Ryanodine Receptor Antagonism Protects the Ischemic Liver and Modulates TNF-α and IL-10

Journal of Surgical Research

Volumn 140, Issue 1, 2007, Pages 121-128

  López Neblina, Fernando ^a   Toledo Pereyra, Luis H ^a,b   Toledo, Alexander H ^c   Walsh, Jon ^a  

^a Trauma   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

calcium channel blockers; dantrolene; IL 10; liver ischemia; TNF

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DANTROLENE; INTERLEUKIN 10; RYANODINE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CALCIUM ANTAGONISM; CELL VACUOLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; LIVER FUNCTION TEST; LIVER HISTOLOGY; LIVER ISCHEMIA; MALE; MOUSE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REPERFUSION INJURY;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CALCIUM; CALCIUM CHANNEL BLOCKERS; DANTROLENE; INTERLEUKIN-10; ISCHEMIC PRECONDITIONING; LIVER; MALE; MICE; MICE, INBRED C57BL; REPERFUSION INJURY; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34247635620     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2006.12.003     Document Type: Article

References (49)

1. Siesjo B.K. Calcium and cell death. Magnesium 8 (1989) 223
2. Lopez-Neblina F., Paez R.A., and Toledo-Pereyra L.H. Mechanism of protection of verapamil by preventing neutrophil infiltration in the ischemic rat kidney. J Surg Res 66 (1996) 469
3. Lopez-Neblina F., Toledo-Pereyra L.H., Suzuki S., et al. Protective effect of combined allopurinol and verapamil given at reperfusion in severe renal ischemia. J Invest Surg 8 (1995) 57
4. Trocha M., and Szelag A. The role of calcium and calcium channel blocking drugs in damage to the liver preserved for transplantation. Ann Transplant 9 (2004) 5
5. Tucci Jr. S., Borelli-Bovo T.J., Cologna A.J., et al. Calcium channel blocker and renal mitochondrial function in warm renal ischemia. Int Braz J Urol 31 (2005) 384
6. Min J.Y., Meissner A., Feng X., Wang J., et al. Dantrolene: Effects on abnormal intracellular Ca++ handling and inotropy in postinfarcted rat myocardium. Eur J Pharmacol 471 (2003) 41
7. Martinez-Sanchez M., Striggow F., Schroder U.H., et al. Na(+) and Ca++ homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures. Neuroscience 128 (2004) 729
8. Suzuki S., Toledo-Pereyra L.H., Rodriguez F.J., et al. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Transplantation 55 (1993) 1265
9. Toledo-Pereyra L.H., and Suzuki S. Cellular and biomolecular mechanisms of liver ischemia and reperfusion injury. Transplant Proc 26 (1994) 325
10. Jassen W., and Roake J. The molecular and cellular basis of reperfusion injury following organ transplantation 12 (1998) 14
11. Berna N., Arnould T., Remacle J., et al. Hypoxia-induced increase in intracellular calcium concentration in endothelial cells: Role of the Na(+)-glucose cotransporter. J Cell Biochem 84 (2001) 115
12. Du C., Koretsky A.P., Izrailtyan I., and Benveniste H. Simultaneous detection of blood volume, oxygenation, and intracellular calcium changes during cerebral ischemia and reperfusion in vivo using diffuse reflectance and fluorescence. J Cereb Blood Flow Metab 5 (2005) 1078
13. Zucchi R., Ronca F., and Ronca-Testoni S. Modulation of sarcoplasmic reticulum function: A new strategy in cardioprotection?. Pharmacol Ther 89 (2001) 47
14. White B.C., Sullivan J.M., DeGracia D.J., et al. Brain ischemia and reperfusion: Molecular mechanisms of neuronal injury. J Neurol Sci 1 (2000) 1
15. Allen D.G., Cairns S.P., Turvey S.E., et al. Intracellular calcium and myocardial function during ischemia. Adv Exp Med Biol 346 (1993) 19
16. Haller H., and Elliott H.L. Review: The central role of calcium in the pathogenesis of cardiovascular disease. J Hum Hypertens 10 (1996) 143
17. Levy J., Zhu Z., and Dunbar J.C. The effect of global brain ischemia in normal and diabetic animals: The influence of calcium channel blockers. Endocrine 25 (2004) 91
18. Saini H.K., and Dhalla N.S. Defective calcium handling in cardiomyocytes isolated from hearts subjected to ischemia-reperfusion. Am J Physiol Heart Circ Physiol 288 (2005) H2260
19. Zhang M., Xu Y.J., Saini H.K., et al. TNF-α as a potential mediator of cardiac dysfunction due to intracellular Ca++-overload. Biochem Biophys Res Commun 327 (2005) 57
20. Colletti L.M., Burtch G.D., Remick D.G., et al. The production of tumor necrosis factor alpha and the development of a pulmonary capillary injury following hepatic ischemia/reperfusion. Transplantation 49 (1990) 268
