Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms

Regulatory Toxicology and Pharmacology

Volumn 59, Issue 1, 2011, Pages 111-124

  Wang, Yun Jan ^a,b   Dou, Jinhui ^a   Cross, Kevin P ^c   Valerio, Luis G ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b GlobalNet Services   (United States)

^c Leadscope Inc   (United States)

Author keywords

Black cohosh; Botanicals; Chasteberry; Computational science; Dietary supplements; Hops; Hormone replacement therapy; Liver toxicity; Menopausal symptoms; Menopause; Modeling; QSAR; Red clover; Safety; Women's health

Indexed keywords

4 HYDROXYACETOPHENONE; 4 VINYLPHENOL; ACETYLCYSTEINE; BENOXAPROFEN; BENZOFURAN DERIVATIVE; CHASTEBERRY EXTRACT; CIMICIFUGA RACEMOSA EXTRACT; DICLOFENAC; FLAVONE; GLUCOSIDE; HERBACEOUS AGENT; HUMULUS LUPULUS EXTRACT; ISOFLAVONE; ISOXANTHOHUMOL; MONOCROTALINE; PHENOL DERIVATIVE; PROTOCATECHUIC ACID; RANOLAZINE; RED CLOVER EXTRACT; UNCLASSIFIED DRUG; VITEX AGNUS CASTUS EXTRACT;

ARTICLE; BOTANY; CHEMICAL COMPOSITION; COMPUTER MODEL; CONTROLLED STUDY; FEMALE; HEPATOBILIARY DISEASE; HUMAN; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; MACHINE LEARNING; MENOPAUSAL SYNDROME; PREDICTION; PRIORITY JOURNAL; PROBABILITY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; UNITED STATES; WOMEN'S HEALTH;

ANIMALS; ARTIFICIAL INTELLIGENCE; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; EXPERT SYSTEMS; FEMALE; HUMANS; LIVER; MENOPAUSE; MODELS, MOLECULAR; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PLANT EXTRACTS; PROBABILITY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RISK ASSESSMENT; RISK FACTORS; SOFTWARE; TOXICITY TESTS; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION; WOMEN'S HEALTH;

ANIMALIA; CIMICIFUGA DAHURICA; HUMULUS; TRIFOLIUM PRATENSE; VITEX AGNUS-CASTUS;

EID: 78751575350     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2010.09.012     Document Type: Article

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