메뉴 건너뛰기




Volumn 110, Issue 5, 2007, Pages 955-964

A critical appraisal of conventional and investigational drug therapy in patients with hypereosinophilic syndrome and clonal eosinophilia

Author keywords

Alemtuzumab; Eosinophilia; Hypereosinophilic syndrome; Imatinib; Mepolizumab; Tyrosine kinase inhibitors

Indexed keywords

ALEMTUZUMAB; ANTIMETABOLITE; BCR ABL PROTEIN; CHLORAMBUCIL; CLADRIBINE; COLCHICINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTARABINE; ETOPOSIDE; HYBRID PROTEIN; HYDROXYUREA; IMATINIB; INTERLEUKIN 5; MEPOLIZUMAB; METHOTREXATE; MIDOSTAURIN; NILOTINIB; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PREDNISONE; PROTEIN FIP1L1 PDGFRA; PROTEIN FIP1L1 PDGFRA T674; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE INHIBITOR; TIOGUANINE; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 34548177003     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.22920     Document Type: Review
Times cited : (28)

References (111)
  • 1
    • 0344987881 scopus 로고    scopus 로고
    • A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
    • Cools J, DeAngelo DJ, Gotlib J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 2003;348:1201-1214.
    • (2003) N Engl J Med , vol.348 , pp. 1201-1214
    • Cools, J.1    DeAngelo, D.J.2    Gotlib, J.3
  • 2
    • 0028323393 scopus 로고
    • The idiopathic hypereosinophilic syndrome
    • Weller PF, Bubley GJ. The idiopathic hypereosinophilic syndrome. Blood. 1994;83:2759-2779.
    • (1994) Blood , vol.83 , pp. 2759-2779
    • Weller, P.F.1    Bubley, G.J.2
  • 3
    • 0016430025 scopus 로고
    • The hypereosinophilic syndrome: Analysis of fourteen cases with review of the literature
    • Chusid MJ, Dale DC, West BC, Wolff SM. The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore). 1975;54:1-27.
    • (1975) Medicine (Baltimore) , vol.54 , pp. 1-27
    • Chusid, M.J.1    Dale, D.C.2    West, B.C.3    Wolff, S.M.4
  • 5
    • 0019966379 scopus 로고    scopus 로고
    • Fauci AS, Harley JB, Roberts WC, Ferrans VJ, Gralnick HR, Bjornson BH. NIH conference. The idiopathic hypereosinophilic syndrome. Clinical, pathophysiologic, and therapeutic considerations. Ann Intern Med. 1982;97:78-92.
    • Fauci AS, Harley JB, Roberts WC, Ferrans VJ, Gralnick HR, Bjornson BH. NIH conference. The idiopathic hypereosinophilic syndrome. Clinical, pathophysiologic, and therapeutic considerations. Ann Intern Med. 1982;97:78-92.
  • 6
    • 4243139496 scopus 로고    scopus 로고
    • Relationship between idiopathic hypereosinophilic syndrome, eosinophilic leukemia, and systemic mastocytosis
    • Bain BJ. Relationship between idiopathic hypereosinophilic syndrome, eosinophilic leukemia, and systemic mastocytosis. Am J Hematol. 2004;77:82-85.
    • (2004) Am J Hematol , vol.77 , pp. 82-85
    • Bain, B.J.1
  • 7
    • 33645666161 scopus 로고    scopus 로고
    • Atypical myeloproliferative disorders: Diagnosis and management
    • Tefferi A, Elliott MA, Pardanani A. Atypical myeloproliferative disorders: diagnosis and management. Mayo Clin Proc. 2006;81:553-563.
    • (2006) Mayo Clin Proc , vol.81 , pp. 553-563
    • Tefferi, A.1    Elliott, M.A.2    Pardanani, A.3
  • 8
    • 21344440247 scopus 로고    scopus 로고
    • Molecular classification and pathogenesis of eosinophilic disorders: 2005 update
    • Gotlib J. Molecular classification and pathogenesis of eosinophilic disorders: 2005 update. Acta Haematol. 2005;114:7-25.
    • (2005) Acta Haematol , vol.114 , pp. 7-25
    • Gotlib, J.1
  • 9
    • 3042678647 scopus 로고    scopus 로고
    • Clinical and molecular features of FIP1L1-PDGFRA(+) chronic eosinophilic leukemias
    • Vandenberghe P, Wlodarska I, Michaux L, et al. Clinical and molecular features of FIP1L1-PDGFRA(+) chronic eosinophilic leukemias. Leukemia. 2004;18:734-742.
    • (2004) Leukemia , vol.18 , pp. 734-742
    • Vandenberghe, P.1    Wlodarska, I.2    Michaux, L.3
  • 10
    • 0038487039 scopus 로고    scopus 로고
    • Cytogenetic and molecular genetic aspects of eosinophilic leukaemias
    • Bain BJ. Cytogenetic and molecular genetic aspects of eosinophilic leukaemias. Br J Haematol. 2003;122:173-179.
    • (2003) Br J Haematol , vol.122 , pp. 173-179
    • Bain, B.J.1
  • 11
    • 0033104707 scopus 로고    scopus 로고
    • Clonality of isolated eosinophils in the hypereosinophilic syndrome
    • Chang HW, Leong KH, Koh DR, Lee SH. Clonality of isolated eosinophils in the hypereosinophilic syndrome. Blood. 1999;93:1651-1657.
    • (1999) Blood , vol.93 , pp. 1651-1657
    • Chang, H.W.1    Leong, K.H.2    Koh, D.R.3    Lee, S.H.4
  • 12
    • 0025093035 scopus 로고
    • Hypereosinophilic syndrome with evolution to myeloproliferative disorder: Temporal relationship to loss of Y chromosome and c-N-ras activation
    • Needleman SW, Mane SM, Gutheil JC, Kapil V, Heyman MR, Testa JR. Hypereosinophilic syndrome with evolution to myeloproliferative disorder: temporal relationship to loss of Y chromosome and c-N-ras activation. Hematol Pathol. 1990;4:149-155.
