Reducing the burden of influenza-associated complications with antiviral therapy

Infection

Volumn 37, Issue 3, 2009, Pages 186-196

  Ruf, B R ^a   Szucs, T ^b  

^a Klinikum St Georg   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

SIALIDASE INHIBITOR; ANTIVIRUS AGENT; ENZYME INHIBITOR; SIALIDASE; ZANAMIVIR;

ANTIBIOTIC THERAPY; ANTIVIRAL THERAPY; BACTERIAL PNEUMONIA; BRONCHITIS; CENTRAL NERVOUS SYSTEM; CROUP; HEALTH CARE COST; HEALTH CARE SYSTEM; HEART; HIGH RISK POPULATION; HOSPITALIZATION; HUMAN; INCIDENCE; INFLUENZA; MEDLINE; OTITIS MEDIA; PARAINFLUENZA VIRUS; PHARYNGITIS; REVIEW; SINUSITIS; SKELETAL MUSCLE; VACCINATION; AGE; COST OF ILLNESS; DRUG ANTAGONISM; ECONOMICS; RISK FACTOR; TREATMENT OUTCOME;

AGE FACTORS; ANTIVIRAL AGENTS; COST OF ILLNESS; ENZYME INHIBITORS; HEALTH CARE COSTS; HUMANS; INFLUENZA, HUMAN; NEURAMINIDASE; RISK FACTORS; TREATMENT OUTCOME; ZANAMIVIR;

EID: 67650233633     PISSN: 03008126     EISSN: None     Source Type: Journal    
DOI: 10.1007/s15010-009-8241-1     Document Type: Review

References (96)

1. Centers for Disease Control and Prevention (CDC): Key facts about seasonal influenza (flu). Revised 30 August 2006. Available online at: http://www.cdc.gov/flu/keyfacts.htm
2. W.W. Thompson D.K. Shay E. Weintraub L. Brammer N. Cox L.J. Anderson K. Fukuda 2003 Mortality associated with influenza and respiratory syncytial virus in the United States JAMA 289 179 186 (Pubitemid 36068705)
3. F. Ansaldi G. Icardi R. Gasparini C. Campello S. Puzelli A. Bella I. Donatelli S. Salmaso P. Crovari 2005 New A/H3N2 influenza variant: a small genetic evolution but a heavy burden on the Italia population during the 2004-2005 season J Clin Microbiol 43 3027 3029
4. T.P. Ng K.H. Pwee M. Niti L.G. Goh 2002 Influenza in Singapore: assessing the burden of illness in the community Ann Acad Med Singap 31 182 188
5. A.M. McBean J.D. Babish J.L. Warren 1993 The impact and cost of influenza in the elderly Arch Intern Med 153 2105 2111
