Dendritic cells as a tool to induce transplantation tolerance: Obstacles and opportunities

Transplantation

Volumn 91, Issue 1, 2011, Pages 2-7

  Van Kooten, Cees ^a   Lombardi, Giovanna ^b   Gelderman, Kyra A ^a   Sagoo, Pervinder ^b   Buckland, Matthew ^b   Lechler, Robert ^b   Cuturi, Maria Cristina ^c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b GUY S HOSPITAL   (United Kingdom)

^c UNIVERSITÉ DE NANTES   (France)

Author keywords

Cellular therapy; Dendritic cells; Tolerance

Indexed keywords

ALLOANTIGEN;

CANCER THERAPY; CELL THERAPY; CROSS PRESENTATION; DENDRITIC CELL; EXPERIMENTAL TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; REVIEW; TRANSPLANTATION TOLERANCE; VACCINATION; VIRAL GENE THERAPY;

ANIMALS; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; MICE; ORGAN TRANSPLANTATION; RATS; TRANSPLANTATION IMMUNOLOGY;

EID: 78751645810     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31820263b3     Document Type: Review

References (65)

1. Goldman M, Wood K. European research on cell and organ transplantation: Towards novel opportunities? Transpl Int 2007;20:1016.
2. Mueller DL. Mechanisms maintaining peripheral tolerance. Nat Immunol 2010;11:21.
3. Ohnmacht C, Pullner A, King SB, et al. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 2009;206:549.
4. Lutz MB, Suri RM, Niimi M, et al. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol 2000;30:1813.
5. Morelli AE, Thomson AW. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 2007;7:610.
6. Buckland M, Lombardi G. Aspirin and the induction of tolerance by dendritic cells. Handb Exp Pharmacol 2009;197.
7. Adorini L, Penna G. Induction of tolerogenic dendritic cells by vitamin D receptor agonists. Handb Exp Pharmacol 2009;251.
8. van Kooten C, Stax AS, Woltman AM, et al. Handbook of experimental pharmacology "dendritic cells": The use of dexamethasone in the induction of tolerogenic DCs. Handb Exp Pharmacol 2009;233.
9. Turnquist HR, Thomson AW. Taming the lions: Manipulating dendritic cells for use as negative cellular vaccines in organ transplantation. Curr Opin Organ Transplant 2008;13:350.
10. Sato K, Eizumi K, Fukaya T, et al. Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease. Blood 2009;113:4780.
11. Cook CH, Bickerstaff AA, Wang JJ, et al. Spontaneous renal allograft acceptance associated with "regulatory" dendritic cells and IDO. J Immunol 2008;180:3103.
12. Li Q, Guo Z, Xu X, et al. Pulmonary stromal cells induce the generation of regulatory DC attenuating T-cell-mediated lung inflammation. Eur J Immunol 2008;38:2751.
13. Xia S, Guo Z, Xu X, et al. Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver tolerance. Blood 2008;112:3175.
14. Spaggiari GM, Abdelrazik H, Becchetti F, et al. MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: Central role of MSC-derived prostaglandin E2. Blood 2009;113:6576.
15. Chabannes D, Hill M, Merieau E, et al. A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. Blood 2007;110:3691.
16. Ricardo SD, van Goor H, Eddy AA. Macrophage diversity in renal injury and repair. J Clin Invest 2008;118:3522.
17. Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009;9:162.
18. Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity? Trends Immunol 2002;23:445.
19. Dai H, Zhu H, Lei P, et al. Programmed death-1 signaling is essential for the skin allograft protection by alternatively activated dendritic cell infusion in mice. Transplantation 2009;88:864.
20. Tuettenberg A, Huter E, Hubo M, et al. The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells. J Immunol 2009;182:3349.
21. Awasthi A, Carrier Y, Peron JP, et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol 2007;8:1380.
22. Fitzgerald DC, Zhang GX, El-Behi M, et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol 2007;8:1372.
23. Ilarregui JM, Croci DO, Bianco GA, et al. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 2009;10:981.
24. Collison LW, Workman CJ, Kuo TT, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007;450:566.
25. Hultqvist M, Olsson LM, Gelderman KA, et al. The protective role of ROS in autoimmune disease. Trends Immunol 2009;30:201.
26. Kraaij MD, Savage N D L, Van der Kooij SW, et al. Induction of regulatory T cells by macrophages is dependent on reactive oxygen species production. Proc Natl Acad Sci USA 2010;107:17686.
27. De Wilde V, Van Rompaey N, Hill M, et al. Endotoxin-induced myeloid-derived suppressor cells inhibit alloimmune responses via heme oxygenase-1. Am J Transplant 2009;9:2034.
28. Moreau A, Hill M, Thébault P, et al. Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates. FASEB J 2009;23:3070.
29. Silk KM, Fairchild PJ. Harnessing dendritic cells for the induction of transplantation tolerance. Curr Opin Organ Transplant 2009;14:344.
30. Thomson AW. Tolerogenic dendritic cells: All present and correct? Am J Transplant 2010;10:214.
31. Hutchinson JA, Brem-Exner BG, Riquelme P, et al. A cell-based approach to the minimization of immunosuppression in renal transplantation. Transpl Int 2008;21:742.