    • (1990) Hematol Pathol , vol.4 , pp. 149-155
    • Needleman, S.W.1    Mane, S.M.2    Gutheil, J.C.3    Kapil, V.4    Heyman, M.R.5    Testa, J.R.6
  • 13
    • 0027715874 scopus 로고
    • Hypereosinophilic syndrome terminating in acute myelogenous leukemia
    • Higuchi W, Koike T, Ihizumi T, Shibata A. Hypereosinophilic syndrome terminating in acute myelogenous leukemia. Acta Haematol. 1993;90:165-166.
    • (1993) Acta Haematol , vol.90 , pp. 165-166
    • Higuchi, W.1    Koike, T.2    Ihizumi, T.3    Shibata, A.4
  • 14
    • 0027958133 scopus 로고
    • Clonal proliferation of type 2 helper T cells in a man with the hypereosinophilic syndrome
    • Cogan E, Schandene L, Crusiaux A, Cochaux P Velu T, Goldman M. Clonal proliferation of type 2 helper T cells in a man with the hypereosinophilic syndrome. N Engl J Med. 1994;330:535-538.
    • (1994) N Engl J Med , vol.330 , pp. 535-538
    • Cogan, E.1    Schandene, L.2    Crusiaux, A.3    Cochaux, P.4    Velu, T.5    Goldman, M.6
  • 15
    • 0344809973 scopus 로고    scopus 로고
    • Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia
    • Simon HU, Plotz SG, Dummer R, Blaser K. Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia. N Engl J Med. 1999;341:1112-1120.
    • (1999) N Engl J Med , vol.341 , pp. 1112-1120
    • Simon, H.U.1    Plotz, S.G.2    Dummer, R.3    Blaser, K.4
  • 16
    • 0042784918 scopus 로고    scopus 로고
    • Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome
    • Roufosse F, Schandene L, Sibille C, et al. Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome. Br J Haematol. 2000;109:540-548.
    • (2000) Br J Haematol , vol.109 , pp. 540-548
    • Roufosse, F.1    Schandene, L.2    Sibille, C.3
  • 17
    • 0025923025 scopus 로고    scopus 로고
    • Romagnani S. Human TH1 and TH2 subsets: doubt no more. Immunol Today. 1991;12:256-257.
    • Romagnani S. Human TH1 and TH2 subsets: doubt no more. Immunol Today. 1991;12:256-257.
  • 18
    • 21344463757 scopus 로고    scopus 로고
    • Modern diagnosis and treatment of primary eosinophilia
    • Tefferi A. Modern diagnosis and treatment of primary eosinophilia. Acta Haematol. 2005;114:52-60.
    • (2005) Acta Haematol , vol.114 , pp. 52-60
    • Tefferi, A.1
  • 19
    • 33646245681 scopus 로고    scopus 로고
    • Eosinophilia: Secondary, clonal and idiopathic
    • Tefferi A, Patnaik MM, Pardanani A. Eosinophilia: secondary, clonal and idiopathic. Br J Haematol. 2006;133:468-492.
    • (2006) Br J Haematol , vol.133 , pp. 468-492
    • Tefferi, A.1    Patnaik, M.M.2    Pardanani, A.3
  • 20
    • 0019840413 scopus 로고
    • A clinicopathologic correlation of the idiopathic hypereosinophilic syndrome. Il. Clinical manifestations
    • Schooley RT, Flaum MA, Gralnick HR, Fauci AS. A clinicopathologic correlation of the idiopathic hypereosinophilic syndrome. Il. Clinical manifestations. Blood. 1981;58:1021-1026.
    • (1981) Blood , vol.58 , pp. 1021-1026
    • Schooley, R.T.1    Flaum, M.A.2    Gralnick, H.R.3    Fauci, A.S.4
  • 21
    • 0024318613 scopus 로고
    • Effective therapy for a severe case of the idiopathic hypereosinophilic syndrome
    • Marshall GM, White L. Effective therapy for a severe case of the idiopathic hypereosinophilic syndrome. Am J Pediatr Hematol Oncol. 1989;11:178-183.
    • (1989) Am J Pediatr Hematol Oncol , vol.11 , pp. 178-183
    • Marshall, G.M.1    White, L.2
  • 22
    • 0026630494 scopus 로고
    • Prolonged clinical response to vincristine treatment in two patients with idiopathic hypereosinophilic syndrome
    • Sakamoto K, Erdreich-Epstein A, deClerck Y, Coates T. Prolonged clinical response to vincristine treatment in two patients with idiopathic hypereosinophilic syndrome. Am J Pediatr Hematol Oncol. 1992;14:348-351.
    • (1992) Am J Pediatr Hematol Oncol , vol.14 , pp. 348-351
    • Sakamoto, K.1    Erdreich-Epstein, A.2    deClerck, Y.3    Coates, T.4
  • 23
    • 0030886435 scopus 로고    scopus 로고
    • 2-Chlorodeoxyadenosine therapy for idiopathic hypereosinophilic syndrome
    • Ueno NT, Zhao S, Robertson LE, Consoli U, Andreeff M. 2-Chlorodeoxyadenosine therapy for idiopathic hypereosinophilic syndrome. Leukemia. 1997;11:1386-1390.
    • (1997) Leukemia , vol.11 , pp. 1386-1390
    • Ueno, N.T.1    Zhao, S.2    Robertson, L.E.3    Consoli, U.4    Andreeff, M.5
  • 24
    • 0028587182 scopus 로고
    • Interferon-α treatment of six patients with the idiopathic hypereosinophilic syndrome
    • Butterfield JH, Gleich GJ. Interferon-α treatment of six patients with the idiopathic hypereosinophilic syndrome. Ann Intern Med. 1994;121:648-653.
    • (1994) Ann Intern Med , vol.121 , pp. 648-653
    • Butterfield, J.H.1    Gleich, G.J.2
  • 25
    • 0025755974 scopus 로고
    • Successful long-term control of idiopathic hypereosinophilic syndrome with etoposide
    • Smit AJ, van Essen LH, de Vries EG. Successful long-term control of idiopathic hypereosinophilic syndrome with etoposide. Cancer. 1991;67:2826-2827.
