Synthesis and biological activity of 7H-benzo[4,5]indolo[2,3-b]-quinoxaline derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 794-798

  Shibinskaya, Marina O ^a   Karpenko, Alexander S ^a   Lyakhov, Sergey A ^a,b   Andronati, Sergey A ^a,b   Zholobak, Nadezhda M ^c   Spivak, Nikolay Ya ^c   Samochina, Natalia A ^d   Shafran, Lev M ^d   Zubritsky, Mykhail Ju ^e   Galat, Valerij F ^e  

^a A V BOGATSKY PHYSICO CHEMICAL INSTITUTE   (Ukraine)

^b ODESSA NATIONAL UNIVERSITY   (Ukraine)

^c ZABOLOTNY INSTITUTE OF MICROBIOLOGY AND VIROLOGY   (Ukraine)

^d Ukrainian Research Institute of Medicine Transport   (Ukraine)

^e L M LITVINENKO INSTITUTE OF PHYSICAL ORGANIC AND COAL CHEMISTRY   (Ukraine)

Author keywords

7H benzo 4,5 indolo 2,3 b quinoxaline; Anti viral activity; DNA affinity; Interferon induction

Indexed keywords

7 (2 (PIPERIDIN 1 YLETHYL) 7H BENZO[4,5]INDOLO[2,3 B]QUINOXALINE; 7 (2 BROMOETHYL) 7H BENZO[4,5]INDOLO[2,3 B]QUINOXALINE; 7 (2 MORPHOLIN 4 YLETHYL) 7H BENZO[4,5]INDOLO[2,3 B]QUINOXALINE; 7 [2 (2 METHYLPIPERIDIN 1 YL)ETHYL] 7H BENZO[4,5]INDOLO[2,3 B]QUINOXALINE; 7 [2 (4 METHYLPIPERAZIN 1 YL)ETHYL] 7H BENZO[4,5]INDOLO[2,3 B]QUINOXALINE; 7 [2 (4 METHYLPIPERIDIN 1 YL)ETHYL] 7H BENZO[4,5]INDOLO[2,3-B]QUINOXALINE; 7H BENZO[4,5]INDOLO[2,3 B]QUINOXALINE; 7H BENZO[4,5]INDOLO[2,3 B]QUINOXALINE DERIVATIVE; [2 (7H BENZO[4,5]INDOLO[2,3 B]QUINOXALIN 7 YL)ETHYL]DIETHYLAMINE; [2 (7H BENZO[4,5]INDOLO[2,3 B]QUINOXALIN 7 YL)ETHYL]DIMETHYLAMINE; [2 (7H BENZO[4,5]INDOLO[2,3 B]QUINOXALIN 7 YL)ETHYL]DIPROPYLAMINE; ANTIVIRUS AGENT; DNA; INTERFERON; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN;

ANIMALS; ANTIVIRAL AGENTS; CATTLE; DNA; FIBROBLASTS; INDOLES; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; QUINOXALINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VESICULOVIRUS;

EID: 79151476740     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.040     Document Type: Article

References (20)

1. M.O. Shibinskaya, S.A. Lyakhov, A.V. Mazepa, S.A. Andronati, A.V. Turov, N.M. Zholobak, and N.Ya. Spivak Eur. J. Med. Chem. 45 2010 1237 1243
2. S.A. Lyakhov, Abstract Book of 6th International Symposium on Molecular Aspects of Chemoterapy, Gdansk, Poland, 1997. p. 137.
3. Y.I. Suveyzdis, S.A. Lyakhov, L.A. Litvinova, S.A. Andronati, S.L. Rybalko, and S.T. Dyadyun Pharmazie 55 2000 733 736
4. S.A. Lyakhov, L.A. Litvinova, S.A. Andronati, L.K. Berezina, B.N. Galkin, V.E. Osetrov, T.O. Filippova, and N.Ya. Golovenko Ukr. Biokhim. Zh 73 2001 108 113
5. S.A. Lyakhov, L.A. Litvinova, Y. Suveyzdis, S.A. Andronati, S.L. Rybalko, and S.T. Dyadyun Pharm. Chem. J. 34 2000 474 475
6. S. Alcaro, A. Arena, S. Neri, R. Ottana, F. Ortuso, B. Pavone, and M.G. Vigorita Bioorg. Med. Chem. 12 2004 1781 1791
7. A. Arena, N. Arena, R. Ciurleo, A. de Gregorio, R. Maccari, R. Ottana, B. Pavone, A. Tramice, A. Trincone, and M.G. Vigorita Eur. J. Med. Chem. 43 2008 2656 2664
8. S. Alcaro, A. Arena, R. Di Bella, S. Neri, R. Ottana, F. Ortuso, B. Pavone, and M.G. Vigorita Arkivoc 5 2004 334 348
9. A.S. Karpenko, I.V. Dorovskikh, S.A. Lyakhov, S.A. Andronati, N.M. Zholobak, N.Ya. Spivak, J.V. Nekhoroshkova, and L.M. Shafran Ukrainica Bioorganica Acta 6 2008 42 48
10. K.E. Miller, J.M. Grace, and T.L. Macdonald Bioorg. Med. Chem. Lett. 4 1994 1643 1648
11. J. Harmenberg, A. kesson-Johansson, A. Gräslund, T. Malmfors, J. Bergman, B. Wahren, S. kerfeldt, L. Lundblad, and S. Cox Antivir. Res. 15 1991 193 204
12. L.M. Wilhelmsson, N. Kingi, and J. Bergman J. Med. Chem. 51 2008 7744 7750
13. F. Gago Methods 14 1998 277 292
14. D. Reha, M. Kabelac, F. Ryjacek, J. Sponer, J.E. Sponer, M. Elstner, S. Suhai, and P. Hobza J. Am. Chem. Soc. 124 2002 3366 3376
15. V.V. Kostjukov, N.M. Khomytova, and M.P. Evstigneev Biopolymers 91 2009 773 790
16. W.A. Denny Acridine-4-carboxamides and the concept of minimal DNA M. Demeunynck, C. Bailly, W.D. Wilson, DNA and RNA Binders from Small Molecules to Drugs 2002 Wiley-VCH 482 503
17. A.S. Karpenko, M.O. Shibinskaya, N.M. Zholobak, Z.M. Olevinskaya, S.A. Lyakhov, L.A. Litvinova, N.Ya. Spivak, and S.A. Andronati Pharm. Chem. J. 40 2006 595 602
18. E. Schunck, and L. Marchlewski Chem. Ber. 28 1895 2525 2531
19. I. Antonini, P. Polucci, L.R. Kelland, E. Menta, N. Pescalli, and S. Martelli J. Med. Chem. 42 1999 2535 2541
20. S.A. Glantz Primer of Biostatistics fourth ed. 1997 McGraw-Hill Inc. New York