Neuropsychiatric Aspects of Schizophrenia

CNS Neuroscience and Therapeutics

Volumn 17, Issue 1, 2011, Pages 45-51

  Gur, Raquel E ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cognitive deficits; Genomic; Neuropsychopharmacology; Schizophrenia

Indexed keywords

BRAIN REGION; EMOTIONALITY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; NEUROBIOLOGY; NEUROPSYCHIATRY; PHENOTYPE; REVIEW; SCHIZOPHRENIA; SOCIAL COGNITION;

AFFECTIVE SYMPTOMS; BRAIN MAPPING; COGNITION DISORDERS; HUMANS; MAGNETIC RESONANCE IMAGING; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 78751533160     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/j.1755-5949.2010.00220.x     Document Type: Review

References (37)

1. Kraepelin E. Dementia praecox and paraphrenia. Edinburgh E. & S. Livingston, 1919.
2. Bleuler E. Dementia praecox or the group of schizophrenias. New York, NY International Universities Press, 1950.
3. Heinrichs R. The primacy of cognition in schizophrenia. Am Psychol 2005;60:229-242.
4. Heaton RK, Gladsjo JA, Palmer BW, et al. Stability and course of neuropsychological deficits in schizophrenia. Arch Gen Psychiatry 2001;58:24-32.
5. Cornblatt BA, Keilp JG. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull 1994;20:31-46.
6. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology 1998;12:426-445.
7. Saykin AJ, Gur RC, Gur RE, et al. Neuropsychological function in schizophrenia: Selective impairment in memory and learning. Arch Gen Psychiatry 1991;48:618-624.
8. Green MF, Kern RS, Braff DL, Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the "right stuff"? Schizophr Bull 2000;26:119-136.
9. Palmer BW, Dawes SE, Heaton RK. What do we know about neuropsychological aspects of schizophrenia? Neuropsychol Rev 2009;19:365-384.
10. Saykin AJ, Shtasel DL, Gur RE, et al. Neuropsychological deficits in neuroleptic-naive, first-episode schizophrenic patients. Arch Gen Psychiatry 1994;51:124-131.
11. Zanelli J, Reichenberg A, Morgan K, et al. Specific and generalized neuropsychological deficits: A comparison of patients with various first-episode psychosis presentations. Am J Psychiatry 2010;167:78-85.
12. Censits DM, Ragland JD, Gur RC, Gur RE. Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: A longitudinal study. Schizophr Res 1997;24:289-298.
13. Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 1996;153:321-330.
14. Gur RE, Arnold SE. Neurobiology of schizophrenia. In Schatzberg AF, Nemeroff CB, editors. The textbook of psychopharmacology, Vol. 46, 4th ed., Washington D.C.: The American Psychiatric Publishing, 2009;945-963.
15. Calhoun VD, Eichele T, Pearlson G. Functional brain networks in schizophrenia: A review. Front Hum Neurosci 2009;3:1-12.
16. Simpson EH, Kellendonk C, Kandel E. A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia. Neuron 2010;65:585-596.
17. Braff DL, Freedman R, Schork NJ, Gottesman II. Deconstructing schizophrenia: An overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull 2007;33:21-32.
18. Gur RE, Calkins ME, Gur RC, et al. The consortium on the genetics of schizophrenia: Neurocognitive endophenotypes. Schizophr Bull 2007;33:49-68.
19. Shenton ME, Dickey CC, Frumin M, McCarley RW. A review of MRI findings in schizophrenia. Schizophr Res 2001;49:1-52.
20. Gur RE, Keshavan MS, Lawrie SM. Deconstructing psychosis with human brain imaging. Schizophr Bull 2007; 33:921-931.
21. Ford JM, Gray M, Whitfield SL, et al. Acquiring and inhibiting prepotent responses in schizophrenia: Event-related brain potentials and functional magnetic resonance imaging. Arch Gen Psychiatry 2004;61:119-129.
22. Barch DM, Csernansky JG. Abnormal parietal cortex activation during working memory in schizophrenia: Verbal phonological coding disturbances versus domain-general executive dysfunction. Am J Psychiatry 2007;164:1090-1098.
23. Tan HY, Sust S, Buckholtz JW, et al. Dysfunctional prefrontal regional specialization and compensation in schizophrenia. Am J Psychiatry 2006;163:1969-1977.
24. Nuechterlein KH, Pashler HE, Subotnik KL. Translating basic attentional paradigms to schizophrenia research: Reconsidering the nature of the deficits. Dev Psychopathol 2006;18:831-851.
25. Gur RE, Turetsky BI, Loughead J, et al. Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imaging. Am J Psychiatry 2007;164:442-449.
26. Aleman A, Hijman R, de Haan EH, Kahn RS. Memory impairment in schizophrenia: A meta-analysis. Am J Psychiatry 1999;156:1358-1366.
27. Ongür D, Cullen TJ, Wolf DH, Rohan M, Barreira P, Zalesak M, Heckers S. The neural basis of relational memory deficits in schizophrenia. Arch Gen Psychiatry 2006;63:356-65.
28. Ragland JD, Laird AR, Ranganath C, Blumenfeld RS, Gonzales SM, Glahn DC. Prefrontal activation deficits during episodic memory in schizophrenia. Am J Psychiatry 2009;166:863-874.
29. Wolf DH, Turetsky BI, Loughead J, Elliott MA, Pratiwadi R, Gur RE, Gur RC. Auditory oddball fMRI in schizophrenia: Association of negative symptoms with regional hypoactivation to novel distractors. Brain Imaging Behav 2008;2:132-145.
30. Andreasen NC. The scale for the assessment of negative symptoms (SANS). Iowa City The University of Iowa, 1984.
31. Gur RE, Kohler CG, Ragland JD, Siegel SJ, Lesko K, Bilker WB, Gur RC Flat affect in schizophrenia: Relation to emotion processing and neurocognitive measures. Schizophr Bull 2006;32:279-287.
32. Habel U, Klein M, Shah NJ, Toni I, Zilles K, Falkai P, Schneider F. Genetic load on amygdala hypofunction during sadness in nonaffected brothers of schizophrenia patients. Am J Psychiatry 2004;161:1806-1813.
33. Phillips ML, Williams L, Senior C, et al. A differential neural response to threatening and non-threatening negative facial expressions in paranoid and non-paranoid schizophrenics. Psychiatry Res 1999;92:11-31.
34. Gur RE, McGrath C, Chan RM, et al. An fMRI study of facial emotion processing in patients with schizophrenia. Am J Psychiatry 2002;159:1992-1999.
35. Kosaka H, Omori M, Murata T, et al. Differential amygdala response during facial recognition in patients with schizophrenia: An fMRI study. Schizophr Res 2002;57:87-95.
36. Takahashi H, Koeda M, Oda K, et al. An fMRI study of differential neural response to affective pictures in schizophrenia. Neuroimage 2004;22:1247-1254.
37. Gur RE, Loughead J, Kohler CG, et al. Limbic activation associated with misidentification of fearful faces and flat affect in schizophrenia. Arch Gen Psychiatry 2007;64:1356-1366.