Synthesis, physicochemical characterization, and biological activities of new carnosine derivatives stable in human serum as potential neuroprotective agents

Journal of Medicinal Chemistry

Volumn 54, Issue 2, 2011, Pages 611-621

  Bertinaria, Massimo ^a   Rolando, Barbara ^a   Giorgis, Marta ^a   Montanaro, Gabriele ^a   Guglielmo, Stefano ^a   Buonsanti, M Federica ^a,b   Carabelli, Valentina ^a   Gavello, Daniela ^a   Daniele, Pier Giuseppe ^a   Fruttero, Roberta ^a   Gasco, Alberto ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b Bracco Imaging SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; AMIDE; BETA ALANYL N PROPYL HISTIDINAMIDE DITRIFLUOROACETATE; CARNOSINE; COPPER ION; LEAD; LOW DENSITY LIPOPROTEIN; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; BIOLOGICAL TRAIT; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG SYNTHESIS; HIPPOCAMPUS; LIPOPHILICITY; MALE; NERVE CELL NECROSIS; NONHUMAN; PH; PHYSICAL CHEMISTRY; RAT; STOICHIOMETRY;

ALDEHYDES; ANIMALS; ANTIOXIDANTS; BLOOD-BRAIN BARRIER; CARNOSINE; CATIONS, DIVALENT; CELL DEATH; CHELATING AGENTS; COPPER; DIPEPTIDES; DRUG STABILITY; FREE RADICAL SCAVENGERS; HIPPOCAMPUS; HUMANS; LIPOPROTEINS, LDL; MALE; MICE; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATION-REDUCTION; PROTEIN CARBONYLATION; RATS; RATS, WISTAR; SERUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78751672539     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101394n     Document Type: Article

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