Structure-toxicity analysis of Type-2 Alkenes: In vitro neurotoxicity

Toxicological Sciences

Volumn 95, Issue 1, 2007, Pages 136-146

  LoPachin, Richard M ^a,d   Barber, David S ^b   Geohagen, Brian C ^a   Gavin, Terrence ^c   He, Deke ^a   Das, Soma ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c IONA COLLEGE   (United States)

^d MONTEFIORE MEDICAL CENTER   (United States)

Author keywords

Acrolein; Acrylamide; Adduct formation; Distal axonopathy; Neurodegeneration; Synapse

Indexed keywords

ACROLEIN; ACRYLAMIDE; ALDEHYDE DERIVATIVE; ALKENE; HYDRALAZINE; KETONE DERIVATIVE; NETHYLMALEIMIDE; NETHYLMALEIMIDE SENSITIVE FACTOR; NEUROTRANSMITTER; SYNAPTOBREVIN; SYNAPTOPHYSIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; THIOL GROUP;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; HYPOTHESIS; IN VITRO STUDY; MALE; MICHAEL ADDITION; NEUROTOXICITY; NONHUMAN; PROTEIN CROSS LINKING; PROTEIN TRANSPORT; RAT; STRUCTURE ANALYSIS; SYNAPTOSOME; TOXICITY TESTING;

ACROLEIN; ACRYLAMIDE; ACRYLATES; ALDEHYDES; ALKENES; ALLYL COMPOUNDS; ANIMALS; BLOTTING, WESTERN; BRAIN; BUTANONES; CROSS-LINKING REAGENTS; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLMALEIMIDE; HYDRALAZINE; MALE; MEMBRANE FUSION PROTEINS; NEURONS; PROPANOLS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; SULFHYDRYL REAGENTS; SYNAPTIC VESICLES; SYNAPTOSOMES; TANDEM MASS SPECTROMETRY;

EID: 33845606362     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl127     Document Type: Article

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