Structure-activity comparison of the cytotoxic properties of diethyl maleate and related molecules: Identification of diethyl acetylenedicarboxylate as a thiol cross-linking agent

Chemical Research in Toxicology

Volumn 24, Issue 1, 2011, Pages 81-88

  West, James D ^a   Stamm, Chelsea E ^a   Kingsley, Philip J ^b  

^a 931 College Mall   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CARBOXYLIC ACID DERIVATIVE; DIETHYL ACETYLENEDICARBOXYLIC ACID DERIVATIVE; DIETHYL MALEIC ACID DERIVATIVE; MALEIC ACID DERIVATIVE; THIOL; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CHEMICAL REACTION; CROSS LINKING; CYTOTOXICITY; HUMAN; HUMAN CELL; INCUBATION TIME; MOLECULE; OLIGOMERIZATION; STRUCTURE ACTIVITY RELATION;

ACETYLCYSTEINE; ALKYNES; CATALYTIC DOMAIN; CELL LINE, TUMOR; CROSS-LINKING REAGENTS; GLUTATHIONE PEROXIDASE; HUMANS; MALEATES; SACCHAROMYCES CEREVISIAE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 78651473811     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100292n     Document Type: Article

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