Functional brain networks in schizophrenia: A review

Frontiers in Human Neuroscience

Volumn 3, Issue AUG, 2009, Pages

  Calhoun, Vince D ^a,b,c,d   Eichele, Tom ^e   Pearlson, Godfrey ^c,d  

^a MIND RESEARCH NETWORK   (United States)

^b University of New Mexico   (United States)

^c INSTITUTE OF LIVING   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF BERGEN   (Norway)

Author keywords

fMRI; Functional connectivity; Functional network connectivity; Independent component analysis; Schizophrenia

Indexed keywords

EID: 74049153140     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/neuro.09.017.2009     Document Type: Article

References (92)

1. Andreasen, N. C., Nopoulos, P., O'Leary, D. S., Miller, D. D., Wassink, T., and Flaum, M. (1999). Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms. Biol. Psychiatry 46, 908-920.
2. Assaf, M., Jagannathan, K., Calhoun, V. D., Kraut, M., Hart, J., and Pearlson, G. D. (2009). Temporal sequence of hemispheric network activation during semantic processing: a functional network connectivity analysis. Brain Cogn. 70, 238-246.
3. Beckmann, C. F., De Luca, M., Devlin, J. T., and Smith, S. M. (2005). Investigations into resting-state connectivity using independent component analysis. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 360, 1001-1013.
4. Bell, A. J., and Sejnowski, T. J. (1995). An information maximisation approach to blind separation and blind deconvolution. Neural Comput. 7, 1129-1159.
5. Birn, R. M., Murphy, K., and Bandettini, P. A. (2008). The effect of respiration variations on independent component analysis results of resting state functional connectivity. Hum. Brain Mapp. 29, 740-750.
6. Biswal, B., Yetkin, F. Z., Haughton, V. M., and Hyde, J. S. (1995). Functional connectivity in the motor cortex of resting human brain using echoplanar MRI. Magn. Reson. Med. 34, 537-541.
7. Biswal, B. B., Van Kylen, J., and Hyde, J. S. (1997). Simultaneous assessment of flow and BOLD signals in resting-state functional connectivity maps. NMR Biomed. 10, 165-170.
8. Bluhm, R. L., Miller, J., Lanius, R. A., Osuch, E. A., Boksman, K., Neufeld, R., Theberge, J., Schaefer, B., and Williamson, P. (2007). Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network. Schizophr. Bull. 33, 1004-1012.
9. Bokde, A. L., Lopez-Bayo, P., Meindl, T., Pechler, S., Born, C., Faltraco, F., Teipel, S. J., Moller, H. J., and Hampel, H. (2006). Functional connectivity of the fusiform gyrus during a face-matching task in subjects with mild cognitive impairment. Brain 129(Pt 5), 1113-1124.
10. Boksman, K., Theberge, J., Williamson, P., Drost, D. J., Malla, A., Densmore, M., Takhar, J., Pavlosky, W., Menon, R. S., and Neufeld, R. W. (2005). A 4.0-T fMRI study of brain connectivity during word fluency in first-episode schizophrenia. Schizophr. Res. 75, 247-263.
11. Cacioppo, J. T., Tassinary, L. G., and Berntson, G. G. (2000). Handbook of Psychophysiology. Cambridge, Cambridge University Press.
12. Calhoun, V. D., and Adali, T. (In Press). Feature-based fusion of medical imaging data. IEEE Trans. Inf. Tech. Biomed.
13. Calhoun, V. D., Adali, T., Giuliani, N., Pekar, J. J., Pearlson, G. D., and Kiehl, K. A. (2006a). A method for multimodal analysis of independent source differences in schizophrenia: combining gray matter structural and auditory oddball functional data. Hum. Brain Mapp. 27, 47-62.
14. Calhoun, V. D., Adali, T., Kiehl, K. A., Astur, R. S., Pekar, J. J., and Pearlson, G. D. (2006b). A Method for Multi-task fMRI Data Fusion Applied to Schizophrenia. Hum. Brain Mapp. 27, 598-610.
15. Calhoun, V. D., Adali, T., Pearlson, G. D., and Pekar, J. J. (2001a). A Method for making group inferences from functional MRI data using independent component analysis. Hum. Brain Mapp. 14, 140-151.
