Immunity and vaccines against sexually transmitted Chlamydia trachomatis infection

Current Opinion in Infectious Diseases

Volumn 24, Issue 1, 2011, Pages 56-61

  Howie, Sarah E M ^a   Horner, Patrick J ^b   Horne, Andrew W ^c   Entrican, Gary ^d  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Chlamydia trachomatis; immunity; vaccination

Indexed keywords

BACTERIAL VACCINE; BACTERIUM ANTIBODY;

ANTIBODY RESPONSE; ARTICLE; BACTERIAL IMMUNITY; CD4+ T LYMPHOCYTE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HOST CELL; HUMAN; IMMUNE RESPONSE; LIFE CYCLE; NONHUMAN; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; BACTERIAL VACCINES; CHLAMYDIA TRACHOMATIS; HOST-PATHOGEN INTERACTIONS; HUMANS; LYMPHOGRANULOMA VENEREUM;

EID: 78751537870     PISSN: 09517375     EISSN: 14736527     Source Type: Journal    
DOI: 10.1097/QCO.0b013e3283421081     Document Type: Article

References (56)

1. Thomson NR, Holden MT, Carder C, et al. Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates. Genome Res 2008; 18:161-171.
2. Carey AJ, Beagley KW. Chlamydia trachomatis, a hidden epidemic: effects on female reproduction and options for treatment. Am J Reprod Immunol 2010; 63:576-586.
3. Cunningham KA, Beagley KW. Male genital tract chlamydial infection: implications for pathology and infertility. Biol Reprod 2008; 79:180-189.
4. Ouzounova-Raykova V, Ouzounova I, Mitov I. Chlamydia trachomatis infection as a problem among male partners of infertile couples. Andrologia 2009; 41:14-19.
5. Lyytikainen E, Kaasila M, Hiltunen-Back E, et al. A discrepancy of Chlamydia trachomatis incidence and prevalence trends in Finland 1983-2003. BMC Infect Dis 2008; 8:169.
6. Lyytikainen E, Kaasila M, Koskela P, et al. Chlamydia trachomatis seropre-valence atlas of Finland 1983-2003. Sex Transm Infect 2008; 84:19-22.
7. Agrawal T, Gupta R, Dutta R, et al. Protective or pathogenic immune response to genital chlamydial infection in women: a possible role of cytokine secretion profile of cervical mucosal cells. Clin Immunol 2009; 130:347-354.
8. Gupta R, Vardhan H, Srivastava P, et al. Modulation of cytokines and transcription factors (T-Bet and GATA3) in CD4 enriched cervical cells of Chlamydia trachomatis infected fertile and infertile women upon stimulation with chlamydial inclusion membrane proteins B and C. Reprod Biol Endocrinol 2009; 7:84.
9. Wyrick PB. Chlamydia trachomatis persistence in vitro: an overview. J Infect Dis 2010; 201 (Suppl 2):S88-S95.
10. Huston WM, Theodoropoulos C, Mathews SA, Timms P. Chlamydia trachomatis responds to heat shock, penicillin induced persistence, and IFN-gamma persistence by altering levels of the extracytoplasmic stress response protease HtrA. BMC Microbiol 2008; 8:190.
11. Gupta R, Salhan S, Mittal A. Seroprevalence of antibodies against Chlamydia trachomatis inclusion membrane proteins B and C in infected symptomatic women. J Infect Dev Ctries 2009; 3:1 91-198.
12. Gray RT, Beagley KW, Timms P, Wilson DP. Modeling the impact of potential vaccines on epidemics of sexually transmitted Chlamydia trachomatis infec tion. J Infect Dis 2009; 199:1680-1688.
13. Carlson JH, Whitmire WM, Crane DD, et al. The Chlamydia trachomatis plasmid is a transcriptional regulator of chromosomal genes and a virulence factor. Infect Immun 2008; 76:2273-2283.
14. Heinz E, Tischler P, Rattei T, et al. Comprehensive in silico prediction and analysis of chlamydial outer membrane proteins reflects evolution and lifestyle of the Chlamydiae. BMC Genomics 2009; 10:634.
15. Liu X, Afrane M, Clemmer DE, et al. Identification of Chlamydia trachomatis outer membrane complex proteins by differential proteomics. J Bacteriol 2010; 192:2852-2860.
