N-cadherin expression in human prostate carcinoma cell lines: An epithelial-mesenchymal transformation mediating adhesion with stromal cells

American Journal of Pathology

Volumn 155, Issue 3, 1999, Pages 787-798

  Tran, Nhan L ^a   Nagle, Raymond B ^a   Cress, Anne E ^a   Heimark, Ronald L ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; BETA CATENIN; NERVE CELL ADHESION MOLECULE; PLAKOGLOBIN; UVOMORULIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; CYTOARCHITECTURE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; STROMA CELL; TUMOR DIFFERENTIATION;

EID: 0032887119     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65177-2     Document Type: Article

References (77)

1. Cussenot O, Valeri A, Berthon P, Fournier G, Mangin P: Hereditary prostate cancer and other genetic predispositions to prostate cancer. Urologia Internationalis 1998, 60 Suppl 2:30-34
2. Gittes RF: Carcinoma of the prostate. N Engl J Med 1991, 324:236-245
3. Villers A, McNeal JE, Redwine EA, Freiha FS, Stamey TA: The role of perineural space invasion in the local spread of prostatic adenocarcinoma. J Urol 1989, 142:763-768
4. McNeal JE, Villers AA, Redwine EA, Freina FS, Stamey TA: Capsular penetration in prostate cancer. Significance for natural history and treatment. Am J Surg Pathol 1990, 14:240-247
5. Knox JD, Cress AE, Clark V, Manriquez L, Affinito KS, Dalkin BL, Nagle RB: Differential expression of extracellular matrix molecules and the alpha 6-integrins in the normal and neoplastic prostate. Am J Pathol 1994, 145:167-174
6. Bostwick DG: Prostatic intraepithelial neoplasia (PIN). Urology 1989, 34:16-22
7. Cress AE, Rabinovitz I, Zhu W, Nagle RB; The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression. Cancer Metastasis Rev 1995, 14:219-228
8. Otto T, Rembrink K, Goepel M, Meyer-Schwickerath M, Rubben H: E-cadherin: a marker for differentiation and invasiveness in prostatic carcinoma. Urological Res 1993, 21:359-362
9. Takeichi M: Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 1995, 7:619-627
10. Rajasekaran AK, Hojo M, Huima T, Rodriguez-Boulan E: Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions. J Cell Biol 1996, 132:451-463
11. Ozawa M, Baribault H, Kemler R: The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J 1989, 8:1711-1717
12. Nagafuchi A, Shirayoshi Y, Okazaki K, Yasuda K, Takeichi M: Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature 1987, 329:341-343
13. Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R: The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. Proc Natl Acad Sci USA 1991, 88:9156-9160
14. McCrea PD, Turck CW, Gumbiner B: A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science 1991, 254:1359-1361
15. Reynolds AB, Daniel J, McCrea PD, Wheelock MJ, Wu J, Zhang Z: Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol Cell Biol 1994, 14:8333-8342
16. Daniel JM, Reynolds AB: The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. Mol Cell Biol 1995, 15:4819-4824
17. Boiler K, Vestweber D, Kemler R: Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells. J Cell Biol 1985, 100:327-332
18. Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K, Birchmeier W: E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 1991, 51:6328-6337
19. Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato Y, Takeichi M, Abe O: Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res 1989, 49:2128-2133
20. Bussemakers MJ, Schalken JA: The role of cell adhesion molecules and proteases in tumor invasion and metastasis. World J Urol 1996, 14:151-156
21. Ruijter E, van dK, Aalders T, Ruiter D, Miller G, Debruyne F, Schalken J: Heterogeneous expression of E-cadherin and p53 in prostate cancer: clinical implications. BIOMED-II Markers for Prostate Cancer Study Group. Mod Pathol 1998, 11:276-281
22. Birchmeier C, Birchmeier W, Brand S: Epithelial-mesenchymal transitions in cancer progression. Acta Anat 1996, 156:217-226
23. Birchmeier W, Behrens J: Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1994, 1198:11-26
24. Giroldi LA, Schalken J: Decreased expression of the intercellular adhesion molecule E-cadherin in prostate cancer: biological significance and clinical implications. Cancer Metast Rev 1993, 12:29-37
25. Umbas R, Schalken JA, Aalders TW, Carter BS, Karthaus HF, Schaafsma HE, Debruyne FM, Isaacs WB: Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer. Cancer Res 1992, 52:5104-5109
