Structure-function relationship of conotoxin lt14a, a potential analgesic with low cytotoxicity

Peptides

Volumn 32, Issue 2, 2011, Pages 300-305

  Sun, Dandan ^a   Ren, Zhenghua ^a   Zeng, Xiayun ^a   You, Yuwen ^a   Pan, Wuguang ^a   Zhou, Maojun ^a   Wang, Lei ^a   Xu, Anlong ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Analgesic; Conotoxin; lt14a; NMR; Solution structure

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALANINE; ANALGESIC AGENT; CONOTOXIN; CONOTOXIN LT14A; CYSTEINE; LYSINE; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

AMIDATION; AMINO ACID SUBSTITUTION; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA SHEET; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONTROLLED STUDY; CONUS LITTERATUS; CONUS SNAIL; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG RECEPTOR BINDING; FEMALE; HOT PLATE TEST; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PAIN; PRIORITY JOURNAL; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANALGESICS; ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; CONOTOXINS; CONUS SNAIL; FEMALE; HEP G2 CELLS; HUMANS; MASS SPECTROMETRY; MEPERIDINE; MICE; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PAIN THRESHOLD; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

CONUS LITTERATUS; MUS;

EID: 78751675268     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2010.11.012     Document Type: Article

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