    • (1991) Cancer , vol.67 , pp. 2826-2827
    • Smit, A.J.1    van Essen, L.H.2    de Vries, E.G.3
  • 26
    • 0036063077 scopus 로고    scopus 로고
    • Response of idiopathic hypereosinophilic syndrome to treatment with imatinib mesylate
    • Ault P Cortes J, Roller C, Kaled ES, Kantarjian H. Response of idiopathic hypereosinophilic syndrome to treatment with imatinib mesylate. Leuk Res. 2002;26:881-884.
    • (2002) Leuk Res , vol.26 , pp. 881-884
    • Ault, P.1    Cortes, J.2    Roller, C.3    Kaled, E.S.4    Kantarjian, H.5
  • 27
    • 0025114790 scopus 로고
    • Interferon-alpha for the hypereosinophilic syndrome
    • Zielinski RM, Lawrence WD. Interferon-alpha for the hypereosinophilic syndrome. Ann Intern Med. 1990;113:716-718.
    • (1990) Ann Intern Med , vol.113 , pp. 716-718
    • Zielinski, R.M.1    Lawrence, W.D.2
  • 28
    • 0027272194 scopus 로고
    • Sustained remission of idiopathic hypereosinophilic syndrome following alpha-interferon therapy
    • Fruehauf S, Fiehn C, Haas R, Doehner H, Hunstein W. Sustained remission of idiopathic hypereosinophilic syndrome following alpha-interferon therapy. Acta Haematol. 1993;89:91-93.
    • (1993) Acta Haematol , vol.89 , pp. 91-93
    • Fruehauf, S.1    Fiehn, C.2    Haas, R.3    Doehner, H.4    Hunstein, W.5
  • 29
    • 0028566469 scopus 로고
    • Response of six patients with idiopathic hypereosinophilic syndrome to interferon alfa
    • Butterfield JH, Gleich GJ. Response of six patients with idiopathic hypereosinophilic syndrome to interferon alfa. J Allergy Clin Immunol. 1994;94:1318-1326.
    • (1994) J Allergy Clin Immunol , vol.94 , pp. 1318-1326
    • Butterfield, J.H.1    Gleich, G.J.2
  • 30
    • 0028089085 scopus 로고
    • Alpha-interferon treatment for idiopathic hypereosinophilic syndrome
    • Bockenstedt PL, Santinga JT, Bolling SF. Alpha-interferon treatment for idiopathic hypereosinophilic syndrome. Am J Hematol. 1994;45:248-251.
    • (1994) Am J Hematol , vol.45 , pp. 248-251
    • Bockenstedt, P.L.1    Santinga, J.T.2    Bolling, S.F.3
  • 31
    • 0028991833 scopus 로고
    • Treatment of the hypereosinophilic syndrome with interferon-alpha
    • Papo T, Piette JC, Hermine O. Treatment of the hypereosinophilic syndrome with interferon-alpha. Ann Intern Med. 1995;123:155-156.
    • (1995) Ann Intern Med , vol.123 , pp. 155-156
    • Papo, T.1    Piette, J.C.2    Hermine, O.3
  • 32
    • 0034672270 scopus 로고    scopus 로고
    • Interferon alpha prevents spontaneous apoptosis of clonal Th2 cells associated with chronic hypereosinophilia
    • Schandene L, Roufosse F, de Lavareille A, et al. Interferon alpha prevents spontaneous apoptosis of clonal Th2 cells associated with chronic hypereosinophilia. Blood. 2000;96:4285-4292.
    • (2000) Blood , vol.96 , pp. 4285-4292
    • Schandene, L.1    Roufosse, F.2    de Lavareille, A.3
  • 33
    • 0025737818 scopus 로고
    • Cyclosporin for hypereosinophilic syndrome
    • Zabel P, Schlaak M. Cyclosporin for hypereosinophilic syndrome. Ann Hematol. 1991;62:230-231.
    • (1991) Ann Hematol , vol.62 , pp. 230-231
    • Zabel, P.1    Schlaak, M.2
  • 34
    • 0030909695 scopus 로고    scopus 로고
    • Treatment of hypereosinophilic syndrome in a child using cyclosporine: Implication for a primary T-cell abnormality
    • Nadarajah S, Krafchik B, Roifman C, Horgan-Bell C. Treatment of hypereosinophilic syndrome in a child using cyclosporine: implication for a primary T-cell abnormality. Pediatrics. 1997;99:630-633.
    • (1997) Pediatrics , vol.99 , pp. 630-633
    • Nadarajah, S.1    Krafchik, B.2    Roifman, C.3    Horgan-Bell, C.4
  • 35
    • 0024287372 scopus 로고
    • Hypereosinophilia syndrome with cutaneous manifestations, "burning hand" syndrome and increased immunoglobulin levels. Treatment with a combination of DADPS and disodium cromoglycate
    • Lindscheid KR, Zabel M. Hypereosinophilia syndrome with cutaneous manifestations, "burning hand" syndrome and increased immunoglobulin levels. Treatment with a combination of DADPS and disodium cromoglycate. Z Hautkr. 1988;63:338-343.
    • (1988) Z Hautkr , vol.63 , pp. 338-343
    • Lindscheid, K.R.1    Zabel, M.2
  • 36
    • 0028263363 scopus 로고
    • Eosinophilic endomyocarditis post partum or pregnancy-related cardiomyopathy
    • Gehrke D, Herzum M, Schonian U, et al. Eosinophilic endomyocarditis post partum or pregnancy-related cardiomyopathy. Herz. 1994;19:176-181.
    • (1994) Herz , vol.19 , pp. 176-181
    • Gehrke, D.1    Herzum, M.2    Schonian, U.3
  • 37
    • 15444344193 scopus 로고    scopus 로고
    • Loffler fibroblastic endocarditis in the thrombotic stages in isolated right ventricular tissue eosinophilia
    • Hagendorff A, Hummelgen M, Omran H, et al. Loffler fibroblastic endocarditis in the thrombotic stages in isolated right ventricular tissue eosinophilia. Z Kardiol. 1998;87:293-299.
    • (1998) Z Kardiol , vol.87 , pp. 293-299
    • Hagendorff, A.1    Hummelgen, M.2    Omran, H.3
  • 38
    • 0023925480 scopus 로고
    • Hypereosinophilic syndrome with multiple organ dysfunction treated by allogeneic bone marrow transplantation
    • Archimbaud E, Guyotat D, Guillaume C, Godard J. Fiere D. Hypereosinophilic syndrome with multiple organ dysfunction treated by allogeneic bone marrow transplantation. Am J Hematol. 1988;27:302-303.
