A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus

Journal of Biological Chemistry

Volumn 285, Issue 32, 2010, Pages 24729-24739

  Michelow, Ian C ^a   Dong, Mingdong ^b   Mungall, Bruce A ^c   Yantosca, L Michael ^a   Lear, Calli ^d   Ji, Xin ^e   Karpel, Marshall ^a   Rootes, Christina L ^c   Brudner, Matthew ^a   Houen, Gunnar ^f   Eisen, Damon P ^g   Kinane, T Bernard ^a   Takahashi, Kazue ^a   Stahl, Gregory L ^h   Olinger, Gene G ^d   Spear, Gregory T ^e   Ezekowitz, R Alan B ^a,i   Schmidt, Emmett V ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b AARHUS UNIVERSITY   (Denmark)

^c CSIRO   (Australia)

^d UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

^f STATENS SERUM INSTITUT   (Denmark)

^g VICTORIAN INFECTIOUS DISEASES REFERENCE LABORATORY   (Australia)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMIC FORCE MICROSCOPY; BINDING ENERGY; BODY FLUIDS; CARBOHYDRATES; LIGANDS; MOLECULES; OLIGOMERS; SURFACE PLASMON RESONANCE; VIRUSES;

BINDING AFFINITIES; BINDING DYNAMICS; BINDING LECTIN; BIOWEAPONS; BOVINE SERUM ALBUMINS; CALRETICULIN; CARBOHYDRATE LIGANDS; CARBOHYDRATE-RECOGNITION DOMAINS; CHIMERIC PROTEINS; COGNATE LIGANDS; COOPERATIVITY; COST-EFFECTIVE PRODUCTION; EBOLA VIRUS; ENVELOPE SURFACE; FUSION PROTEINS; GLYCOSYLATED; LIGAND RECOGNITION; N-ACETYLGLUCOSAMINE; NECK REGION; QUATERNARY STRUCTURE; TAPPING-MODE ATOMIC FORCE MICROSCOPY; WILD TYPES;

PROTEINS;

BOVINE SERUM ALBUMIN; CALRETICULIN; CHIMERIC PROTEIN; COMPLEMENT COMPONENT C4; L FICOLIN; LECTIN; MANNAN; MANNOSE BINDING LECTIN; N ACETYLGLUCOSAMINE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; COMPLEMENT; FICOLIN; HYBRID PROTEIN; RECOMBINANT PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DRUG STRUCTURE; EBOLA VIRUS; HUMAN; HUMAN CELL; IMMUNOTHERAPY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; STRUCTURE ACTIVITY RELATION; WILD TYPE; ATOMIC FORCE MICROSCOPY; CHEMISTRY; DRUG DESIGN; KINETICS; MEDICINAL CHEMISTRY; METABOLISM; PROCEDURES; SURFACE PLASMON RESONANCE; TUMOR CELL LINE;

ANTIVIRAL AGENTS; CALRETICULIN; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; COMPLEMENT SYSTEM PROTEINS; DRUG DESIGN; EBOLAVIRUS; HUMANS; KINETICS; LECTINS; MANNOSE-BINDING LECTIN; MICROSCOPY, ATOMIC FORCE; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE;

EID: 77955283062     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.106260     Document Type: Article

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