메뉴 건너뛰기




Volumn 30, Issue 5, 2010, Pages 515-528

Clevidipine: A short-acting intravenous dihydropyridine calcium channel blocker for the management of hypertension

Author keywords

Acute postoperative hypertension; Antihypertensive; Blood pressure; Clevidipine; Dihydropyridine calcium channel blocker; Hypertensive emergency; Hypertensive urgency; Perioperative hypertension

Indexed keywords

BENZODIAZEPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLEVIDIPINE; CLONIDINE; DIHYDROPYRIDINE; DILTIAZEM; ENALAPRILAT; ESMOLOL; FENOLDOPAM; GLYCERYL TRINITRATE; HYDRALAZINE; LABETALOL; LOOP DIURETIC AGENT; METOPROLOL; NICARDIPINE; NIFEDIPINE; NITROPRUSSIDE SODIUM; PHENTOLAMINE; PROPOFOL; VERAPAMIL;

EID: 77951754712     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.30.5.515     Document Type: Review
Times cited : (23)

References (42)
  • 1
    • 0038460302 scopus 로고    scopus 로고
    • The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: The JNC 7 report
    • Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 2003;289:2560-2572
    • (2003) JAMA , vol.289 , pp. 2560-2572
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3
  • 2
    • 0004270125 scopus 로고    scopus 로고
    • 8th ed. Philadelphia: Lippincott Williams & Wilkins
    • Kaplan NM. Clinical hypertension, 8th ed. Philadelphia: Lippincott Williams & Wilkins; 2002:4.
    • (2002) Clinical Hypertension , vol.4
    • Kaplan, N.M.1
  • 3
    • 34250885768 scopus 로고    scopus 로고
    • Hypertensive crises: Challenges and management
    • Marik P, Varon J. Hypertensive crises: challenges and management. Chest 2007;131:1949-1962
    • (2007) Chest , vol.131 , pp. 1949-1962
    • Marik, P.1    Varon, J.2
  • 4
    • 33748184291 scopus 로고    scopus 로고
    • Hypertension in the intensive care unit
    • Slama M, Modeliar S. Hypertension in the intensive care unit. Curr Opin Cardiol 2006;21:279-287
    • (2006) Curr Opin Cardiol , vol.21 , pp. 279-287
    • Slama, M.1    Modeliar, S.2
  • 6
    • 0016430364 scopus 로고
    • Hypertension in the immediate postoperative period
    • Gal TJ, Cooperman LH. Hypertension in the immediate postoperative period. Br J Anaesth 1975;47:70-74
    • (1975) Br J Anaesth , vol.47 , pp. 70-74
    • Gal, T.J.1    Cooperman, L.H.2
  • 7
    • 0034986749 scopus 로고    scopus 로고
    • Survey of cancellation rate of hypertensive patients undergoing anaesthesia and elective surgery
    • Dix P, Howell S. Survey of cancellation rate of hypertensive patients undergoing anaesthesia and elective surgery. Br J Anaesth 2001;86:798-803
    • (2001) Br J Anaesth , vol.86 , pp. 798-803
    • Dix, P.1    Howell, S.2
  • 8
    • 0029859248 scopus 로고    scopus 로고
    • Should a moratorium be placed on sublingual nifedipine capsules given for hypertensive emergencies and pseudoemergencies?
    • Grossman E, Messerli FH, Grodzicki T, et al. Should a moratorium be placed on sublingual nifedipine capsules given for hypertensive emergencies and pseudoemergencies? JAMA 1996;276:1328-1331
    • (1996) JAMA , vol.276 , pp. 1328-1331
    • Grossman, E.1    Messerli, F.H.2    Grodzicki, T.3
  • 9
    • 0021688620 scopus 로고
    • Pharmacology of combined alpha-beta blockade. II. Haemodynamic effects of labetalol
    • Lund-Johansen P. Pharmacology of combined alpha-beta blockade. II. Haemodynamic effects of labetalol. Drugs 1984;28(suppl 2):35-50.
    • (1984) Drugs , vol.28 , Issue.SUPPL. 2 , pp. 35-50
    • Lund-Johansen, P.1
  • 11
    • 0024460803 scopus 로고
    • Esmolol attenuation of hemodynamic changes in resuscitation of hypertensive and coronary patients
