Extracellular signal-regulated kinase (ERK) is involved in LPS-induced disturbances in intestinal motility

Neurogastroenterology and Motility

Volumn 23, Issue 2, 2011, Pages

  Gonzalo, S ^a   Grasa, L ^a   Arruebo, M P ^a   Plaza, M A ^a   Murillo, M D ^a  

^a UNIVERSIDAD DE ZARAGOZA   (Spain)

Author keywords

Cyclooxygenase 2; ERK MAPK; Free radicals; Gastrointestinal motility; Lipopolysaccharide

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ACETYLCHOLINE; ALDEHYDE; CYCLOOXYGENASE 2; LIPOPOLYSACCHARIDE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POTASSIUM CHLORIDE; PROSTAGLANDIN E2; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DUODENUM; DUODENUM MOTILITY; ELECTROSTIMULATION; ENZYME PHOSPHORYLATION; EXPERIMENTAL RABBIT; GANGLION; INTESTINE MOTILITY; LIPID PEROXIDATION; MALE; MYENTERIC PLEXUS; NEUROMUSCULAR FUNCTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION;

EID: 78651463153     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2010.01632.x     Document Type: Article

References (40)

1. Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 2004; 68: 320-44.
2. Cobb MH, Goldsmith EJ. How MAP kinases are regulated. J Biol Chem 1995; 270: 14843-6.
3. Scherle PA, Jones EA, Favata MF et al. Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes. J Immunol 1998; 161: 5681-6.
4. Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 2001; 13: 85-94.
5. Van der Bruggen T, Nijenhuis S, Van Raaij E, Verhoef J, Van Asbeck BS. Lipopolysaccharide-induced tumor necrosis factor alpha production by human monocytes involves the raf-1/MEK1-MEK2/ERK1-ERK2 pathway. Infect Immun 1999; 67: 3824-9.
6. Liu MK, Herrera-Velit P, Brownsey RW, Reiner NE. CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J Immunol 1994; 153: 2642-52.
7. Glauser MP, Zanetti G, Baumgartner JD, Cohen J. Septic shock: pathogenesis. Lancet 1991; 338: 732-6.
8. Eskandari MK, Kalff JC, Billiar TR, Lee KK, Bauer AJ. LPS-induced muscularis macrophage nitric oxide suppresses rat jejunal circular muscle activity. Am J Physiol 1999; 277: G478-86.
9. Rebollar E, Arruebo MP, Plaza MA, Murillo MD. Effect of lipopolysaccharide on rabbit small intestine muscle contractility in vitro: role of prostaglandins. Neurogastroenterol Motil 2002; 14: 633-42.
10. Gonzalo S, Grasa L, Arruebo MP, Plaza MA, Murillo MD. Inhibition of p38 MAPK improves intestinal disturbances and oxidative stress induced in a rabbit endotoxemia model. Neurogastroenterol Motil 2010; 22: 564-72, e123
11. 2+ sensitization in rat ileal longitudinal smooth muscle. Am J Physiol Gastrointest Liver Physiol 2007; 293: G699-710.
12. Grasa L, Arruebo MP, Plaza MA, Murillo MD. A downregulation of nNOS is associated to dysmotility evoked by lipopolysaccharide in rabbit duodenum. J Physiol Pharmacol 2008; 59: 511-24.
13. Amador P, Garcia-Herrera J, Marca MC et al. Intestinal D-galactose transport in an endotoxemia model in the rabbit. J Membr Biol 2007; 215: 125-33.
14. Grasa L, Arruebo MP, Plaza MA, Murillo MD. The role of tyrosine kinase in prostaglandin E2 and vanadate-evoked contractions in rabbit duodenum in vitro. J Physiol Pharmacol 2006; 57: 279-89.
15. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990; 186: 407-21.
16. Levine RL, Williams JA, Stadtman ER, Shacter E. Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol 1994; 233: 346-57.
17. Gonzalo S, Grasa L, Fagundes DS, Arruebo MP, Plaza MA, Murillo MD. JNK and ERK1/2 contribute to the alteration of intestinal contractility and oxidative stress status in rabbit endotoxemia. In: Sharkey K, Szurszewski J, Tack J, eds. Neurogastroenterology and Motility Joint International Meeting. Chicago, IL: Wiley-Blackwell, 2009; 25.
18. Duncan M, Mouihate A, Mackie K et al. Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats. Am J Physiol Gastrointest Liver Physiol 2008; 295: G78-87.
