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Volumn 11, Issue 1, 2011, Pages 44-55

Current treatment concepts of Philadelphia-negative MPN

Author keywords

Jak2; Philadelphia negative mpn; Treatment concepts

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA INTERFERON; ANAGRELIDE; AZACITIDINE; BEVACIZUMAB; CHLORAMBUCIL; CYTOTOXIC AGENT; DANAZOL; DASATINIB; HYDROXYUREA; IMATINIB; INCB 18424; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; LENALIDOMIDE; LESTAURTINIB; MEPOLIZUMAB; MIDOSTAURIN; NILOTINIB; PEGINTERFERON ALPHA; PHOSPHORUS 32; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POMALIDOMIDE; PROTEIN TYROSINE KINASE INHIBITOR; SEMAXANIB; TG 101348; THALIDOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VATALANIB; XL 019;

EID: 78951485869     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/156800911793743592     Document Type: Review
Times cited : (8)

References (94)
  • 3
    • 0025213422 scopus 로고
    • Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia
    • Cortelazzo, S.; Viero, P.; Finazzi, G.; D'Emilio, A.; Rodeghiero, F.; Barbui, T. Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia. J. Clin. Oncol. 1990, 8, 556-562.
    • (1990) J. Clin. Oncol , vol.8 , pp. 556-562
    • Cortelazzo, S.1    Viero, P.2    Finazzi, G.3    D'Emilio, A.4    Rodeghiero, F.5    Barbui, T.6
  • 5
    • 21444457418 scopus 로고    scopus 로고
    • When and how to treat essential thrombocythemia
    • Barbui, T.; Finazzi, G. When and how to treat essential thrombocythemia. N. Engl. J. Med. 2005, 353, 85-86.
    • (2005) N. Engl. J. Med , vol.353 , pp. 85-86
    • Barbui, T.1    Finazzi, G.2
  • 8
    • 33947262701 scopus 로고    scopus 로고
    • Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: Interaction with treatment, standard risk factors, and Jak2 mutation status
    • Carobbio, A.; Finazzi, G.; Guerini, V.; Spinelli, O.; Delaini, F.; Marchioli, R.; Borrelli, G.; Rambaldi, A.; Barbui, T. Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status. Blood 2007, 109, 2310-2313.
    • (2007) Blood , vol.109 , pp. 2310-2313
    • Carobbio, A.1    Finazzi, G.2    Guerini, V.3    Spinelli, O.4    Delaini, F.5    Marchioli, R.6    Borrelli, G.7    Rambaldi, A.8    Barbui, T.9
  • 11
    • 54049129367 scopus 로고    scopus 로고
    • The JAK2 V617F mutation and thrombosis
    • Austin, S. K.; Lambert, J. R. The JAK2 V617F mutation and thrombosis. Br. J. Haematol. 2008, 143, 307-320.
    • (2008) Br. J. Haematol , vol.143 , pp. 307-320
    • Austin, S.K.1    Lambert, J.R.2
  • 12
    • 55049131023 scopus 로고    scopus 로고
    • Is JAK2 V617F mutation more than a diagnostic index? A meta-analysis of clinical outcomes in essential thrombocythemia
    • Dahabreh, I. J.; Zoi, K.; Giannouli, S.; Zoi, C.; Loukopoulos, D.; Voulgarelis, M. Is JAK2 V617F mutation more than a diagnostic index? A meta-analysis of clinical outcomes in essential thrombocythemia. Leuk. Res. 2009, 33, 67-73.
    • (2009) Leuk. Res , vol.33 , pp. 67-73
    • Dahabreh, I.J.1    Zoi, K.2    Giannouli, S.3    Zoi, C.4    Loukopoulos, D.5    Voulgarelis, M.6
  • 13
    • 50849103654 scopus 로고    scopus 로고
    • Effect of JAK2 V617F on thrombotic risk in patients with essential thrombocythemia: Measuring the uncertain
    • Ziakas, P. D. Effect of JAK2 V617F on thrombotic risk in patients with essential thrombocythemia: measuring the uncertain. Haematologica 2008, 93(9), 1412-1414.