21. Sakr M.F., McClain C.J., Gavaler J.S., et al. FK 506 pretreatment is associated with reduced levels of tumor necrosis factor and interleukin 6 following hepatic ischemia/reperfusion. J Hepatol 17 (1993) 301
22. Shito M., Wakabayashi G., Ueda M., et al. Interleukin 1 receptor blockade reduces tumor necrosis factor production, tissue injury, and mortality after hepatic ischemia-reperfusion in the rat. Transplantation 63 (1997) 143
23. Teoh N.C., and Farrell G.C. Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection. J Gastroenterol Hepatol 18 (2003) 891
24. Suzuki S., and Toledo-Pereyra L.H. Interleukin-1 and tumor necrosis factor production as the initial stimulants of liver ischemia and reperfusion injury. J Surg Res 57 (1994) 253
25. Neuman M.G. Apoptosis in diseases of the liver. Crit Rev Clin Lab Sci 38 (2001) 109
26. Lee N.K., and Lee S.Y. Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs). J Biochem Mol Biol 31 (2002) 61
27. Eichhorst S.T. Modulation of apoptosis as a target for liver disease. Expert Opin Ther Targets 9 (2005) 83
28. Toledo-Pereyra L.H., Lopez-Neblina F., Reuben J., et al. Selectin inhibition modulates Akt/MAPK signaling and chemokine expression after liver ischemia-reperfusion. J Inv Surg 17 (2004) 320
29. Lopez-Neblina F., Toledo A.H., and Toledo-Pereyra L.H. Molecular biology of apoptosis in ischemia and reperfusion. J Invest Surg 18 (2005) 335
30. Lai E.W., Toledo-Pereyra L.H., Walsh J., et al. The role of MAP kinases in trauma and ischemia-reperfusion. J Invest Surg 17 (2004) 45
31. Girndt M., and Kohler H. Interleukin-10 (IL-10): An update on its relevance for cardiovascular risk. Nephrol Dial Transplant 18 (2003) 1976
32. De Waal Malefyt R., Abrams J., Bennett B., et al. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J Exp Med 174 (1991) 1209
33. De Waal Malefyt R., Haanen J., Spits H., et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 174 (1991) 915
34. Kuhn R., Lohler J., Rennick D., et al. Interleukin-10- deficient mice develop chronic enterocolitis. Cell 75 (1993) 263
35. Rennick D.M., and Fort M.M. Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10-/-) mice and intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 278 (2000) G829
36. Powrie F., and Coffman R.L. Inhibition of cell-mediated immunity by IL4 and IL-10. Res Immunol 144 (1993) 639
37. Herfarth H.H., Mohanty S.P., Rath H.C., et al. Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers. Gut 39 (1996) 836
38. Herfarth H.H., Bocker U., Janardhanam R., et al. Subtherapeutic corticosteroids potentiate the ability of interleukin 10 to prevent chronic inflammation in rats. Gastroenterology 115 (1998) 856
39. Barbara G., Xing Z., Hogaboam C.M., et al. Interleukin 10 gene transfer prevents experimental colitis in rats. Gut 46 (2000) 344
40. Rott O., Fleischer B., and Cash E. Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur J Immunol 24 (1994) 1434
41. Van Laethem J.L., Marchant A., Delvaux A., et al. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis. Gastroenterology 108 (1995) 1917
42. Pennline K.J., Roque-Gaffney E., and Monahan M. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin Immunol Immunopathol 71 (1994) 169
43. Yoshidome H., Kato A., Edwards M.J., et al. Interleukin-10 inhibits pulmonary NF-kappaB activation and lung injury induced by hepatic ischemia-reperfusion. Am J Physiol 277 (1999) L919
44. Yoshidome H., Kato A., Edwards M.J., et al. Interleukin-10 suppresses hepatic ischemia/reperfusion injury in mice: Implications of a central role for nuclear factor kappaB. Hepatology 30 (1999) 203
45. Van Laethem J.L., Marchant A., Delvaux A., et al. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis. Gastroenterology 108 (1995) 1917
46. Pennline K.J., Roque-Gaffney E., and Monahan M. Recombinant human IL-10 prevents the onset of diabetes in the non-obese diabetic mouse. Clin Immunol Immunopathol 71 (1994) 169
47. Gerard C., Bruyns C., Marchant A., et al. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 177 (1993) 547
48. Persson S., Mikulowska A., Narula S., et al. Interleukin-10 suppresses the development of collagen type II-induced arthritis and ameliorates sustained arthritis in rats. Scand J Immunol 44 (1996) 607
49. Tanaka Y., Otsuka T., Hotokebuchi T., et al. Effect of IL-10 on collagen-induced arthritis in mice. Inflamm Res 45 (1996) 283