19. Park H, Calrk E, Cullen JJ, Conklin JL. Effect of endotoxin on opossum oesophageal motor function. Neurogastroenterol Motil 2000; 12: 215-21.
20. Cullen JJ, Park H, Ephgrave KS, Conklin JL. Lipopolysaccharide temporarily impairs sphincter of Oddi motility. Nitric Oxide 2001; 5: 547-54.
21. Weng TI, Chen WJ, Wu HY, Liu SH. Uropathogenic Escherichia coli alters muscle contractions in rat urinary bladder via a nitric oxide synthase-related signaling pathway. J Infect Dis 2006; 194: 1774-82.
22. Pons L, Droy-Lefaix MT, Braquet P, Bueno L. Role of free radicals and platelet-activating factor in the genesis of intestinal motor disturbances induced by Escherichia coli endotoxins in rats. Gastroenterology 1991; 100: 946-53.
23. De Winter BY, Van Nassauw L, De Man JG et al. Role of oxidative stress in the pathogenesis of septic ileus in mice. Neurogastroenterol Motil 2005; 17: 251-61.
24. Kim SH, Kim J, Sharma RP. Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression. Pharmacol Res 2004; 49: 433-39.
25. Ajizian SJ, English BK, Meals EA. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. J Infect Dis 1999; 179: 939-44.
26. Koide N, Ito H, Mu MM et al. Inhibition of extracellular signal-regulated kinase 1/2 augments nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells. FEMS Immunol Med Microbiol 2005; 45: 213-19.
27. Watters JJ, Sommer JA, Pfeiffer ZA, Prabhu U, Guerra AN, Bertics PJ. A differential role for the mitogen-activated protein kinases in lipopolysaccharide signaling: the MEK/ERK pathway is not essential for nitric oxide and interleukin 1beta production. J Biol Chem 2002; 277: 9077-87.
28. Cagnol S, Chambard JC. ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence. Febs J 2010; 277: 2-21.
29. Gonzalo S, Fagundes DS, Castro M et al. Inhibition of p38 MAPK improves altered intestinal contractility and ameliorates oxidative stress in rabbit endotoxemia. In: Sharkey K, Tack J, Szurszewski J, eds. Neurogastroenterology and Motility Joint International Meeting. Lucerne, Switzerland: Wiley-Blackwell, 2008; 66.
30. Nagano S, Otsuka T, Niiro H et al. Molecular mechanisms of lipopolysaccharide-induced cyclooxygenase-2 expression in human neutrophils: involvement of the mitogen-activated protein kinase pathway and regulation by anti-inflammatory cytokines. Int Immunol 2002; 14: 733-40.
31. Niiro H, Otsuka T, Ogami E et al. MAP kinase pathways as a route for regulatory mechanisms of IL-10 and IL-4 which inhibit COX-2 expression in human monocytes. Biochem Biophys Res Commun 1998; 250: 200-5.
32. Grishin AV, Wang J, Potoka DA et al. Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway. J Immunol 2006; 176: 580-8.
33. Ben-Shaul V, Sofer Y, Bergman M, Zurovsky Y, Grossman S. Lipopolysaccharide-induced oxidative stress in the liver: comparison between rat and rabbit. Shock 1999; 12: 288-93.
34. Cario E, Rosenberg IM, Brandwein SL, Beck PL, Reinecker HC, Podolsky DK. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors. J Immunol 2000; 164: 966-72.
35. Ruiz PA, Kim SC, Sartor RB, Haller D. 15-deoxy-delta12, 14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity. J Biol Chem 2004; 279: 36103-11.
36. Clark JA, Black AR, Leontieva OV et al. Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells. J Biol Chem 2004; 279: 9233-47.
37. Nasser Y, Fernandez E, Keenan CM et al. Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function. Am J Physiol Gastrointest Liver Physiol 2006; 291: G912-27.
38. Fu XB, Yang YH, Sun TZ, Chen W, Li JY, Sheng ZY. Rapid mitogen-activated protein kinase by basic fibroblast growth factor in rat intestine after ischemia/reperfusion injury. World J Gastroenterol 2003; 9: 1312-7.
39. McCubrey JA, Lahair MM, Franklin RA. Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal 2006; 8: 1775-89.
40. Fagundes DS, Gonzalo S, Arruebo MP, Plaza MA, Murillo MD. Melatonin and Trolox ameliorate duodenal LPS-induced disturbances and oxidative stress. Dig Liver Dis 2010; 42: 40-4.