-
1
-
-
12844251988
-
Alcohol
-
10.1016/j.alcohol.2004.07.007
-
McClain, C.J., Mokshagundam, S.P., and Barve, S.S.: et al. 'Mechanisms of non-alcoholic steatohepatitis', Alcohol, 2004, 34, p. 67-7910.1016/j.alcohol.2004.07.007
-
(2004)
Mechanisms of non-alcoholic steatohepatitis
, vol.34
, pp. 67-79
-
-
McClain, C.J.1
Mokshagundam, S.P.2
Barve, S.S.3
-
4
-
-
34047192773
-
Liver Int.
-
10.1111/j.1478-3231.2007.01483.x
-
Méndez-Sánchez, N., Arrese, M., Zamora-Valdés, D., and Uribe, M.: 'Current concepts in the pathogenesis of nonalcoholic fatty liver disease', Liver Int., 2007, 27, p. 423-43310.1111/j.1478-3231.2007.01483.x
-
(2007)
Current concepts in the pathogenesis of nonalcoholic fatty liver disease
, vol.27
, pp. 423-433
-
-
Méndez-Sánchez, N.1
Arrese, M.2
Zamora-Valdés, D.3
Uribe, M.4
-
5
-
-
34249868222
-
Semin. Liver Dis.
-
10.1055/s-2007-979470
-
Lalor, P.F., Faint, J., Aarbodem, Y., Hubscher, S.G., and Adams, D.H.: 'The role of cytokines and chemokines in the development of steatohepatitis', Semin. Liver Dis., 2007, 27, p. 173-19310.1055/s-2007-979470
-
(2007)
The role of cytokines and chemokines in the development of steatohepatitis
, vol.27
, pp. 173-193
-
-
Lalor, P.F.1
Faint, J.2
Aarbodem, Y.3
Hubscher, S.G.4
Adams, D.H.5
-
7
-
-
34248681601
-
Hepatoclogy
-
10.1002/hep.21614
-
Rahman, S.M., Schroeder-Gloeckler, J.M., and Janssen, R.C.: et al. 'CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis', Hepatoclogy, 2007, 45, p. 1108-111710.1002/hep.21614
-
(2007)
CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
, vol.45
, pp. 1108-1117
-
-
Rahman, S.M.1
Schroeder-Gloeckler, J.M.2
Janssen, R.C.3
-
8
-
-
33646014467
-
Liver Int.
-
10.1111/j.1478-3231.2005.01191.x
-
Abiru, S., Migita, K., and Maeda, Y.: et al. 'Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis', Liver Int., 2006, 26, p. 39-4510.1111/j.1478-3231.2005.01191.x
-
(2006)
Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis
, vol.26
, pp. 39-45
-
-
Abiru, S.1
Migita, K.2
Maeda, Y.3
-
9
-
-
0034799113
-
Am. J. Gastroenterol.
-
10.1111/j.1572-0241.2001.04667.x
-
Willner, I.R., Waters, B., Patil, S.R., Reuben, A., Morelli, J., and Riely, C.A.: 'Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease', Am. J. Gastroenterol., 2001, 96, p. 2957-296110.1111/j.1572-0241.2001.04667.x
-
(2001)
Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease
, vol.96
, pp. 2957-2961
-
-
Willner, I.R.1
Waters, B.2
Patil, S.R.3
Reuben, A.4
Morelli, J.5
Riely, C.A.6
-
10
-
-
33751193496
-
Trends Mol. Med.
-
10.1016/j.molmed.2006.10.001
-
Videla, L.A., Rodrigo, R., Araya, J., and Poniachik, J.: 'Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease', Trends Mol. Med., 2006, 12, p. 555-55810.1016/j.molmed.2006.10.001
-
(2006)
Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease
, vol.12
, pp. 555-558
-
-
Videla, L.A.1
Rodrigo, R.2
Araya, J.3
Poniachik, J.4
-
11
-
-
0032168152
-
Biochem. J.
-
Heinrich, P.C., Behrmann, I., Muller-Newen, G., Schaper, F., and Graeve, L.: 'Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway', Biochem. J., 1998, 334, (Pt 2), p. 297-314
-
(1998)
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
, vol.334
, Issue.PART 2
, pp. 297-314
-
-
Heinrich, P.C.1
Behrmann, I.2
Muller-Newen, G.3
Schaper, F.4
Graeve, L.5
-
12
-
-
0032530159
-
Proc. Natl. Acad. Sci.