    • letter, in French
    • Marty J, Kirsteter P, Cantineau JP, et al. Esmolol attenuation of hemodynamic changes in resuscitation of hypertensive and coronary patients [letter, in French]. Ann Fr Anesth Reanim 1989;8(suppl):R95.
    • (1989) Ann Fr Anesth Reanim , vol.8 , Issue.SUPPL.
    • Marty, J.1    Kirsteter, P.2    Cantineau, J.P.3
  • 12
    • 0031980173 scopus 로고    scopus 로고
    • Esmolol for the management of pediatric hypertension after cardiac operations
    • Wiest DB, Garner SS, Uber WE, Sade RM. Esmolol for the management of pediatric hypertension after cardiac operations. J Thorac Cardiovasc Surg 1998;115:890-897
    • (1998) J Thorac Cardiovasc Surg , vol.115 , pp. 890-897
    • Wiest, D.B.1    Garner, S.S.2    Uber, W.E.3    Sade, R.M.4
  • 14
    • 0034058827 scopus 로고    scopus 로고
    • Perioperative use of dihydropyridine calcium channel blockers
    • Poelaert J, Roosens C. Perioperative use of dihydropyridine calcium channel blockers. Acta Anesthesiol Scand 2000;44:528-535
    • (2000) Acta Anesthesiol Scand , vol.44 , pp. 528-535
    • Poelaert, J.1    Roosens, C.2
  • 15
    • 0033753786 scopus 로고    scopus 로고
    • 2+ currents: Steady-state and kinetic electrophysiological studies in guinea pig ventricular myocytes
    • 2+ currents: steady-state and kinetic electrophysiological studies in guinea pig ventricular myocytes. J Cardiovasc Pharmacol 2000;36:592-600.
    • (2000) J Cardiovasc Pharmacol , vol.36 , pp. 592-600
    • Yi, X.1    Vivien, B.2    Lynch, C.3
  • 16
    • 1942439737 scopus 로고    scopus 로고
    • HPLC enantiomer separation of a chiral 1,4-dihydropyridine monocarboxylic acid
    • Lammerhofer M, Gyllenhaal O, Lindner W. HPLC enantiomer separation of a chiral 1,4-dihydropyridine monocarboxylic acid. J Pharm Biomed Anal 2004;35:259-266
    • (2004) J Pharm Biomed Anal , vol.35 , pp. 259-266
    • Lammerhofer, M.1    Gyllenhaal, O.2    Lindner, W.3
  • 17
    • 0032807949 scopus 로고    scopus 로고
    • Circulatory effects and pharmacology of clevidipine, a novel ultra-short-acting and vascular selective calcium antagonist, in hypertensive humans
    • Schwieler JH, Ericsson H, Loefdahl P, et al. Circulatory effects and pharmacology of clevidipine, a novel ultra-short-acting and vascular selective calcium antagonist, in hypertensive humans. J Cardiovasc Pharmacol 1999;34:268-274
    • (1999) J Cardiovasc Pharmacol , vol.34 , pp. 268-274
    • Schwieler, J.H.1    Ericsson, H.2    Loefdahl, P.3
  • 18
    • 0033003861 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of clevidipine in healthy volunteers after intravenous infusion
    • Ericsson H, Fakt C, Hoglund L, et al. Pharmacokinetics and pharmacodynamics of clevidipine in healthy volunteers after intravenous infusion. Eur J Clin Pharmacol 1999;55:61-67
    • (1999) Eur J Clin Pharmacol , vol.55 , pp. 61-67
    • Ericsson, H.1    Fakt, C.2    Hoglund, L.3
  • 19
    • 0035111455 scopus 로고    scopus 로고
    • Enantioselective pharmacokinetics of the enantiomers of clevidipine following intravenous infusion of the racemate in essential hypertensive patients
    • Ericsson H, Schwieler J, Lindmark BO, et al. Enantioselective pharmacokinetics of the enantiomers of clevidipine following intravenous infusion of the racemate in essential hypertensive patients. Chirality 2001;13:130-134
    • (2001) Chirality , vol.13 , pp. 130-134
    • Ericsson, H.1    Schwieler, J.2    Lindmark, B.O.3
  • 20
    • 0032922805 scopus 로고    scopus 로고
    • Clinical and pharmacokinetic results with a new ultrashort-acting calcium antagonist, clevidipine, following gradually increasing intravenous doses to healthy volunteers