    • (1988) Am J Hematol , vol.27 , pp. 302-303
    • Archimbaud, E.1    Guyotat, D.2    Guillaume, C.3    Godard, J.4    Fiere, D.5
  • 39
    • 0030042049 scopus 로고    scopus 로고
    • Allogeneic bone marrow transplantation in a patient with hypereosinophilic syndrome
    • Esteva-Lorenzo FJ, Meehan KR, Spitzer TR, Mazumder A. Allogeneic bone marrow transplantation in a patient with hypereosinophilic syndrome. Am J Hematol. 1996;51:164-165.
    • (1996) Am J Hematol , vol.51 , pp. 164-165
    • Esteva-Lorenzo, F.J.1    Meehan, K.R.2    Spitzer, T.R.3    Mazumder, A.4
  • 40
    • 0030937955 scopus 로고    scopus 로고
    • Allogeneic bone marrow transplantation for hypereosinophilic syndrome with advanced myelofibrosis
    • Sadoun A, Lacotte L, Delwail V, et al. Allogeneic bone marrow transplantation for hypereosinophilic syndrome with advanced myelofibrosis. Bone Marrow Transplant. 1997;19:741-743.
    • (1997) Bone Marrow Transplant , vol.19 , pp. 741-743
    • Sadoun, A.1    Lacotte, L.2    Delwail, V.3
  • 41
    • 0036205204 scopus 로고    scopus 로고
    • Allogeneic blood stem cell transplantation following non-myeloablative conditioning for hypereosinophilic syndrome
    • Juvonen E, Volin L, Koponen A, Ruutu T. Allogeneic blood stem cell transplantation following non-myeloablative conditioning for hypereosinophilic syndrome. Bone Marrow Transplant. 2002;29:457-458.
    • (2002) Bone Marrow Transplant , vol.29 , pp. 457-458
    • Juvonen, E.1    Volin, L.2    Koponen, A.3    Ruutu, T.4
  • 42
    • 11144304104 scopus 로고    scopus 로고
    • Hypereosinophilic syndrome: Long-term remission following allogeneic stem cell transplant in spite of transient eosinophilia post-transplant
    • Cooper MA, Akard LP, Thompson JM, Dugan MJ, Jansen J. Hypereosinophilic syndrome: long-term remission following allogeneic stem cell transplant in spite of transient eosinophilia post-transplant. Am J Hematol. 2005;78:33-36.
    • (2005) Am J Hematol , vol.78 , pp. 33-36
    • Cooper, M.A.1    Akard, L.P.2    Thompson, J.M.3    Dugan, M.J.4    Jansen, J.5
  • 43
    • 18644362639 scopus 로고    scopus 로고
    • Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome
    • Ueno NT, Anagnostopoulos A, Rondon G, et al. Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome. Br J Haematol. 2002;119:131-134.
    • (2002) Br J Haematol , vol.119 , pp. 131-134
    • Ueno, N.T.1    Anagnostopoulos, A.2    Rondon, G.3
  • 44
    • 33746967701 scopus 로고    scopus 로고
    • Allogeneic bone marrow transplantation for hypereosinophilic syndrome: Long-term follow-up with eradication of FIP1L1-PDGFRA fusion transcript
    • Halaburda K, Prejzner W, Szatkowski D, Limon J, Hellmann A. Allogeneic bone marrow transplantation for hypereosinophilic syndrome: long-term follow-up with eradication of FIP1L1-PDGFRA fusion transcript. Bone Marrow Transplant. 2006;38:319-320.
    • (2006) Bone Marrow Transplant , vol.38 , pp. 319-320
    • Halaburda, K.1    Prejzner, W.2    Szatkowski, D.3    Limon, J.4    Hellmann, A.5
  • 45
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996;2:561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 46
    • 31444455008 scopus 로고    scopus 로고
    • Chronic myeloproliferative disorders: A tyrosine kinase tale
    • De Keersmaecker K, Cools J. Chronic myeloproliferative disorders: a tyrosine kinase tale. Leukemia. 2006;20:200-205.
    • (2006) Leukemia , vol.20 , pp. 200-205
    • De Keersmaecker, K.1    Cools, J.2
  • 47
    • 0031454003 scopus 로고    scopus 로고
    • CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
    • Carroll M, Ohno-Jones S, Tamura S, et al. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood. 1997;90:4947-4952.
    • (1997) Blood , vol.90 , pp. 4947-4952
    • Carroll, M.1    Ohno-Jones, S.2    Tamura, S.3
  • 48
  • 49
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    • Kantarjian H, Sawyers C, Hochhaus A, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med. 2002;346:645-652.
    • (2002) N Engl J Med , vol.346 , pp. 645-652
    • Kantarjian, H.1    Sawyers, C.2    Hochhaus, A.3
  • 50
    • 0035823530 scopus 로고    scopus 로고
    • Case report: Rapid and complete control of idiopathic hypereosinophilia with imatinib mesylate
    • Schaller JL, Burkland GA. Case report: rapid and complete control of idiopathic hypereosinophilia with imatinib mesylate. MedGenMed. 2001;3:9-9.
    • (2001) MedGenMed , vol.3 , pp. 9-9
    • Schaller, J.L.1    Burkland, G.A.2
  • 52
    • 2942568925 scopus 로고    scopus 로고
    • Rapid and complete response to imatinib mesylate (STI-571) in a patient with idiopathic hypereosinophilia. [abstract]
    • Nolasco I, Carvalho S, Parreira A, et al. Rapid and complete response to imatinib mesylate (STI-571) in a patient with idiopathic hypereosinophilia. [abstract]. Blood. 2002;100:346b.
    • (2002) Blood , vol.100
    • Nolasco, I.1    Carvalho, S.2    Parreira, A.3
  • 53
    • 1342279452 scopus 로고    scopus 로고
    • Imatinib therapy for hypereosinophilic syndrome and eosinophilia-associated myeloproliferative disorders. [review]
    • Pardanani A, Tefferi A. Imatinib therapy for hypereosinophilic syndrome and eosinophilia-associated myeloproliferative disorders. [review]. Leuk Res. 2004;28(suppl 1):S47-S52.