    • (2008) Haematologica , vol.93 , Issue.9 , pp. 1412-1414
    • Ziakas, P.D.1
  • 14
    • 2942579910 scopus 로고    scopus 로고
    • Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation
    • Barbui, T.; Barosi, G.; Grossi, A.; Gugliotta, L.; Liberato, L. N.; Marchetti, M.; Mazzucconi, M. G.; Rodeghiero, F.; Tura, S. Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation. Haematologica 2004, 89, 215-232.
    • (2004) Haematologica , vol.89 , pp. 215-232
    • Barbui, T.1    Barosi, G.2    Grossi, A.3    Gugliotta, L.4    Liberato, L.N.5    Marchetti, M.6    Mazzucconi, M.G.7    Rodeghiero, F.8    Tura, S.9
  • 17
    • 0018181405 scopus 로고
    • Vascular occlusive episodes and venous haematocrit in primary proliferative polycythaemia
    • Pearson, T. C.; Wetherley-Mein, G. Vascular occlusive episodes and venous haematocrit in primary proliferative polycythaemia. Lancet 1978, 2, 1219-1222.
    • (1978) Lancet , vol.2 , pp. 1219-1222
    • Pearson, T.C.1    Wetherley-Mein, G.2
  • 19
    • 13444256042 scopus 로고    scopus 로고
    • Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia
    • Elliott, M. A.; Tefferi, A. Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia. Br. J. Haematol. 2005, 128, 275-290.
    • (2005) Br. J. Haematol , vol.128 , pp. 275-290
    • Elliott, M.A.1    Tefferi, A.2
  • 23
    • 0029858926 scopus 로고    scopus 로고
    • Interferon-alpha in the treatment of essential thrombocythemia
    • Lengfelder, E.; Griesshammer, M.; Hehlmann, R. Interferon-alpha in the treatment of essential thrombocythemia. Leuk. Lymphoma 1996, 22 Suppl 1, 135-142.
    • (1996) Leuk. Lymphoma , vol.22 , Issue.SUPPL. 1 , pp. 135-142
    • Lengfelder, E.1    Griesshammer, M.2    Hehlmann, R.3
  • 24
    • 35548934821 scopus 로고    scopus 로고
    • Myeloproliferative disease in pregnancy and other management issues
    • Barbui, T.; Finazzi, G. Myeloproliferative disease in pregnancy and other management issues. Hematol. Am. Soc. Hematol. Educ. Program 2006, 246-252.
    • (2006) Hematol. Am. Soc. Hematol. Educ. Program , pp. 246-252
    • Barbui, T.1    Finazzi, G.2
  • 25
    • 0028844554 scopus 로고
    • Gruppo Italiano Studio Policitemia
    • Polycythemia vera: the natural history of 1213 patients followed for 20 years
    • Polycythemia vera: the natural history of 1213 patients followed for 20 years. Gruppo Italiano Studio Policitemia. Ann. Intern. Med. 1995, 123, 656-664.
    • (1995) Ann. Intern. Med , vol.123 , pp. 656-664
  • 26
    • 0001148171 scopus 로고
    • Complications and causes of death in polycythaemia vera
    • Chievitz, E.; Thiede, T. Complications and causes of death in polycythaemia vera. Acta. Med. Scand. 1962, 172, 513-523.
    • (1962) Acta. Med. Scand , vol.172 , pp. 513-523
    • Chievitz, E.1    Thiede, T.2
  • 29
    • 0022703490 scopus 로고
    • Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols
    • Berk, P. D.; Goldberg, J. D.; Donovan, P. B.; Fruchtman, S. M.; Berlin, N. I.; Wasserman, L. R. Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols. Semin. Hematol. 1986, 23, 132-143.