16. Calhoun, V. D., Adali, T., Pearlson, G. D., and Pekar, J. J. (2001b). Spatial and temporal independent component analysis of functional MRI data containing a pair of task-related waveforms. Hum. Brain Mapp. 13, 43-53.
17. Calhoun, V. D., Kiehl, K. A., Liddle, P. F., and Pearlson, G. D. (2004). Aberrant localization of synchronous hemodynamic activity in auditory cortex reliably characterizes schizophrenia. Biol. Psychiatry 55, 842-849.
18. Calhoun, V. D., Kiehl, K. A., and Pearlson, G. D. (2008a). Modulation of temporally coherent brain networks estimated using ICA at rest and during cognitive tasks. Hum. Brain Mapp. 29, 828-838.
19. Calhoun, V. D., Pearlson, G. D., Maciejewski, P., and Kiehl, K. A. (2008b). Temporal lobe and 'default' hemodynamic brain modes discriminate between schizophrenia and bipolar disorder. Hum. Brain Mapp. 29, 1265-1275.
20. Calhoun, V. D., Pekar, J. J., McGinty, V. B., Adali, T., Watson, T. D., and Pearlson, G. D. (2002). Different activation dynamics in multiple neural systems during simulated driving. Hum. Brain Mapp. 16, 158-167.
21. Caprihan, A., Pearlson, G. D., and Calhoun, V. D. (2008). Application of principal component analysis to distinguish patients with schizophrenia from healthy controls based on fractional anisotropy measurements. Neuroimage 42, 675-682.
22. Clark, L., Iversen, S. D., and Goodwin, G. M. (2001). A neuropsychological investigation of prefrontal cortex involvement in acute mania. Am. J. Psychiatry 158, 1605-1611.
23. Cordes, D., Haughton, V. M., Arfanakis, K., Carew, J. D., Turski, P. A., Moritz, C. H., Quigley, M. A., and Meyerand, M. E. (2001). Frequencies contributing to functional connectivity in the cerebral cortex in "restingstate" data. AJNR Am. J. Neuroradiol. 22, 1326-1333.
24. Cordes, D., Haughton, V. M., Arfanakis, K., Wendt, G. J., Turski, P. A., Moritz, C. H., Quigley, M. A., and Meyerand, M. E. (2000). Mapping functionally related regions of brain with functional connectivity MR imaging. AJNR Am. J. Neuroradiol. 21, 1636-1644.
25. Critchley, H. D. (2005). Neural mechanisms of autonomic, affective, and cognitive integration. J. Comp. Neurol. 493, 154-166.
26. Damoiseaux, J. S., and Greicius, M. D. (2009). Greater than the sum of its parts: a review of studies combining structural connectivity and restingstate functional connectivity. Brain Struct. Funct. (in press).
27. Damoiseaux, J. S., Rombouts, S. A., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., and Beckmann, C. F. (2006). Consistent resting-state networks across healthy subjects. Proc. Natl. Acad. Sci. U.S.A. 103, 13848-13853.
28. Deco, G., Jirsa, V., McIntosh, A. R., Sporns, O., and Kotter, R. (2009). Key role of coupling, delay, and noise in resting brain fluctuations. Proc. Natl. Acad. Sci. U.S.A. 106, 10302-10307.
29. Demirci, O., Stevens, M. C., Andreasen, N. C., Michael, A., Liu, J., White, T., Pearlson, G. D., Clark, V. P., and Calhoun, V. D. (2009). Investigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls. Neuroimage 46, 419-431.
30. Eichele, T., Specht, K., Moosmann, M., Jongsma, M. L., Quiroga, R. Q., Nordby, H., and Hugdahl, K. (2005). Assessing the spatiotemporal evolution of neuronal activation with single-trial event-related potentials and functional MRI. Proc. Natl. Acad. Sci. U.S.A. 102, 17798-17803.
31. Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., and Raichle, M. E. (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc. Natl. Acad. Sci. U.S.A. 102, 9673-9678.
32. Fox, M. D., Zhang, D., Snyder, A. Z., and Raichle, M. E. (2009). The global signal and observed anticorrelated resting state brain networks. J. Neurophysiol. 101, 3270-3283.
33. Fransson, P. (2006). How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations. Neuropsychologia 44, 2836-2845.
34. Friston, K. J. (1995). Functional and effective connectivity in neuroimaging: a sysnthesis. Hum. Brain Mapp. 2, 56-78.
35. Friston, K. J., and Frith, C. D. (1995). Schizophrenia: a disconnection syndrome? Clin. Neurosci. 3, 89-97.
