Role of NF-κB and cytokine in experimental cancer cachexia

World Journal of Gastroenterology

Volumn 9, Issue 7, 2003, Pages 1567-1570

  Zhou, Wei ^a   Jiang, Zhi Wei ^a   Tian, Jie ^a   Jiang, Jun ^a   Li, Ning ^a   Li, Jie Shou ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INTERLEUKIN 6; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CACHEXIA; CANCER; CANCER CELL; COLON ADENOCARCINOMA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; FOOD INTAKE; GASTROCNEMIUS MUSCLE; GEL MOBILITY SHIFT ASSAY; LOW DRUG DOSE; MALE; MOUSE; MUSCLE ATROPHY; NONHUMAN; PATHOGENESIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SPLEEN; WEIGHT REDUCTION; ADENOCARCINOMA; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CANCER TRANSPLANTATION; COLON TUMOR; EATING; METABOLISM;

ADENOCARCINOMA; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BODY COMPOSITION; CACHEXIA; COLONIC NEOPLASMS; EATING; INDOMETHACIN; INTERLEUKIN-6; MALE; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; NF-KAPPA B; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT LOSS;

EID: 0043066619     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v9.i7.1567     Document Type: Article

References (33)

1. Kurzrock R. The role of cytokines in cancer-related fatigue. Cancer 2001; 92(Suppl): 1684-1688
2. Tisdale MJ. Wasting in cancer. J Nutr 1999; 129(Suppl): 243S-246S
3. Barton BE, Murphy TF. Cancer cachexia is mediated in part by the induction of IL-6-like cytokines from the spleen. Cytokine 2001; 16: 251-257
4. Barton BE. IL-6-like cytokines and cancer cachexia: Consequences of chronic inflammation. Immunol Res 2001; 23: 41-58
5. O'Riordain MG, Falconer JS, Maingay J, Fearon KC, Ross JA. Peripheral blood cells from weight-losing cancer patients control the hepatic acute phase response by a primarily interleukin-6 dependent mechanism. Int J Oncol 1999; 15: 823-827
6. Baeuerle PA, Baltimore D. NK-kappa B: Ten years after. Cell 1996; 87: 13-20
7. Schwartz SA, Hernandez A, Mark Evers B. The role of NF-kappaB/IkappaB proteins in cancer: Implications for novel treatment strategies. Surg Oncol 1999; 8: 143-153
8. Wang T, Zhang X, Li JJ. The role of NF-kappaB in the regulation of cell stress responses. Int Immunopharmacol 2002; 2: 1509-1520
9. Strassmann G, Jacob CO, Fong M, Bertolini DR. Mechanisms of paraneoplastic syndromes of colon-26: Involvement of interleukin 6 in hypercalcemia. Cytokine 1993; 5: 463-468
10. Tanaka M, Miyazaki H, Takeda Y, Takeo S. Detection of serum cytokine levels in experimental cancer cachexia of colon 26 adenocarcinoma-bearing mice. Cancer Lett 1993; 72: 65-70
11. Strassmann G, Fong M, Kenney JS, Jacob CO. Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J Clin Invest 1992; 89: 1681-1684
12. Tanaka Y, Eda H, Tanaka T, Udagawa T, Ishikawa T, Horii I, Ishitsuka H, Kataoka T, Taguchi T. Experimental cancer cachexia induced by transplantable colon 26 adenocarcinoma in mice. Cancer Res 1990; 50: 2290-2295
13. Lundholm K, Gelin J, Hyltander A, Lonnroth C, Sandstrom R, Svaninger G, Korner U, Gulich M, Karrefors I, Nordi B. Anti-inflammatory treatment may prolong survival in undernourished patients with metastatic solid tumors. Cancer Res 1994; 54: 5602-5606
14. Gong JP, Liu CA, Wu CX, Li SW, Shi YJ, Li XH. Nuclear factor kB activity in patients with acute severe cholangitis. World J Gastroenterol 2002; 8: 346-349