-
10.1073/pnas.95.19.11107
-
Sengupta, T.K., Talbot, E.S., Scherle, P.A., and Ivashkiv, L.B.: 'Rapid inhibition of interleukin-6 signalling and Stat3 activation mediated by mitogen-activated protein kinases', Proc. Natl. Acad. Sci., 1998, 95, p. 11107-1111210.1073/pnas.95.19.11107
-
(1998)
Rapid inhibition of interleukin-6 signalling and Stat3 activation mediated by mitogen-activated protein kinases
, vol.95
, pp. 11107-11112
-
-
Sengupta, T.K.1
Talbot, E.S.2
Scherle, P.A.3
Ivashkiv, L.B.4
-
13
-
-
4644237206
-
Hepatology
-
10.1002/hep.20400
-
Hong, F., Radaeva, S., Pan, H.N., Tian, Z., Veech, R., and Gao, B.: 'Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease', Hepatology, 2004, 40, p. 933-94110.1002/hep.20400
-
(2004)
Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease
, vol.40
, pp. 933-941
-
-
Hong, F.1
Radaeva, S.2
Pan, H.N.3
Tian, Z.4
Veech, R.5
Gao, B.6
-
14
-
-
11144357516
-
Nat. Med.
-
10.1038/nm980
-
Inoue, H., Ogawa, W., and Ozaki, M.: et al. 'Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo', Nat. Med., 2004, 10, p. 168-17410.1038/nm980
-
(2004)
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
, vol.10
, pp. 168-174
-
-
Inoue, H.1
Ogawa, W.2
Ozaki, M.3
-
15
-
-
3142723189
-
Proc. Natl. Acad. Sci. USA
-
10.1073/pnas.0402511101, 0027-8424
-
Ueki, K., Kondo, T., Tseng, Y.H., and Kahn, C.R.: 'Central role of suppressors of cytokine signalling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse', Proc. Natl. Acad. Sci. USA, 2004, 101, p. 10422-1042710.1073/pnas.0402511101 0027-8424
-
(2004)
Central role of suppressors of cytokine signalling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse
, vol.101
, pp. 10422-10427
-
-
Ueki, K.1
Kondo, T.2
Tseng, Y.H.3
Kahn, C.R.4
-
18
-
-
0036212767
-
Nat. Biotechnol.
-
10.1038/nbt0402-370
-
Schoeberl, B., Eichler-Jonsson, C., Gilles, E.D., and Muller, G.: 'Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors', Nat. Biotechnol., 2002, 20, p. 370-37510.1038/nbt0402-370
-
(2002)
Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
, vol.20
, pp. 370-375
-
-
Schoeberl, B.1
Eichler-Jonsson, C.2
Gilles, E.D.3
Muller, G.4
-
19
-
-
0037448456
-
FEBS Lett.
-
10.1016/S0014-5793(02)03842-5
-
Yamada, S., Shionoa, S., Joob, A., and Yoshimura, A.: 'Control mechanism of JAK/STAT signal transduction pathway', FEBS Lett., 2003, 534, p. 190-19610.1016/S0014-5793(02)03842-5
-
(2003)
Control mechanism of JAK/STAT signal transduction pathway
, vol.534
, pp. 190-196
-
-
Yamada, S.1
Shionoa, S.2
Joob, A.3
Yoshimura, A.4
-
20
-
-
33751543926
-
Biotechnol. Bioeng.
-
10.1002/bit.21026
-
Singh, A., Jayaraman, A., and Hahn, J.: 'Modeling regulatory mechanisms in IL-6 signal transduction in hepatocytes', Biotechnol. Bioeng., 2006, 95, (5), p. 850-86210.1002/bit.21026
-
(2006)
Modeling regulatory mechanisms in IL-6 signal transduction in hepatocytes
, vol.95
, Issue.5
, pp. 850-862
-
-
Singh, A.1
Jayaraman, A.2
Hahn, J.3
-
21
-
-
78751696592
-
Proc. Foundations of Systems Biology 2007
-
Stuttgart, Germany, p.
-
Huang, Z., Chu, Y., Senocak, F., Jayaraman, A., and Hahn, J.: 'Model update of signal transduction pathways in hepatocytes based upon sensitivity analysis', Proc. Foundations of Systems Biology 2007, Stuttgart, Germany 2007, p. 45-50
-
(2007)
Model update of signal transduction pathways in hepatocytes based upon sensitivity analysis
, pp. 45-50
-
-
Huang, Z.1
Chu, Y.2
Senocak, F.3
Jayaraman, A.4
Hahn, J.5
-
22
-
-
22044437986
-
Neoplasia
-
10.1593/neo.04571
-
Corvinus, F.M., Orth, C., and Morigg, R.: et al. 'Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth', Neoplasia, 2005, 7, (6), p. 545-55510.1593/neo.04571
-
(2005)
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth
, vol.7
, Issue.6
, pp. 545-555
-
-
Corvinus, F.M.1
Orth, C.2
Morigg, R.3
-
23
-
-
9144249648
-
Gastroenterology
-
10.1053/j.gastro.2003.10.066
-
Judd, L.M., Alderman, B.M., and Howlett, M.: et al. 'Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130', Gastroenterology, 2004, 126, (1), p. 196-20710.1053/j.gastro.2003.10.066
-
(2004)
Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130
, vol.126
, Issue.1
, pp. 196-207
-
-
Judd, L.M.1
Alderman, B.M.2
Howlett, M.3
-
24
-
-
0041677606
-
Biochem. J.