    • (1986) Semin. Hematol , vol.23 , pp. 132-143
    • Berk, P.D.1    Goldberg, J.D.2    Donovan, P.B.3    Fruchtman, S.M.4    Berlin, N.I.5    Wasserman, L.R.6
  • 31
    • 0031047229 scopus 로고    scopus 로고
    • Interferon alfa: Effects of long-term treatment for polycythemia vera
    • Silver, R. T. Interferon alfa: effects of long-term treatment for polycythemia vera. Semin. Hematol. 1997, 34, 40-50.
    • (1997) Semin. Hematol , vol.34 , pp. 40-50
    • Silver, R.T.1
  • 32
    • 33746307253 scopus 로고    scopus 로고
    • Long-term effects of the treatment of polycythemia vera with recombinant interferon-alpha
    • Silver, R. T. Long-term effects of the treatment of polycythemia vera with recombinant interferon-alpha. Cancer 2006, 107, 451-458.
    • (2006) Cancer , vol.107 , pp. 451-458
    • Silver, R.T.1
  • 34
    • 0031841069 scopus 로고    scopus 로고
    • Myelofibrosis with myeloid metaplasia in young individuals: Disease characteristics, prognostic factors and identification of risk groups
    • Cervantes, F.; Barosi, G.; Demory, J. L.; Reilly, J.; Guarnone, R.; Dupriez, B.; Pereira, A.; Montserrat, E. Myelofibrosis with myeloid metaplasia in young individuals: disease characteristics, prognostic factors and identification of risk groups. Br. J. Haematol. 1998, 102, 684-690.
    • (1998) Br. J. Haematol , vol.102 , pp. 684-690
    • Cervantes, F.1    Barosi, G.2    Demory, J.L.3    Reilly, J.4    Guarnone, R.5    Dupriez, B.6    Pereira, A.7    Montserrat, E.8
  • 36
    • 0029767865 scopus 로고    scopus 로고
    • Prognostic factors in agnogenic myeloid metaplasia: A report on 195 cases with a new scoring system
    • Dupriez, B.; Morel, P.; Demory, J. L.; Lai, J. L.; Simon, M.; Plantier, I.; Bauters, F. Prognostic factors in agnogenic myeloid metaplasia: a report on 195 cases with a new scoring system. Blood 1996, 88, 1013-1018.
    • (1996) Blood , vol.88 , pp. 1013-1018
    • Dupriez, B.1    Morel, P.2    Demory, J.L.3    Lai, J.L.4    Simon, M.5    Plantier, I.6    Bauters, F.7
  • 37
    • 33745811661 scopus 로고    scopus 로고
    • Palliative goals, patient selection, and perioperative platelet management: Outcomes and lessons from 3 decades of splenectomy for myelofibrosis with myeloid metaplasia at the Mayo Clinic
    • Mesa, R. A.; Nagorney, D. S.; Schwager, S.; Allred, J.; Tefferi, A. Palliative goals, patient selection, and perioperative platelet management: outcomes and lessons from 3 decades of splenectomy for myelofibrosis with myeloid metaplasia at the Mayo Clinic. Cancer 2006, 107, 361-370.
    • (2006) Cancer , vol.107 , pp. 361-370
    • Mesa, R.A.1    Nagorney, D.S.2    Schwager, S.3    Allred, J.4    Tefferi, A.5
  • 38
    • 66149113655 scopus 로고    scopus 로고
    • The role of cytogenetic abnormalities as a prognostic marker in primary myelofibrosis: Applicability at the time of diagnosis and later during disease course
    • Tam, C. S.; Abruzzo, L. V.; Lin, K. I.; Cortes, J.; Lynn, A.; Keating, M. J.; Thomas, D. A.; Pierce, S.; Kantarjian, H.; Verstovsek, S. The role of cytogenetic abnormalities as a prognostic marker in primary myelofibrosis: applicability at the time of diagnosis and later during disease course. Blood 2009, 113, 4171-4178.