    • (2004) Leuk Res , vol.28 , Issue.SUPPL. 1
    • Pardanani, A.1    Tefferi, A.2
  • 55
    • 0038341142 scopus 로고    scopus 로고
    • Eosinophils are derived from the neoplastic clone in patients with systemic mastocytosis and eosinophilia
    • Pardanani A, Reeder T, Li CY, Tefferi A. Eosinophils are derived from the neoplastic clone in patients with systemic mastocytosis and eosinophilia. Leuk Res. 2003;27:883-885.
    • (2003) Leuk Res , vol.27 , pp. 883-885
    • Pardanani, A.1    Reeder, T.2    Li, C.Y.3    Tefferi, A.4
  • 56
    • 33745093948 scopus 로고    scopus 로고
    • Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): Detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib
    • Florian S, Esterbauer H, Binder T, et al. Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib. Leuk Res. 2006;30:1201-1205.
    • (2006) Leuk Res , vol.30 , pp. 1201-1205
    • Florian, S.1    Esterbauer, H.2    Binder, T.3
  • 57
    • 0141992961 scopus 로고    scopus 로고
    • Hypereosinophilic syndrome with elevated serum tryptase versus systemic mast cell disease associated with eosinophilia: 2 distinct entities?
    • Tefferi A, Pardanani A, Li CY. Hypereosinophilic syndrome with elevated serum tryptase versus systemic mast cell disease associated with eosinophilia: 2 distinct entities? Blood. 2003;102:3073-3074.
    • (2003) Blood , vol.102 , pp. 3073-3074
    • Tefferi, A.1    Pardanani, A.2    Li, C.Y.3
  • 58
    • 0038792233 scopus 로고    scopus 로고
    • Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness
    • Klion AD, Noel P, Akin C, et al. Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness. Blood. 2003;101:4660-4666.
    • (2003) Blood , vol.101 , pp. 4660-4666
    • Klion, A.D.1    Noel, P.2    Akin, C.3
  • 59
    • 10744228476 scopus 로고    scopus 로고
    • Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome
    • Cortes J, Ault P Koller C, et al. Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome. Blood. 2003;101:4714-4716.
    • (2003) Blood , vol.101 , pp. 4714-4716
    • Cortes, J.1    Ault, P.2    Koller, C.3
  • 60
    • 22144448600 scopus 로고    scopus 로고
    • Imatinib therapy in hypereosinophilic syndrome: A case of molecular remission
    • Cervetti G, Galimberti S, Carulli G, Petrini M. Imatinib therapy in hypereosinophilic syndrome: a case of molecular remission. Leuk Res. 2005;29:1097-1098.
    • (2005) Leuk Res , vol.29 , pp. 1097-1098
    • Cervetti, G.1    Galimberti, S.2    Carulli, G.3    Petrini, M.4
  • 61
    • 4444278121 scopus 로고    scopus 로고
    • Reversal of cardiac abnormalities in a young man with idiopathic hypereosinophilic syndrome using a tyrosine kinase inhibitor
    • Ascione L, De Michele M, Accadia M, Spadaro P, Rumolo S, Tuccillo B. Reversal of cardiac abnormalities in a young man with idiopathic hypereosinophilic syndrome using a tyrosine kinase inhibitor. Eur J Echocardiogr. 2004;5:386-390.
    • (2004) Eur J Echocardiogr , vol.5 , pp. 386-390
    • Ascione, L.1    De Michele, M.2    Accadia, M.3    Spadaro, P.4    Rumolo, S.5    Tuccillo, B.6
  • 62
    • 0346249716 scopus 로고    scopus 로고
    • The FIP1L1-PDGFalpha kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia
    • Cools J, Stover EH, Wlodarska I, Marynen P, Gilliland DG. The FIP1L1-PDGFalpha kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia. Curr Opin Hematol. 2004;11:51-57.
    • (2004) Curr Opin Hematol , vol.11 , pp. 51-57
    • Cools, J.1    Stover, E.H.2    Wlodarska, I.3    Marynen, P.4    Gilliland, D.G.5
  • 63
    • 33646532818 scopus 로고    scopus 로고
    • FIP1L1-PDGFRA in eosinophilic disorders: Prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature
    • Pardanani A, Ketterling RP, Li CY, et al. FIP1L1-PDGFRA in eosinophilic disorders: prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature. Leuk Res. 2006;30:965-970.
    • (2006) Leuk Res , vol.30 , pp. 965-970
    • Pardanani, A.1    Ketterling, R.P.2    Li, C.Y.3
  • 64
    • 8344230641 scopus 로고    scopus 로고
    • Seshadri T, Seymour JF, McArthur GA. Oligospermia in a patient receiving imatinib therapy for the hypereosinophilic syndrome. N Engl J Med. 2004;351:2134-2135.
    • Seshadri T, Seymour JF, McArthur GA. Oligospermia in a patient receiving imatinib therapy for the hypereosinophilic syndrome. N Engl J Med. 2004;351:2134-2135.
  • 65
    • 0142183434 scopus 로고    scopus 로고
    • Serum concentration of cardiac troponin T in patients with hypereosinophilic syndrome treated with imatinib is predictive of adverse outcomes
    • Pitini V, Arrigo C, Azzarello D, et al. Serum concentration of cardiac troponin T in patients with hypereosinophilic syndrome treated with imatinib is predictive of adverse outcomes. Blood. 2003;102:3456-3457.
    • (2003) Blood , vol.102 , pp. 3456-3457
    • Pitini, V.1    Arrigo, C.2    Azzarello, D.3
  • 66
    • 24644523246 scopus 로고    scopus 로고
    • Resistance to tyrosine kinase inhibitors: Calling on extra forces
    • Cools J, Maertens C, Marynen P. Resistance to tyrosine kinase inhibitors: calling on extra forces. Drug Resist Updat. 2005;8:119-129.
