Insulin stimulates interleukin-6 expression and release in LS14 human adipocytes through multiple signaling pathways

Endocrinology

Volumn 149, Issue 11, 2008, Pages 5415-5422

  LaPensee, Christopher R ^a   Hugo, Eric R ^a   Ben Jonathan, Nira ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DERIVATIVE; INSULIN; INTERLEUKIN 6; PROTEASOME; PROTEIN KINASE INHIBITOR;

ADIPOCYTE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE TIME EFFECT RELATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOREGULATION; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

ADIPOCYTES; CELL LINE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; INSULIN; INTERLEUKIN-6; ISOQUINOLINES; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; SULFONAMIDES; TIME FACTORS;

EID: 54349084538     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0549     Document Type: Article

References (39)

1. Kamimura D, Ishihara K, Hirano T 2003 IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 149:1-38
2. Path G, Bornstein SR, Gurniak M, Chrousos GP, Scherbaum WA, Hauner H 2001 Human breast adipocytes express interleukin-6 (IL-6) and its receptor system: increased IL-6 production by β-adrenergic activation and effects of IL-6 on adipocyte function. J Clin Endocrinol Metab 86:2281-2288
3. van Hall G, Steensberg A, Sacchetti M, Fischer C, Keller C, Schjerling P, Hiscock N, Moller K, Saltin B, Febbraio MA, Pedersen BK 2003 Interleukin-6 stimulates lipolysis and fat oxidation in humans. J Clin Endocrinol Metab 88:3005-3010
4. Trujillo ME, Sullivan S, Harten I, Schneider SH, Greenberg AS, Fried SK 2004 Interleukin-6 regulates human adipose tissue lipid metabolism and leptin production in vitro. J Clin Endocrinol Metab 89:5577-5582
5. Rotter V, Nagaev I, Smith U 2003 Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-α, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278:45777-45784
6. Fasshauer M, Kralisch S, Klier M, Lossner U, Bluher M, Klein J, Paschke R 2003 Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 301:1045-1050
7. Lagathu C, Bastard JP, Auclair M, Maachi M, Capeau J, Caron M 2003 Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem Biophys Res Commun 311:372-379
8. Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson SL, Ohlsson C, Jansson JO 2002 Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8:75-79
9. Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF 2003 Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 52:812-817
10. Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, Vidal H, Hainque B 2000 Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 85:3338-3342
11. Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S 2007 Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56:1010-1013
12. Yudkin JS 2003 Adipose tissue, insulin action and vascular disease: inflammatory signals. Int J Obes Relat Metab Disord 27(Suppl 3):S25-S28
13. Vicennati V, Vottero A, Friedman C, Papanicolaou DA 2002 Hormonal regulation of interleukin-6 production in human adipocytes. Int J Obes Relat Metab Disord 26:905-911
14. Fasshauer M, Klein J, Lossner U, Paschke R 2003 Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor α, growth hormone, and IL-6 in 3T3-L1 adipocytes. Horm Metab Res 35:147-152
15. Hugo ER, Brandebourg TD, Comstock CE, Gersin KS, Sussman JJ, Ben Jonathan N 2006 LS14: a novel human adipocyte cell line that produces prolactin. Endocrinology 147:306-313
16. Pfaffl MW, Horgan GW, Dempfle L 2002 Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30:e36
17. Nam S, Smith DM, Dou QP 2001 Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J Biol Chem 276:13322-13330
18. Ahima RS 2006 Adipose tissue as an endocrine organ. Obesity (Silver Spring) 14(Suppl 5):242S-249S
19. Fried SK, Bunkin DA, Greenberg AS 1998 Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83:847-850
20. Fain JN 2006 Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 74:443-477
21. Antunes TT, Gagnon A, Chen B, Pacini F, Smith TJ, Sorisky A 2006 Interleukin-6 release from human abdominal adipose cells is regulated by thyroid-stimulating hormone: effect of adipocyte differentiation and anatomic depot. Am J Physiol Endocrinol Metab 290:E1140-E1144
22. Harkins JM, Moustaid-Moussa N, Chung YJ, Penner KM, Pestka JJ, North CM, Claycombe KJ 2004 Expression of interleukin-6 is greater in preadipocytes than in adipocytes of 3T3-L1 cells and C57BL/6J and ob/ob mice. J Nutr 134:2673-2677
23. Antunes TT, Gagnon A, Bell A, Sorisky A 2005 Thyroid-stimulating hormone stimulates interleukin-6 release from 3T3-L1 adipocytes through a cAMP-protein kinase A pathway. Obes Res 13:2066-2071
24. Elks ML, Manganiello VC 1985 Antilipolytic action of insulin: role of cAMP phosphodiesterase activation. Endocrinology 116:2119-2121
25. Vaandrager AB, de Jonge HR 1996 Signalling by cGMP-dependent protein kinases. Mol Cell Biochem 157:23-30
26. Jacob A, Molkentin JD, Smolenski A, Lohmann SM, Begum N 2002 Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs. Am J Physiol Cell Physiol 283:C704-C713
27. Bergandi L, Silvagno F, Russo I, Riganti C, Anfossi G, Aldieri E, Ghigo D, Trovati M, Bosia A 2003 Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 23:2215-2221
28. Dendorfer U, Oettgen P, Libermann TA 1995 Interleukin-6 gene expression by prostaglandins and cyclic AMP mediated by multiple regulatory elements. Am J Ther 2:660-665
29. Gudi T, Casteel DE, Vinson C, Boss GR, Pilz RB 2000 NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation. Oncogene 19:6324-6333
30. Ciani E, Guidi S, Bartesaghi R, Contestabile A 2002 Nitric oxide regulates cGMP-dependent cAMP-responsive element binding protein phosphorylation and Bcl-2 expression in cerebellar neurons: implication for a survival role of nitric oxide. J Neurochem 82:1282-1289
31. Broderick KE, Zhang T, Rangaswami H, Zeng Y, Zhao X, Boss GR, Pilz RB 2007 Guanosine 3′,5′-cyclic monophosphate (cGMP)/cGMP-dependent protein kinase induce interleukin-6 transcription in osteoblasts. Mol Endocrinol 21:1148-1162
32. Martinez-deMena R, Obregon MJ 2005 Insulin increases the adrenergic stimulation of 5′ deiodinase activity and mRNA expression in rat brown adipocytes; role of MAPK and PI3K. J Mol Endocrinol 34:139-151
33. Lee DH, Goldberg AL 1998 Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol 8:397-403
34. Lee MJ, Fried SK 2006 Multilevel regulation of leptin storage, turnover, and secretion by feeding and insulin in rat adipose tissue. J Lipid Res 47:1984-1993
35. Rau H, Reaves BJ, O'Rahilly S, Whitehead JP 1999 Truncated human leptin (δ133) associated with extreme obesity undergoes proteasomal degradation after defective intracellular transport. Endocrinology 140:1718-1723
36. Bennett RG, Fawcett J, Kruer MC, Duckworth WC, Hamel FG 2003 Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme. J Endocrinol 177:399-405
37. Bradley RL, Cheatham B 1999 Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes. Diabetes 48:272-278
38. Wang ZV, Schraw TD, Kim JY, Khan T, Rajala MW, Follenzi A, Scherer PE 2007 Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol 27:3716-3731
39. Huising MO, Kruiswijk CP, Flik G 2006 Phylogeny and evolution of class-I helical cytokines. J Endocrinol 189:1-25