Effects of dantrolene on ischemia-reperfusion injury in animal models: A review of outcomes in heart, brain, liver, and kidney

Journal of Investigative Medicine

Volumn 58, Issue 7, 2010, Pages 875-882

  Boys, Joshua A ^a   Toledo, Alexander H ^b   Anaya Prado, Roberto ^c   Lopez Neblina, Fernando ^d   Toledo Pereyra, Luis H ^a,e  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^d UNIVERSIDAD AUTÓNOMA DE BAJA CALIFORNIA   (Mexico)

^e MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Brain; Calcium; Dantrolene; Heart; Ischemia reperfusion injury; Kidney; Liver; Ryanodine receptors

Indexed keywords

CALMODULIN; DANTROLENE; INTERLEUKIN 10; TUMOR NECROSIS FACTOR; BIOLOGICAL MARKER; CALCIUM;

ANAPHYLAXIS; APLASTIC ANEMIA; BRAIN FUNCTION; BRAIN ISCHEMIA; CELL CYCLE; CELL VIABILITY; DIARRHEA; DISEASE MARKER; DIZZINESS; DROWSINESS; DRUG DOSE INCREASE; DRUG EFFECT; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG SOLUBILITY; FATIGUE; GASTROINTESTINAL HEMORRHAGE; HEART ARRHYTHMIA; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEPATITIS; HUMAN; INOTROPISM; KIDNEY FUNCTION; KIDNEY ISCHEMIA; LIVER FUNCTION; LIVER FUNCTION TEST; LIVER ISCHEMIA; LIVER TOXICITY; MALAISE; MALIGNANT HYPERTHERMIA; MEDICAL LITERATURE; NONHUMAN; PHLEBITIS; REPERFUSION INJURY; RESPIRATORY FAILURE; REVIEW; TISSUE NECROSIS; TREATMENT OUTCOME; WEAKNESS; ANIMAL MODEL; APOPTOSIS; BRAIN INFARCTION SIZE; CALCIUM HOMEOSTASIS; CANINE MODEL; CARDIAC MUSCLE CELL; CENTRAL NERVOUS SYSTEM; GERBIL MODEL; HEART INFARCTION SIZE; ISOLATED HEART; MORTALITY; MUSCLE CELL; NERVE CELL NECROSIS; RABBIT MODEL; RAT MODEL;

ANIMALIA; CANIS FAMILIARIS; GERBILLINAE; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 78651515878     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/JIM.0b013e3181e5d719     Document Type: Review

References (46)

