메뉴 건너뛰기




Volumn 8, Issue 5, 1996, Pages 395-400

Circulating serum levels of IL-1ra in patients with relapsing remitting multiple sclerosis are normal during remission phases but significantly increased either during exacerbations or in response to IFN-β treatment

Author keywords

Interferon; Interleukins; Interleukins 1 receptor antagonist; Multiple sclerosis

Indexed keywords

BETA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

EID: 0030015204     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1996.0054     Document Type: Article
Times cited : (73)

References (50)
  • 1
    • 0024444624 scopus 로고
    • Pathology, histochemistry and immunocytochemistry of lesions in acute multiple sclerosis
    • Adams CW, Poston RN, Buk SJ (1989) Pathology, histochemistry and immunocytochemistry of lesions in acute multiple sclerosis. J Natural Sci 92:291.
    • (1989) J Natural Sci , vol.92 , pp. 291
    • Adams, C.W.1    Poston, R.N.2    Buk, S.J.3
  • 2
    • 0022644493 scopus 로고
    • Immunocytochemical characterization of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth
    • Woodrofe MN, Bellamy AS, Feldmann M, Davison AN, Cuzner ML (1986) Immunocytochemical characterization of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth. J Neurol Sci 74:135.
    • (1986) J Neurol Sci , vol.74 , pp. 135
    • Woodrofe, M.N.1    Bellamy, A.S.2    Feldmann, M.3    Davison, A.N.4    Cuzner, M.L.5
  • 4
    • 0028990462 scopus 로고
    • Immunologic mechanisms and therapy in multiple sclerosis
    • Hafler DA, Weiner HL (1995) Immunologic mechanisms and therapy in multiple sclerosis. Immunol Rev 144:75-107.
    • (1995) Immunol Rev , vol.144 , pp. 75-107
    • Hafler, D.A.1    Weiner, H.L.2
  • 5
    • 0028990468 scopus 로고
    • Critical influences of the cytokine orchestration on the outcome of mylein antigen-specific T cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Olsson T (1995) Critical influences of the cytokine orchestration on the outcome of mylein antigen-specific T cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Rev 144:245-268.
    • (1995) Immunol Rev , vol.144 , pp. 245-268
    • Olsson, T.1
  • 6
    • 0009743563 scopus 로고
    • Immunosuppressive therapy in multiple sclerosis: Pros and cons
    • Noseworthy JH (1994) Immunosuppressive therapy in multiple sclerosis: pros and cons. Int. MSJ 1:79-89.
    • (1994) Int. MSJ , vol.1 , pp. 79-89
    • Noseworthy, J.H.1
  • 7
    • 0028348216 scopus 로고
    • Chronic systemic high-dose recombinant interferon-alfa-2a reduces exacerbation rate, MRI signs of disease activity, and lymphocyte interferon-gamma production in relapsing remitting multiple sclerosis
    • Durelli L, Bongioanni MR, Cavallo R, Ferrero M, Ferri R, Ferrio MF, Bradac GD, Riva A, Vai S, Geuna M, Bergamini L, B ergamasco B (1994) Chronic systemic high-dose recombinant interferon-alfa-2a reduces exacerbation rate, MRI signs of disease activity, and lymphocyte interferon-gamma production in relapsing remitting multiple sclerosis. Neurology 44:406-413.
    • (1994) Neurology , vol.44 , pp. 406-413
    • Durelli, L.1    Bongioanni, M.R.2    Cavallo, R.3    Ferrero, M.4    Ferri, R.5    Ferrio, M.F.6    Bradac, G.D.7    Riva, A.8    Vai, S.9    Geuna, M.10    Bergamini, L.11    Bergamasco, B.12
  • 9
    • 0023039442 scopus 로고
    • Systemic recombinant alpha-2 interferon therapy in relapsing multiple sclerosis
    • Camenga DL, Johnson KP, Alter M et al. (1986) Systemic recombinant alpha-2 interferon therapy in relapsing multiple sclerosis. Arch Neurol 43:1239-1246.
    • (1986) Arch Neurol , vol.43 , pp. 1239-1246
    • Camenga, D.L.1    Johnson, K.P.2    Alter, M.3
  • 10
    • 0023221133 scopus 로고
    • Treatment of multiple sclerosis with gamma-interferon: Exacerbations associated with activation of the immune system
    • Panitch HS, Heracl RL, Schindler J, Johnson KP (1987) Treatment of multiple sclerosis with gamma-interferon: exacerbations associated with activation of the immune system. Neurology 37:1097-1120.