-
10.1042/BJ20030407
-
Heinrich, P.C., Behrmann, I., Haan, S., Hermanns, H.M., Muller-Newen, G., and Schaper, F.: 'Principles of interleukin (IL)-6-type cytokine signalling and its regulation', Biochem. J., 2003, 374, p. 1-2010.1042/BJ20030407
-
(2003)
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
, vol.374
, pp. 1-20
-
-
Heinrich, P.C.1
Behrmann, I.2
Haan, S.3
Hermanns, H.M.4
Muller-Newen, G.5
Schaper, F.6
-
25
-
-
48649103514
-
BMC Syst. Biol.
-
10.1186/1752-0509-2-64
-
Huang, Z., Senocak, F., Jayaraman, A., and Hahn, J.: 'Integrated modeling and experimental approach for determining transcription factor profiles from fluorescent reporter data', BMC Syst. Biol., 2008, 2, p. 6410.1186/1752-0509-2-64
-
(2008)
Integrated modeling and experimental approach for determining transcription factor profiles from fluorescent reporter data
, vol.2
, pp. 64
-
-
Huang, Z.1
Senocak, F.2
Jayaraman, A.3
Hahn, J.4
-
26
-
-
38949143767
-
IET Syst. Biol.
-
10.1049/iet-syb:20060053
-
Chu, Y., Jayaraman, A., and Hahn, J.: 'Parameter sensitivity analysis of IL-6 signaling pathways', IET Syst. Biol., 2007, 1, (6), p. 342-35210.1049/iet-syb:20060053
-
(2007)
Parameter sensitivity analysis of IL-6 signaling pathways
, vol.1
, Issue.6
, pp. 342-352
-
-
Chu, Y.1
Jayaraman, A.2
Hahn, J.3
-
29
-
-
84953649167
-
J. Chem. Phys.
-
10.1063/1.1680571, 0021-9606
-
Cukier, R.I., Fortuin, C.M., Shuler, K.E., Petschek, A.G., and Schaibly, J.H.: 'Study of the sensitivity of coupled reaction systems to uncertainties in rate coefficients-I theory', J. Chem. Phys., 1973, 59, (8), p. 3873-387810.1063/1.1680571 0021-9606
-
(1973)
Study of the sensitivity of coupled reaction systems to uncertainties in rate coefficients-I theory
, vol.59
, Issue.8
, pp. 3873-3878
-
-
Cukier, R.I.1
Fortuin, C.M.2
Shuler, K.E.3
Petschek, A.G.4
Schaibly, J.H.5
-
30
-
-
0019926821
-
Comput. Chem. Eng.
-
10.1016/0098-1354(82)80003-3, 0098-1354
-
McRae, G.J., Tilden, J.W., and Seinfeld, J.H.: 'Global sensitivity analysis-a computational implementation of the Fourier amplitude sensitivity test (FAST)', Comput. Chem. Eng., 1982, 6, (1), p. 15-2510.1016/0098-1354(82)80003-3 0098-1354
-
(1982)
Global sensitivity analysis-a computational implementation of the Fourier amplitude sensitivity test (FAST)
, vol.6
, Issue.1
, pp. 15-25
-
-
McRae, G.J.1
Tilden, J.W.2
Seinfeld, J.H.3
-
32
-
-
15844394066
-
Reliab. Eng. Syst. Saf.
-
10.1016/j.ress.2004.09.006, 0951-8320
-
Helton, J.C., Davis, F.J., and Johnson, J.D.: 'A comparison of uncertainty and sensitivity analysis results obtained with random and Latin hypercube sampling', Reliab. Eng. Syst. Saf., 2005, 89, p. 305-33010.1016/j.ress.2004.09.006 0951-8320
-
(2005)
A comparison of uncertainty and sensitivity analysis results obtained with random and Latin hypercube sampling
, vol.89
, pp. 305-330
-
-
Helton, J.C.1
Davis, F.J.2
Johnson, J.D.3
-
33
-
-
0033895382
-
Technometrics
-
10.2307/1271432, 0040-1706
-
McKay, M.D., Beckman, R.J., and Conover, W.J.: 'A comparison of three methods for selecting values of input variables in the analysis of output from a computer code', Technometrics, 2000, 42, (1), p. 55-6110.2307/1271432 0040-1706
-
(2000)
A comparison of three methods for selecting values of input variables in the analysis of output from a computer code
, vol.42
, Issue.1
, pp. 55-61
-
-
McKay, M.D.1
Beckman, R.J.2
Conover, W.J.3
-
34
-
-
13844296861
-
FEBS Lett.