    • Ericsson H, Fakt C, Jolin-Mellgard A, et al. Clinical and pharmacokinetic results with a new ultrashort-acting calcium antagonist, clevidipine, following gradually increasing intravenous doses to healthy volunteers. Br J Clin Pharmacol 1999;47:531-538
    • (1999) Br J Clin Pharmacol , vol.47 , pp. 531-538
    • Ericsson, H.1    Fakt, C.2    Jolin-Mellgard, A.3
  • 21
    • 0033760624 scopus 로고    scopus 로고
    • Pharmacokinetics and pulmonary extraction of clevidipine, a new vasodilating ultrashort-acting dihydropyridine, during cardiopulmonary bypass
    • Vuylsteke A, Milner Q, Ericsson H, et al. Pharmacokinetics and pulmonary extraction of clevidipine, a new vasodilating ultrashort-acting dihydropyridine, during cardiopulmonary bypass. Br J Anaesth 2000;85:683-689
    • (2000) Br J Anaesth , vol.85 , pp. 683-689
    • Vuylsteke, A.1    Milner, Q.2    Ericsson, H.3
  • 22
    • 34748878874 scopus 로고    scopus 로고
    • Clevidipine effectively and rapidly controls blood pressure preoperatively in cardiac surgery patients: The results of the randomized, placebo-controlled efficacy study of clevidipine assessing its preoperative antihypertensive effect in cardiac surgery-1 (ESCAPE-1)
    • Levy JH, Mancao MY, Gitter R, et al. Clevidipine effectively and rapidly controls blood pressure preoperatively in cardiac surgery patients: the results of the randomized, placebo-controlled efficacy study of clevidipine assessing its preoperative antihypertensive effect in cardiac surgery-1 (ESCAPE-1). Anesth Analg 2007;105:918-925
    • (2007) Anesth Analg , vol.105 , pp. 918-925
    • Levy, J.H.1    Mancao, M.Y.2    Gitter, R.3
  • 23
    • 0033960750 scopus 로고    scopus 로고
    • Coronary and systemic hemodynamic effects of clevidipine, an ultra-short-acting calcium antagonist, for treatment of hypertension after coronary artery surgery
    • Kieler-Jensen N, Jolin-Mellgard A, Nordlander M, et al. Coronary and systemic hemodynamic effects of clevidipine, an ultra-short-acting calcium antagonist, for treatment of hypertension after coronary artery surgery. Acta Anaesthesiol Scand 2000;44:186-193
    • (2000) Acta Anaesthesiol Scand , vol.44 , pp. 186-193
    • Kieler-Jensen, N.1    Jolin-Mellgard, A.2    Nordlander, M.3
  • 24
    • 0344980193 scopus 로고    scopus 로고
    • Cardiac inotropic vs. chronotropic selectivity of isradipine, nifedipine and clevidipine, a new ultrashort-acting dihydropyridine
    • Segawa D, Sjoequist PO, Nordlander M, et al. Cardiac inotropic vs. chronotropic selectivity of isradipine, nifedipine and clevidipine, a new ultrashort-acting dihydropyridine. Eur J Pharmacol 1999;380:123-128
    • (1999) Eur J Pharmacol , vol.380 , pp. 123-128
    • Segawa, D.1    Sjoequist, P.O.2    Nordlander, M.3
  • 25
    • 0036016019 scopus 로고    scopus 로고
    • Effects of fenoldopam, a dopamine D-1 agonist, and clevidipine, a calcium channel antagonist, in acute renal failure in anesthetized rats
    • Stephens CT, Jandhyala BS. Effects of fenoldopam, a dopamine D-1 agonist, and clevidipine, a calcium channel antagonist, in acute renal failure in anesthetized rats. Clin Exp Hypertens 2002;24:301-313
    • (2002) Clin Exp Hypertens , vol.24 , pp. 301-313
    • Stephens, C.T.1    Jandhyala, B.S.2
  • 26
    • 0033836301 scopus 로고    scopus 로고
    • Calcium antagonist protects the myocardium from reperfusion injury by interfering with mechanisms directly related to reperfusion: An experimental study with the ultrashort-acting calcium antagonist clevidipine