6. Office of Technology Assessment. Washington, DC, 1984.
7. E. Levy 1996 French economic evaluations of influenza and influenza vaccination Pharmacoeconomics 9 63 66
8. D.E. Irwin L.B. Weatherby W.Y. Huang D.M. Rosenberg S.F. Cook A.M. Walker 2001 Impact of patient characteristics on the risk of influenza/ILI-related complications BMC Health Serv Res 1 8
9. A. Sessa B. Costa F. Bamfi G. Bettoncelli G. D'Ambrosio 2001 The incidence, natural history and associated outcomes of influenza-like illness and clinical influenza in Italy Fam Pract 18 629 634
10. L. Kaiser O.N. Keene J.M. Hammond M. Elliott F.G. Hayden 2000 Impact of zanamivir on antibiotic use for respiratory events following acute influenza in adolescents and adults Arch Intern Med 160 3234 3240
11. H.W. Kim C.D. Brandt J.O. Arrobio B. Murphy R.M. Chanock R.H. Parrott 1979 Influenza A and B virus infection in infants and young children during the years 1957-1976 Am J Epidemiol 109 464 479
12. R.J. Whitley F.G. Hayden K.S. Reisinger N. Young R. Dutkowski D. Ipe R.G. Mills P. Ward 2001 Oral oseltamivir treatment of influenza in children Pediatr Infect Dis J 20 127 133
13. M.N. Tsolia I. Logotheti N.G. Papadopoulos M. Mavrikou N.P. Spyridis P. Drossatou D. Kafetzis A. Konstantopoulos Outpatient Flu Study Group 2006 Impact of influenza infection in healthy children examined as outpatients and their families Vaccine 24 5970 5976
14. R.B. Belshe P.M. Mendelman J. Treanor J. King W.C. Gruber P. Piedra D.I. Bernstein F.G. Hayden K. Kotloff K. Zangwill D. Iacuzio M. Wolff 1998 The efficacy of live attenuated, coldadapted, trivalent, intranasal influenzavirus vaccine in children N Engl J Med 338 1405 1412
15. A.M. Connolly R.L. Salmon B. Lervy D.H. Williams 1993 What are the complications of influenza and can they be prevented? Experience from the 1989 epidemic of H3N2 influenza A in general practice BMJ 306 1452 1454
16. L. Kaiser C. Wat T. Mills P. Mahoney P. Ward F. Hayden 2003 Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations Arch Intern Med 163 1667 1672
17. J.K. Taubenberger D.M. Morens 2008 The pathology of influenza virus infections Annu Rev Pathol 3 499 522
18. C.R. Meier P.N. Napalkov Y. Wegmüller T. Jefferson H. Jick 2000 Population-based study on incidence, risk factors, clinical complications and drug utilisation associated with influenza in the United Kingdom Eur J Clin Microbiol Infect Dis 19 834 842
19. S.K. Bowles W. Lee A.E. Simor M. Vearncombe M. Loeb S. Tamblyn M. Fearon Y. Li A. McGeer Oseltamivir Compassionate Use Program Group 2002 Use of oseltamivir during influenza outbreaks in Ontario nursing homes, 1999-2000 J Am Geriatr Soc 50 608 616
20. A. McGeer K.A. Green A. Plevneshi A. Shigayeva N. Siddiqi J. Raboud D.E. Low 2007 Toronto Invasive Bacterial Diseases Network: Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada Clin Infect Dis 45 1568 1575
21. T.E. Minor E.C. Dick J.W. Baker J.J. Ouellette M. Cohen C.E. Reed 1976 Rhinovirus and influenza type A infections as precipitants of asthma Am Rev Respir Dis 113 149 153
22. K.G. Nicholson J. Kent D.C. Ireland 1993 Respiratory viruses and exacerbations of asthma in adults BMJ 307 982 986
23. H. Teichtahl N. Buckmaster E. Pertnikovs 1997 The incidence of respiratory tract infection in adults requiring hospitalization for asthma Chest 112 591 596
24. S. Kondo K. Abe 1991 The effects of influenza virus infection on FEV1 in asthmatic children. The time-course study Chest 100 1235 1238