    • (1987) Neurology , vol.37 , pp. 1097-1120
    • Panitch, H.S.1    Heracl, R.L.2    Schindler, J.3    Johnson, K.P.4
  • 11
    • 0027418515 scopus 로고
    • Interferon-beta 1b is effective in relapsing remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The Interferon-beta Multiple Sclerosis Study group (1993) Interferon-beta 1b is effective in relapsing remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43:655-661.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 12
    • 0027521002 scopus 로고
    • Interferon beta-1 beta is effective in relapsing-remitting multiple sclerosis
    • Paty DW, Li DKB, the UBC MS/MRI Study Group and the IFN-beta Multiple Sclerosis Study Group (1993) Interferon beta-1 beta is effective in relapsing-remitting multiple sclerosis. Neurology 43, 662-667.
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.W.1    Li, D.K.B.2
  • 13
    • 0029161628 scopus 로고
    • The IFN-beta Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group (1995) Neurology 45:1277-1285.
    • (1995) Neurology , vol.45 , pp. 1277-1285
  • 14
    • 84907109913 scopus 로고
    • Suppression of experimental allergic encephalomyelitis by interferon
    • Abreu SL (1982) Suppression of experimental allergic encephalomyelitis by interferon. Immunol Com 11:1-7.
    • (1982) Immunol Com , vol.11 , pp. 1-7
    • Abreu, S.L.1
  • 16
    • 0021801133 scopus 로고
    • Effect of rat and beta human interferon on hyperacute experimental allergic encephalomyelitis in rats
    • Hertz F, Deghenghi R (1985) Effect of rat and beta human interferon on hyperacute experimental allergic encephalomyelitis in rats. Agents Actions 16:397-403.
    • (1985) Agents Actions , vol.16 , pp. 397-403
    • Hertz, F.1    Deghenghi, R.2
  • 17
    • 0025213264 scopus 로고
    • Interferon beta augments suppressor cell function in multiple sclerosis
    • Noronha A, Toscas A, Jensen MA (1990) Interferon beta augments suppressor cell function in multiple sclerosis. Ann Neurol 27:207-210.
    • (1990) Ann Neurol , vol.27 , pp. 207-210
    • Noronha, A.1    Toscas, A.2    Jensen, M.A.3
  • 18
    • 0024318227 scopus 로고
    • Human biologic response modification by interferon in absence of measurable serum concentrations: A comparative study of subcutaneous and intravenous interferon-beta serine
    • Goldstein D, Sielaff KM, Storer BE, Brown RR, Datta SP, Witt PL, Teitelbaum AP, Smalley RV, Borden EC (1989) Human biologic response modification by interferon in absence of measurable serum concentrations: A comparative study of subcutaneous and intravenous interferon-beta serine. J Natl Cancer Inst 81:1061-1068.
    • (1989) J Natl Cancer Inst , vol.81 , pp. 1061-1068
    • Goldstein, D.1    Sielaff, K.M.2    Storer, B.E.3    Brown, R.R.4    Datta, S.P.5    Witt, P.L.6    Teitelbaum, A.P.7    Smalley, R.V.8    Borden, E.C.9
  • 19
    • 0024594158 scopus 로고
    • Interferon-beta impairs induction of HLA-DR antigen expression in cultured human astrocytes
    • Barna BP, Chou SM, Jacobs B et al (1989) Interferon-beta impairs induction of HLA-DR antigen expression in cultured human astrocytes. J Neuroimmunol 23:45-53.
    • (1989) J Neuroimmunol , vol.23 , pp. 45-53
    • Barna, B.P.1    Chou, S.M.2    Jacobs, B.3
  • 20
    • 0028983447 scopus 로고
    • Interferon-beta downregulates interferon-gamma-induced class II MHC molecule expression and morphological changes in primary cultures of human brain microvessel endothelial cells
    • Huynh HK, Oger J, Dorovini-Zis K (1995) Interferon-beta downregulates interferon-gamma-induced class II MHC molecule expression and morphological changes in primary cultures of human brain microvessel endothelial cells. J Neuroimmunol 60:63-73.
    • (1995) J Neuroimmunol , vol.60 , pp. 63-73
    • Huynh, H.K.1    Oger, J.2    Dorovini-Zis, K.3
  • 21
    • 0021911348 scopus 로고
    • On the presence of la-positive EC and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation
