Chlamydial protease-like activity factor-insights into immunity and vaccine development

Journal of Reproductive Immunology

Volumn 83, Issue 1-2, 2009, Pages 179-184

  Murthy, Ashlesh K ^a   Guentzel, M Neal ^a   Zhong, Guangming ^b   Arulanandam, Bernard P ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Bacterial clearance; Chlamydia trachomatis; Mechanisms; Pathology; Protective immunity

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL VACCINE; CHLAMYDIAL PROTEASE LIKE ACTIVITY FACTOR; CPG OLIGODEOXYNUCLEOTIDE; INTERLEUKIN 12; RECOMBINANT CHLAMYDIAL PROTEASE LIKE ACTIVITY FACTOR; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; CD4+ T LYMPHOCYTE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG SYNTHESIS; IMMUNE RESPONSE; IMMUNITY; INFECTION RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; VACCINATION; VAGINITIS;

ANIMALS; BACTERIAL VACCINES; BIOLOGICAL MARKERS; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; DISEASE MODELS, ANIMAL; ENDOPEPTIDASES; HUMANS; IMMUNITY; MICE; SEXUALLY TRANSMITTED DISEASES, BACTERIAL;

EID: 70449697889     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2009.05.007     Document Type: Review

References (40)

1. Berry L.J., Hickey D.K., Skelding K.A., Bao S., Rendina A.M., Hansbro P.M., Gockel C.M., and Beagley K.W. Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection. Infect. Immun. 72 (2004) 1019-1028
2. Brunham R.C., and Rey-Ladino J. Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine. Nat. Rev. Immunol. 5 (2005) 149-161
3. Cong Y., Jupelli M., Guentzel M.N., Zhong G., Murthy A.K., and Arulanandam B.P. Intranasal immunization with chlamydial protease-like activity factor and CpG deoxynucleotides enhances protective immunity against genital Chlamydia muridarum infection. Vaccine 25 (2007) 3773-3780
4. Crane D.D., Carlson J.H., Fischer E.R., Bavoil P., Hsia R.C., Tan C., Kuo C.C., and Caldwell H.D. Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigen. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 1894-1899
5. Dong F., Pirbhai M., Zhong Y., and Zhong G. Cleavage-dependent activation of a Chlamydia-secreted protease. Mol. Microbiol. 52 (2004) 1487-1494
6. Dong F., Su H., Huang Y., Zhong Y., and Zhong G. Cleavage of host keratin 8 by a Chlamydia-secreted protease. Infect. Immun. 72 (2004) 3863-3868
7. Dong F., Zhong Y., Arulanandam B., and Zhong G. Production of a proteolytically active protein, chlamydial protease/proteasome-like activity factor, by five different Chlamydia species. Infect. Immun. 73 (2005) 1868-1872
8. Fan P., Dong F., Huang Y., and Zhong G. Chlamydia pneumoniae secretion of a protease-like activity factor for degrading host cell transcription factors required for major histocompatibility complex antigen expression. Infect. Immun. 70 (2002) 345-349
9. Fan T., Lu H., Hu H., Shi L., McClarty G.A., Nance D.M., Greenberg A.H., and Zhong G. Inhibition of apoptosis in Chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J. Exp. Med. 187 (1998) 487-496
10. Huang Z., Feng Y., Chen D., Wu X., Huang S., Wang X., Xiao X., Li W., Huang N., Gu L., Zhong G., and Chai J. Structural basis for activation and inhibition of the secreted Chlamydia protease CPAF. Cell Host Microbe 4 (2008) 529-542
11. + T cells in antichlamydial immunity defined by Chlamydia-specific T-lymphocyte clones. Infect. Immun. 62 (1994) 5195-5197
12. Kiselev A.O., Stamm W.E., Yates J.R., and Lampe M.F. Expression, processing, and localization of PmpD of Chlamydia trachomatis serovar L2 during the chlamydial developmental cycle. PLoS ONE 2 (2007) e568
13. Kumar Y., and Valdivia R.H. Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds. Cell Host Microbe 4 (2008) 159-169
14. Li W., Guentzel M.N., Seshu J., Zhong G., Murthy A.K., and Arulanandam B.P. Induction of cross-serovar protection against genital chlamydial infection by a targeted multisubunit vaccination approach. Clin. Vaccine Immunol. 14 (2007) 1537-1544
15. + T cells produce sufficient IFN-gamma to mediate robust protective immunity against genital Chlamydia muridarum infection. J. Immunol. 180 (2008) 3375-3382
16. Magee D.M., Williams D.M., Smith J.G., Bleicker C.A., Grubbs B.G., Schachter J., and Rank R.G. Role of CD8 T cells in primary Chlamydia infection. Infect. Immun. 63 (1995) 516-521
17. + T cells. Infect. Immun. 68 (2000) 6979-6987
18. Morrison R.P., and Caldwell H.D. Immunity to murine chlamydial genital infection. Infect. Immun. 70 (2002) 2741-2751