    • (2005) Drug Resist Updat , vol.8 , pp. 119-129
    • Cools, J.1    Maertens, C.2    Marynen, P.3
  • 67
    • 0036098784 scopus 로고    scopus 로고
    • Receptor tyrosine kinase mutations in myeloid neoplasms
    • Gupta R, Knight CL, Bain BJ. Receptor tyrosine kinase mutations in myeloid neoplasms. Br J Haematol. 2002;117:489-508.
    • (2002) Br J Haematol , vol.117 , pp. 489-508
    • Gupta, R.1    Knight, C.L.2    Bain, B.J.3
  • 68
    • 33744457928 scopus 로고    scopus 로고
    • The second generation of BCR-ABL tyrosine kinase inhibitors
    • Tauchi T, Ohyashiki K. The second generation of BCR-ABL tyrosine kinase inhibitors. Int J Hematol. 2006;83:294-300.
    • (2006) Int J Hematol , vol.83 , pp. 294-300
    • Tauchi, T.1    Ohyashiki, K.2
  • 69
    • 33749325184 scopus 로고    scopus 로고
    • Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: High efficacy of drug combinations
    • Bradeen HA, Eide CA, O'Hare T, et al. Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations. Blood. 2006;108:2332-2338.
    • (2006) Blood , vol.108 , pp. 2332-2338
    • Bradeen, H.A.1    Eide, C.A.2    O'Hare, T.3
  • 70
    • 29144464371 scopus 로고    scopus 로고
    • Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia
    • Manley PW, Cowan-Jacob SW, Mestan J. Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia. Biochim Biophys Acta. 2005;1754:3-13.
    • (2005) Biochim Biophys Acta , vol.1754 , pp. 3-13
    • Manley, P.W.1    Cowan-Jacob, S.W.2    Mestan, J.3
  • 71
    • 13844251975 scopus 로고    scopus 로고
    • Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
    • Weisberg E, Manley PW, Breitenstein W, et al. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell. 2005;7:129-141.
    • (2005) Cancer Cell , vol.7 , pp. 129-141
    • Weisberg, E.1    Manley, P.W.2    Breitenstein, W.3
  • 72
    • 24644435728 scopus 로고    scopus 로고
    • AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has in vitro activity against imatinib-resistant chronic myeloid leukemia
    • Golemovic M, Verstovsek S, Giles F, et al. AMN107, a novel aminopyrimidine inhibitor of Bcr-Abl, has in vitro activity against imatinib-resistant chronic myeloid leukemia. Clin Cancer Res. 2005;11:4941-4947.
    • (2005) Clin Cancer Res , vol.11 , pp. 4941-4947
    • Golemovic, M.1    Verstovsek, S.2    Giles, F.3
  • 73
    • 24644464172 scopus 로고    scopus 로고
    • AMN107, a novel aminopyrimidine inhibitor of p190 Bcr-Abl activation and of in vitro proliferation of Philadelphia-positive acute lymphoblastic leukemia cells
    • Verstovsek S, Golemovic M, Kantarjian H, et al. AMN107, a novel aminopyrimidine inhibitor of p190 Bcr-Abl activation and of in vitro proliferation of Philadelphia-positive acute lymphoblastic leukemia cells. Cancer. 2005;104:1230-1236.
    • (2005) Cancer , vol.104 , pp. 1230-1236
    • Verstovsek, S.1    Golemovic, M.2    Kantarjian, H.3
  • 74
    • 27144551665 scopus 로고    scopus 로고
    • The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo
    • Stover EH, Chen J, Lee BH, et al. The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo. Blood. 2005;106:3206-3213.
    • (2005) Blood , vol.106 , pp. 3206-3213
    • Stover, E.H.1    Chen, J.2    Lee, B.H.3
  • 75
    • 33749983643 scopus 로고    scopus 로고
    • Activity of AMN107, a novel aminopyrimidine tyrosine kinase inhibitor, against human FIP1L1-PDGFR-alpha-expressing cells
    • Verstovsek S, Giles FJ, Quintas-Cardama A, et al. Activity of AMN107, a novel aminopyrimidine tyrosine kinase inhibitor, against human FIP1L1-PDGFR-alpha-expressing cells. Leuk Res. 2006;30:1499-1505.
    • (2006) Leuk Res , vol.30 , pp. 1499-1505
    • Verstovsek, S.1    Giles, F.J.2    Quintas-Cardama, A.3
  • 76
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med. 2006;354:2542-2551.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 78
    • 33745059630 scopus 로고    scopus 로고
    • The FIP1L1-PDGFRA T6741 mutation can be inhibited by the tyrosine kinase inhibitor AMN107 (nilotinib)
    • von Bubnoff N, Gorantla SP, Thone S, Peschel C, Duyster J. The FIP1L1-PDGFRA T6741 mutation can be inhibited by the tyrosine kinase inhibitor AMN107 (nilotinib). Blood. 2006;107:4970-4971.
    • (2006) Blood , vol.107 , pp. 4970-4971
    • von Bubnoff, N.1    Gorantla, S.P.2    Thone, S.3    Peschel, C.4    Duyster, J.5
  • 79
    • 33645822530 scopus 로고    scopus 로고
    • New assignments for multitasking signal transduction inhibitors
    • Zhang Z, Meier KE. New assignments for multitasking signal transduction inhibitors. Mol Pharmacol. 2006;69:1510-1512.
    • (2006) Mol Pharmacol , vol.69 , pp. 1510-1512
    • Zhang, Z.1    Meier, K.E.2
  • 80
    • 31544459272 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
    • Schittenhelm MM, Shiraga S, Schroeder A, et al. Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res. 2006;66:473-481.
    • (2006) Cancer Res , vol.66 , pp. 473-481
    • Schittenhelm, M.M.1    Shiraga, S.2    Schroeder, A.3
  • 81
    • 34548169822 scopus 로고    scopus 로고
    • Dasatinib BMS354825, a multi-targeted kinase inhibitor with activity against multiple myeloma [ASH Annual Meeting Abstracts, Abstract 1571
    • Deng Q, Mitsiades N, Negri J, et al. Dasatinib (BMS354825): a multi-targeted kinase inhibitor with activity against multiple myeloma [ASH Annual Meeting Abstracts]. Blood. 2005;106. Abstract 1571.
