The ATP site of protein kinases as target for drug development: From natural compounds to Gleevec

Israel Medical Association Journal

Volumn 4, Issue 8, 2002, Pages 633-635

 

^a Graziani), Yosef   (Israel)

Author keywords

ATP site; Genistein; Gleevec; MAP kinases; Phosphorylation of tyrosine residues; pp60v src src gene protein product; Protein kinases; Quercetin; Resveratrol; Tyrphostins

Indexed keywords

ADENOSINE TRIPHOSPHATE; GENISTEIN; HEXOKINASE; IMATINIB; ISOFLAVONE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE INHIBITOR; QUERCETIN; RESVERATROL; TYROSINE; TYRPHOSTIN;

CANCER CHEMOTHERAPY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; EDITORIAL; GENE TARGETING; HUMAN; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; BINDING SITES; DRUG DESIGN; HISTORY, 20TH CENTURY; HUMANS; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PYRIMIDINES; SIGNAL TRANSDUCTION;

EID: 0036339229     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (17)

1. The effect of flavonoids on aerobic glycolysis and growth of tumor cells
2. Bioflavenoid regulation of ATPase and hexokinase activity in Ehrlich ascites cell mitochondria
3. Regulation of protein kinases activity by quercetin in Ehrlich ascites tumor cells
4. Identification of a transformation-specific antigen induced by an avian sarcoma virus
5. Protein kinase activity associated with the avian sarcoma virus src gene product
6. An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates
7. Characterization of the Rous sarcoma virus transforming gene product. In vitro phosphorylation with ATP and GTP as phosphate donors
8. The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo
9. Genistein, a specific inhibitor of tyrosine specific protein kinases
10. Kinase inhibitors from Polygonum cuspidatum
11. The cell membrane and cell signals: New targets for novel anticancer drugs
12. The cell membrane and cell signals as targets in cancer chemotherapy
13. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors
14. Tyrosine kinase inhibition: An approach to drug development
15. Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia
16. From oncogene to drug: Development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents
17. The mitogen-activated protein kinase signaling cascade: From bench to bedside