    • Traugott U, Scheinberg LC, Raine CS (1985) On the presence of la-positive EC and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation. J Neuroimmunol 8:1-14.
    • (1985) J Neuroimmunol , vol.8 , pp. 1-14
    • Traugott, U.1    Scheinberg, L.C.2    Raine, C.S.3
  • 23
    • 0024508369 scopus 로고
    • Immune hormones (cytokines); pathogenicrole in autoimmune rheumatic diseases and endocrine diseases
    • Bendtzen K (1989) Immune hormones (cytokines); pathogenicrole in autoimmune rheumatic diseases and endocrine diseases. Autoimmunity 2:177-189.
    • (1989) Autoimmunity , vol.2 , pp. 177-189
    • Bendtzen, K.1
  • 24
    • 0028646202 scopus 로고    scopus 로고
    • Cytokines and natural regulators of cytokines
    • Bendtzen K. Cytokines and natural regulators of cytokines. Immunol Letters 43:111-123.
    • Immunol Letters , vol.43 , pp. 111-123
    • Bendtzen, K.1
  • 25
    • 0025021471 scopus 로고
    • Primary structure and functional expression of from complementary DNA of a human interleukin-1 receptor antagonist
    • Eisenberg SP, Evans RJ, Arend WP, Verderberr E, Brewer MT, Hannum CH, Thompson RC (1990) Primary structure and functional expression of from complementary DNA of a human interleukin-1 receptor antagonist. Nature 343:341-346.
    • (1990) Nature , vol.343 , pp. 341-346
    • Eisenberg, S.P.1    Evans, R.J.2    Arend, W.P.3    Verderberr, E.4    Brewer, M.T.5    Hannum, C.H.6    Thompson, R.C.7
  • 27
    • 0025777448 scopus 로고
    • Interleukin-1 and interleukin-1 antagonism
    • Dinarello CA (1991) Interleukin-1 and interleukin-1 antagonism. Blood 77:1627-1652.
    • (1991) Blood , vol.77 , pp. 1627-1652
    • Dinarello, C.A.1
  • 28
    • 0028898529 scopus 로고
    • Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation
    • Casini-Riggi V, Kam L, Chong YJT, Fiochhi C, Pizzarro T, Cominelli F (1995) Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation. J Immunol 154:2434-2440.
    • (1995) J Immunol , vol.154 , pp. 2434-2440
    • Casini-Riggi, V.1    Kam, L.2    Chong, Y.J.T.3    Fiochhi, C.4    Pizzarro, T.5    Cominelli, F.6
  • 29
    • 0027397839 scopus 로고
    • B alance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis
    • Miller LC, Lynch EA, Isa S, Logan JW, Dinarello CA, Steere AC (1993) B alance of synovial fluid IL-1 beta and IL-1 receptor antagonist and recovery from Lyme arthritis. Lancet 341:146-148.
    • (1993) Lancet , vol.341 , pp. 146-148
    • Miller, L.C.1    Lynch, E.A.2    Isa, S.3    Logan, J.W.4    Dinarello, C.A.5    Steere, A.C.6
  • 31
    • 0026787848 scopus 로고
    • High concentration of the interleukin-1 receptor antagonist in serum of patients with Hodgkin's disease
    • Gruss HJ, Doelken G, Brach MA, Herrmann F (1992) High concentration of the interleukin-1 receptor antagonist in serum of patients with Hodgkin's disease. Lancet 340:968.
    • (1992) Lancet , vol.340 , pp. 968
    • Gruss, H.J.1    Doelken, G.2    Brach, M.A.3    Herrmann, F.4
  • 33
    • 0027751693 scopus 로고
    • Increased levels of intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor receptor in the cerebrospinal fluid of patients with multiple sclerosis
    • Tsukada N, Matsuda M, Miyagi K, Yanagisawa N (1993) Increased levels of intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor receptor in the cerebrospinal fluid of patients with multiple sclerosis. Neurology 43:2679-2682.
    • (1993) Neurology , vol.43 , pp. 2679-2682
    • Tsukada, N.1    Matsuda, M.2    Miyagi, K.3    Yanagisawa, N.4
  • 34
    • 0027761344 scopus 로고
    • Interleukin and receptor autagonist production in human monocytes is induced by IL-1α, IL-3, IL-4 and GM-CSF
    • Jenkins JP, Arend WP (1993) Interleukin and receptor autagonist production in human monocytes is induced by IL-1α, IL-3, IL-4 and GM-CSF. Cytokine 5:407-415.
    • (1993) Cytokine , vol.5 , pp. 407-415
    • Jenkins, J.P.1    Arend, W.P.2
  • 36
    • 0024767078 scopus 로고
    • Production of interleukin-1 (IL-1) and a specific IL-inhibitor during human monocyte-macrophage differentiation: Influence of GM-CSF
