Metformin decreases GnRH- and activin-induced gonadotropin secretion in rat pituitary cells: Potential involvement of adenosine 5′ monophosphate-activated protein kinase (PRKA)

Biology of Reproduction

Volumn 84, Issue 2, 2011, Pages 351-362

  Tosca, Lucie ^a   Froment, Pascal ^a   Rame, Christelle ^a   McNeilly, J R ^b   McNeilly, A S ^b   Maillard, Virginie ^a   Dupont, Joelle ^a  

^a UMR85 PHYSIOLOGIE DE LA REPRODUCTION ET DES COMPORTEMENTS   (France)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Anterior pituitary; Cell growth; Gonadotropin secretion; Gonadotropin releasing hormone; Mechanisms of hormone

Indexed keywords

ACTIVIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; FOLLITROPIN BETA SUBUNIT; GONADORELIN; LUTEINIZING HORMONE; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE 3; SMAD2 PROTEIN;

ACTH SECRETING CELL; ANIMAL CELL; ARTICLE; DRUG MECHANISM; FOLLITROPIN RELEASE; GONADOTROPIN RELEASE; GONADOTROPIN SECRETING CELL; GROWTH HORMONE SECRETING CELL; HYPOPHYSIS CELL; NONHUMAN; PRIORITY JOURNAL; PROLACTIN SECRETING CELL; PROTEIN PHOSPHORYLATION; RAT; TSH SECRETING CELL;

ACETYL-COA CARBOXYLASE; ACTIVINS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOWN-REGULATION; ENZYME ACTIVATION; FEMALE; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; ISOENZYMES; LUTEINIZING HORMONE; METFORMIN; PHOSPHORYLATION; PITUITARY GLAND; PYRAZOLES; PYRIMIDINES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; RATTUS;

EID: 78751680738     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.110.087023     Document Type: Article

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