Synergistic effects of combined phytochemicals and skin cancer prevention in SENCAR mice

Cancer Prevention Research

Volumn 3, Issue 2, 2010, Pages 170-178

  Kowalczyk, Magdalena C ^a   Kowalczyk, Piotr ^a   Tolstykh, Olga ^a   Hanausek, Margaret ^a,b   Walaszek, Zbigniew ^a,b   Slaga, Thomas J ^a,b,c  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b University of Texas Health Science Center at San Antonio   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CALCIUM DEXTRO GLUCARATE; CYCLINE; CYCLOOXYGENASE 2; CYTOCHROME P450 1B1; DIMETHYLBENZ[A]ANTHRACENE; ELLAGIC ACID; GRAPE SEED EXTRACT; MESSENGER RNA; PLANT MEDICINAL PRODUCT; PROTEIN BCL 2; PROTEIN C FOS; PROTEIN C JUN; PROTEIN P21; RESVERATROL; SACCHARATE CALCIUM; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER PREVENTION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET THERAPY; DRUG POTENCY; DRUG POTENTIATION; EPIDERMIS; EPIDERMIS HYPERPLASIA; FEMALE; GENE MUTATION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KERATINOCYTE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; ONCOGENE C FOS; ONCOGENE H RAS; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVE TO CARCINOGENESIS MOUSE; SKIN CANCER; SKIN CARCINOGENESIS;

ADMINISTRATION, TOPICAL; ANIMALS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL PROLIFERATION; CHEMOPREVENTION; DIET; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; ELLAGIC ACID; FEMALE; GENES, RAS; GLUCARIC ACID; GRAPE SEED EXTRACT; MICE; MICE, INBRED SENCAR; MUTATION; PHYTOTHERAPY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN NEOPLASMS; STILBENES;

EID: 77949721987     PISSN: 19406207     EISSN: None     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-09-0196     Document Type: Article

References (41)