36. Frith, C. D., Friston, K. J., Herold, S., Silbersweig, D., Fletcher, P., Cahill, C., Dolan, R. J., Frackowiak, R. S., and Liddle, P. F. (1995). Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. Br. J. Psychiatry 167, 343-349.
37. Garrity, A., Pearlson, G. D., McKiernan, K., Lloyd, D., Kiehl, K. A., and Calhoun, V. D. (2007). Aberrant 'default mode' functional connectivity in schizophrenia. Am. J. Psychiatry 164, 450-457.
38. Genovese, C. R., Lazar, N. A., and Nichols, T. (2002). Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 15, 870-878.
39. Glover, G. H., Li, T. Q., and Ress, D. (2000). Image-based method for retrospective correction of physiological motion effects in fMRI: RETROICOR. Magn. Reson. Med. 44, 162-167.
40. Greicius, M. D., Srivastava, G., Reiss, A. L., and Menon, V. (2004). Defaultmode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc. Natl. Acad. Sci. U.S.A. 101, 4637-4642.
41. Gusnard, D. A., Akbudak, E., Shulman, G. L., and Raichle, M. E. (2001). Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc. Natl. Acad. Sci. U.S.A. 98, 4259-4264.
42. Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C. J., Wedeen, V. J., and Sporns, O. (2008). Mapping the structural core of human cerebral cortex. PLoS Biol. 6, e159.
43. Hampson, M., Tokoglu, F., Sun, Z., Schafer, R. J., Skudlarski, P., Gore, J. C., and Constable, R. T. (2006). Connectivity-behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability. Neuroimage 31, 513-519.
44. Heinrichs, R. W., and Zakzanis, K. K. (1998). Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 12, 426-445.
45. Herbster, A. N., Nichols, T., Wiseman, M. B., Mintun, M. A., DeKosky, S. T., and Becker, J. T. (1996). Functional connectivity in auditory-verbal shortterm memory in Alzheimer's disease. Neuroimage 4, 67-77.
46. Honey, G. D., Pomarol-Clotet, E., Corlett, P. R., Honey, R. A., McKenna, P. J., and Bullmore, E. T. (2005). Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function. Brain 128, 2597-2611.
47. Jafri, M., Pearlson, G. D., Stevens, M., and Calhoun, V. D. (2008). A method for functional network connectivity among spatially independent restingstate components in schizophrenia. Neuroimage 39, 1666-1681.
48. Josin, G. M., and Liddle, P. F. (2001). Neural network analysis of the pattern of functional connectivity between cerebral areas in schizophrenia. Biol. Cybern. 84, 117-122.
49. Kelly, A. M., Uddin, L. Q., Biswal, B. B., Castellanos, F. X., and Milham, M. P. (2008). Competition between functional brain networks mediates behavioral variability. Neuroimage 39, 527-537.
50. Kiehl, K. A., Stevens, M. C., Celone, K., Kurtz, M., and Krystal, J. H. (2005). Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biol. Psychiatry 57, 1029-1040.
51. Kim, D., Manoach, D. S., Mathalon, D., Turner, J., Brown, G., Ford, J. M., Gollub, R. L., White, T., Wible, C. G., Belger, A., Bockholt, H. J., Clark, V. P., Lauriello, J., O'Leary, D., McCarthy, G., Mueller, B., Lim, K., Andreasen, N. C., Potkin, S., and Calhoun, V. D. (In Press). Dysregulation of working memory and default-mode networks in schizophrenia during a Sternberg item recognition paradigm: an independent component analysis of the multisite Mind and fBIRN studies. Hum. Brain Mapp. (in press).
52. Kim, D., Mathalon, D., Ford, J. M., Mannell, M., Turner, J., Brown, G., Belger, A., Gollub, R. L., Lauriello, J., Wible, C. G., O'Leary, D., Lim, K., Potkin, S., and Calhoun, V. D. (2009). Auditory oddball deficits in schizophrenia: an independent component analysis of the fMRI multisite function BIRN study. Schizophr. Bull. 35, 67-81.
53. Kiviniemi, V., Kantola, J. H., Jauhiainen, J., Hyvarinen, A., and Tervonen, O. (2003). Independent component analysis of nondeterministic fMRI signal sources. Neuroimage 19(Pt 1), 253-260.