-
10.1016/j.febslet.2005.01.009
-
Zi, Z.K., Cho, K.H., Sung, M.H., Xia, X.F., Zheng, J.S., and Sun, Z.R.: 'In silico identification of the key components and steps in INF-γ induced JAK-STAT signalling pathway', FEBS Lett., 2005, 579, p. 1101-110810.1016/j.febslet.2005.01.009
-
(2005)
In silico identification of the key components and steps in INF-γ induced JAK-STAT signalling pathway
, vol.579
, pp. 1101-1108
-
-
Zi, Z.K.1
Cho, K.H.2
Sung, M.H.3
Xia, X.F.4
Zheng, J.S.5
Sun, Z.R.6
-
35
-
-
40349100263
-
Br. J. Pharmacol.
-
S414-S42710.1038/bjp.2008.1
-
Fischer, P., and Hilfiker-Kleiner, D.: 'Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects', Br. J. Pharmacol., 2008, 153, p. S414-S42710.1038/bjp.2008.1
-
(2008)
Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects
, vol.153
-
-
Fischer, P.1
Hilfiker-Kleiner, D.2
-
36
-
-
12144290834
-
Biochem. J.
-
10.1042/BJ20030893
-
Fischer, P., Lehmann, U., and Sobota, R.M.: et al. 'The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling', Biochem. J., 2004, 378, p. 449-46010.1042/BJ20030893
-
(2004)
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
, vol.378
, pp. 449-460
-
-
Fischer, P.1
Lehmann, U.2
Sobota, R.M.3
-
37
-
-
0038614944
-
Nat. Immunol.
-
10.1038/ni932
-
Lang, R., Pauleau, A.L., and Parganas, E.: et al. 'SOCS3 regulates the plasticity of gp130 signalling', Nat. Immunol., 2003, 4, p. 546-55010.1038/ni932
-
(2003)
SOCS3 regulates the plasticity of gp130 signalling
, vol.4
, pp. 546-550
-
-
Lang, R.1
Pauleau, A.L.2
Parganas, E.3
-
38
-
-
1842523505
-
J. Endocrinol.
-
10.1677/joe.0.1810129
-
Fasshauer, M., Kralisch, S., and Klier, M.: et al. 'Insulin resistance-inducing cytokines differentially regulate SOCS mRNA expression via growth factor- and Jak/Stat-signalling pathways in 3T3-L1 adipocytes', J. Endocrinol., 2004, 181, p. 129-13810.1677/joe.0.1810129
-
(2004)
Insulin resistance-inducing cytokines differentially regulate SOCS mRNA expression via growth factor- and Jak/Stat-signalling pathways in 3T3-L1 adipocytes
, vol.181
, pp. 129-138
-
-
Fasshauer, M.1
Kralisch, S.2
Klier, M.3
-
39
-
-
33845761551
-
Lab Chip
-
10.1039/b612516f, 1473-0197
-
King, K.R., Wang, S., Irimia, D., Jayaraman, A., Toner, M., and Yarmush, M.L.: 'A high-throughput microfluidic real-time gene Expression living cell array', Lab Chip, 2007, 7, p. 7710.1039/b612516f 1473-0197
-
(2007)
A high-throughput microfluidic real-time gene Expression living cell array
, vol.7
, pp. 77
-
-
King, K.R.1
Wang, S.2
Irimia, D.3
Jayaraman, A.4
Toner, M.5
Yarmush, M.L.6
-
40
-
-
0035977654
-
Biophys. Chem.
-
10.1016/S0301-4622(00)00212-X
-
Roth, C.M., Kohen, R.L., Walton, S.P., and Yarmush, M.L.: 'Coupling of inflammatory cytokine signalling pathways probed by measurements of extracellular acidification rate', Biophys. Chem., 2001, 89, p. 1-1210.1016/S0301-4622(00)00212-X
-
(2001)
Coupling of inflammatory cytokine signalling pathways probed by measurements of extracellular acidification rate
, vol.89
, pp. 1-12
-
-
Roth, C.M.1
Kohen, R.L.2
Walton, S.P.3
Yarmush, M.L.4
|