26. Morion RA, Ewing CM, Nagafuchi A, Tsukita S, Isaacs WB: Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells. Cancer Res 1993, 53:3585-3590
27. Horoszweicz JC, Leong SS, Chu TM, Wajsman ZL, Friedman M, Papsidero L, Kim J, Chai LS, Kakati S, Arya SK, Sandberg AA: The LNCaP cell line - a new model for studies on human prostatic carcinoma. In: G.P. Murphy (ed.), Models for Prostate Cancer 1980. New York, Alan R. Liss, Inc., pp 115-132
28. Stone KR, Mickey DD, Wunderli H, Mickey GH, Paulson DF: Isolation of a human prostate carcinoma cell line (DU 145). Int J Cancer 1978, 21:274-281
29. Kaighn ME, Narayan KS, Ohnuki Y, Lechner JF, Jones LW: Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest Urol 1979, 17:16-23
30. Muraki J, Addonizio JC, Choudhury MS, Fischer J, Eshghi M, Davidian MM, Shapiro LR, Wilmot PL, Nagamatsu GR, Chiao JW: Establishment of new human prostatic cancer cell line (JCA-1). Urology 1990, 36:79-84
31. Miyatani S, Shimamura K, Hatta M, Nagafuchi A, Nose A, Matsunaga M, Hatta K, Takeichi M: Neural cadherin: role in selective cell-cell adhesion. Science 1989, 245:631-635
32. Marcantonio EE, Hynes RO: Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi. J Cell Biol 1988, 106:1765-1772
33. Cowin P, Kapprell HP, Franke WW, Tamkun J, Hynes RO: Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell 1986, 46:1063-1073
34. Nagle RB, McDaniel KM, Clark VA, Payne CM: The use of antikeratin antibodies in the diagnosis of human neoplasms. Am J Clin Pathol 1983, 79:458-466
35. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685
36. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987, 162:156-159
37. Reid RA, Hemperly JJ: Human N-cadherin: nucleotide and deduced amino acid sequence. Nucleic Acids Research 1990, 18:5896
38. Franke WW, Goldschmidt MD, Zimbelmann R, Mueller HM, Schiller DL, Cowin P: Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein. Proc Natl Acad Sci USA 1989, 86:4027-4031
39. Roark EF, Paradies NE, Lagunowich LA, Grunwald GB: Evidence for endogenous proteases, mRNA level and insulin as multiple mechanisms of N-cadherin down-regulation during retinal development. Development 1992, 114:973-984
40. Suzuki S, Sano K, Tanihara H: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. Cell Regulat 1991, 2:261-270
41. McCandless JR, Cress AE, Rabinovitz I, Payne CM, Bowden GT, Knox JD, and Nagle RB. A human xenogratt model for testing early events of epithelial neoplastic invasion. Int J Oncol 1997, 10:279-285
42. Urushihara H, Takeichi M, Hakura A, Okada TS: Different cation requirements for aggregation of BHK cells and their transformed derivatives. J Cell Sci 1976, 22:685-695
43. Rokhlin OW, Cohen MB: Expression of cellular adhesion molecules on human prostate tumor cell lines Prostate 1995, 26:205-212
44. Geiger B, Volberg T, Ginsberg D, Bitzur S, Sabanay I, Hynes RO: Broad spectrum pan-cadherin antibodies, reactive with the C-terminal 24 amino acid residues of N-cadherin. J Cell Sci 1990, 97:607-614
45. Shimazui T, Bringuier PP, van BH, Ruijter E, Akaza H, Debruyne FM, Oosterwijk E, Schalken JA: Decreased expression of alpha-catenin is associated with poor prognosis of patients with localized renal cell carcinoma. Int J Cancer 1997, 74:523-528
46. Ronnov-Jessen L, Celis JE, Van DB, Petersen OW: A fibroblast-associated antigen: characterization in fibroblasts and immunoreactivity in smooth muscle differentiated stromal cells. J Histochem Cytochem 1992, 40:475-486
47. Lazard D, Sastre X, Frid MG, Glukhova MA, Thiery JP, Koteliansky VE: Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. Proc Natl Acad Sci USA 1993, 90:999-1003
48. Gleave ME, Hsieh JT, von EA, Chung LW: Prostate and bone fibroblasts induce human prostate cancer growth in vivo: implications for bidirectional tumor-stromal cell interaction in prostate carcinoma growth and metastasis. J Urol 1992, 147:1151-1159
49. Camps JL. Chang SM, Hsu TC, Freeman MR, Hong SJ, Zhau HE, von Eschenbach AC, Chung LW: Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci USA 1990, 87:75-79
50. Mo YY, Reynolds AB: Identification of murine p120 isoforms and heterogeneous expression of p120cas isoforms in human tumor cell lines. Cancer Res 1996, 56:2633-2640
