A modeled structure of an aptamer-gp120 complex provides insight into the mechanism of HIV-1 neutralization

Biochemistry

Volumn 49, Issue 28, 2010, Pages 5880-5890

  Joubert, Marisa K ^a,f   Kinsley, Nichole ^b   Capovilla, Alexio ^b,c   Sewell, B Trevor ^d   Jaffer, Mohamed A ^d   Khati, Makobetsa ^a,e  

^a DSI CSIR Nanotechnology Innovation Centre   (South Africa)

^b Elevation Biotech   (South Africa)

^c UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

^e UNIVERSITY OF CAPE TOWN   (South Africa)

^f AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMERS; BINDING AFFINITIES; BINDING ASSAYS; CONFORMATIONAL CHANGE; DIRECT CONTACT; ENERGY MINIMIZATION; ENVELOPE GLYCOPROTEINS; HOST CELLS; HYDROGEN BONDING NETWORK; POINT MUTATIONS; RNA APTAMER; SECONDARY STRUCTURES; THREE-DIMENSIONAL MODEL;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; HYDROGEN BONDS; MOLECULAR DYNAMICS; MONOCLONAL ANTIBODIES; ORGANIC ACIDS; RNA; SCANNING ELECTRON MICROSCOPY; SURFACE PLASMON RESONANCE; THREE DIMENSIONAL;

CRYSTAL STRUCTURE;

APTAMER; EPITOPE; GLYCOPROTEIN GP 120; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRON MICROSCOPY; ENERGY TRANSFER; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SURFACE PLASMON RESONANCE; VIRUS INHIBITION; VIRUS NEUTRALIZATION;

ANTIBODIES, MONOCLONAL; BINDING SITES; EPITOPES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; HYDROGEN BONDING; MOLECULAR DYNAMICS SIMULATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77954576691     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100301k     Document Type: Article

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