Transcriptional inactivation of the tissue inhibitor of metalloproteinase-3 gene by DNA hypermethylation of the 5'-CpG island in human gastric cancer cell lines

International Journal of Cancer

Volumn 86, Issue 5, 2000, Pages 632-635

  Kang, Shin Hyeok ^a   Choi, Hyun Ho ^a   Kim, Sang Gyun ^a   Jong, Hyun Soon ^a   Kim, Noe Kyeong ^a,b   Kim, Seong Jin ^c   Bang, Yung Jue ^a,b  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INVASION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE INACTIVATION; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; MOLECULAR CLONING; MULTIGENE FAMILY; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SOUTHERN BLOTTING; STOMACH CARCINOGENESIS; TRANSCRIPTION REGULATION;

ANIMALS; BLOTTING, SOUTHERN; CPG ISLANDS; DNA METHYLATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; REGULATORY SEQUENCES, NUCLEIC ACID; STOMACH NEOPLASMS; TISSUE INHIBITOR OF METALLOPROTEINASE-3; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0034059499     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(20000601)86:5<632::AID-IJC5>3.0.CO;2-5     Document Type: Article

References (21)

1. AHONEN, M., BAKER, A.H. and KAHARI, V.-M., Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells. Cancer Res., 58, 2310-2315 (1998).
2. BACHMAN, K.E., HERMAN, J.G., CORN, P.G., MERLO, A., COSTELLO, J.F., CAVENEE, W.K., BAYLIN, S.B. and GRAFF, J.R., Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggests a suppressor role in kidney, brain and other cancers. Cancer Res., 59, 798-802 (1999).
3. BIAN, J., WANG, Y., SMITH, M.R., KIM, H., JACOBS, C., JACKMAN, J., KUNG, H.-F., COLBURN, N.H. and SUN, Y., Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3. Carcinogenesis, 17, 1805-1811 (1996).
4. BIRKEDAL-HANSEN, H., MOORE, W.G., BODDEN, M.K., WINDSOR. L.J., BIRKEDAL-HANSEN, B., DECARLO, A. and ENGLER, J.A., Matrix metalloproteinases: a review. Crit. Rev. oral. Biol. Med., 4, 197-250 (1993).
5. CASTAGNINO, P., SORIANO, J.V., MONTESANO, R. and BOTTARO, D.P., Induction of tissue inhibitor of metalloproteinases-3 is a delayed early cellular response to hepatocyte growth factor. Oncogene, 17, 481-492 (1998).
6. CHEN, R.Z., PETTERSSON, U., BEARD, C., JACKSON-GRUSBY, L. and JAENISCH, R., DNA hypomethylation leads to elevated mutation rates. Nature (Lond.), 395, 89-93 (1998).
7. CHOMCZYNSKI, P. and SACCHI, N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159 (1987).
8. GOMEZ, D.E., ALONSO, D.F., YOSHIJI, H. and THORGEIRSSON, U.P., Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. Europ. J. Cell Biol., 74, 111-122 (1997).
9. HERMAN, J.G., GRAFF, J.R., MYOHANEN, S., NELKIN, B.D. and BAYLIN, S.B., Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. nat. Acad. Sci. (Wash.), 93, 9821-9826 (1996).
10. HERMAN, J.G., LATIF, F., WENG, Y., LERMAN, M.I., ZBAR, B., LIU, S., SAMID, D., DUAN, D.S., GNARRA, J.R. and LINEHAN, W.M., Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc. nat. Acad. Sci. (Wash.). 91, 9700-9704 (1994).
11. LECO, K.J., KHOKHA, R., PAVLOFF, N., HAWKES, S.P. and EDWARDS, D.R., Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J. biol. Chem., 269, 9352-9360 (1994).
12. LIOTTA, L.A., STEEG, P.S. and STETLER-STEVENSON, W.G., Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell. 64, 327-336 (1991).
13. MERLO, A., HERMAN, J.G., MAO, L., LEE, D.J., GABRIELSON, E., BURGER, P.C., BAYLIN, S.B. and SIDRANSKY, D., 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor of p16/CDK2/MTS1 in human cancers. Nature (Med.), 1, 686-692 (1995).
14. PARK, J.-G. and 14 OTHERS, Establishment and characterization of human gastric carcinoma cell lines. Int. J. Cancer. 70, 443-449 (1997).
15. PENNIE, W.D., HEGAMYER, G.A., YOUNG, M.R. and COLBURN, N.H., Specific methylation events contribute to the transcriptional repression of the mouse tissue inhibitor of metalloproteinase-3 gene in neoplastic cells. Cell Growth Differentiation, 10, 279-286 (1999).
16. ROBERTSON, K.D., HAYWARD, S.D., LING, P.D., SAMID, D. and AMBINDER, R.F., Transcriptional activation of the EBV latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial. Mol. cell. Biol. 15, 6150-6159 (1995).
17. SAKAI, T., TOGICHIDA, J.. OHTANI, N., YANDELL, D.W., RAPAPORT, J.M. and DRYJA, T.P., Allele specific hypermethylation of the retinoblastoma tumor-suppressor gene. Amer. J. hum. Genet., 48, 880-888 (1991).
18. STOHR, H., ROOMP, K., FELBOR, U. and WEBER, B.H., Genomic organization of the human tissue inhibitor of metalloproteases-3 (TIMP3). Genome Res., 5, 483-487 (1995).
19. SU, S., DEHNADE, F. and ZAFARULLAH, M., Regulation of tissue inhibitor of metalloproteinases-3 gene expression by transforming growth factor- and dexamethasone in bovine and human articular chondrocytes. DNA Cell Biol., 15, 1039-1048 (1996).
20. SUN, Y., HEGAMYER, G., KIM, H., SITHANANDAM, K., LI, H., WATTS, R. and COLBURN, N.H., Molecular cloning of mouse tissue inhibitor of metalloproteinase-3 and its promoter specific lack of expression in neoplastic JB6 cells may reflect altered gene methylation. J biol. Chem., 270, 19312-19319 (1995).
21. 1 progression, mitogenic stimulation, differentiation, and senescence. J. biol. Chem., 269, 18953-18960 (1994).