    • (2005) Blood , pp. 106
    • Deng, Q.1    Mitsiades, N.2    Negri, J.3
  • 82
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006;354:2531-2541.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 83
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64:7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 84
    • 33644840580 scopus 로고    scopus 로고
    • Targeted therapy for metastatic renal cell carcinoma
    • Patel PH, Chaganti RS, Motzer RJ. Targeted therapy for metastatic renal cell carcinoma. Br J Cancer. 2006;94:614-619.
    • (2006) Br J Cancer , vol.94 , pp. 614-619
    • Patel, P.H.1    Chaganti, R.S.2    Motzer, R.J.3
  • 85
    • 31544460436 scopus 로고    scopus 로고
    • Phase 1 of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer
    • Siu LL, Awada A, Takimoto CH, et al. Phase 1 of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer. Clin Cancer Res. 2006;12:144-151.
    • (2006) Clin Cancer Res , vol.12 , pp. 144-151
    • Siu, L.L.1    Awada, A.2    Takimoto, C.H.3
  • 86
    • 20044382799 scopus 로고    scopus 로고
    • Phase 1 clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
    • Strumberg D, Richly H, Hilger RA, et al. Phase 1 clinical and pharmacokinetic study of the novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol. 2005;23:965-972.
    • (2005) J Clin Oncol , vol.23 , pp. 965-972
    • Strumberg, D.1    Richly, H.2    Hilger, R.A.3
  • 87
    • 20344362911 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours
    • Awada A, Hendlisz A, Gil T, et al. Phase I safety and pharmacokinetics of BAY 43-9006 administered for 21 days on/7 days off in patients with advanced, refractory solid tumours. Br J Cancer. 2005;92:1855-1861.
    • (2005) Br J Cancer , vol.92 , pp. 1855-1861
    • Awada, A.1    Hendlisz, A.2    Gil, T.3
  • 88
    • 19744365702 scopus 로고    scopus 로고
    • A small molecule-kinase interaction map for clinical kinase inhibitors
    • Fabian MA, Biggs WH 3rd, Treiber DK, et al. A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol. 2005;23:329-336.
    • (2005) Nat Biotechnol , vol.23 , pp. 329-336
    • Fabian, M.A.1    Biggs 3rd, W.H.2    Treiber, D.K.3
  • 89
    • 33747203008 scopus 로고    scopus 로고
    • Sorafenib is a potent inhibitor of FIP1L1-PDGFRalpha and the imatinib resistant FIP1L1-PDGFRalpha T6741 mutant
    • Lierman E, Folens C, Stover EH, et al. Sorafenib is a potent inhibitor of FIP1L1-PDGFRalpha and the imatinib resistant FIP1L1-PDGFRalpha T6741 mutant. Blood. 2006;108:1374-1376.
    • (2006) Blood , vol.108 , pp. 1374-1376
    • Lierman, E.1    Folens, C.2    Stover, E.H.3
  • 90
    • 0026760470 scopus 로고
    • Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251
    • Andrejauskas-Buchdunger E, Regenass U. Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251. Cancer Res. 1992;52:5353-5358.
    • (1992) Cancer Res , vol.52 , pp. 5353-5358
    • Andrejauskas-Buchdunger, E.1    Regenass, U.2
  • 91
    • 0033036759 scopus 로고    scopus 로고
    • Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent
    • Fabbro D, Buchdunger E, Wood J, et al. Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent. Pharmacol Ther. 1999;82:293-301.
    • (1999) Pharmacol Ther , vol.82 , pp. 293-301
    • Fabbro, D.1    Buchdunger, E.2    Wood, J.3
  • 92
    • 18844478996 scopus 로고    scopus 로고
    • PKC412-a protein kinase inhibitor with a broad therapeutic potential
    • Fabbro D, Ruetz S, Bodis S, et al. PKC412-a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 2000;15:17-28.
    • (2000) Anticancer Drug Des , vol.15 , pp. 17-28
    • Fabbro, D.1    Ruetz, S.2    Bodis, S.3
  • 93
    • 0035281737 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C
    • Propper DJ, McDonald AC, Man A, et al. Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C. J Clin Oncol. 2001;19:1485-1492.
    • (2001) J Clin Oncol , vol.19 , pp. 1485-1492
    • Propper, D.J.1    McDonald, A.C.2    Man, A.3
  • 94
    • 0036595143 scopus 로고    scopus 로고
    • Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
    • Weisberg E, Boulton C, Kelly LM, et al. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell. 2002;1:433-443.
    • (2002) Cancer Cell , vol.1 , pp. 433-443
    • Weisberg, E.1    Boulton, C.2    Kelly, L.M.3
  • 95
    • 19944427559 scopus 로고    scopus 로고
    • Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412
    • Stone RM, DeAngelo DJ, Klimek V, et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood. 2005;105:54-60.
    • (2005) Blood , vol.105 , pp. 54-60
    • Stone, R.M.1    DeAngelo, D.J.2    Klimek, V.3
  • 96
    • 0142119964 scopus 로고    scopus 로고
    • PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRalpha-induced myeloproliferative disease
    • Cools J, Stover EH, Boulton CL, et al. PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRalpha-induced myeloproliferative disease. Cancer Cell. 2003;3:459-469.
    • (2003) Cancer Cell , vol.3 , pp. 459-469
    • Cools, J.1    Stover, E.H.2    Boulton, C.L.3
  • 97
    • 1842474941 scopus 로고    scopus 로고
    • The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: Implications for diagnosis, classification, and management
    • Gotlib J, Cools J, Malone JM 3rd, Schrier SL, Gilliland DG, Coutre SE. The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management. Blood. 2004,103:2879-2891.
    • (2004) Blood , vol.103 , pp. 2879-2891
    • Gotlib, J.1    Cools, J.2    Malone 3rd, J.M.3    Schrier, S.L.4    Gilliland, D.G.5    Coutre, S.E.6
  • 98
    • 34548189325 scopus 로고    scopus 로고
    • le Coutre P, Hochhaus A, Heim D, et al. A phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to patients with hypereosiniphilic syndrome (HES) [ASH Annual Meeting Abstracts]. Blood. 2006;108. Abstract 4912.
    • le Coutre P, Hochhaus A, Heim D, et al. A phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to patients with hypereosiniphilic syndrome (HES) [ASH Annual Meeting Abstracts]. Blood. 2006;108. Abstract 4912.
