Potential role of proprotein convertase SKI-1 in the mineralization of primary bone

Cells Tissues Organs

Volumn 189, Issue 1-4, 2008, Pages 25-32

  Gorski, Jeff P ^a   Huffman, Nichole T ^a   Cui, Chaoying ^c   Henderson, Ellen P ^a   Midura, Ronald J ^b   Seidah, Nabil G ^d  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c TIBET UNIVERSITY   (China)

^d CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Biomineralization; Bone cell biology; Calcification mechanisms; Extracellular matrix; Intramembranous bone; Laser microscopy; Protease; Proteins; SKI 1

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; BONE ACIDIC GLYCOPROTEIN 75; BONE SIALOPROTEIN; COMPLEMENT COMPONENT C1S; FURIN; GLYCOPROTEIN; ISOENZYME; KALLIKREIN; PLASMIN; PROTEINASE INHIBITOR; SERINE PROTEINASE; SITE 1 PROTEASE; SUBTILISIN KEXIN ISOENZYME 1; THROMBIN; UNCLASSIFIED DRUG; UROKINASE;

ANIMAL CELL; BIOMINERALIZATION; BONE MINERALIZATION; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME MECHANISM; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; RAT; TISSUE CULTURE;

ANIMALS; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; IMMUNOBLOTTING; MICE; MODELS, BIOLOGICAL; OSTEOBLASTS; PROPROTEIN CONVERTASES; SERINE ENDOPEPTIDASES; SULFONES;

EID: 57449107098     PISSN: 14226405     EISSN: None     Source Type: Journal    
DOI: 10.1159/000151723     Document Type: Conference Paper

References (23)

1. Basak, S., N.A. Stewart, M. Chretien, A. Basak (2004) Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1. FEBS Lett 573: 186-194.
2. Benjannet, S., D. Rhainds, R. Essalmani, J. Mayne, L. Wickham, W. Jin, M.C. Asselin, J. Hamelin, M. Varret, D. Allard, M. Trillard, M. Abifadel, A. Tebon, A.D. Attie, D.J. Rader, C. Boileau, L. Brissette, M. Chretien, A. Prat, N.G. Seidah (2004) NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J Biol Chem 279: 48865-48875.
3. Chen, Y., B.S. Bal, J.P. Gorski (1992) Calcium and collagen binding properties of osteopontin, bone sialoprotein, and bone acidic glycoprotein-75 from bone. J Biol Chem 267: 24871-24878.
4. Elagoz, A., S. Benjannet, A. Mammarbassi, L. Wickham, N.G. Seidah (2002) Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity. J Biol Chem 277: 11265-11275.
5. Goldberg, H.A., K.J. Warner, M.J. Stillman, G.K. Hunter (1996) Determination of the hydroxyapatite-nucleating region of bone sialoprotein. Connect Tissue Res 35: 385-392.
6. Gorski, J.P. (1998) Is all bone the same? Distinctive distributions and properties of non-collagenous matrix proteins in lamellar vs. woven bone imply the existence of different underlying osteogenic mechanisms. Crit Rev Oral Biol Med 9: 201-223.
7. Gorski, J.P., D. Griffin, G. Dudley, C. Stanford, R. Thomas, C. Huang, E. Lai, B. Karr, M. Solursh (1990) Bone acidic glycoprotein-75 is a major synthetic product of osteoblastic cells and localized as 75- and/or 50-kDa forms in mineralized phases of bone and growth plate and in serum. J Biol Chem 265: 14956-14963.
8. Gorski, J.P., A. Wang, D. Lovitch, D. Law, K. Powell, R.J. Midura (2004) Extracellular bone acidic glycoprotein-75 defines condensed mesenchyme regions to be mineralized and localizes with bone sialoprotein during intramembranous bone formation. J Biol Chem 279: 25455-25463.
9. Huffman, N.T., J.A. Keightley, C. Chaoying, R.J. Midura, D. Lovitch, P.A. Veno, S.L. Dallas, J.P. Gorski (2007) Association of specific proteolytic processing of bone sialoprotein and bone acidic glycoprotein-75 with mineralization within biomineralization foci. J Biol Chem 282: 26002-26013.
10. Kimmel, D.B., W.S. Jee (1980) A quantitative histologic analysis of the growing long bone metaphysis. Calcif Tissue Int 32: 113-122.
11. Leighton, M., K.E. Kadler (2003) Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network. J Biol Chem 278: 18478-18484.
12. Mark, H., A. Nilsson, U. Nannmark, B. Rydevik (2004) Effects of fracture fixation stability on ossification in healing fractures. Clin Orthop Relat Res 419: 245-250.
13. Midura, R.J., A. Wang, D. Lovitch, D. Law, K. Powell, J.P. Gorski (2004) Bone acidic glycoprotein-75 delineates the extracellular sites of future bone sialoprotein accumulation and apatite nucleation in osteoblastic cultures. J Biol Chem 279: 25464-25473.
14. Okada, T., K. Haze, S. Nadanaka, H. Yoshida, N.G. Seidah, Y. Hirano, R. Sato, M. Negishi, K. Mori (2003) A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. J Biol Chem 278: 31024-31032.
15. Pasquato, A., P. Pullikotil, M.C. Asselin, M. Vacatello, L. Paolillo, F. Ghezzo, F. Basso, C. Di Bello, M. Dettin, N.G. Seidah (2006) The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors. J Biol Chem 281: 23471-23481.
16. Pullikotil, P., S. Benjannet, J. Mayne N.G. Seidah (2007) The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization. J Biol Chem 282: 27402-27413.
17. Seidah, N.G., M. Chretien (1999) Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res 848: 45-62.
18. Seidah, N.G., A.M. Khatib, A. Prat (2006) The proprotein convertases and their implication in sterol and/or lipid metabolism. Biol Chem 387: 871-877.
19. Seidah, N.G., S.J. Mowla, J. Hamelin, A.M. Mamarbachi, S. Benjannet, B.B. Toure, A. Basak, J.S. Munzer, J. Marcinkiewicz, M. Zhong, J.C. Barale, C. Lazure, R.A. Murphy, M. Chretien, M. Marcinkiewicz (1999) Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. Proc Natl Acad Sci USA 96: 1321-1326.
20. Seidah, N.G., A. Prat (2002) Precursor convertases in the secretory pathway, cytosol and extracellular milieu. Essays Biochem 38: 79-94.
21. Steiglitz, B.M., M. Ayala, K. Narayanan, A. George, D.S. Greenspan (2004) Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1. J Biol Chem 279: 980-986.
22. Turner, C.H., M.R. Forwood, J.Y. Rho, T. Yoshikawa (1994) Mechanical loading thresholds for lamellar and woven bone formation. J Bone Miner Res 9: 87-97.
23. Wang, A., J.A. Martin, L.A. Lembke, R.J. Midura (2000) Reversible suppression of in vitro biomineralization by activation of protein kinase A. J Biol Chem 275: 11082-11091.