) Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. Prostaglandins Leukot Essent Fatty Acids 77: 163-172.
26. Prescott SM, Zimmerman GA, Stafforini DM, McIntyre TM (2000) Plateletactivating factor and related lipid mediators. Annu Rev Biochem 69: 419-445.
27. Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, et al. (2008) Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133: 235-249.
28. Crowe CR, Chen K, Pociask DA, Alcorn JF, Krivich C, et al. (2009) Critic al role of IL-17RA in immunopathology of influenza infection. J Immunol 183: 5301-5310.
29. van der Sluijs KF, van Elden LJ, Nijhuis M, Schuurman R, Florquin S, et al. (2006) Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia. Am J Physiol Lung Cell Mol Physiol 290: L194-199.
30. Lin KL, Suzuki Y, Nakano H, Ramsburg E, Gunn MD (2008) CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenzainduced pulmonary immune pathology and mortality. J Immunol 180: 2562-2572.
31. Sakai S, Kawamata H, Mantani N, Kogure T, Shimada Y, et al. (2000) Therapeutic effect of anti-macrophage inflammatory protein 2 antibody on influenza virus-induced pneumonia in mice. J Virol 74: 2472-2476.
32. Seki M, Kohno S, Newstead MW, Zeng X, Bhan U, et al. Critical role of IL-1 receptor-associated kinase-M in regulating chemokine-dependent deleterious inflammation in murine influenza pneumonia. J Immunol 184: 1410-1418.
33. Barnard DL (2009) Animal models for the study of influenza pathogenesis and therapy. Antiviral Res 82: A110-122.
34. Perrone LA, Plowden JK, Garcia-Sastre A, Katz JM, Tumpey TM (2008) H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog 4: e1000115.
35. Lee YM, Hybertson BM, Cho HG, Repine JE (2002) Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces. J Lab Clin Med 140: 312-319.
36. Gabrijelcic J, Acuna A, Profita M, Paterno A, Chung KF, et al. (2003) Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression. Eur Respir J 22: 290-297.
37. White MR, Crouch E, Vesona J, Tacken PJ, Batenburg JJ, et al. (2005) Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus. Am J Physiol Lung Cell Mol Physiol 289: L606-616.
38. Tumpey TM, Garcia-Sastre A, Taubenberger JK, Palese P, Swayne DE, et al. (2005) Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice. J Virol 79: 14933-14944.
39. McNamee LA, Harmsen AG (2006) Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection. Infect Immun 74: 6707-6721.
40. Colamussi ML, White MR, Crouch E, Hartshorn KL (1999) Influenza A virus accelerates neutrophil apoptosis and markedly potentiates apoptotic effects of bacteria. Blood 93: 2395-2403.
41. McCullers JA, Rehg JE (2002) Lethal synergism between influenza virus and Streptococcus pneumoniae: characterization of a mouse model and the role of platelet-activating factor receptor. J Infect Dis 186: 341-350.
42. McCullers JA, Iverson AR, McKeon R, Murray PJ (2008) The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza. Scand J Infect Dis 40: 11-17.
43. Chignard M, Balloy V (2000) Neutrophil recruitment and increased permeability during acute lung injury induced by lipopolysaccharide. Am J Physiol Lung Cell Mol Physiol 279: L1083-1090.
44. Bruder D, Srikiatkhachorn A, Enelow RI (2006) Cellular immunity and lung injury in respiratory virus infection. Viral Immunol 19: 147-155.
45. Culley FJ (2009) Natural killer cells in infection and inflammation of the lung. Immunology 128: 151-163.
46. Mandelboim O, Lieberman N, Lev M, Paul L, Arnon TI, et al. (2001) Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature 409: 1055-1060.
47. Mandi Y, Farkas G, Koltai M, Beladi I, Mencia-Huerta JM, et al. (1989) The effect of the platelet-activating factor antagonist, BN 52021, on human natural killer cell-mediated cytotoxicity. Immunology 67: 370-374.
48. Jin Y, Damaj BB, Maghazachi AA (2005) Human resting CD162, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and plateletactivating factor. Eur J Immunol 35: 2699-2708.
49. Santiago HC, Braga Pires MF, Souza DG, Roffe E, Cortes DF, et al. (2006) Platelet activating factor receptor-deficient mice present delayed interferongamma upregulation and high susceptibility to Leishmania amazonensis infection. Microbes Infect 8: 2569-2577.
50. McGill J, Heusel JW, Legge KL (2009) Innate immune control and regulation of influenza virus infections. J Leukoc Biol 86: 803-812.
51. Watanabe Y, Hashimoto Y, Shiratsuchi A, Takizawa T, Nakanishi Y (2005) Augmentation of fatality of influenza in mice by inhibition of phagocytosis. Biochem Biophys Res Commun 337: 881-886.
52. Hashimoto Y, Moki T, Takizawa T, Shiratsuchi A, Nakanishi Y (2007) Evidence for phagocytosis of influenza virus-infected, apoptotic cells by neutrophils and macrophages in mice. J Immunol 178: 2448-2457.
53. Schmitz N, Kurrer M, Bachmann MF, Kopf M (2005) Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol 79: 6441-6448.
54. Maines TR, Szretter KJ, Perrone L, Belser JA, Bright RA, et al. (2008) Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response. Immunol Rev 225: 68-84.
55. Nourshargh S, Larkin SW, Das A, Williams TJ (1995) Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor. Blood 85: 2553-2558.
56. Young RE, Thompson RD, Nourshargh S (2002) Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta and tumour necrosis factor-alpha in mouse cremasteric venules. Br J Pharmacol 137: 1237-1246.
57. Marathe GK, Davies SS, Harrison KA, Silva AR, Murphy RC, et al. (1999) Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. J Biol Chem 274: 28395-28404.
58. Souza DG, Fagundes CT, Sousa LP, Amaral FA, Souza RS, et al. (2009) Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection. Proc Natl Acad Sci U S A 106: 14138-14143.
59. Zheng BJ, Chan KW, Lin YP, Zhao GY, Chan C, et al. (2008) Delayed antiviralplus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus. Proc Natl Acad Sci U S A 105: 8091-8096.
60. Russo RC, Guabiraba R, Garcia CC, Barcelos LS, Roffe E, et al. (2009) Role of the chemokine receptor CXCR2 in bleomycin-induced pulmonary inflammation and fibrosis. Am J Respir Cell Mol Biol 40: 410-421.
61. Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, et al. (2007) Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease. Am J Respir Crit Care Med 176: 556-564.
62. Dolgachev VA, Ullenbruch MR, Lukacs NW, Phan SH (2009) Role of stem cell factor and bone marrow-derived fibroblasts in airway remodeling. Am J Pathol 174: 390-400.