Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia

New England Journal of Medicine

Volumn 341, Issue 15, 1999, Pages 1112-1120

  Simon, Hans Uwe ^a   Plötz, Sabine Gisela ^b   Dummer, Reinhard ^a   Blaser, Kurt ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 5;

ADULT; ARTICLE; CHILD; EOSINOPHIL; EOSINOPHILIA; FLOW CYTOMETRY; HUMAN; LYMPHOCYTE ACTIVATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; AGED; AGED, 80 AND OVER; CHILD, PRESCHOOL; CLONE CELLS; EOSINOPHILIA; FEMALE; GENE EXPRESSION; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, GAMMA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; HYPEREOSINOPHILIC SYNDROME; IMMUNOPHENOTYPING; INTERLEUKIN-5; MALE; MIDDLE AGED; T-LYMPHOCYTES;

EID: 0344809973     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199910073411503     Document Type: Article

References (22)

1. Simon HU, Blaser K. Inhibition of programmed eosinophil death: a key pathogenic event for eosinophilia? Immunol Today 1995;16:53-5.
2. Simon HU, Yousefi S, Schranz C, Schapowal A, Bachert C, Blaser K. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 1997;158:3902-8.
3. Sanderson CJ. Interleukin-5, eosinophils, and disease. Blood 1992;79: 3101-9.
4. Weller PF, Bubley GJ. The idiopathic hypereosinophilic syndrome. Blood 1994;83:2759-79.
5. Cogan E, Schandené L, Crusiaux A, Cochaux P, Velu T, Goldman M. Brief report: clonal proliferation of type 2 helper T cells in a man with the hypereosinophilic syndrome. N Engl J Med 1994;330:535-8.
6. Brugnoni D, Airo P, Rossi G, et al. A case of hypereosinophilic syndrome is associated with the expansion of a CD3-CD4+ T-cell population able to secrete large amounts of interleukin-5. Blood 1996;87:1416-22.
7. Simon HU, Yousefi S, Dommann-Scherrer CC, et al. Expansion of cytokine-producing CD4-CD8-T cells associated with abnormal Fas expression and hypereosinophilia. J Exp Med 1996;183:1071-82.
8. Akdis CA, Blesken T, Akdis M, Wüthrich B, Blaser K. Role of interleukin 10 in specific immunotherapy. J Clin Invest 1998;102:98-106.
9. Azzawi M, Bradley B, Jeffery PK, et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990;142:1407-13.
10. Bourguin A, Tung R, Galili N, Sklar J. Rapid, nonradioactive detection of clonal T-cell receptor gene rearrangements in lymphoid neoplasms. Proc Natl Acad Sci U S A 1990;87:8536-40.
11. Dibbert B, Daigle I, Braun D, et al. Role for Bcl-xL in delayed eosinophil apoptosis mediated by granulocyte-macrophage colony-stimulating factor and interleukin-5. Blood 1998;92:778-83.
12. Kamarashev J, Burg G, Kempf W, Hess Schmid M, Dummer R. Comparative analysis of histological and immunohistological features in mycosis fungoides and Sézary syndrome. J Cutan Pathol 1998;25:407-12.
13. Nagata S, Suda T. Fas and Fas ligand: lpr and gld mutations. Immunol Today 1995;16:39-43.
14. Egle A, Villunger A, Kos M, et al. Modulation of Apo-1/Fas (CD95)-induced programmed cell death in myeloma cells by interferon-alpha 2. Eur J Immunol 1996;26:3119-26.
15. Selleri C, Sato T, Del Vecchio L, et al. Involvement of Fas-mediated apoptosis in the inhibitory effects of interferon-alpha in chronic myelogenous leukemia. Blood 1997;89:957-64.
16. Buechner SA, Wernli M, Harr T, Hahn S, Itin P, Erb P. Regression of basal cell carcinoma by intralesional interferon-alpha treatment is mediated by CD95 (Apo-1/Fas)-CD95 ligand-induced suicide. J Clin Invest 1997; 100:2691-6.
17. Wood GS, Bourguin A, Crooks CF, Sklar J. Quantitation of T-cell DNA in cutaneous lymphoid infiltrates. Am J Pathol 1991;138:1503-9.
18. Meyer JC, Hassam S, Dummer R, et al. A realistic approach to the sensitivity of PCR-DGGE and its application as a sensitive tool for the detection of clonality in cutaneous T-cell proliferations. Exp Dermatol 1997; 6:122-7.
19. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994;84:1361-92.
20. Willemze R, Kerl H, Sterry W, et al. EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. Blood 1997;90:354-71.
21. Bogen SA, Pelley D, Charif M, et al. Immunophenotypic identification of Sézary cells in peripheral blood. Am J Clin Pathol 1996;106:739-48.
22. Dummer R, Heald PW, Nestle FO, et al. Sézary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon-gamma receptor beta-chain). Blood 1996;88:1383-9.