16. Skilton RJ, Cutcliffen LT, Barlow D, et al. Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the devel opmental cycle. PLoS One 2009; 4:e7723.
17. Ajonuma LC, Fok KL, Ho LS, et al. CFTR is required for cellular entry and internalization of Chlamydia trachomatis. Cell Biol Int 2010; 34:593-600.
18. He Q, Tsang LL, Ajonuma LC, Chan HC. Abnormally up-regulated cystic fibrosis transmembrane conductance regulator expression and uterine fluid accumulation contribute to Chlamydia trachomatis-induced female infertility. Fertil Steril 2010; 93:2608-2614.
19. Abromaitis S, Stephens RS. Attachment and entry of Chlamydia have distinct requirements for host protein disulfide isomerase. PLoS Pathog 2009; 5:e1000357.
20. Davis CH, Raulston JE, Wyrick PB. Protein disulfide isomerase, a component of the estrogen receptor complex, is associated with Chlamydia trachomatis serovar E attached to human endometrial epithelial cells. Infect Immun 2002; 70:3413-3418.
21. Borth N, Massier J, Franke C, et al. Chlamydial protease CT441 interacts with SRAP1 co-activator of estrogen receptor alpha and partially alleviates its coactivation activity. J Steroid Biochem Mol Biol 2010; 119:89-95.
22. Cocchiaro JL, Valdivia RH. New insights into Chlamydia intracellular survival mechanisms. Cell Microbiol 2009; 11:1571-1578.
23. Betts HJ, Wolf K, Fields KA. Effector protein modulation of host cells: examples in the Chlamydia spp. arsenal. Curr Opin Microbiol 2009; 12:81-87.
24. Murthy AK, Guentzel MN, Zhong G, Arulanandam BP. Chlamydial protease- like activity factor: insights into immunity and vaccine development. J Reprod Immunol 2009; 83:179-184.
25. Mehlitz A, Banhart S, Maurer AP, et al. Tarp regulates early Chlamydia- induced host cell survival through interactions with the human adaptor protein SHC1. J Cell Biol 2010; 190:143-157.
26. Abdul-Sater AA, Koo E, Hacker G, Ojcius DM. Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intra cellular pathogen Chlamydia trachomatis. J Biol Chem 2009; 284:26789-26796.
27. Zhong G. Killing me softly: chlamydial use of proteolysis for evading host defenses. Trends Microbiol 2009; 17:467-474.
28. Vignola MJ, Kashatus DF, Taylor GA, et al. cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis. J Biol Chem 2010; 285:21625-21635.
29. McGettrick AF, O'Neill LA. Localisation and trafficking of Toll-like receptors: an important mode of regulation. Curr Opin Immunol 2010; 22:20-27.
30. Shaw MH, ReimerT, Kim YG, Nunez G. NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Curr Opin Immunol 2008; 20:377-382.
31. Joyee AG, Yang X. Role of toll-like receptors in immune responses to chlamydial infections. Curr Pharm Des 2008; 14:593-600.
32. De la Torre E, Mulla MJ, Yu AG, et al. Chlamydia trachomatis infection modulates trophoblast cytokine/chemokine production. J Immunol 2009; 182:3735-3745.
33. Refaat B, Al-Azemi M, Geary I, etal. Role of activinsand inducible nitric oxide in the pathogenesis of ectopic pregnancy in patients with or without Chlamydia trachomatis infection. Clin Vaccine Immunol 2009; 16:1493-1503.
34. Batteiger BE, Xu F, Johnson RE, Rekart ML. Protective immunity to Chlamydia trachomatis genital infection: evidence from human studies. J Infect Dis 2010; 201 (Suppl 2):S178-S189.
35. Li Z, Chen C, Chen D, et al. Characterization of fifty putative inclusion membrane proteins encoded in the Chlamydia trachomatis genome. Infect Immun 2008; 76:2746-2757.
36. Gupta R, SrivastavaP, Vardhan H, etal. Host immune responses to chlamydial inclusion membrane proteins B and C in Chlamydia trachomatis infected women with or without fertility disorders. Reprod Biol Endocrinol 2009; 7:38.
