Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus

Peptides

Volumn 29, Issue 9, 2008, Pages 1521-1525

  Yuan, Duo Duo ^a   Liu, Li ^a   Shao, Xiao Xia ^a   Peng, Can ^a   Chi, Cheng Wu ^a,b   Guo, Zhan Yun ^a  

^a TONGJI UNIVERSITY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Conotoxin; Cysteine framework; Signal peptide

Indexed keywords

CONOTOXIN; SIGNAL PEPTIDE; SNAIL VENOM;

ARTICLE; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR CLONING; PRIORITY JOURNAL; PURIFICATION; SEQUENCE ANALYSIS; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; CONOTOXINS; CONUS SNAIL; CYSTEINE; MOLECULAR SEQUENCE DATA; PROTEIN SORTING SIGNALS; SEQUENCE ALIGNMENT;

CONUS CARACTERISTICUS; GASTROPODA;

EID: 49049104343     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2008.05.015     Document Type: Article

References (21)

1. Aguilar M.B., Lopez-Vera E., Ortiz E., Becerril B., Possani L.D., Olivera B.M., et al. A novel conotoxin from Conus delessertii with posttranslationally modified lysine residues. Biochemistry 44 (2005) 11130-11136
2. Brown M.A., Begley G.S., Czerwiec E., Stenberg L.M., Jacobs M., Kalume D.E., et al. Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation. Biochemistry 44 (2005) 9150-9159
3. Buczek O., Wei D., Babon J.J., Yang X.D., Fiedler B., Chen P., et al. Structure and sodium channel activity of an excitatory I1-superfamily conotoxin. Biochemistry 46 (2007) 9925-9940
4. Buczek O., Yoshikami D., Watkins M., Bulaj G., Jimenez E.C., and Olivera B.M. Characterization of d-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily. FEBS J 272 (2005) 4178-4188
5. Fan C.X., Chen X.K., Zhang C., Wang L.X., Duan K.L., He L.L., et al. A novel conotoxin from Conus betulinus, kappa-BtX, unique in cysteine pattern and in function as a specific BK channel modulator. J Biol Chem 278 (2003) 12624-12633
6. Han Y.H., Wang Q., Jiang H., Miao X.W., Chen J.S., and Chi C.W. Sequence diversity of T-superfamily conotoxins from Conus marmoreus. Toxicon 45 (2005) 481-487
7. Imperial J.S., Bansal P.S., Alewood P.F., Daly N.L., Craik D.J., Sporing A., et al. A novel conotoxin inhibitors of Kv1 6 channel and nAChR subtypes defines a new superfamily of conotoxins. Biochemistry 45 (2006) 8331-8340
8. Jiang H., Xu C.Q., Wang C.Z., Fan C.X., Zhao T.Y., Chen J.S., et al. Two novel O-superfamily conotoxins from Conus vexillum. Toxicon 47 (2006) 425-436
9. Jimenez E.C., Shetty R.P., Lirazan M., Rivier J., Walker C., Abogadie F.C., et al. Novel excitatory Conus peptides define a new conotoxin superfamily. J Neurochem 85 (2003) 610-621
10. Kauferstein S., Huys I., Kuch U., Melaun C., Tytgat J., and Mebs D. Novel conopeptides of the I-superfamily occur in several clades of cone snails. Toxicon 44 (2004) 539-548
11. Lirazan M.B., Hooper D., Corpuz G.P., Ramilo C.A., Bandyopadhyay P., Cruz L.J., et al. The spasmodic peptide defines a new conotoxin superfamily. Biochemistry 39 (2000) 1583-1588
12. Liu L., Wu X.C., Yuan D.D., Shao X.X., Chi C.W., and Wang C.G. Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus. Toxicon 51 (2008) 1331-1337
13. Olivera B.M. Conus venom peptides, receptor and ion channel targets, and drug design: 50 million years of neuropharmacology. Mol Biol Cell 8 (1997) 2101-2109
14. Olivera B.M., and Cruz L.J. Conotoxins, in retrospect. Toxicon 39 (2001) 7-14
15. Peng C., Liu L., Shao X.X., Chi C.W., and Wang C.G. Identification of a novel class of conotoxins defined as V-conotoxins with unique cysteine pattern and signal peptide sequence. Peptides 29 (2008) 985-991
16. Peng C., Tang S.J., Pi C.H., Liu J.L., Wang F., Wang L., et al. Discovery of a novel class of conotoxin from Conus litteratus, lt14a, with unique cysteine pattern. Peptides 27 (2006) 2174-2181
17. Pi C., Liu J., Peng C., LiuY, Jiang X.H., Zhao Y., et al. Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus. Genomics 88 (2006) 809-819
18. Santos A.D., Mcintosh J.M., Hillyard D.R., Cruz L.J., and Olivera B.M. The A-superfamily of conotoxins. J Biol Chem 279 (2004) 17596-17606
19. Terlau H., and Olivera B.M. Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol Rev 84 (2004) 41-68
20. Wang Q., Han Y.H., Jiang H., Yuan D.D., and Chi C.W. Two different groups of signal sequence in M-superfamily conotoxins. Toxicon 51 (2008) 813-822
21. Yuan D.D., Han Y.H., Wang C.G., and Chi C.W. From the identification of gene organization of α conotoxins to the cloning of novel toxins. Toxicon 49 (2007) 1135-1149