15. Liu Z, Yu Y, Jiang Y, Li J. Growth hormone increases lung NF-kappaB activation and lung microvascular injury induced by lipopolysaccharide in rats. Ann Clin Lab Sci 2002; 32: 164-170
16. Tisdale MJ. Cancer anorexia and cachexia. Nutrition 2001; 17: 438-442
17. Cahlin C, Korner A, Axelsson H, Wang W, Lundholm K, Svanberg E. Experimental cancer cachexia: The role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 B1 background and eicosanoid-dependent cachexia. Cancer Res 2000; 60: 5488-5493
18. Karayiannakis AJ, Syrigos KN, Polychronidis A, Pitiakoudis M, Bounovas A, Simopoulos K. Serum levels of tumor necrosis factor-alpha and nutritional status in pancreatic cancer patients. Anticancer Res 2001; 21: 1355-1358
19. Llovera M, Carbo N, Lopez-Soriano J, Garcia-Martinez C, Busquets S, Alvarez B, Agell N, Costelli P, Lopez-Soriano FJ, Celada A, Argiles JM. Different cytokines modulate ubiquitin gene expression in rat skeletal muscle. Cancer Lett 1998; 133: 83-87
20. Costelli P, Bossola M, Muscaritoli M, Grieco G, Bonelli G, Bellantone R, Doglietto GB, Baccino FM, Fanelli FR. Anticytokine treatment prevents the increase in the activity of ATP-ubiquitin- and Ca(2+)-dependent proteolytic systems in the muscle of tumour-bearing rats. Cytokine 2002; 19: 1-5
21. Tisdale MJ. The 'cancer cachectic factor'. Support Care Cancer 2003; 11: 73-78
22. Llovera M, Garcia-Martinez C, Agell N, Lopez-Soriano FJ, Argiles JM. TNF can directly induce the expression of ubiquitin-dependent proteolytic system in rat soleus muscles. Biochem Biophys Res Commun 1997; 230: 238-241
23. Carbo N, Busquets S, Van Royen M, Alvarez B, Lopez-Soriano FJ, Argiles JM. TNF-alpha is involved in activating DNA fragmentation in skeletal muscle. Br J Cancer 2002; 86: 1012-1016
24. Strassmann G, Kambayashi T. Inhibition of experimental cancer cachexia by anti-cytokine and anti-cytokine-receptor therapy. Cytokines Mol Ther 1995; 1: 107-113
25. Carbo N, Lopez-Soriano J, Costelli P, Busquets S, Alvarez B, Baccino FM, Quinn LS, Lopez-Soriano FJ, Argiles JM. Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats. Br J Cancer 2000; 83: 526-531
26. Strassmann G, Masui Y, Chizzonite R, Fong M. Mechanisms of experimental cancer cachexia. Local involvement of IL-1 in colon-26 tumor. J Immunol 1993; 150: 2341-2345
27. Gelin J, Andersson C, Lundholm K. Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. Cancer Res 1991; 51: 880-885
28. Niu Q, Li T, Liu A. Cytokines in experimental cancer cachexia. Zhonghua Zhongliu Zazhi 2001; 23: 382-384
29. Tanaka Y, Tanaka T, Ishitsuka H. Antitumor activity of indomethacin in mice bearing advanced colon 26 carcinoma compared with those with early transplants. Cancer Res 1989; 49: 5935-5939
30. Cai E, Chen Z, Wu W. The effects of lipopolysaccharide and antiinflammatory drugs on nuclear factor-kappa B in pulmonary intravascular macrophage. Zhonghua Jiehe He Huxi Zazhi 1999; 22: 283-286
31. Crinelli R, Antonelli A, Bianchi M, Gentilini L, Scaramucci S, Magnani M. Selective inhibition of NF-κB activation and TNF-alpha production in macrophages by red blood cell-mediated delivery of dexamethasone. Blood Cells Mol Dis 2000; 26: 211-222
32. Chang CK, Llanes S, Schumer W. Effect of dexamethasone on NF-κB activation, tumor necrosis factor formation, and glucose dyshomeostasis in septic rats. J Surg Res 1997; 72: 141-145
33. Amann R, Peskar BA. Anti-inflammatory effects of aspirin and sodium salicylate. Eur J Pharmacol 2002; 447: 1-9