    • Segawa D, Sjoequist PO, Wang QD, et al. Calcium antagonist protects the myocardium from reperfusion injury by interfering with mechanisms directly related to reperfusion: an experimental study with the ultrashort-acting calcium antagonist clevidipine. J Cardiovasc Pharmacol 2000;36:338-343
    • (2000) J Cardiovasc Pharmacol , vol.36 , pp. 338-343
    • Segawa, D.1    Sjoequist, P.O.2    Wang, Q.D.3
  • 27
    • 4644318383 scopus 로고    scopus 로고
    • Failure to demonstrate myocardial protective effects of the ultra short-acting calcium antagonist clevidipine in a closed-chest reperfusion porcine model
    • Odenstedt J, Mansson C, Grip L. Failure to demonstrate myocardial protective effects of the ultra short-acting calcium antagonist clevidipine in a closed-chest reperfusion porcine model. J Cardiovasc Pharmacol 2004;44:407-415
    • (2004) J Cardiovasc Pharmacol , vol.44 , pp. 407-415
    • Odenstedt, J.1    Mansson, C.2    Grip, L.3
  • 28
    • 0035005388 scopus 로고    scopus 로고
    • Short-acting calcium antagonist clevidipine protects against reperfusion injury via local nitric oxide-related mechanisms in the jeopardised myocardium
    • Gourine A, Gonon A, Sjoequist PO, et al. Short-acting calcium antagonist clevidipine protects against reperfusion injury via local nitric oxide-related mechanisms in the jeopardised myocardium. Cardiovasc Res 2001;51:100-107
    • (2001) Cardiovasc Res , vol.51 , pp. 100-107
    • Gourine, A.1    Gonon, A.2    Sjoequist, P.O.3
  • 29
    • 0034079587 scopus 로고    scopus 로고
    • Pharmacokinetics and arteriovenous differences in clevidipine concentration following a short- and a long-term intravenous infusion in healthy volunteers
    • Ericsson H, Bredburg U, Eriksson U, et al. Pharmacokinetics and arteriovenous differences in clevidipine concentration following a short- and a long-term intravenous infusion in healthy volunteers. Anesthesiology 2000;92:993-1001.
    • (2000) Anesthesiology , vol.92 , pp. 993-1001
    • Ericsson, H.1    Bredburg, U.2    Eriksson, U.3
  • 30
    • 0032979711 scopus 로고    scopus 로고
    • In vitro hydrolysis rate and protein binding of clevidipine, a new ultrashort-acting calcium antagonist metabolised by esterases, in different animal species and man
    • Ericsson H, Tholander B, Regardh CG. In vitro hydrolysis rate and protein binding of clevidipine, a new ultrashort-acting calcium antagonist metabolised by esterases, in different animal species and man. Eur J Pharm Sci 1999;8:29-37.
    • (1999) Eur J Pharm Sci , vol.8 , pp. 29-37
    • Ericsson, H.1    Tholander, B.2    Regardh, C.G.3
  • 31
    • 0032961372 scopus 로고    scopus 로고
    • Pharmacokinetics of new calcium channel antagonist clevidipine in the rat, rabbit, and dog and pharmacokinetic/pharmacodynamic relationship in anesthetized dogs
    • Ericsson H, Tholander B, Bjorkman JA, et al. Pharmacokinetics of new calcium channel antagonist clevidipine in the rat, rabbit, and dog and pharmacokinetic/pharmacodynamic relationship in anesthetized dogs. Drug Metab Dispos 1999;27: 558-564
    • (1999) Drug Metab Dispos , vol.27 , pp. 558-564
    • Ericsson, H.1    Tholander, B.2    Bjorkman, J.A.3
  • 32
    • 18344372737 scopus 로고    scopus 로고
    • Clevidipine in adult cardiac surgical patients, a dose-finding study
    • Bailey JM, Lu W, Levy JH, et al. Clevidipine in adult cardiac surgical patients, a dose-finding study. Anesthesiology 2002;96:1086-1094
    • (2002) Anesthesiology , vol.96 , pp. 1086-1094
    • Bailey, J.M.1    Lu, W.2    Levy, J.H.3
  • 33
    • 33645836309 scopus 로고    scopus 로고
    • Human cytochrome P450 induction and inhibition potential of clevidipine and its primary metabolite H152/81
