Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 2, 2011, Pages 771-782

  Makadia, Pankaj ^a,b   Shah, Shailesh R ^b   Pingali, Harikishore ^a   Zaware, Pandurang ^a   Patel, Darshit ^a   Pola, Suresh ^a   Thube, Baban ^a   Priyadarshini, Priyanka ^a   Suthar, Dinesh ^a   Shah, Maanan ^a   Giri, Suresh ^a   Trivedi, Chitrang ^a   Jain, Mukul ^a   Patel, Pankaj ^a   Bahekar, Rajesh ^a  

^a ZYDUS RESEARCH CENTRE   (India)

^b M S UNIVERSITY OF BARODA   (India)

Author keywords

Metabolic syndrome; Oxazole; Oxime; PPAR agonist; PPAR pan agonist; Thiazole

Indexed keywords

(2 METHYL 4 [1 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) THIAZOL 5 YLMETHOXYIMINO] ETHYL] PHENOXY) ACETIC ACID; 2 [2 METHYL 4 [ [((4 METHYL 2 (4 (TRIFLUOROMETHYL) PHENYL)THIAZOL 5 YL)METHOXY)IMINO]BUTYL]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [((4 METHYL 2 (4 (TRIFLUOROMETHYL) PHENYL)THIAZOL 5 YL)METHOXY)IMINO]PROPYL]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [((5 METHYL 2 (4 TOLYL))OXAZOL 4 YL) METHOXY)IMINO]BUTYL]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [((5 METHYL 2 (4 TOLYL))OXAZOL 4 YL) METHOXY)IMINO]ETHYL]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [((5 METHYL 2 (4 TOLYL))OXAZOL 4 YL) METHOXY)IMINO]PROPYL]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [((5 METHYL 2 PHENYLOXAZOL 4 YL) METHOXY)IMINO]BUTYL]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [((5 METHYL 2 PHENYLOXAZOL 4 YL) METHOXY)IMINO]ETHYL]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [((5 METHYL 2 PHENYLOXAZOL 4 YL) METHOXY)IMINO]PROPYL]PHENOXY]ACETIC ACID; 2 [4 (1 [[(4 METHYL 2 (4 (TRIFLUOROMETHYL)PHENYL) THIAZOL 5 YL)METHOXY)IMINO]PROPYL]PHENOXY]ACETIC ACID; 2 [4 (1 [[(5 METHYL 2 PHENYLOXAZOL 4 YL)METHOXY) IMINO]ETHYL]PHENOXY]ACETIC ACID; 2 [4 (1 [[(5 METHYL 2 PHENYLOXAZOL 4 YL)METHOXY) IMINO]PROPYL]PHENOXY]ACETIC ACID; 2 [4 [1 [((4 METHYL 2 (4 (TRIFLUOROMETHYL)PHENYL) THIAZOL 5 YL)METHOXY)IMINO]ETHYL]PHENOXY]ACETIC ACID; 2 [4 [1 [((5 METHYL 2 (4 TOLYL)OXAZOL 4 YL)METHOXY) IMINO]ETHYL]PHENOXY]ACETIC ACID; 2 [4 [1 [((5 METHYL 2 (4 TOLYL)OXAZOL 4 YL)METHOXY) IMINO]PROPYL]PHENOXY]ACETIC ACID; 2 [4 [CYCLOHEXYL[((4 METHYL 2 (4 (TRIFLUOROMETHYL) PHENYL)THIAZOL 5 YL)METHOXY)IMINO]METHYL]PHENOXY]ACETIC ACID; 2 [4 [CYCLOHEXYL[((5 METHYL 2 (4 TOLYL)OXAZOL 4 YL) METHOXY)IMINO]METHYL] 2 METHYLPHENOXY]ACETIC ACID; 2 [4 [CYCLOHEXYL[((5 METHYL 2 PHENYLOXAZOL 4 YL) METHOXY)IMINO]METHYL] 2 METHYLPHENOXY]ACETIC ACID; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; BEZAFIBRATE; OXAZOLE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PIRINIXIC ACID; ROSIGLITAZONE; TESAGLITAZAR; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GLUCOSE BLOOD LEVEL; HAMSTER; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; CRICETINAE; DISEASE MODELS, ANIMAL; ETHER, ETHYL; HEP G2 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MICE; MICE, OBESE; OXIMES; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PPAR ALPHA; PPAR DELTA; PPAR GAMMA; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

ANIMALIA;

EID: 78651496725     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.12.023     Document Type: Article

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