1. 2+ release channel from skeletal muscle sarcoplasmic reticulum. J Biol Chem. 1995;270:25557-25563.
2. Balam Ortiz EO, Carvajal K, Cruz D. Protective effect of dantrolene in post-ischemic reperfusion myocardial damage [in Spanish]. Arch Inst Cardiol Mex. 1999;69:311-319.
3. Krause GS, White BC, Aust SD, et al. Brain cell death following ischemia and reperfusion: a proposed biochemical signal-transduction, transcription, and translation take time, sequence. Crit Care Med. 1988;16:714-726.
4. Ankarcrona M, Dypbukt JM, Bonfoco E, et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 1995;15:951-973.
5. Paschen W, Doutheil J. Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury? J Cereb Blood Flow Metab. 1999;19:1-18.
6. Krause, Gerbershagen MU, Fiege M, et al. Dantrolene-a review of its pharmacology, therapeutic use and new developments. Anaesthesia. 2004;59(4):364-373.
7. Snyder HR Jr, Davis CS, Bickerton RK, et al. 1-[(5-Arylfurfurylidene) amino]-hydantoins. A new class of muscle relaxants. J Med Chem. 1967;10:807-810.
8. Fill M, Copellio JA. Ryanodine receptor calcium release channels. Physiol Rev. 2002;82:893-922.
9. Giannini G, Conti A, Mammarella S, et al. The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues. J Cell Biol. 1995;128:893-904.
10. 2+ release channels. Molecular mechanism and isoform selectivity. J Biol Chem. 2001;276(17):13810-13816.
11. Davidenko J, Delmar M, Oates R, et al. Electrophysiological actions of dantrolene sodium in isolated sinoatrial and atrioventricular nodes and in a model of ischemia. J Pharmacol Exp Ther. 1986;238(1):206-216.
12. Turner DJ, Segura BJ, Cowles RA, et al. Functional overlap of IP (3) - and cADP-ribose-sensitive calcium stores in guinea pig myenteric neurons. Am J Physiol Gastrointest Liver Physiol. 2001;281(1):G208-G215.
13. Salinska E, Sobczuk A, Lazarewicz JW. Dantrolene antagonizes the glycineB site of the NMDA receptor. Neurosci Lett. 2008;432(2):137-140.
14. 2+/calmodulin-dependent protein kinase II. Am J Physiol Heart Circ Physiol. 2008;295(4):H1669-H1683.
15. Kobayashi S, Yano M, Suetomi T, et al. Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. J Am Coll Cardiol. 2009;53(21):1993-2005.
16. Kobayashi S, Bannister ML, Gangopadhyay JP, et al. Dantrolene stabilizes domain interactions with the ryanodine receptor. J Biol Chem. 2004;280:6580-6587.
17. Flewellen EH, Nelson PE, Jones WP, et al. Dantrolene dose-response in awake man: implications for management of malignant hyperthermia. Anesthesiology. 1983;59:275-280.
18. Lerman J, McLeod ME, Strong HA. Pharmacokinetics of intravenous dantrolene in children. Anesthesiology. 1989;70:625-629.
19. Piper HM, Garcia-Dorado D, Ovize M. A fresh look at reperfusion injury. Cardiovasc Res. 1998;38:291-300.
20. Garcia-Dorado D, Inserte J, Ruiz-Meana M, et al. Gap junction uncoupler prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion. Circulation. 1997;96:3579-3586.
21. Preckel B, Schlack W, Comfere T, et al. Effect of dantrolene in an in vivo and in vitro model of myocardial reperfusion injury. Acta Anaesthesiol Scand. 2000;44:194-201.
22. 3 adenosine receptor stimulation modulates sarcoplasmic reticulum Ca (2+) release in rat heart. Cardiovasc Res. 2001;50(1):56-64.
23. Yu G, Zucchi R, Ronca-Testoni S, et al. Protection of ischemic rat heart by dantrolene, an antagonist of the sarcoplasmic reticulum calcium release channel. Basic Res Cardiol. 2000;95:137-143.
24. Mitchell MB, Winter CB, Banerjee A, et al. Inhibition of sarcoplasmic reticulum calcium release reduces myocardial stunning. J Surg Res. 1993;54(5):411-417.
25. Pelleg A, Roth A, Shargordsky B, et al. Effects of dantrolene sodium on occlusion and reperfusion arrhythmias in the canine heart. Methods Find Exp Clin Pharmacol. 1985;7(5):239-243. (Pubitemid 15030618)
26. Paul-Pletzer K, Yamamoto T, Bhat MB, et al. Identification of a dantrolene binding sequence on the skeletal muscle ryanodine receptor. J Biol Chem. 2002;277:34918-34923.
27. Muehlschlegel S, Sims JR. Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit. Neurocrit Care. 2009;10(1):103-115.
28. Li F, Hayashi T, Jin G, et al. The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers. Brain Res. 2005;1048:59-68.
29. Yano M, Yamamoto T, Ikeda Y, et al. Dantrolene ameliorates delayed cell death and concomitant DNA fragmentation in the rat hippocampal CA1 neurons subjected to mild ischemia. Resuscitation. 2001;50:117-125.
30. Zhang M, Xu YJ, Saini HK, et al. Dantrolene protects against ischemic, delayed neuronal death in gerbil brain. Neurosci Lett. 1993;158:105-108.
31. Phillis JW, Diaz FG, O'Regan MH, et al. Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex. Brain Res. 2002;957:12-24.
32. Gwak M, Park P, Kim K, et al. The effects of dantrolene on hypoxic-ischemic injury in the neonatal rat brain. Anesth Analg. 2008;106:227-233.
33. Kross J, Fleischer JE, Milde JH, et al. No dantrolene protection in a dog model of complete cerebral ischaemia. Neurol Res. 1993;15:37-40.
34. Wei H, Perry DC. Dantrolene is cytoprotective in two models of neuronal cell death. J Neurochem. 1996;67(6):2390-2398.
35. Nakayama R, Yano T, Ushijima K, et al. Effects of dantrolene on extracellular glutamate concentration and neuronal death in the rat hippocampal CA1 region subjected to transient ischemia. Anesthesiology. 2002;96:705-710.
36. Kim JH, Kim KT, Kim MH, et al. Comparison of the cerebral protective effects of thiopental, propofol and dantrolene on focal cerebral ischemia induced by temporary middle cerebral artery occlusion in the rat under the monitoring of compressed spectral array. J Korean Neurosurg Soc. 2002;32(3):239-245.
37. López-Neblina F, Toledo-Pereyra LH, Toledo AH, et al. Ryanodine receptor antagonism protects the ischemic liver and modulates TNF-alpha and IL-10. J Surg Res. 2007;140:121-128.
38. Wu D, Chen X, Ding R, et al. Ischemia/reperfusion induce renal tubule apoptosis by inositol 1, 4, 5-trisphosphate receptor and L-type Ca channel opening. Am J Nephrol. 2008;28:487-499.
39. Pierobon N, Renard-Rooney DC, Gaspers LD, et al. Ryanodine receptors in liver. J Biol Chem. 2006;281:34086-34095.
40. Hardy KJ, Tancheroen S, Shulkes A. Hepatic ischemia-reperfusion injury modification during liver surgery in rats. Liver Transpl Surg. 1995;1:302-310.
41. Chin S, Ikeda M, Ozaki M, et al. Protective effect of diltiazem on hepatic ischemia-reperfusion injury in rats by improving tissue blood flow. Transplant Proc. 2005;37(10):4556-4559.
42. Linas S, Whittenburg D, Parsons P, et al. Mild renal ischemia activates primed neutrophils to cause acute renal failure. Kidney Int. 1992;42:610-616.
43. Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol. 2006;17:1503-1520.
44. Fellner SK, Arendshorst WJ. Angiotensin II, reactive oxygen species, and Ca2+ signaling in afferent arterioles. Am J Physiol Renal Physiol. 2005;289: F1012-1019.
45. Thai TL, Fellner SK, Arendshorst WJ. ADP-ribosyl cyclase and ryanodine receptor activity contribute to basal renal vasomotor tone and agonist-induced renal vasoconstriction in vivo. Am J Physiol Renal Physiol. 2007;293: F1107-F1114.
46. Yusufi AN, Cheng J, Thompson MA, et al. cADP-ribose/ryanodine channel/Ca2+Yrelease signal transduction pathway in mesangial cells. Am J Physiol Renal Physiol. 2001;281: F91-F102.