A physiologically based pharmacokinetic model for atrazine and its main metabolites in the adult male C57BL/6 mouse

Toxicology and Applied Pharmacology

Volumn 251, Issue 1, 2011, Pages 16-31

  Lin, Zhoumeng ^a   Fisher, Jeffrey W ^a   Ross, Matthew K ^b   Filipov, Nikolay M ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

Atrazine; Chlorotriazine herbicides; DACT; PBPK modeling

Indexed keywords

2 AMINO 4 CHLORO 6 ETHYLAMINO 1,3,5 TRIAZINE; ATRAZINE; DEETHYLATRAZINE; DRUG METABOLITE; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; C57BL MOUSE; DOSIMETRY; DRUG BLOOD LEVEL; ERYTHROCYTE; FEMALE; KIDNEY; LIVER; MALE; MOUSE; NERVOUS SYSTEM; NONHUMAN; PLASMA PROTEIN BINDING; PROTEIN BINDING; TISSUE; TOXICOKINETICS;

ADMINISTRATION, ORAL; AGE FACTORS; ANIMALS; ATRAZINE; BIOTRANSFORMATION; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HERBICIDES; MALE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; TISSUE DISTRIBUTION;

MUS; RATTUS; RODENTIA;

EID: 78751605212     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.11.009     Document Type: Article

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