Heat denatured enzymatically inactive recombinant chlamydial protease-like activity factor induces robust protective immunity against genital chlamydial challenge

Vaccine

Volumn 28, Issue 11, 2010, Pages 2323-2329

  Chaganty, Bharat K R ^a   Murthy, Ashlesh K ^a   Evani, Shankar J ^a   Li, Weidang ^a   Guentzel, M Neal ^a   Chambers, James P ^a   Zhong, Guangming ^b   Arulanandam, Bernard P ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Chlamydia trachomatis; Reproductive sequelae; Vaccines

Indexed keywords

BACTERIAL PROTEIN; CYTOKERATIN 8; GAMMA INTERFERON; GLUTATHIONE TRANSFERASE; RECOMBINANT CHLAMYDIA PROTEASE LIKE ACTIVITY FACTOR; RECOMBINANT ENZYME; RECOMBINANT INTERLEUKIN 12; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ARTICLE; CELL FREE SYSTEM; CHLAMYDIA; CHLAMYDIASIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME DENATURATION; FEMALE; GENITAL TRACT INFECTION; HEAT TREATMENT; HUMORAL IMMUNITY; HYDROSALPINX; IMMUNE RESPONSE; IMMUNITY; IMMUNIZATION; MOUSE; NONHUMAN; OVIDUCT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TREATMENT RESPONSE;

ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; CHLAMYDIA INFECTIONS; CHLAMYDIA MURIDARUM; ENDOPEPTIDASES; FEMALE; GENITALIA, FEMALE; HOT TEMPERATURE; INTERFERON-GAMMA; LYMPHOCYTES; LYMPHOGRANULOMA VENEREUM; MICE; MICE, INBRED BALB C; PROTEIN DENATURATION; SPLEEN; VACCINES, INACTIVATED; VACCINES, SYNTHETIC;

EID: 77049094406     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.12.064     Document Type: Article

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