19. Morrison S.G., and Morrison R.P. A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection. J. Immunol. 175 (2005) 7536-7542
20. + T cells. Cell. Immunol. 242 (2006) 110-117
21. Murthy A.K., Cong Y., Murphey C., Guentzel M.N., Forsthuber T.G., Zhong G., and Arulanandam B.P. Chlamydial protease-like activity factor induces protective immunity against genital chlamydial infection in transgenic mice that express the human HLA-DR4 allele. Infect. Immun. 74 (2006) 6722-6729
22. Murthy A.K., Chambers J.P., Meier P.A., Zhong G., and Arulanandam B.P. Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production. Infect. Immun. 75 (2007) 666-676
23. Murthy A.K., Chaganty B.K.R., Li W., Guentzel M.N., Chambers J.P., Seshu J., Zhong G., and Arulanandam B.P. A limited role for antibody in protective immunity induced by rCPAF and CpG vaccination against primary genital Chlamydia muridarum challenge. FEMS Immunol Med Microbiol 55 (2009) 271-279
24. Pal S., Theodor I., Peterson E.M., and de la Maza L.M. Monoclonal immunoglobulin A antibody to the major outer membrane protein of the Chlamydia trachomatis mouse pneumonitis biovar protects mice against a chlamydial genital challenge. Vaccine 15 (1997) 575-582
25. Pal S., Peterson E.M., and de la Maza L.M. Vaccination with the Chlamydia trachomatis major outer membrane protein can elicit an immune response as protective as that resulting from inoculation with live bacteria. Infect. Immun. 73 (2005) 8153-8160
26. Pal S., Peterson E.M., Rappuoli R., Ratti G., and de la Maza L.M. Immunization with the Chlamydia trachomatis major outer membrane protein, using adjuvants developed for human vaccines, can induce partial protection in a mouse model against a genital challenge. Vaccine 24 (2006) 766-775
27. Pirbhai M., Dong F., Zhong Y., Pan K.Z., and Zhong G. The secreted protease factor CPAF is responsible for degrading pro-apoptotic BH3-only proteins in Chlamydia trachomatis-infected cells. J. Biol. Chem. 281 (2006) 31495-31501
28. Ramsey K.H., Soderberg L.S., and Rank R.G. Resolution of chlamydial genital infection in B-cell-deficient mice and immunity to reinfection. Infect. Immun. 56 (1988) 1320-1325
29. Rank R.G., Ramsey K.H., Pack E.A., and Williams D.M. Effect of gamma interferon on resolution of murine chlamydial genital infection. Infect. Immun. 60 (1992) 4427-4429
30. Rekart M.L., and Brunham R.C. Epidemiology of chlamydial infection: are we losing ground?. Sex Transm. Infect. 84 (2008) 87-91
31. Savijoki K., Alvesalo J., Vuorela P., Leinonen M., and Kalkkinen N. Proteomic analysis of Chlamydia pneumoniae-infected HL cells reveals extensive degradation of cytoskeletal proteins. FEMS Immunol. Med. Microbiol. 54 (2008) 375-384
32. Sharma J., Bosnic A.M., Piper J.M., and Zhong G. Human antibody responses to a Chlamydia-secreted protease factor. Infect. Immun. 72 (2004) 7164-7171
33. Sharma J., Dong F., Pirbhai M., and Zhong G. Inhibition of proteolytic activity of a chlamydial proteasome/protease-like activity factor by antibodies from humans infected with Chlamydia trachomatis. Infect. Immun. 73 (2005) 4414-4419
34. Sharma J., Zhong Y., Dong F., Piper J.M., Wang G., and Zhong G. Profiling of human antibody responses to Chlamydia trachomatis urogenital tract infection using microplates arrayed with 156 chlamydial fusion proteins. Infect. Immun. 74 (2006) 1490-1499
35. Shaw A.C., Vandahl B.B., Larsen M.R., Roepstorff P., Gevaert K., Vandekerckhove J., Christiansen G., and Birkelund S. Characterization of a secreted Chlamydia protease. Cell. Microbiol. 4 (2002) 411-424
36. + T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract. Infect. Immun. 63 (1995) 3302-3308
37. Su H., Feilzer K., Caldwell H.D., and Morrison R.P. Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice. Infect. Immun. 65 (1997) 1993-1999
38. Zhong G., Fan T., and Liu L. Chlamydia inhibits interferon gamma-inducible major histocompatibility complex class II expression by degradation of upstream stimulatory factor 1. J. Exp. Med. 189 (1999) 1931-1938
39. Zhong G., Liu L., Fan T., Fan P., and Ji H. Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon gamma-inducible major histocompatibility complex class I expression in Chlamydia-infected cells. J. Exp. Med. 191 (2000) 1525-1534
40. Zhong G., Fan P., Ji H., Dong F., and Huang Y. Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors. J. Exp. Med. 193 (2001) 935-942