    • (2009) Blood , vol.113 , pp. 4171-4178
    • Tam, C.S.1    Abruzzo, L.V.2    Lin, K.I.3    Cortes, J.4    Lynn, A.5    Keating, M.J.6    Thomas, D.A.7    Pierce, S.8    Kantarjian, H.9    Verstovsek, S.10
  • 41
    • 0033135848 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation for agnogenic myeloid metaplasia: A European Group for Blood and Marrow Transplantation, Societe Francaise de Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study
    • Guardiola, P.; Anderson, J. E.; Bandini, G.; Cervantes, F.; Runde, V.; Arcese, W.; Bacigalupo, A.; Przepiorka, D.; O'Donnell, M. R.; Polchi, P.; Buzyn, A.; Sutton, L.; Cazals-Hatem, D.; Sale, G.; de Witte, T.; Deeg, H. J.; Gluckman, E. Allogeneic stem cell transplantation for agnogenic myeloid metaplasia: a European Group for Blood and Marrow Transplantation, Societe Francaise de Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study. Blood 1999, 93, 2831-2838.
    • (1999) Blood , vol.93 , pp. 2831-2838
    • Guardiola, P.1    Anderson, J.E.2    Bandini, G.3    Cervantes, F.4    Runde, V.5    Arcese, W.6    Bacigalupo, A.7    Przepiorka, D.8    O'Donnell, M.R.9    Polchi, P.10    Buzyn, A.11    Sutton, L.12    Cazals-Hatem, D.13    Sale, G.14    de Witte, T.15    Deeg, H.J.16    Gluckman, E.17
  • 42
    • 20844457922 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning in intermediateor high-risk patients with myelofibrosis with myeloid metaplasia
    • Rondelli, D.; Barosi, G.; Bacigalupo, A.; Prchal, J. T.; Popat, U.; Alessandrino, E. P.; Spivak, J. L.; Smith, B. D.; Klingemann, H. G.; Fruchtman, S.; Hoffman, R. Allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning in intermediateor high-risk patients with myelofibrosis with myeloid metaplasia. Blood 2005, 105, 4115-4119.
    • (2005) Blood , vol.105 , pp. 4115-4119
    • Rondelli, D.1    Barosi, G.2    Bacigalupo, A.3    Prchal, J.T.4    Popat, U.5    Alessandrino, E.P.6    Spivak, J.L.7    Smith, B.D.8    Klingemann, H.G.9    Fruchtman, S.10    Hoffman, R.11
  • 44
  • 47
    • 0031903305 scopus 로고    scopus 로고
    • rHuEpo for the treatment of anemia in myelofibrosis with myeloid metaplasia. Experience in 6 patients and meta-analytical approach
    • Rodriguez, J. N.; Martino, M. L.; Dieguez, J. C.; Prados, D. rHuEpo for the treatment of anemia in myelofibrosis with myeloid metaplasia. Experience in 6 patients and meta-analytical approach. Haematologica 1998, 83, 616-621.
    • (1998) Haematologica , vol.83 , pp. 616-621
    • Rodriguez, J.N.1    Martino, M.L.2    Dieguez, J.C.3    Prados, D.4
  • 48
    • 21344468831 scopus 로고    scopus 로고
    • Efficacy and tolerability of danazol as a treatment for the anaemia of myelofibrosis with myeloid metaplasia: Long-term results in 30 patients
    • Cervantes, F.; Alvarez-Larran, A.; Domingo, A.; Arellano-Rodrigo, E.; Montserrat, E. Efficacy and tolerability of danazol as a treatment for the anaemia of myelofibrosis with myeloid metaplasia: long-term results in 30 patients. Br. J. Haematol. 2005, 129, 771-775.
    • (2005) Br. J. Haematol , vol.129 , pp. 771-775
    • Cervantes, F.1    Alvarez-Larran, A.2    Domingo, A.3    Arellano-Rodrigo, E.4    Montserrat, E.5
  • 54
    • 77949535491 scopus 로고    scopus 로고
    • Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis
    • Santos, F. P.; Kantarjian, H. M.; Jain, N.; Manshouri, T.; Thomas, D. A.; Garcia-Manero, G.; Kennedy, D.; Estrov, Z.; Cortes, J.; Verstovsek, S. Phase 2 study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis. Blood 2010, 115, 1131-1136.
