Design, synthesis, and biological evaluation of the first podophyllotoxin analogues as potential vascular-disrupting agents

ChemMedChem

Volumn 5, Issue 12, 2010, Pages 2016-2025

  Labruère, Raphaël ^a,b   Gautier, Benoît ^b   Testud, Marlène ^a   Seguin, Johanne ^c   Lenoir, Christine ^b   Desbène Finck, Stéphanie ^a   Helissey, Philippe ^a   Garbay, Christiane ^b   Chabot, Guy G ^c   Vidal, Michel ^b   Giorgi Renault, Sylviane ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b Laboratoire de Pharmacochimie   (France)

^c Centre National de la Recherche Scientifique   (France)

Author keywords

Antitumor agents; Antivascular agents; Azapodophyllotoxins; Nitrogen heterocycles; Podophyllotoxin analogues

Indexed keywords

4 METHYL 6,7 (METHYLENEDIOXY) 9 (3',4',5' TRIMETHOXYBIPHENYL 4 YL) 4,9 DIHYDROFURO[3,4 B]QUINOLIN 1 (3H)ONE; 4 METHYL 6,7 (METHYLENEDIOXY) 9 (3,4,5 TRIMETHOXYBENZYL) 4,9 DIHYDROFURO[3,4 B]QUINOLIN 1 (3H)ONE; 4 METHYL 6,7 (METHYLENEDIOXY) 9 [2 (3,4,5 TRIMETHOXYPHENYL)ETHYL] 4,9 DIHYDROFURO[3,4 B]QUINOLIN 1 (3H)ONE; 4 METHYL 6,7 (METHYLENEDIOXY) 9 [2 (3,4,5 TRIMETHOXYPHENYL)ETHYNYL] 4,9 DIHYDROFURO[3,4 B]QUINOLIN 1 (3H)ONE; 6,7 (METHYLENEDIOXY) 9 [2 (3,4,5 TRIMETHOXYPHENYL)ETHENYL] 4,9 DIHYDROFURO[3,4 B]QUINOLIN 1 (3H)ONE; COLCHICINE; COMBRESTATIN A 4; ETOPOSIDE; PODOPHYLLOTOXIN; PODOPHYLLOTOXIN DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONFORMATION; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENDOTHELIUM CELL; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 78651481077     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000305     Document Type: Article

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