54. Kiviniemi, V., Starck, T., Remes, J., Long, X., Nikkinen, J., Haapea, M., Veijola, J., Moilanen, I., Isohanni, M., Zang, Y. F., and Tervonen, O. (2009). Functional segmentation of the brain cortex using high model order group PICA. Hum. Brain Mapp.
55. Laufs, H., Krakow, K., Sterzer, P., Eger, E., Beyerle, A., Salek-Haddadi, A., and Kleinschmidt, A. (2003). Electroencephalographic signatures of attentional and cognitive default modes in spontaneous brain activity fluctuations at rest. Proc. Natl. Acad. Sci. U.S.A. 100, 11053-11058.
56. Lawrie, S. M., Buechel, C., Whalley, H. C., Frith, C. D., Friston, K. J., and Johnstone, E. C. (2002). Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol. Psychiatry 51, 1008-1011.
57. Leopold, D. A., Murayama, Y., and Logothetis, N. K. (2003). Very slow activity fluctuations in monkey visual cortex: implications for functional brain imaging. Cereb. Cortex 13, 422-433.
58. Liang, M., Zhou, Y., Jiang, T., Liu, Z., Tian, L., Liu, H., and Hao, Y. (2006). Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging. Neuroreport 17, 209-213.
59. Liddle, P. F., Friston, K. J., Frith, C. D., Hirsch, S. R., Jones, T., and Frackowiak, R. S. (1992). Patterns of cerebral blood flow in schizophrenia. Br. J. Psychiatry 160, 179-186.
60. Liu, J., Xu, L., and Calhoun, V. D. (2008). Extracting Principle Components for Discriminant Analysis of FMRI Images ICASSP. Las Vegas, NV, IEEE, pp. 449-452.
61. Logothetis, N. K., and Wandell, B. A. (2004). Interpreting the BOLD signal. Annu. Rev. Physiol. 66, 735-769.
62. Lowe, M. J., Mock, B. J., and Sorenson, J. A. (1998). Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations. Neuroimage 7, 119-132.
63. Mantini, D., Perrucci, M. G., Del Gratta, C., Romani, G. L., and Corbetta, M. (2007). Electrophysiological signatures of resting state networks in the human brain. Proc. Natl. Acad. Sci. U.S.A. 104, 13170-13175.
64. McKeown, M. J., Makeig, S., Brown, G. G., Jung, T. P., Kindermann, S. S., Bell, A. J., and Sejnowski, T. J. (1998). Analysis of fMRI data by blind separation into independent spatial components. Hum. Brain Mapp. 6, 160-188.
65. McKiernan, K. A., Kaufman, J. N., Kucera-Thompson, J., and Binder, J. R. (2003). A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging. J. Cogn. Neurosci. 15, 394-408.
66. Meyer-Lindenberg, A., Kohn, P., Mervis, C. B., Kippenhan, J. S., Olsen, R. K., Morris, C. A., and Berman, K. F. (2004). Neural basis of genetically determined visuospatial construction deficit in Williams syndrome. Neuron 43, 623-631.
67. Meyer-Lindenberg, A., Poline, J. B., Kohn, P. D., Holt, J. L., Egan, M. F., Weinberger, D. R., and Berman, K. F. (2001). Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. Am. J. Psychiatry 158, 1809-1817.
68. Mikula, S., and Niebur, E. (2006). A novel method for visualizing functional connectivity using principal component analysis. Int. J. Neurosci. 116, 419-429.
69. Murphy, K., Birn, R. M., Handwerker, D. A., Jones, T. B., and Bandettini, P. A. (2009). The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? Neuroimage 44, 893-905.
70. Pereira, F., Mitchell, T., and Botvinick, M. (2009). Machine learning classifiers and fMRI: a tutorial overview. Neuroimage 45(Suppl. 1), S199-S209.
71. Popa, D., Popescu, A. T., and Pare, D. (2009). Contrasting activity profile of two distributed cortical networks as a function of attentional demands. J. Neurosci. 29, 1191-1201.
72. Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., and Shulman, G. L. (2001). A default mode of brain function. Proc. Natl. Acad. Sci. U.S.A. 98, 676-682.
73. Raichle, M. E., and Mintun, M. A. (2006). Brain work and brain imaging. Annu. Rev. Neurosci. 29, 449-476.
74. Scheeringa, R., Bastiaansen, M. C., Petersson, K. M., Oostenveld, R., Norris, D. G., and Hagoort, P. (2008). Frontal theta EEG activity correlates negatively with the default mode network in resting state. Int. J. Psychophysiol. 67, 242-251.
