Combined treatment with GH, insulin, and indomethacin alleviates cancer cachexia in a mouse model

Journal of Endocrinology

Volumn 208, Issue 2, 2011, Pages 131-136

  Chen, Si Zeng ^a   Qiu, Zheng Guo ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CYTOKINE; GLUCOSE; GROWTH HORMONE; INDOMETACIN; INSULIN; INTERLEUKIN 6; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; ASTHENIA; BODY WEIGHT; CACHEXIA; CANCER CACHEXIA; COLON ADENOCARCINOMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE FREE SURVIVAL; DRUG EFFICACY; MALE; MOUSE; NEOPLASM; NONHUMAN; NUTRITION; PRIORITY JOURNAL; SURVIVAL TIME; SYMPTOM; TREATMENT OUTCOME; TUMOR VOLUME; WEIGHT REDUCTION;

ADENOCARCINOMA; ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; CACHEXIA; COLONIC NEOPLASMS; CYTOKINES; DRUG COMBINATIONS; GROWTH HORMONE; INDOMETHACIN; INJECTIONS, INTRAPERITONEAL; INSULIN; MALE; MICE; MICE, INBRED BALB C; NUTRITIONAL PHYSIOLOGICAL PHENOMENA; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 78951486337     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-10-0341     Document Type: Article

References (22)

1. Agustsson T, Rydén M, Hoffstedt J, van Harmelen V, Dicker A, Laurencikiene J, Isaksson B, Permert J & Arner P 2007 Mechanism of increased lipolysis in cancer cachexia. Cancer Research 67 5531-5537. (doi:10.1158/0008-5472. CAN-06-4585)
2. Andersson CX, Sopasakis VR, Wallerstedt E & Smith U 2007 Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes. Journal of Biological Chemistry 282 9430-9435. (doi:10.1074/jbc. M609980200)
3. Argilés JM, Almendro V, Busquets S & López-Soriano FJ 2004 The pharmacological treatment of cachexia. Current Drug Targets 5 265-277. (doi:10.2174/1389450043490505)
4. Argilés JM, Busquets S, Toledo M & López-Soriano FJ 2009 The role of cytokines in cancer cachexia. Current Opinion in Supportive and Palliative Care 3 263-268. (doi:10.1097/SPC.0b013e3283311d09)
5. Berman RS, Harrison LE, Pearlstone DB, Burt M & Brennan MF 1999 Growth hormone, alone and in combination with insulin, increases whole body and skeletal muscle protein kinetics in cancer patients after surgery. Annals of Surgery 229 1-10. (doi:10.1097/00000658-199901000-00001)
6. Carli F, Webster JD & Halliday D 1997 Growth hormone modulates amino acid oxidation in the surgical patient: leucine kinetics during the fasted and fed state using moderate nitrogenous and caloric diet and recombinant human growth hormone. Metabolism 46 23-28. (doi:10.1016/S0026-0495(97)90162-1) (Pubitemid 27052019)
7. Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E & Ahmad S 2001 Insulin inhibits intranuclear nuclear factor κB and stimulates IκB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? Journal of Clinical Endocrinology and Metabolism 86 3257-3265. (doi:10.1210/jc.86.7.3257)
8. Ebrahimi B, Tucker SL, Li D, Abbruzzese JL & Kurzrock R 2004 Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis. Cancer 101 2727-2736. (doi:10.1002/cncr.20672)
9. Jatoi A 2008 Weight loss in patients with advanced cancer: effects, causes, and potential management. Current Opinion in Supportive and Palliative Care 2 45-48. (doi:10.1097/SPC.0b013e3282f4b734)
10. Khan AS, Smith LC, Anscombe IW, Cummings KK, Pope MA & Draghia-Akli R 2005 Growth hormone releasing hormone plasmid supplementation, a potential treatment for cancer cachexia, does not increase tumor growth in nude mice. Cancer Gene Therapy 12 54-60. (doi:10.1038/sj.cgt.7700767)
11. LaPensee CR, Hugo ER & Ben-Jonathan N 2008 Insulin stimulates interleukin-6 expression and release in LS14 human adipocytes through multiple signaling pathways. Endocrinology 149 5415-5422. (doi:10.1210/en.2008-0549)
12. Lelbach A, Muzes G & Feher J 2007 Current perspectives of catabolic mediators of cancer cachexia. Medical Science Monitor 13 168-173.
13. Lundholm K, Daneryd P, Körner U, Hyltander A & Bosaeus I 2004 Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia. International Journal of Oncology 24 505-512.
14. Lundholm K, Körner U, Gunnebo L, Sixt-Ammilon P, Fouladiun M, Daneryd P & Bosaeus I 2007 Insulin treatment in cancer cachexia: effects on survival, metabolism, and physical functioning. Clinical Cancer Research 13 2699-2706. (doi:10.1158/1078-0432.CCR-06-2720)
15. Mantovani G & Madeddu C 2010 Cancer cachexia: medical management. Supportive Care in Cancer 18 1-9. (doi:10.1007/s00520-009-0722-3)
16. McMillan DC 2009 Systemic inflammation, nutritional status and survival in patients with cancer. Current Opinion in Clinical Nutrition and Metabolic Care 12 223-226. (doi:10.1097/MCO.0b013e32832a7902)
17. O'Connor JC, McCusker RH, Strle K, Johnson RW, Dantzer R & Kelley KW 2008 Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology. Cellular Immunology 252 91-110. (doi:10.1016/j.cellimm.2007.09.010)
18. Redelman D, Welniak LA, Taub D & Murphy WJ 2008 Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network. Cellular Immunology 252 111-121. (doi:10.1016/j.cellimm.2007.12.003)
19. Saini A, Al-Shanti N & Stewart CE 2006 Waste management - cytokines, growth factors and cachexia. Cytokine and Growth Factor Reviews 17 475-486. (doi:10.1016/j.cytogfr.2006.09.006) (Pubitemid 44793120)
20. Senn JJ, Klover PJ, Nowak IA & Mooney RA 2002 Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51 3391-3399. (doi:10. 2337/diabetes.51.12.3391)
21. Tisdale MJ 2009 Mechanisms of cancer cachexia. Physiological Reviews 89 381-410. (doi:10.1152/physrev.00016.2008)
22. Zhou W, Jiang ZW, Tian J, Jiang J, Li N & Li JS 2003 Role of NF-κB and cytokine in experimental cancer cachexia.World Journal of Gastroenterology 9 1567-1570.