32. Hutchinson JA, Riquelme P, Brem-Exner BG, et al. Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation. Transpl Int 2008;21:728.
33. Lechler RI, Batchelor JR. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med 1982;155:31.
34. Josien R, Heslan M, Brouard S, et al. Critical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion. Blood 1998;92:4539.
35. Sun J, Sheil AG, Wang C, et al. Tolerance to rat liver allografts: IV. Acceptance depends on the quantity of donor tissue and on donor leukocytes. Transplantation 1996;62:1725.
36. Pêeche H, Trinite B, Martinet B, et al. Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors. Am J Transplant 2005;5:255.
37. Bériou G, Pêche H, Guillonneau C, et al. Donor-specific allograft tolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppression. Transplantation 2005;79:969.
38. Turnquist HR, Raimondi G, Zahorchak AF, et al. Rapamycinconditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol 2007;178:7018.
39. Mirenda V, Berton I, Read J, et al. Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: An efficient way to induce indirect pathway regulation. J Am Soc Nephrol 2004;15:987.
40. Morse MA, Coleman RE, Akabani G, et al. Migration of human dendritic cells after injection in patients with metastatic malignancies. Cancer Res 1999;59:56.
41. de Vries IJ, Krooshoop DJ, Scharenborg NM, et al. Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state. Cancer Res 2003;63:12.
42. Ridolfi R, Riccobon A, Galassi R, et al. Evaluation of in vivo labelled dendritic cell migration in cancer patients. J Transl Med 2004;2:27.
43. Toromanoff A, Adjali O, Larcher T, et al. Lack of immunotoxicity after regional intravenous (RI) delivery of rAAV to nonhuman primate skeletal muscle. Mol Ther 2010;18:151.
44. Dhodapkar MV, Steinman RM, Krasovsky J, et al. Antigen-specific inhibition of effector T Cell function in humans after injection of immature dendritic cells. J Exp Med 2001;193:233.
45. Stax AM, Gelderman KA, Schlagwein N, et al. Induction of donorspecific T-cell hyporesponsiveness using dexamethasone-treated dendritic cells in two fully mismatched rat kidney transplantation models. Transplantation 2008;86:1275.
46. Lechler R, Ng WF, Steinman RM. Dendritic cells in transplantation-Friend or foe? Immunity 2001;14:357.
47. Inaba K, Turley S, Yamaide F, et al. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J Exp Med 1998;188:2163.
48. Bevan MJ. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J Exp Med 1976;143:1283.
49. Kushwah R, Oliver JR, Zhang J, et al. Apoptotic dendritic cells induce tolerance in mice through suppression of dendritic cell maturation and induction of antigen-specific regulatory T cells. J Immunol 2009;183:7104.
50. Wang Z, Larregina AT, Shufesky WJ, et al. Use of the inhibitory effect of apoptotic cells on dendritic cells for graft survival via T-cell deletion and regulatory T cells. Am J Transplant 2006;6:1297.
51. Terness P, Oelert T, Ehser S, et al. Mitomycin C-treated dendritic cells inactivate autoreactive T cells: Toward the development of a tolerogenic vaccine in autoimmune diseases. Proc Natl Acad Sci USA 2008;105:18442.
52. Woltman AM, De Fijter JW, Kamerling SW, et al. Rapamycin induces apoptosis in monocyte-and CD34-derived dendritic cells but not in monocytes and macrophages. Blood 2001;98:174.
53. Williams MA, Onami TM, Adams AB, et al. Cutting edge: Persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen. J Immunol 2002;169:5387.
54. Yu G, Xu X, Vu MD, et al. NK cells promote transplant tolerance by killing donor antigen-presenting cells. J Exp Med 2006;203:1851.
55. Finkelman FD, Lees A, Birnbaum R, et al. Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J Immunol 1996;157:1406.
56. Yamazaki S, Dudziak D, Heidkamp GF, et al. CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. J Immunol 2008;181:6923.
57. Tanriver Y, Ratnasothy K, Bucy RP, et al. Targeting MHC class I monomers to dendritic cells inhibits the indirect pathway of allorecognition and the production of IgG alloantibodies leading to long-term allograft survival. J Immunol 2010;184:1757.
58. Martin P, Del Hoyo GM, Anjuère F, et al. Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. Blood 2002;100:383.
59. Sharma MD, Baban B, Chandler P, et al. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2, 3-dioxygenase. J Clin Invest 2007;117:2570.
60. Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat Immunol 2004;5:1219.
61. Ochando JC, Homma C, Yang Y, et al. Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol 2006;7:652.
62. Tsang JY, Tanriver Y, Jiang S, et al. Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice. J Clin Invest 2008;118:3619.
63. Terness P, Kleist C, Simon H, et al. Mitomycin C-treated antigenpresenting cells as a tool for control of allograft rejection and autoimmunity: From bench to bedside. Hum Immunol 2009;70:506.
64. Sagoo P, Perucha E, Sawitzki B, et al. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 2010;120:1848.
65. Newell KA, Asare A, Kirk AD, et al. Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest 2010;120:1836.