  • 99
    • 0026643596 scopus 로고
    • Interleukin-5, eosinophils, and disease
    • Sanderson CJ. Interleukin-5, eosinophils, and disease. Blood. 1992;79:3101-3109.
    • (1992) Blood , vol.79 , pp. 3101-3109
    • Sanderson, C.J.1
  • 100
    • 0032732953 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys
    • Zia-Amirhosseini P, Minthorn E, Benincosa LJ, et al. Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys. J Pharmacol Exp Ther. 1999;291:1060-1067.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 1060-1067
    • Zia-Amirhosseini, P.1    Minthorn, E.2    Benincosa, L.J.3
  • 101
    • 0033406772 scopus 로고    scopus 로고
    • Mapping and characterization of the epitope(s) of Sch 55700, a humanized mAb, that inhibits human IL-5
    • Zhang J, Kuvelkar R, Murgolo NJ, et al. Mapping and characterization of the epitope(s) of Sch 55700, a humanized mAb, that inhibits human IL-5. Int Immunol. 1999;11:1935-1943.
    • (1999) Int Immunol , vol.11 , pp. 1935-1943
    • Zhang, J.1    Kuvelkar, R.2    Murgolo, N.J.3
  • 102
    • 0001269056 scopus 로고    scopus 로고
    • Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity
    • Egan RW, Athwal D, Bodmer MW, et al. Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity. Arzneimittelforschung. 1999;49:779-790.
    • (1999) Arzneimittelforschung , vol.49 , pp. 779-790
    • Egan, R.W.1    Athwal, D.2    Bodmer, M.W.3
  • 103
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, Brinke A, Khan J, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 2000;356:2144-2148.
    • (2000) Lancet , vol.356 , pp. 2144-2148
    • Leckie, M.J.1    Brinke, A.2    Khan, J.3
  • 104
    • 0037393468 scopus 로고    scopus 로고
    • Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
    • Menzies-Gow A, Flood-Page P, Sehmi R, et al. Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J Allergy Clin Immunol. 2003;111:714-719.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 714-719
    • Menzies-Gow, A.1    Flood-Page, P.2    Sehmi, R.3
  • 105
    • 0242361303 scopus 로고    scopus 로고
    • Reversal of hypereosinophilic syndrome and lymphomatoid papulosis with mepolizumab and imatinib
    • Koury MJ, Newman JH, Murray JJ. Reversal of hypereosinophilic syndrome and lymphomatoid papulosis with mepolizumab and imatinib. Am J Med. 2003,115:587-589.
    • (2003) Am J Med , vol.115 , pp. 587-589
    • Koury, M.J.1    Newman, J.H.2    Murray, J.J.3
  • 106
    • 0346816643 scopus 로고    scopus 로고
    • Use of anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis
    • Plotz SG, Simon HU, Darsow U, et al. Use of anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis. N Engl J Med. 2003;349:2334-2339.
    • (2003) N Engl J Med , vol.349 , pp. 2334-2339
    • Plotz, S.G.1    Simon, H.U.2    Darsow, U.3
  • 107
    • 34548160293 scopus 로고    scopus 로고
    • Rothenberg ME, Gleich GJ, Roufosse FE, Rosenwasser LJ, Weller PF. Steroid-sparing effects of anti-IL-5 monoclonal antibody (mepolizumab) therapy in patients with HES: a multicenter, randomized, double-blind, placebo-controlled trial [ASH Annual Meeting Abstracts]. Blood. 2006;108. Abstract 373.
    • Rothenberg ME, Gleich GJ, Roufosse FE, Rosenwasser LJ, Weller PF. Steroid-sparing effects of anti-IL-5 monoclonal antibody (mepolizumab) therapy in patients with HES: a multicenter, randomized, double-blind, placebo-controlled trial [ASH Annual Meeting Abstracts]. Blood. 2006;108. Abstract 373.
  • 108
    • 0029912735 scopus 로고    scopus 로고
    • Surface and mRNA expression of the CD52 antigen by human eosinophils but not by neutrophils
    • Eisner J, Hochstetter R, Spiekermann K, Kapp A. Surface and mRNA expression of the CD52 antigen by human eosinophils but not by neutrophils. Blood. 1996,88:4684-4693.
    • (1996) Blood , vol.88 , pp. 4684-4693
    • Eisner, J.1    Hochstetter, R.2    Spiekermann, K.3    Kapp, A.4
  • 109
    • 1242338010 scopus 로고    scopus 로고
    • Alemtuzumab therapy for refractory idiopathic hypereosinophilic syndrome
    • Sefcick A, Sowter D, DasGupta E, Russell NH, Byrne JL. Alemtuzumab therapy for refractory idiopathic hypereosinophilic syndrome. Br J Haematol. 2004;124:558-559.
    • (2004) Br J Haematol , vol.124 , pp. 558-559
    • Sefcick, A.1    Sowter, D.2    DasGupta, E.3    Russell, N.H.4    Byrne, J.L.5
  • 110
    • 10344259603 scopus 로고    scopus 로고
    • Alemtuzumab therapy for refractory idiopathic hypereosinophilic syndrome with abnormal T cells: A case report
    • Pitini V, Teti D, Arrigo C, Righi M. Alemtuzumab therapy for refractory idiopathic hypereosinophilic syndrome with abnormal T cells: a case report. Br J Haematol. 2004,127:477-477.
    • (2004) Br J Haematol , vol.127 , pp. 477-477
    • Pitini, V.1    Teti, D.2    Arrigo, C.3    Righi, M.4
  • 111
    • 34548183379 scopus 로고    scopus 로고
    • Alemtuzumab (CAMPATH-1H™) is effective therapy for hypereosinophilic syndrome HES, ASH Annual Meeting Abstracts, Abstract 4902
    • Quintas-Cardama A, Tefferi A, Cortes J, et al. Alemtuzumab (CAMPATH-1H™) is effective therapy for hypereosinophilic syndrome (HES) [ASH Annual Meeting Abstracts]. Blood. 2006;108. Abstract 4902.
    • (2006) Blood , pp. 108
    • Quintas-Cardama, A.1    Tefferi, A.2    Cortes, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.