25. G. Rohde A. Wiethege I. Borg M. Kauth T.T. Bauer A. Gillissen A. Bufe G. Schultze-Werninghaus 2003 Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study Thorax 58 37 42
26. W.C. Tan X. Xiang D. Qiu T.P. Ng S.F. Lam R.G. Hegele 2003 Epidemiology of respiratory viruses in patients hospitalized with nearfatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease Am J Med 115 272 277
27. D.M. Perrotta M. Decker W.P. Glezen 1985 Acute respiratory disease hospitalizations as a measure of impact of epidemic influenza Am J Epidemiol 122 468 476
28. L. Simonsen K. Fukuda L.B. Schonberger N.J. Cox 2000 The impact of influenza epidemics on hospitalizations J Infect Dis 181 831 837
29. W.H. Barker 1986 Excess pneumonia and influenza associated hospitalization during influenza epidemics in the United States, 1970-78 Am J Public Health 76 761 765
30. W.W. Thompson D.K. Shay E. Weintraub L. Brammer C.B. Bridges N.J. Cox K. Fukuda 2004 Influenza-associated hospitalizations in the United States JAMA 292 1333 1340
31. V.H. Menec C. Black L. MacWilliam F.Y. Aoki 2003 The impact of influenza-associated respiratory illnesses on hospitalizations, physician visits, emergency room visits, and mortality Can J Public Health 94 59 63
32. C.M. Wong L. Yang K.P. Chan G.M. Leung K.H. Chan Y. Guan T.H. Lam A.J. Hedley J.S. Peiris 2006 Influenza-associated hospitalization in a subtropical city PLoS Med 3 e121
33. C.M. Wong K.P. Chan A.J. Hedley J.S. Peiris 2004 Influenza-associated mortality in Hong Kong Clin Infect Dis 39 1611 1617
34. P.M. Olsen A. Hornsleth P.A. Krasilnikoff 1992 Varying clinical pictures among young children with influenza virus type A infections Ugeskr Laeger 154 560 563
35. Y.H. Wang Y.C. Huang L.Y. Chang H.T. Kao P.Y. Lin C.G. Huang T.Y. Lin 2003 Clinical characteristics of children with influenza A virus infection requiring hospitalization J Microbiol Immunol Infect 36 111 116
36. K.M. Neuzil B.G. Mellen P.F. Wright E.F. Mitchel Jr M.R. Griffin 2000 The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children N Engl J Med 342 225 231
37. K.G. Hultén S.L. Kaplan B.E. Gonzalez W.A. Hammerman L.B. Lamberth J. Versalovic E.O. Mason Jr 2006 Three-year surveillance of community onset health care-associated Staphylococcus aureus infections in children Pediatr Infect Dis J 25 349 353
38. Centers for Disease ControlPrevention 2007 Severe methicillin-resistent Staphylococcus aureus communityacquired pneumonia associated with influenza - Louisiana and Georgia, December 2006-January 2007 MMWR Morb Mortal Wkly Rep 56 325 329
39. S.S. Chiu Y.L. Lau K.H. Chan W.H. Wong J.S. Peiris 2002 Influenza-related hospitalizations among children in Hong Kong N Engl J Med 347 2097 2103
40. H.S. Izurieta W.W. Thompson P. Kramarz D.K. Shay R.L. Davis F. DeStefano S. Black H. Shinefield K. Fukuda 2000 Influenza and the rates of hospitalization for respiratory disease among infants and young children N Engl J Med 342 232 239
41. A.E. Fiore D.K. Shay P. Haber J.K. Iskander T.M. Uyeki G. Mootrey J.S. Bresee N.J. Cox 2007 Advisory Committee on Immunization Practices (ACIP):, Centers for Disease Control and Prevention (CDC): Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2007 MMWR Morb Mortal Wkly Rep 56 1 54
42. R.J. Pitman A. Melegaro D. Gelb M.R. Siddiqui N.J. Gay W.J. Edmunds 2007 Assessing the burden of influenza and other respiratory infections in England and Wales J Infect 54 530 538
43. Nicholson KG, Webster RG, Hay AJ: Textbook of influenza. Nicholson KG, Webster RG, Hay AJ (eds) Blackwell, London 1998.
