Structural features of aminoquinolines necessary for antagonist activity against botulinum neurotoxin

Toxicon

Volumn 35, Issue 9, 1997, Pages 1439-1451

  Sheridan, R E ^a   Deshpande, S S ^a   Nicholson, J D ^b   Adler, M ^a  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^b DAKKRO Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOQUINOLINE; 4 AMINO 7 CHLOROQUINOLINE; 7 CHLORO 4 (4 DIETHYLAMINOBUTYLAMINO)QUINOLINE; 8 (4 AMINO 1 METHYLBUTYLAMINO) 5 HEXYLOXY 6 METHOXY 4 METHYLQUINOLINE; 8 AMINOQUINOLINE; 8 HYDROXY 5 QUINOLINESULFONIC ACID; 8 QUINOLINOL; AJ 47404; AMINOQUINOLINE DERIVATIVE; AMODIAQUINE; ANTIMALARIAL AGENT; AV 78164; BM 07365; BOTULINUM TOXIN; CHLOROQUINE; MEFLOQUINE; MEPACRINE; PRIMAQUINE; PYRIMETHAMINE; QUININE; QUINOLINE; TACRINE; UNCLASSIFIED DRUG; ZK 35054; ZP 13923;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG TOXICITY; HEMIDIAPHRAGM; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINOQUINOLINES; ANIMALS; BOTULINUM TOXINS; MALE; MICE; NEUROMUSCULAR JUNCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; CINCHONA PUBESCENS;

EID: 0030723415     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(96)00208-5     Document Type: Article

References (20)

1. Bark, I. C. and Wilson, M. C. (1994) Regulated vesicular fusion in neurons: snapping together the details. Proceeding of the National Acedemy of Sciences of the U.S.A. 91, 4621-4624.
2. 125I-labeled botulinum neurotoxins with nerve terminals. II. Autoradiographic evidence for its uptake into motor nerves by acceptor-mediated endocytosis. Journal of Cell Biology 103, 535-544.
3. DasGupta, B. R. (1990) Structure and biological activity of botulinum neurotoxin. Journal of Physiology (Paris) 84, 220-228.
4. de Paiva, A. and Dolly, J. O. (1990) Light chain of botulinum neurotoxin is active in mammalian motor nerve terminals when delivered via liposomes. FEBS Letters 277, 171-174.
5. Deshpande, S. S., Sheridan, R. E. and Adler, M. (1997) Efficacy of certain quinolines as pharmacological antagonists in botulinum neurotoxin poisoning. Toxicon 34, 849-855.
6. Ginsburg, H., Nissani, E. and Krugliak, M. (1989) Alkalinization of the food vacuole of malaria parasites by quinoline drugs and alkylamines is not correlated with their antimalarial activity. Biochemical Pharmacology 38, 2645-2654.
7. Molgo, J., Comella, J. X., Angaut-Petit, D., Pecot-Dechavassine, M., Tabti, N., Laille, L., Mallart, A. and Thesleff, S. (1990) Presynaptic actions of botulinal neurotoxins at vertebrate neuromuscular junctions. Journal of Physiology (Paris) 84, 152-166.
8. Montecucco, C. and Schiavo, G. (1993) Tetanus and botulism neurotoxins: a new group of zinc proteases. Trends in Biological Sciences 18, 324-327.
9. Nodiff, E. A., Chatterjee, S. and Musallam, H. A. (1991) Antimalarial activity of the 8-aminoquinolines. Progress in Medicinal Chemistry 28, 1-40.
10. Oblatt-Montal, M., Yamazaki, M., Nelson, R. and Montal, M. (1995) Formation of ion channels in lipid bilayers by a peptide with the predicted transmembrane sequence of botulinum neurotoxin A. Protein Science 4, 1490-1497.
11. Poulain, B., Wadsworth, J. D. F., Maisey, E. A., Shone, C. C., Melling, J., Tauc, L. and Dolly, J. O. (1989) Inhibition of transmitter release by botulinum neurotoxin A: contribution of various fragments to the intoxication process. European Journal of Biochemistry 185, 197-203.
12. Schmid, A., Benz, R., Just, I. and Aktories, K. (1994) Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes. Journal of Biological Chemistry 269, 16706-16711.
13. Sellin, L. C. (1985) The pharmacological mechanism of botulism. Trends in Pharmacological Sciences 6, 80-82.
14. Sheridan, R. E. (1996) Protonophore antagonism of botulinum toxin in mouse muscle. Toxicon 34, 849-855.
15. Simpson, L. L. (1982) The interactions between aminoquinolines and presynaptically acting neurotoxins. Journal of Pharmacology and Experimental Therapeutics 222, 43-48.
16. Simpson, L. L. (1983) Ammonium chloride and methylamine hydrochloride antagonize clostridial neurotoxins. Journal of Pharmacology and Experimental Therapeutics 225, 546-552.
17. Simpson, L. L. and DasGupta, B. R. (1983) Botulinum neurotoxin type E: studies on mechanism of action and on structure-activity relationships. Journal of Pharmacology and Experimental Therapeutics 224, 135-140.
18. 2 neurotoxins. Journal of Pharmacology and Experimental Therapeutics 269, 256-262.
19. Wissner, A. (1990) HMO version 1.1: a Huckel Molecular Orbital Program for the Macintosh. Tetrahedron Computer Methodology 3, 63-71.
20. Zarchin, S., Krugliak, M. and Ginsburg, H. (1986) Digestion of the host erythrocyte by malaria parasites is the primary target for quinoline-containing antimalarials. Biochemical Pharmacology 35, 2435-2442.