    • (2010) Blood , vol.115 , pp. 1131-1136
    • Santos, F.P.1    Kantarjian, H.M.2    Jain, N.3    Manshouri, T.4    Thomas, D.A.5    Garcia-Manero, G.6    Kennedy, D.7    Estrov, Z.8    Cortes, J.9    Verstovsek, S.10
  • 55
    • 0034176014 scopus 로고    scopus 로고
    • Splenectomy in myelofibrosis with myeloid metaplasia: A single-institution experience with 223 patients
    • Tefferi, A.; Mesa, R. A.; Nagorney, D. M.; Schroeder, G.; Silverstein, M. N. Splenectomy in myelofibrosis with myeloid metaplasia: a single-institution experience with 223 patients. Blood 2000, 95, 2226-2233.
    • (2000) Blood , vol.95 , pp. 2226-2233
    • Tefferi, A.1    Mesa, R.A.2    Nagorney, D.M.3    Schroeder, G.4    Silverstein, M.N.5
  • 58
    • 34249826968 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor of vascular endothelial growth factor (VEGF), has modest activity in myelofibrosis with myeloid metaplasia
    • Giles, F. J.; List, A. F.; Carroll, M.; Cortes, J. E.; Valickas, J.; Chen, B. L.; Masson, E.; Jacques, C.; Laurent, D.; Albitar, M.; Feldman, E. J.; Roboz, G. J. PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor of vascular endothelial growth factor (VEGF), has modest activity in myelofibrosis with myeloid metaplasia. Leuk. Res. 2007, 31, 891-897.
    • (2007) Leuk. Res , vol.31 , pp. 891-897
    • Giles, F.J.1    List, A.F.2    Carroll, M.3    Cortes, J.E.4    Valickas, J.5    Chen, B.L.6    Masson, E.7    Jacques, C.8    Laurent, D.9    Albitar, M.10    Feldman, E.J.11    Roboz, G.J.12
  • 61
    • 0344809973 scopus 로고    scopus 로고
    • Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia
    • Simon, H. U.; Plotz, S. G.; Dummer, R.; Blaser, K. Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia. N. Engl. J. Med. 1999, 341, 1112-1120.
    • (1999) N. Engl. J. Med , vol.341 , pp. 1112-1120
    • Simon, H.U.1    Plotz, S.G.2    Dummer, R.3    Blaser, K.4
  • 64
    • 38349101871 scopus 로고    scopus 로고
    • Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms
    • Tefferi, A.; Vardiman, J. W. Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia 2008, 22, 14-22.
    • (2008) Leukemia , vol.22 , pp. 14-22
    • Tefferi, A.1    Vardiman, J.W.2
  • 66
    • 63349097828 scopus 로고    scopus 로고
    • Imatinib has limited therapeutic activity for hypereosinophilic syndrome patients with unknown or negative PDGFRalpha mutation status
    • Jain, N.; Cortes, J.; Quintas-Cardama, A.; Manshouri, T.; Luthra, R.; Garcia-Manero, G.; Kantarjian, H.; Verstovsek, S. Imatinib has limited therapeutic activity for hypereosinophilic syndrome patients with unknown or negative PDGFRalpha mutation status. Leuk. Res. 2009, 33, 837-839.
    • (2009) Leuk. Res , vol.33 , pp. 837-839
    • Jain, N.1    Cortes, J.2    Quintas-Cardama, A.3    Manshouri, T.4    Luthra, R.5    Garcia-Manero, G.6    Kantarjian, H.7    Verstovsek, S.8
  • 69
    • 41449117618 scopus 로고    scopus 로고
    • Primary resistance to imatinib in Fip1-like 1-platelet-derived growth factor receptor alpha-positive eosinophilic leukemia
    • Simon, D.; Salemi, S.; Yousefi, S.; Simon, H. U. Primary resistance to imatinib in Fip1-like 1-platelet-derived growth factor receptor alpha-positive eosinophilic leukemia. J. Allergy Clin. Immunol. 2008, 121, 1054-1056.