1. Bishop JM. Molecular themes in oncogenesis. Cell 1991;64:235-48.
2. Marshall CJ. Tumor suppressor genes. Cell 1991;64:313-26.
3. Boutwell RK. Some biological aspects of skin carcinogenesis. Prog Exp Tumor Res 1964;4:207-50.
4. Slaga TJ, Fischer SM, Nelson K, Gleason GL. Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion. Proc Natl Acad Sci U S A 1980;77:3659-63.
5. DiGiovanni J. Multistage carcinogenesis in mouse skin. Pharmacol Ther 1992;54:63-128.
6. Walaszek Z, Hanausek M, Slaga TJ. Mechanisms of chemoprevention. Chest 2004;125:128-33S.
7. Singh RP, Tyagi AK, Dhanalakshmi S, Agarwal R, Agarwal C. Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. Int J Cancer 2004;108:733-40.
8. Yamaguchi F, Yoshimura Y, Nakazawa H, Ariga T. Free radical scavenging activity of grape seed extract and antioxidants by electron spin resonance spectrometry in an H(2)O(2)/NaOH/DMSO system. J Agric Food Chem 1999;47:2544-8.
9. Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Res Treat 2004;85:1-12.
10. Hassoun EA, Vodhanel J, Abushaban A. The modulatory effects of ellagic acid and vitamin E succinate on TCDD-induced oxidative stress in different brain regions of rats after subchronic exposure. J Biochem Mol Toxicol 2004;18:196-203.
11. Whitley AC, Stoner GD, Darby MV, Walle T. Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acidextensive binding to protein and DNA. Biochem Pharmacol 2003;66:907-15.
12. Loarca-Pina G, Kuzmicky PA, de Mejia EG, Kado NY. Inhibitory effects of ellagic acid on the direct-acting mutagenicity of aflatoxin B1 in the Salmonella microsuspension assay. Mutat Res 1998;398: 183-7.
13. Ferguson LR. Role of plant polyphenols in genomic stability. Mutat Res 2001;475:89-111.
14. Middleton E, Jr., Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 2000;52:673-751.
15. Walaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21:178-90.
16. Yoshimi N, Walaszek Z, Mori H, Hanausek M, Szemraj J, Slaga TJ. Inhibition of azoxymethane-induced rat colon carcinogenesis by potassium hydrogen D-glucarate. Int J Oncol 2000;16:43-8.
17. Hanausek M, Walaszek Z, Slaga TJ. Detoxifying cancer causing agents to prevent cancer. Integr Cancer Ther 2003;2:139-44.
18. Abou-Issa H, Moeschberger M, el-Masry W, Tejwani S, Curley RW, Jr., Webb TE. Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. Anticancer Res 1995;15:805-10.
19. Llopiz N, Puiggros F, Cespedes E, et al. Antigenotoxic effect of grape seed procyanidin extract in Fao cells submitted to oxidative stress. J Agric Food Chem 2004;52:1083-7.
20. Nelson MA, Futscher BW, Kinsella T, Wymer J, Bowden GT. Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors. Proc Natl Acad Sci U S A 1992;89:6398-402.
21. Berenbaum MC. Criteria for analyzing interactions between biologically active agents. Adv Cancer Res 1981;35:269-335.
22. Maga G, Hubscher U. Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci 2003;116:3051-60.
23. Quintanilla M, Brown K, Ramsden M, Balmain A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 1986;322:78-80.
24. Hanausek M, Ganesh P, Walaszek Z, Arntzen CJ, Slaga TJ, Gutterman JU. Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model. Proc Natl Acad Sci U S A 2001;98: 11551-6.
25. Li N, Chen X, Liao J, et al. Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis 2002;23:1307-13.
26. Kim SO, Kundu JK, Shin YK, et al. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin. Oncogene 2005; 24:2558-67.
27. Slebos RJ, Lee MH, Plunkett BS, et al. p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc Natl Acad Sci U S A 1994;91:5320-4.
28. el-Deiry WS, Harper JW, O'Connor PM, et al. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 1994;54: 1169-74.
29. Hockenbery DM. bcl-2, a novel regulator of cell death. Bioessays 1995;17:631-8.
30. Nakagawa K, Yamamura K, Maeda S, Ichihashi M. bcl-2 expression in epidermal keratinocytic diseases. Cancer 1994;74:1720-4.
31. Baldursson B, Syrjanen S, Beitner H. Expression of p21WAF1/CIP1, p53, bcl-2 and Ki-67 in venous leg ulcers with and without squamous cell carcinoma. Acta Derm Venereol 2000;80:251-5.
32. Young MR, Yang HS, Colburn NH. Promising molecular targets for cancer prevention: AP-1, NF-κ B and Pdcd4. Trends Mol Med 2003; 9:36-41.
33. Brown PH, Alani R, Preis LH, Szabo E, Birrer MJ. Suppression of oncogene-induced transformation by a deletion mutant of c-jun. Oncogene 1993;8:877-86.
34. Garg R, Ingle A, Maru G. Dietary turmeric modulates DMBA-induced p21ras, MAP kinases and AP-1/NF-κB pathway to alter cellular responses during hamster buccal pouch carcinogenesis. Toxicol Appl Pharmacol 2008;232:428-39.
35. Barboule N, Mazars P, Baldin V, et al. Expression of p21WAF1/CIP1 is heterogeneous and unrelated to proliferation index in human ovarian carcinoma. Int J Cancer 1995;63:611-5.
36. Jung JM, Bruner JM, Ruan S, et al. Increased levels of p21WAF1/Cip1 in human brain tumors. Oncogene 1995;11:2021-8.
37. Marchetti A, Doglioni C, Barbareschi M, et al. p21 RNA and protein expression in non-small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiation. Oncogene 1996;12:1319-24.
38. Kim KK, Shim JC, Kim JR. Overexpression of p21, cyclin E and decreased expression of p27 in DMBA (7, 12-dimethylbenzanthracene)-induced rat ovarian carcinogenesis. Pathol Int 2003;53:291-6.
39. Guengerich FP, Shimada T. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem Res Toxicol 1991;4:391-407.
40. Safe S. Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicol Lett 2001;120:1-7.
41. Kleiner HE, Vulimiri SV, Reed MJ, Uberecken A, DiGiovanni J. Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a] anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation. ChemRes Toxicol 2002;15:226-35.