44. J.G. Newland V.M. Laurich A.W. Rosenquist K. Heydon D.J. Licht R. Keren T.E. Zaoutis B. Watson R.L. Hodinka S.E. Coffin 2007 Neurologic complications in children hospitalized with influenza: characteristics, incidence, and risk factors J Pediatr 150 306 310 (Pubitemid 46328959)
45. T. Morishima T. Togashi S. Yokota Y. Okuno C. Miyazaki M. Tashiro N. Okabe Collaborative Study Group on Influenza-Associated Encephalopathy in Japan 2002 Encephalitis and encephalopathy associated with an influenza epidemic in Japan Clin Infect Dis 35 512 517
46. T. Togashi Y. Matsuzono M. Narita T. Morishima 2004 Influenzaassociated acute encephalopathy in Japanese children in 1994-2002 Virus Res 103 75 78
47. K. Greaves J.S. Oxford C.P. Price G.H. Clarke T. Crake 2003 The prevalence of myocarditis and skeletal muscle injury during acute viral infection in adults: measurement of cardiac troponins I and T in 152 patients with acute influenza infection Arch Intern Med 163 165 168
48. M.G. Ison V. Campbell C. Rembold J. Dent F.G. Hayden 2005 Cardiac findings during uncomplicated acute influenza in ambulatory adults Clin Infect Dis 40 415 422
49. P. Agyeman A. Duppenthaler U. Heininger C. Aebi 2004 Influenzaassociated myositis in children Infection 32 199 203
50. K.L. Nichol J.D. Nordin D.B. Nelson J.P. Mullooly E. Hak 2007 Effectiveness of influenza vaccine in the community-dwelling elderly N Engl J Med 357 1373 1381
51. S. Gravenstein H.E. Davidson 2002 Current strategies for management of influenza in the elderly population Clin Infect Dis 35 729 737
52. I. Stephenson K.G. Nicholson 2001 Influenza: vaccination and treatment Eur Respir J 17 1282 1293
53. C.B. Bridges W.W. Thompson M.I. Meltzer G.R. Reeve W.J. Talamonti N.J. Cox H.A. Lilac H. Hall A. Klimov K. Fukuda 2000 Effectiveness and cost-benefit of influenza vaccination of healthy working adults: a randomized controlled trial JAMA 284 1655 1663
54. Centers for Disease ControlPrevention 2007 Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2007 MMWR Morb Mortal Wkly Rep 56 1 54
55. R.A. Bright M.J. Medina X. Xu G. Perez-Oronoz T.R. Wallis X.M. Davis L. Povinelli N.J. Cox A.I. Klimov 2005 Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern Lancet 366 1175 1181
56. V.M. Deyde X. Xu R.A. Bright M. Shaw C.B. Smith Y. Zhang Y. Shu L.V. Gubareva N.J. Cox A.I. Klimov 2007 Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide J Infect Dis 196 249 257
57. F.Y. Aoki G. Boivin N. Roberts 2007 Influenza virus susceptibility and resistance to oseltamivir Antivir Ther 12 603 616
58. F.G. Hayden L.V. Gubareva A.S. Monto T.C. Klein M.J. Elliot J.M. Hammond S.J. Sharp M.J. Ossi Zanamivir Family Study Group 2000 Inhaled zanamivir for the prevention of influenza in families. Zanamivir Family Study Group N Engl J Med 343 1282 1289
59. F.G. Hayden A.D. Osterhaus J.J. Treanor D.M. Fleming F.Y. Aoki K.G. Nicholson A.M. Bohnen H.M. Hirst O. Keene K. Wightman 1997 Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. GG167 Influenza Study Group N Engl J Med 337 874 880
60. A.S. Monto A. Webster O. Keene 2003 Randomized, placebo-controlled studies of inhaled zanamivir in the treatment of influenza A and B: pooled efficacy analysis J Antimicrob Chemother 44 23 29
