A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response

International Journal of Immunogenetics

Volumn 36, Issue 1, 2009, Pages 73-78

  Campanella, C ^a   Marino Gammazza, A ^a   Mularoni, L ^b   Cappello, F ^a   Zummo, G ^a   Di Felice, V ^a  

^a UNIVERSITY OF PALERMO   (Italy)

^b Research Unit on Biomedical Informatics   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONIN; HEAT SHOCK PROTEIN 60; PROTEIN GROEL 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; AUTOIMMUNITY; CHLAMYDIA TRACHOMATIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEROTYPE;

AMINO ACID SEQUENCE; AUTOIMMUNITY; BASE SEQUENCE; CHAPERONIN 60; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; GROEL PROTEIN; HUMANS; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); CHLAMYDIA TRACHOMATIS; HOMO SAPIENS;

EID: 58849106383     PISSN: 17443121     EISSN: 1744313X     Source Type: Journal    
DOI: 10.1111/j.1744-313X.2008.00819.x     Document Type: Article

References (40)

1. Akira, S., Takeda, K. Kaisho, T. (2001) Toll-like receptors critical proteins linking innate and acquired immunity. Nature Immunology, 2, 675.
2. Anderton, S.M., Van der Zee, R., Prakken, B., Noordzij, A. Van Eden, W. (1995) Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis. Journal of Experimental Medicine, 181, 943.
3. Bavoil, P., Stephens, R.S. Falkow, S. (1990) A soluble 60 kiloDalton antigen of Chlamydia spp. is a homologue of Escherichia coli GROEL. Molecular Microbiology, 4, 461.
4. Cappello, F., Bellafiore, M., Palma, A., David, S., Marcianò, V., Bartolotta, E., Sciumè, C., Modica, G., Farina, F. Zummo, G. (2003) 60 kDa chaperonin (HSP60) is over-expressed during colorectal carcinogenesis. European Journal of Histochemistry, 47, 105.
5. Cappello, F., Bellafiore, M., Palma, A., Marcianò, V., Martorana, G., Belfiore, P., Martorana, A., Farina, F., Zummo, G. Bucchieri, F. (2002-03) Expression of 60-kD heat shock protein increases during carcinogenesis in the uterine exocervix. Pathobiology, 70, 83.
6. De Maio, A. (1995) The heat-shock response. New Horiz, 3, 198.
7. Deng, L. Mariuzza, R.A. (2007) Recognition of self-peptide-MHC complexes by autoimmune T-cell receptors. Trends in Biochemical Sciences, 32, 500.
8. Di Felice, V., Ardizzone, N., Marciano, V., Bartolotta, T., Cappello, F., Farina, F. Zummo, G. (2005) Senescence-associated HSP60 expression in normal human skin fibroblasts. The Anatomical Record. Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 284, 446.
9. Domeika, M., Domeika, K., Paavonen, J., Mardh, P.A. Witkin, S.S. (1998) Humoral immune response to conserved epitopes of Chlamydia trachomatis and human 60-kDa heat-shock protein in women with pelvic inflammatory disease. Journal of Infectious Diseases, 177, 714.
10. Ellis, R.J. (1990) The molecular chaperon concept. Seminars in Cell Biology, 1, 1.
11. Ellis, R.J. (1999) Molecular chaperones: pathways and networks. Current Biology, 9, R137.
12. Fernando, M.M., Stevens, C.R., Walsh, E.C., De Jager, P.L., Goyette, P., Plenge, R.M., Vyse, T.J. Rioux, J.D. (2008) Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genetic, 4, e1000024.
13. Giles, D.K., Whittimore, J.D., LaRue, R.W., Raulston, J.E. Wyrick, P.B. (2006) Ultrastructural analysis of chlamydial antigen-containing vesicles everting from the Chlamydial trachomatis inclusion. Microbes and Infection, 8, 1579.
14. Jakus, S., Neuer, A., Dieterle, S., Bongiovanni, A.M. Witkin, S.S. (2008) Antibody to the Chlamydia trachomatis 60 k Da heat shock protein in follicular fluid and in vitro fertilization outcome. American Journal of Reproductive Immunology, 59, 85.
15. Jolly, C. Morimoto, R.I. (2000) Role of the heat shock response and molecular chaperones in oncogenesis and cell death. Journal of the National Cancer Institute, 92, 1564.
16. Kirchhoff, S.R., Gupta, S. Knowlton, A.A. (2002) Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation, 105, 2899.
17. Kol, A., Bourcier, T., Lichtman, A.H. Libby, P. (1999) Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. Journal of Clinical Investigation, 103, 571.