    • Zhang JG, Dehal SS, Ho T, et al. Human cytochrome P450 induction and inhibition potential of clevidipine and its primary metabolite H152/81. Drug Metab Disp 2006;34:34:734-737
    • (2006) Drug Metab Disp , vol.34 , Issue.34 , pp. 734-737
    • Zhang, J.G.1    Dehal, S.S.2    Ho, T.3
  • 34
    • 49849098985 scopus 로고    scopus 로고
    • Treatment of acute postoperative hypertension in cardiac surgery patients: An efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial
    • Singla N, Warltier DC, Gandhi SD, et al. Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial. Anesth Analg 2008;107:59-67.
    • (2008) Anesth Analg , vol.107 , pp. 59-67
    • Singla, N.1    Warltier, D.C.2    Gandhi, S.D.3
  • 35
    • 53449096106 scopus 로고    scopus 로고
    • The ECLIPSE trials: Comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients
    • Aronson S, Dyke CM, Stierer KA, et al. The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients. Anesth Analg 2008;107:1110-1121
    • (2008) Anesth Analg , vol.107 , pp. 1110-1121
    • Aronson, S.1    Dyke, C.M.2    Stierer, K.A.3
  • 36
    • 60249101976 scopus 로고    scopus 로고
    • Clevidipine, an intravenous dihydropyridine calcium channel blocker, is safe and effective for the treatment of patients with acute severe hypertension
    • Pollack C, Varon J, Garrison N, et al. Clevidipine, an intravenous dihydropyridine calcium channel blocker, is safe and effective for the treatment of patients with acute severe hypertension. Ann Emerg Med 2009;53:329-338
    • (2009) Ann Emerg Med , vol.53 , pp. 329-338
    • Pollack, C.1    Varon, J.2    Garrison, N.3
  • 37
    • 0042364768 scopus 로고    scopus 로고
    • Comparison of clevidipine with sodium nitroprusside in the control of blood pressure after coronary artery surgery
    • Powroznyk AV, Vuylsteke A, Naughton C, et al. Comparison of clevidipine with sodium nitroprusside in the control of blood pressure after coronary artery surgery. Eur J Anaesthesiol 2003;20:697-703.
    • (2003) Eur J Anaesthesiol , vol.20 , pp. 697-703
    • Powroznyk, A.V.1    Vuylsteke, A.2    Naughton, C.3
  • 38
    • 77951760768 scopus 로고    scopus 로고
    • Available from Accessed September 24, 2008
    • U.S. Food and Drug Administration, Center for Drug Evaluation and Research. Application number NDA 022156. Summary review and medical review. Available from http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm? fuseaction=Search.Label-ApprovalHistory#apphist. Accessed September 24, 2008.
    • Application Number NDA 022156. Summary Review and Medical Review
  • 39
    • 26244449630 scopus 로고    scopus 로고
    • Propofol: The challenges of formulation
    • Baker MT, Naguib M. Propofol: the challenges of formulation. Anesthesiology 2005;103:860-876
    • (2005) Anesthesiology , vol.103 , pp. 860-876
    • Baker, M.T.1    Naguib, M.2
  • 40
    • 0029001266 scopus 로고
    • Postoperative infections traced to contamination of an intravenous anesthetic, propofol
    • Bennett SN, McNeil MM, Bland LA, et al. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med 1995;333:147-154
    • (1995) N Engl J Med , vol.333 , pp. 147-154
    • Bennett, S.N.1    McNeil, M.M.2    Bland, L.A.3
  • 41
    • 77951739927 scopus 로고    scopus 로고
    • U.S. National Institutes of Health Available from Accessed May 11, 2009
    • U.S. National Institutes of Health. ClinicalTrials.gov. Clevidipine. Available from www.clinicaltrials.gov. Accessed May 11, 2009.
    • Clevidipine


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.