75. Shehzad, Z., Kelly, A. M., Reiss, P. T., Gee, D. G., Gotimer, K., Uddin, L. Q., Lee, S. H., Margulies, D. S., Roy, A. K., Biswal, B. B., Petkova, E., Castellanos, F. X., and Milham, M. P. (2009). The resting brain: unconstrained yet reliable. Cereb. Cortex. (in press).
76. Shmuel, A., and Leopold, D. A. (2008). Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: implications for functional connectivity at rest. Hum. Brain Mapp. 29, 751-761.
77. Sirotin, Y. B., and Das, A. (2009). Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity. Nature 457, 475-479.
78. Skudlarski, P., Jagannathan, K., Calhoun, V. D., Hampson, M., Skudlarska, B. A., and Pearlson, G. (2008). Measuring brain connectivity: diffusion tensor imaging validates resting state temporal correlations. Neuroimage 43, 554-561.
79. Sonuga-Barke, E. J., and Castellanos, F. X. (2007). Spontaneous attentional fluctuations in impaired states and pathological conditions: a neurobiological hypothesis. Neurosci. Biobehav. Rev. 31, 977-986.
80. Sorg, C., Riedl, V., Muhlau, M., Calhoun, V. D., L. L., Drzezga, A., Forstl, H., Kurz, A., Zimmer, C., and Wohlschlager, A. (2007). Selective changes of resting-state networks in patients at high risk for Alzheimer's disease-an example for profiling functional brain disorders. Proc. Natl. Acad. Sci. U.S.A. 104, 18760-18765.
81. Sui, J., Adali, T., Clark, V. P., Pearlson, G., and Calhoun, V. D. (2009a). A method for accurate group difference detection by constraining the mixing coefficients in an ICA framework. Hum. Brain Mapp. (in press)
82. Sui, J., Adali, T., Pearlson, G., and Calhoun, V. D. (2009b). An ICA-based method for the identification of optimal FMRI features and components using combined group-discriminative techniques. Neuroimage 46, 73-86.
83. Thomsen, T., Specht, K., Hammar, A., Nyttingnes, J., Ersland, L., and Hugdahl, K. (2004). Brain localization of attentional control in different age groups by combining functional and structural MRI. Neuroimage 22, 912-919.
84. Tregellas, J. R., Tanabe, J. L., Miller, D. E., Ross, R. G., Olincy, A., and Freedman, R. (2004). Neurobiology of smooth pursuit eye movement deficits in schizophrenia: an fMRI study. Am. J. Psychiatry 161, 315-321.
85. Uddin, L. Q., Kelly, A. M., Biswal, B. B., Xavier Castellanos, F., and Milham, M. P. (2009). Functional connectivity of default mode network components: correlation, anticorrelation, and causality. Hum. Brain Mapp. 30, 625-637.
86. Uddin, L. Q., Mooshagian, E., Zaidel, E., Scheres, A., Margulies, D. S., Kelly, A. M., Shehzad, Z., Adelstein, J. S., Castellanos, F. X., Biswal, B. B., and Milham, M. P. (2008). Residual functional connectivity in the split-brain revealed with resting-state functional MRI. Neuroreport 19, 703-709.
87. Van de Ven, V. G., Formisano, E., Prvulovic, D., Roeder, C. H., and Linden, D. E. (2004). Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during rest. Hum. Brain Mapp. 22, 165-178.
88. Vincent, J. L., Patel, G. H., Fox, M. D., Snyder, A. Z., Baker, J. T., Van Essen, D. C., Zempel, J. M., Snyder, L. H., Corbetta, M., and Raichle, M. E. (2007). Intrinsic functional architecture in the anaesthetized monkey brain. Nature 447, 83-86.
89. Whitfield-Gabrieli, S., Thermenos, H. W., Milanovic, S., Tsuang, M. T., Faraone, S. V., McCarley, R. W., Shenton, M. E., Green, A. I., Nieto-Castanon, A., LaViolette, P., Wojcik, J., Gabrieli, J. D., and Seidman, L. J. (2009). Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 106, 1279-1284.
90. Williamson, P. (2007). Are anticorrelated networks in the brain relevant to schizophrenia? Schizophr. Bull. 33, 994.
91. Wise, R. G., Ide, K., Poulin, M. J., and Tracey, I. (2004). Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal. Neuroimage 21, 1652-1664.
92. Zarahn, E., Aguirre, G., and D'Esposito, M. (1997). A trial-based experimental design for fMRI. Neuroimage 6, 122-138.