51. Keirsebilck A, Bonne S, Staes K, van HJ, Nollet F, Reynolds A, Van RF: Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. Genomics 1998, 50:129-146
52. Reynolds AB, Daniel JM, Mo YY, Wu J, Zhang Z: The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. Exp Cell Res 1996, 225: 328-337
53. Oka H, Shiozaki H, Kobayashi K, Inoue M, Tahara H, Kobayashi T, Takatsuka Y, Matsuyoshi N, Hirano S, Takeichi M: Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 1993, 53:1696-1701
54. Shiozaki H, Tahara H, Oka H, Miyata M, Kobayashi K, Tamura S, Iihara K, Doki Y, Hirano S, Takeichi M: Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol 1991, 139:17-23
55. Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WB, Pitha PM, Davison NE, Baylin SB: E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 1995, 55:5195-5199
56. Giroldi LA, Bringuier PP, de WM, Jansen C, van BA, Schalken JA: Role of E boxes in the repression of E-cadherin expression, Biochem Biophys Res Comm 1997, 241:453-458
57. Carter BS, Ewing CM, Ward WS, Treiger BF, Aalders TW, Schalken JA, Epstein JI, Isaacs WB: Allelic loss of chromosomes 16q and 10q in human prostate cancer. Proc Natl Acad Sci USA 1990, 87:8751-8755
58. Bussemakers MJ, van BA, Voller M, Smit FP, Schalken JA: The genes for the calcium-dependent cell adhesion molecules P- and E-cadherin are tandemly arranged in the human genome. Biochem Biophys Res Comm 1994, 203:1291-1294
59. Pan Y, Matsuyama H, Wang N, Yoshihiro S, Haggarth L, Li C, Tribukait B, Ekman P, Bergerheim US: Chromosome 16q24 deletion and decreased E-cadherin expression: possible association with metastatic potential in prostate cancer. Prostate 1998, 36:31-38
60. Suzuki H, Komiya A, Emi M, Kuramochi H, Shiraishi T, Yatani R, Shimazaki J: Three distinct commonly deleted regions of chromosome arm 16q in human primary and metastatic prostate cancers. Genes Chromosomes Cancer 1996, 17:225-233
61. Wallis J, Fox MF, Walsh FS: Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2. Genomics 1994, 22:172-179
62. Hazan RB, Kang L, Whooley BP, Borgen PI: N-cadherin promotes adhesion between invasive breast cancer cells and the stroma. Cell Adhes Commun 1997, 4:399-411
63. Hatta K, Takeichi M: Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development. Nature 1986, 320:447-449
64. Duband JL, Dufour S, Hatta K, Takeichi M, Edelman GM, Thiery JP: Adhesion molecules during somitogenesis in the avian embryo. J Cell Biol 1987, 104:1361-1374
65. Hatta K, Takagi S, Fujisawa H, Takeichi M: Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos. Dev Biol 1987, 120:215-227
66. Wheelock MJ, Knudsen KA: N-cadherin-associated proteins in chicken muscle. Differentiation 1991, 46:35-42
67. Hayward SW, Rosen MA, Cunha GR: Stromal-epithelial interactions in the normal and neoplastic prostate. Br J Urol 1997, 79 Suppl 2:18-26
68. Islam S, Gary TE, Wolf GT, Wheelock MJ, Johnson KR: Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion. J Cell Biol 1996, 135:1643-1654
69. Goncharova EJ, Kam Z, Geiger B: The development of adherens junction components in myofibrillogenesis in cultured cardiac myocytes. Development 1992, 114:173-183
70. Letourneau PC, Shattuck TA, Roche FK, Takeichi M, Lemmon V: Nerve growth cone migration onto Schwann cells involves the calcium-dependent adhesion molecule, N-cadherin. Dev Biol 1990, 138: 430-442
71. Monier-Gavelle F, Duband JL: Control of N-cadherin-mediated intercellular adhesion in migrating neural crest cells in vitro. J Cell Sci 1995, 108:3839-3853
72. Nagle RB, Hao J, Knox JD, Dalkin BL, Clark V, Cress AE: Expression of hemidesmosomal and extracellular matrix proteins by normal and malignant human prostate tissue. Am J Pathol 1995, 146:1498-1507
73. Rabinovitz I, Nagle RB, Cress AE: Integrin alpha 6 expression in human prostate carcinoma cells is associated with a migratory and invasive phenotype in vitro and in vivo. Clin Exp Metast 1995, 13: 431-491
74. Rimm DL, Koslov ER, Kebriaei P, Cianci CD, Morrow JS: Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc Natl Acad Sci USA 1995, 92:8813-8817
75. Watabe M, Nagafuchi A, Tsukita S, Takeichi M: Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line. J Cell Biol 1994, 127:247-256
76. Kemler R: From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genetic 1993, 9:317-321
77. Yap AS, Niessen CM, Gumbiner BM: The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J Cell Biol 1998, 141: 779-789