61. K.G. Nicholson F.Y. Aoki A.D. Osterhaus S. Trottier O. Carewicz C.H. Mercier A. Rode N. Kinnersley P. Ward 2000 Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group Lancet 355 1845 1850
62. J.J. Treanor F.G. Hayden P.S. Vrooman R. Barbarash R. Bettis D. Riff S. Singh N. Kinnersley P. Ward R.G. Mills 2000 Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study Group JAMA 283 1016 1024
63. J.A. Hedrick A. Barzilai U. Behre F.W. Henderson J. Hammond L. Reilly O. Keene 2000 Zanamivir for treatment of symptomatic influenza A and B infection in children five to twelve years of age: a randomized controlled trial Pediatr Infect Dis J 19 410 417
64. N.J. Cooper A.J. Sutton K.R. Abrams A. Wailoo D. Turner G.G. Nicholson 2003 Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and metaanalyses of randomised controlled trials BMJ 326 1235
65. F.Y. Aoki M.D. Macleod P. Paggiaro O. Carewicz A. El Sawy C. Wat M. Griffiths E. Waalberg P. Ward IMPACT Study Group 2003 Early administration of oral oseltamivir increases the benefits of influenza treatment J Antimicrob Chemother 51 123 129
66. N. Kawai H. Ikematsu N. Iwaki T. Maeda I. Satoh N. Hirotsu S. Kashiwagi 2006 A comparison of the effectiveness of oseltamivir for the treatment of influenza A and influenza B: a Japanese multicenter study of the 2003-2004 and 2004-2005 influenza seasons Clin Infect Dis 43 439 444
67. B.A. Sanford V.E. Davison M.A. Ramsay 1986 Staphylococcus aureus adherence to influenza A virus-infected and control cell cultures: evidence for multiple adhesins Proc Soc Exp Biol Med 181 104 111
68. V.T. Peltola K.G. Murti J.A. McCullers 2005 Influenza virus neuraminidase contributes to secondary bacterial pneumonia J Infect Dis 192 249 257
69. J.A. McCullers 2004 Effect of antiviral treatment on the outcome of secondary bacterial pneumonia after influenza J Infect Dis 190 519 526
70. The MIST Study Group 1998 Randomised trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections. The MIST (Management of Influenza in the Southern Hemisphere Trialists) Study Group Lancet 352 1877 1881
71. J. Lalezari K. Campion O. Keene C. Silagy 2001 Zanamivir for the treatment of influenza A and B infection in high-risk patients: a pooled analysis of randomized controlled trials Arch Intern Med 161 212 217
72. P.H. Peters Jr S. Gravenstein P. Norwood V. De Bock A. Van Couter M. Gibbens T.A. von Planta P. Ward 2001 Long-term use of oseltamivir for the prophylaxis of influenza in a vaccinated frail older population J Am Geriatr Soc 49 1025 1031
73. J.A. Cole J.E. Loughlin A.N. Ajene D.M. Rosenberg S.E. Cook A.M. Walker 2002 The effect of zanamivir treatment on influenza complications: a retrospective cohort study Clin Ther 24 1824 1839
74. B.L. Nordstrom I. Sung P. Suter P. Szneke 2005 Risk of pneumonia and other complications of influenza-like illness in patients treated with oseltamivir Curr Med Res Opin 21 761 768
75. C. Enger B.L. Nordstrom B. Thakrar S. Sacks K.J. Rothman 2004 Health outcomes among patients receiving oseltamivir Pharmacoepidemiol Drug Saf 13 227 237
76. Matheson NJ, Harnden AR, Perera R, Sheikh A, Symmonds-Abrahams M: Neuraminidase inhibitors for preventing and treating influenza in children. Cochrane Database Syst Rev 2007; CD002744.