37. Fling SP, Sutherland RA, Steele LN, etal. CD8+T cells recognize an inclusion membrane-associated protein from the vacuolar pathogen Chlamydia trachomatis. Proc Natl Acad Sci USA 2001; 98:1160-1165.
38. El Hakim EA, Gordon UD, Akande VA. The relationship between serum Chlamydia antibody levels and severity of disease in infertile women with tubal damage. Arch Gynecol Obstet 2010; 281:727-733.
39. Frikha-Gargouri O, Gdoura R, Znazen A, et al. Diagnostic value of enzyme- linked immunosorbent assays using hypothetical proteins CT226 and CT795 as antigens in Chlamydia trachomatis serodiagnosis. Diagn Microbiol Infect Dis 2009; 65:224-231.
40. Wills GS, Horner PJ, Reynolds R, et al. Pgp3 antibody enzyme-linked immunosorbent assay, a sensitive and specific assay for seroepidemiological analysis of Chlamydia trachomatis infection. Clin Vaccine Immunol 2009; 16:835-843.
41. CampanellaC, Marino Gammazza A, Mularoni L, etal. A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible auto immune response. Int J Immunogenet 2009; 36:73-78.
42. Naaby-Hansen S, Herr JC. Heat shock proteins on the human sperm surface. J Reprod Immunol 2010; 84:32-40.
43. Huston WM, Armitage CW, Lawrence A, et al. HtrA, RseP, and Tsp proteins do not elicit a pathology-related serum IgG response during sexually trans mitted infection with Chlamydia trachomatis. J Reprod Immunol 2010; 85:168-171.
44. Rodgers AK, Wang J, Zhang Y, et al. Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P. Am J Obstet Gynecol 2010; 203:494.e7-494e.14.
45. Rank RG, Whittum-Hudson JA. Protective immunity to chlamydial genital infection: evidence from animal studies. J Infect Dis 2010; 201 (Suppl 2):S168-S177.
46. Karunakaran KP, Yu H, Foster LJ, Brunham RC. Development of a Chlamydia trachomatis T cell vaccine. Hum Vaccin 2010; 6:1-5.
47. Jiang X, Shen C, Yu H, etal. Differences in innate immune responses correlate with differences in murine susceptibility to Chlamydia muridarum pulmonary infection. Immunology 2010; 129:556-566.
48. Hickey DK, Aldwell FE, Beagley KW. Transcutaneous immunization with a novel lipid-based adjuvant protects against Chlamydia genital and respiratory infections. Vaccine 2009; 27:6217-6225.
49. Hickey DK, Aldwell FE, Beagley KW. Oral immunization with a novel lipid- based adjuvant protects against genital Chlamydia infection. Vaccine 2010; 28:1668-1672.
50. Meoni E, Faenzi E, Frigimelica E, et al. CT043, a protective antigen that induces a CD4+ Th1 response during Chlamydia trachomatis infection in mice and humans. Infect Immun 2009; 77:4168-4176.
51. Soriani M, Petit P, Grifantini R, etal. Exploiting antigenic diversity for vaccine design: the Chlamydia ArtJ paradigm. J BiolChem 2010 [Epub ahead of print].
52. Chaganty BK, Murthy AK, Evani SJ, et al. Heat denatured enzymatically inactive recombinant chlamydial protease-like activity factor induces robust protective immunity against genital chlamydial challenge. Vaccine 2010; 28:2323-2329.
53. Molina DM, Pal S, Kayala MA, etal. Identification of immunodominant antigens of Chlamydia trachomatis using proteome microarrays. Vaccine 2010; 28:3014-3024.
54. Wang J, Chen L, Chen F, etal. A chlamydial type III-secreted effector protein (Tarp) is predominantly recognized by antibodies from humans infected with Chlamydia trachomatis and induces protective immunity against upper genital tract pathologies in mice. Vaccine 2009; 27:2967-2980.
55. Wang J, Zhang Y, Lu C, etal. A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans. J Immunol 2010; 185:1670-1680.
56. Coler RN, Bhatia A, Maisonneuve JF, et al. Identification and characterization of novel recombinant vaccine antigens for immunization against genital Chlamydia trachomatis. FEMS Immunol Med Microbiol 2009; 55:258-270.