    • (2008) J. Allergy Clin. Immunol , vol.121 , pp. 1054-1056
    • Simon, D.1    Salemi, S.2    Yousefi, S.3    Simon, H.U.4
  • 73
    • 34548177003 scopus 로고    scopus 로고
    • A critical appraisal of conventional and investigational drug therapy in patients with hypereosinophilic syndrome and clonal eosinophilia
    • Kalac, M.; Quintas-Cardama, A.; Vrhovac, R.; Kantarjian, H.; Verstovsek, S. A critical appraisal of conventional and investigational drug therapy in patients with hypereosinophilic syndrome and clonal eosinophilia. Cancer 2007, 110, 955-964.
    • (2007) Cancer , vol.110 , pp. 955-964
    • Kalac, M.1    Quintas-Cardama, A.2    Vrhovac, R.3    Kantarjian, H.4    Verstovsek, S.5
  • 74
    • 1842579577 scopus 로고    scopus 로고
    • Safety and efficacy of the monoclonal antiinterleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome
    • Klion, A. D.; Law, M. A.; Noel, P.; Kim, Y. J.; Haverty, T. P.; Nutman, T. B. Safety and efficacy of the monoclonal antiinterleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome. Blood 2004, 103, 2939-2941.
    • (2004) Blood , vol.103 , pp. 2939-2941
    • Klion, A.D.1    Law, M.A.2    Noel, P.3    Kim, Y.J.4    Haverty, T.P.5    Nutman, T.B.6
  • 77
    • 33745093948 scopus 로고    scopus 로고
    • Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): Detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib
    • Florian, S.; Esterbauer, H.; Binder, T.; Mullauer, L.; Haas, O. A.; Sperr, W. R.; Sillaber, C.; Valent, P. Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib. Leuk. Res. 2006, 30, 1201-1205.
    • (2006) Leuk. Res , vol.30 , pp. 1201-1205
    • Florian, S.1    Esterbauer, H.2    Binder, T.3    Mullauer, L.4    Haas, O.A.5    Sperr, W.R.6    Sillaber, C.7    Valent, P.8
  • 78
    • 0030746118 scopus 로고    scopus 로고
    • Hymenoptera sting anaphylaxis and urticaria pigmentosa: Clinical findings and results of venom immunotherapy in ten patients
    • Fricker, M.; Helbling, A.; Schwartz, L.; Muller, U. Hymenoptera sting anaphylaxis and urticaria pigmentosa: clinical findings and results of venom immunotherapy in ten patients. J. Allergy Clin. Immunol. 1997, 100, 11-15.
    • (1997) J. Allergy Clin. Immunol , vol.100 , pp. 11-15
    • Fricker, M.1    Helbling, A.2    Schwartz, L.3    Muller, U.4
  • 79
    • 0036204671 scopus 로고    scopus 로고
    • Mastocytosis: Mediator-related signs and symptoms
    • Castells, M.; Austen, K. F. Mastocytosis: mediator-related signs and symptoms. Int. Arch. Allergy Immunol. 2002, 127, 147-152.
    • (2002) Int. Arch. Allergy Immunol , vol.127 , pp. 147-152
    • Castells, M.1    Austen, K.F.2
  • 80
    • 0034050944 scopus 로고    scopus 로고
    • Clinical and biologic diversity of leukemias occurring in patients with mastocytosis
    • Sperr, W. R.; Horny, H. P.; Lechner, K.; Valent, P. Clinical and biologic diversity of leukemias occurring in patients with mastocytosis. Leuk. Lymphoma 2000, 37, 473-486.