18. Kol, A., Sukhora, G.K., Lichtman, A.H. Libby, P. (1998) Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation, 98, 300.
19. Luna, E., Postol, E., Caldas, C., Mundel, L.R., Porto, G., Iwai, L.K., Ho, P.L., Kalil, J. Coelho, V. (2007) Diversity of physiological cell reactivity to heat shock protein 60 in different mouse strains. Cell Stress and Chaperones, 12, 112.
20. Lyons, J.M., Ito, J.I. Morre, S.A. (2006) Efficacy of an immune modulator in experimental Chlamydia trachomatis infection of the female genital tract. Infectious Diseases in Obstetrics and Gynecology, 14, 61265.
21. Macario, A.J. (1995) Heat-shock proteins and molecular chaperones: implications for pathogenesis, diagnostics, and therapeutics. International Journal of Clinical and Laboratory Research, 25, 59.
22. Okada, T., Ayada, K., Usui, S., Yokota, K., Cui, J., Kawahara, Y. et al (2007) Antibodies against heat shock protein 60 derived from Helicobacter pylori: diagnostic implications in cardiovascular disease. Journal of Autoimmunity, 29, 106.
23. Pochon, N.A. (1996) Genetic complexity of the human hsp60 gene. International Immunology, 8, 221.
24. Quintana, F.J. Cohen, I.R. (2001) Autoantibody patterns in diabetes-prone NOD mice and in standard C57BL/6 mice. Journal of Autoimmunity, 17, 191.
25. Quintana, F.J. Cohen, I.R. (2008) HSP60 speaks to the immune system in many voices. Novartis Foundation Symposium, 291, 101.
26. Raska, M. Weigl, E. (2005) Heat shock proteins in autoimmune diseases. Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 149, 243.
27. Raulston, J.E., Paul, T.R., Knight, S.T. Wyrick, P.B. (1998) Localization of Chlamydia trachomatis heat shock proteins 60 and 70 during infection of a human endometrial epithelial cell line in vitro. Infection and Immunity, 66, 2323.
28. Rottenberg, M.E., Gigliotti-Rothfuchs, A. Wigzell, H. (2002) The role of IFN-gamma in the outcome of chlamydial infection. Current Opinion in Immunology, 14, 444.
29. Samali, A., Cai, J., Zhivotovskij, B., Jones, D.P. Orrenius, S. (1999) Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells. EMBO Journal, 18, 2040.
30. Sasu, S., Verda, D.L., Qureshi, N., Golenbock, D.T. Beasley, D. (2001) Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation. Circulation Research, 89, 244.
31. Shemer-Avni, Y., Wallach, D. Sarov, I. (1988) Inhibition of Chlamydia trachomatis growth by recombinant tumor necrosis factor. Infection and Immunity, 56, 2503.
32. Starnbach, M.N., Loomis, W.P., Ovendale, P., Regan, D., Hess, B., Alderson, M.R. Fling, S.P. (2003) An inclusion membrane protein from Chlamydia trachomatis enters the MHC class I pathway and stimulates a CD8+ T cell response. The Journal of Immunology, 171, 4742.
33. Stephen, R.S. (2003) The cellular paradigm of chlamydial pathogenesis. Trends in Microbiology, 11, 44.
34. Sziller, I., Witkin, S.S., Ziegert, M., Csapó, Z., Ujházy, A. Papp, Z. (1998) Serological responses of patients with ectopic pregnancy to epitopes of the Chlamydia trachomatis 60 kDa heat shock protein. Human Reproduction, 13, 1088.
35. Vabulas, R.M., Ahmad-Nejad, P., Da Costa, C., Miethke, T., Kirschning, C.J., Hacker, H. Wagner, H. (2001) Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signalling in innate immune cells. Journal of Biological Chemistry, 276, 31332.
36. Van Eden, W., Thole, J.E., Van der Zee, R., Noordzij, A., Van Embden, J.D., Hensen, E.J. Cohen, I.R. (1988) Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature, 331, 171.
37. Witkin, S.S. (1999) Immunity to heat shock proteins and pregnancy outcome. Infectious Diseases in Obstetrics and Gynecology, 7, 35.
38. Witkin, S.S. (2002) Immunological aspects of genital chlamydia infections. Best Practice and Research: Clinical Obstetrics and Gynaecology, 16, 865.
39. Witkin, S.S. Linhares, I.M. (2002) Chlamydia trachomatis in subfertile women undergoing uterine instrumentation: an alternative to direct microbial testing or prophylactic antibiotic treatment. Human Reproduction, 17, 1938.
40. Yi, Y., Yang, X. Brunham, R.C. (1997) Autoimmunity to heat shock protein 60 and antigen-specific production of interleukin-10. Infection and Immunity, 65, 1669.