    • Roux-Lombard P, Modoux C, Dayer J-M (1989) Production of interleukin-1 (IL-1) and a specific IL-inhibitor during human monocyte-macrophage differentiation: influence of GM-CSF. Cytokine 1:45-51.
    • (1989) Cytokine , vol.1 , pp. 45-51
    • Roux-Lombard, P.1    Modoux, C.2    Dayer, J.-M.3
  • 37
    • 0026503448 scopus 로고
    • Coordinated antiinflammatory effects of interleukin-4: Interleukin-4 suppresses interleukin-1 production but up-regulates gene expression and synthesis of interleukin-1 receptor antagonist
    • Vannier E, Miller LC, Dinarello CA (1992) Coordinated antiinflammatory effects of interleukin-4: interleukin-4 suppresses interleukin-1 production but up-regulates gene expression and synthesis of interleukin-1 receptor antagonist. Proc Natl Acad Sci USA 89:4076-4080.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4076-4080
    • Vannier, E.1    Miller, L.C.2    Dinarello, C.A.3
  • 38
    • 0026013550 scopus 로고
    • Increased interleukin-1 production by peripheral blood mononuclear cells in patients with multiple sclerosis
    • Matsuda M, Tsukada N, Iyagi K, Yanagisawa N (1991) Increased Interleukin-1 production by peripheral blood mononuclear cells in patients with multiple sclerosis. J Neurol Sci 102:100-104.
    • (1991) J Neurol Sci , vol.102 , pp. 100-104
    • Matsuda, M.1    Tsukada, N.2    Iyagi, K.3    Yanagisawa, N.4
  • 39
    • 0024427260 scopus 로고
    • Immune activation in multiple sclerosis: Study of IL-2, sIL-2R and gamma-IFN levels in serum and cerebrospinal fluid
    • Gallo P, Piccinno MG, Pagni S, Argentiero V, Giometti B, Bozza F, Tavolato B (1989) Immune activation in multiple sclerosis: Study of IL-2, sIL-2R and gamma-IFN levels in serum and cerebrospinal fluid. J Neurol Sci 92:9-15.
    • (1989) J Neurol Sci , vol.92 , pp. 9-15
    • Gallo, P.1    Piccinno, M.G.2    Pagni, S.3    Argentiero, V.4    Giometti, B.5    Bozza, F.6    Tavolato, B.7
  • 41
    • 0026074551 scopus 로고
    • Interleukin-6 is elevated in plasma multiple sclerosis
    • Frei K, Fredrikson S, Fontana A, Link H (1991) Interleukin-6 is elevated in plasma multiple sclerosis. J Neuroimmunol 31:147-153.
    • (1991) J Neuroimmunol , vol.31 , pp. 147-153
    • Frei, K.1    Fredrikson, S.2    Fontana, A.3    Link, H.4
  • 42
    • 0025773147 scopus 로고
    • Association between tumor necrosis factor-alfa and disease progression in patients with multiple sclerosis
    • Sharief MK, Hentges R (1991) Association between tumor necrosis factor-alfa and disease progression in patients with multiple sclerosis. New Engl J Med 325:467-472.
    • (1991) New Engl J Med , vol.325 , pp. 467-472
    • Sharief, M.K.1    Hentges, R.2
  • 43
    • 0025856061 scopus 로고
    • Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alfa and suppressed by soluble IL-1 receptor
    • Jacobs CA, Baker PE, Roux ER, Picha KS, Toivola B, Waugh S, Kennedy MK (1991). Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alfa and suppressed by soluble IL-1 receptor. J Immunol 146:2983-2989.
    • (1991) J Immunol , vol.146 , pp. 2983-2989
    • Jacobs, C.A.1    Baker, P.E.2    Roux, E.R.3    Picha, K.S.4    Toivola, B.5    Waugh, S.6    Kennedy, M.K.7
  • 46
    • 0027371372 scopus 로고
    • The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice
    • Wooley PH, Whalen JD, Chapman DL, B erger AE, Richard KA, A spar DG, Staite ND (1993) The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice. Arthritis Rheum 36:1305-1314.
    • (1993) Arthritis Rheum , vol.36 , pp. 1305-1314
    • Wooley, P.H.1    Whalen, J.D.2    Chapman, D.L.3    Berger, A.E.4    Richard, K.A.5    Aspar, D.G.6    Staite, N.D.7
  • 48
    • 0028828583 scopus 로고
    • Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats
    • Martin D, Near SL (1995) Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats. J Neuroimmunol 61:241-245.
    • (1995) J Neuroimmunol , vol.61 , pp. 241-245
    • Martin, D.1    Near, S.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.