    • (2000) Leuk. Lymphoma , vol.37 , pp. 473-486
    • Sperr, W.R.1    Horny, H.P.2    Lechner, K.3    Valent, P.4
  • 81
    • 0036210049 scopus 로고    scopus 로고
    • Spectrum of associated clonal hematologic non-mast cell lineage disorders occurring in patients with systemic mastocytosis
    • Sperr, W. R.; Horny, H. P.; Valent, P. Spectrum of associated clonal hematologic non-mast cell lineage disorders occurring in patients with systemic mastocytosis. Int. Arch. Allergy Immunol. 2002, 127, 140-142.
    • (2002) Int. Arch. Allergy Immunol , vol.127 , pp. 140-142
    • Sperr, W.R.1    Horny, H.P.2    Valent, P.3
  • 83
    • 0345772088 scopus 로고    scopus 로고
    • Aggressive systemic mastocytosis and related mast cell disorders: Current treatment options and proposed response criteria
    • Valent, P.; Akin, C.; Sperr, W. R.; Escribano, L.; Arock, M.; Horny, H. P.; Bennett, J. M.; Metcalfe, D. D. Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria. Leuk. Res. 2003, 27, 635-641.
    • (2003) Leuk. Res , vol.27 , pp. 635-641
    • Valent, P.1    Akin, C.2    Sperr, W.R.3    Escribano, L.4    Arock, M.5    Horny, H.P.6    Bennett, J.M.7    Metcalfe, D.D.8
  • 87
    • 0344741334 scopus 로고    scopus 로고
    • Treatment of systemic mast cell disease with 2- chlorodeoxyadenosine
    • Pardanani, A.; Hoffbrand, A. V.; Butterfield, J. H.; Tefferi, A. Treatment of systemic mast cell disease with 2- chlorodeoxyadenosine. Leuk. Res. 2004, 28, 127-131.
    • (2004) Leuk. Res , vol.28 , pp. 127-131
    • Pardanani, A.1    Hoffbrand, A.V.2    Butterfield, J.H.3    Tefferi, A.4
  • 89
    • 33645687784 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis
    • Shah, N. P.; Lee, F. Y.; Luo, R.; Jiang, Y.; Donker, M.; Akin, C. Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis. Blood 2006, 108, 286-291.
    • (2006) Blood , vol.108 , pp. 286-291
    • Shah, N.P.1    Lee, F.Y.2    Luo, R.3    Jiang, Y.4    Donker, M.5    Akin, C.6
  • 90
    • 30444446680 scopus 로고    scopus 로고
    • PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: Comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects
    • Gleixner, K. V.; Mayerhofer, M.; Aichberger, K. J.; Derdak, S.; Sonneck, K.; Bohm, A.; Gruze, A.; Samorapoompichit, P.; Manley, P. W.; Fabbro, D.; Pickl, W. F.; Sillaber, C.; Valent, P. PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects. Blood 2006, 107, 752-759.
    • (2006) Blood , vol.107 , pp. 752-759
    • Gleixner, K.V.1    Mayerhofer, M.2    Aichberger, K.J.3    Derdak, S.4    Sonneck, K.5    Bohm, A.6    Gruze, A.7    Samorapoompichit, P.8    Manley, P.W.9    Fabbro, D.10    Pickl, W.F.11    Sillaber, C.12    Valent, P.13
  • 92
    • 26944458584 scopus 로고    scopus 로고
    • The systemic mastocytosis-specific activating cKit mutation D816V can be inhibited by the tyrosine kinase inhibitor AMN107
    • von Bubnoff, N.; Gorantla, S. H.; Kancha, R. K.; Lordick, F.; Peschel, C.; Duyster, J. The systemic mastocytosis-specific activating cKit mutation D816V can be inhibited by the tyrosine kinase inhibitor AMN107. Leukemia 2005, 19(9), 1670-1671.
    • (2005) Leukemia , vol.19 , Issue.9 , pp. 1670-1671
    • von Bubnoff, N.1    Gorantla, S.H.2    Kancha, R.K.3    Lordick, F.4    Peschel, C.5    Duyster, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.