77. C.E. Barr K. Schulman D. Iacuzio J.S. Bradley 2007 Effect of oseltamivir on the risk of pneumonia and use of health care services in children with clinically diagnosed influenza Curr Med Res Opin 23 523 531
78. S.L. Johnston F. Ferrero M.L. Garcia R. Dutkowski 2005 Oral oseltamivir improves pulmonary function and reduces exacerbation frequency for influenza-infected children with asthma Pediatr Infect Dis J 24 225 232
79. J.T. Lin X.Z. Yu D.J. Cui X.Y. Chen J.H. Zhu Y.Z. Wang X.D. Wu H. Gao Z.L. Huo S.H. Zhu S.L. Hu A.X. Wang 2004 A multicenter randomized controlled study of the efficacy and safety of oseltamivir in the treatment of influenza in a high risk population Zhonghua Jie He He Hu Xi Za Zhi 27 455 459
80. A.S. Monto J. Rotthoff E. Teich M.L. Herlocher R. Truscon H.L. Yen S. Elias S.E. Ohmit 2004 Detection and control of influenza outbreaks in well-vaccinated nursing home populations Clin Infect Dis 39 459 464
81. F.G. Hayden R. Belshe C. Villanueva R. Lanno C. Hughes I. Small R. Dutkowski P. Ward J. Carr 2004 Management of influenza in households: a prospective, randomized comparison of oseltamivir treatment with or without postexposure prophylaxis J Infect Dis 189 440 449
82. F.G. Hayden R.B. Belshe R.D. Clover A.J. Hay M.G. Oakes W. Soo 1989 Emergence and apparent transmission of rimantadine-resistant influenza A virus in families N Engl J Med 321 1696 1702
83. P. Diggory C. Fernandez A. Humphrey V. Jones M. Murphy 2001 Comparison of elderly people's technique in using two dry powder inhalers to deliver zanamivir: randomised controlled trial BMJ 322 577 579
84. E.P. Armstrong Z.M. Khan A.S. Perri L.R. Perri 2000 The cost effectiveness of zanamivir and oseltamivir for influenza treatment Formulary 35 979 989
85. A.D. Griffin A.S. Perry D.M. Fleming 2001 Cost-effectiveness analysis of inhaled zanamivir in the treatment of influenza A and B in highrisk patients Pharmacoeconomics 19 293 301
86. A. Burls W. Clark T. Stewart C. Preston S. Bryan T. Jefferson A. Fry-Smith 2002 Zanamivir for the treatment of influenza in adults: a systematic review and economic evaluation Health Technol Assess 6 1 87
87. J.A. Mauskopf S.C. Cates A.D. Griffin D.M. Neighbors S.C. Lamb C. Rutherford 2000 Cost effectiveness of zanamivir for the treatment of influenza in a high risk population in Australia Pharmacoeconomics 17 611 620
88. Brady B, McAuley L, Shukla VK: Economic evaluation of zanamivir for the treatment of influenza. Ottawa, ON. Canadian Coordinating Office for Health Technology Assessment (CCOHTA) 2001; Technology report no. 13.
89. M.B. Rothberg S. Bellantonio D.N. Rose 2003 Management of influenza in adults older than 65 years of age: cost-effectiveness of rapid testing and antiviral therapy Ann Intern Med 139 321 329
90. M.J. Postma P. Jansema H.W. Scheijbeler M.L. van Genugten 2005 Scenarios on costs and savings of influenza treatment and prevention for Dutch healthy working adults Vaccine 23 5365 5371
91. B.J. O'Brien R. Goeree G. Blackhouse M. Smieja M. Loeb 2003 Oseltamivir for treatment of influenza in healthy adults: pooled trial evidence and cost-effectiveness model for Canada Value Health 6 116 125
92. M. Vindt Holm M. Gyldmark E. Holme Hansen 2004 Pharmacoeconomic assessment of oseltamivir in treating influenza - the case of otherwise healthy Danish adolescents and adults Pharm World Sci 26 339 345
93. B. Sander M. Gyldmark F.G. Hayden J. Morris E. Mueller R. Bergemann 2005 Influenza treatment with neuraminidase inhibitors: cost-effectiveness and cost-utility in healthy adults in the United Kingdom Eur J Health Econ 6 244 252
94. N.A. Risebrough S.K. Bowles A.E. Simor A. McGeer P.I. Oh 2005 Economic evaluation of oseltamivir phosphate for postexposure prophylaxis of influenza in long-term care facilities J Am Geriatr Soc 53 444 451
95. K. Reisinger G. Greene R. Aultman B. Sander M. Gyldmark 2004 Effect of influenza treatment with oseltamivir on health outcome and costs in otherwise healthy children Clin Drug Invest 24 395 407 (Pubitemid 38951791)
96. M.B. Rothberg D. Fisher B. Kelly D.N. Rose 2005 Management of influenza symptoms in healthy children: cost-effectiveness of rapid testing and antiviral therapy Arch Pediatr Adolesc Med 159 1055 1062