Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert anti-inflammatory properties by modulating platelet aggregation and VEGF, COX-2 and VCAM gene expressions in rat hippocampal slices subjected to ischemic reperfusion injury.

International Journal of Applied Research in Natural Products

Volumn 2, Issue 1, 2009, Pages 19-26

  Rawal, A K ^a   Nath, D K ^a   Yadav, N ^a   Pande, S ^b   Meshram, S U ^b   Biswas, S K ^a  

^a Dr Ambedkar College   (India)

^b RTM NAGPUR UNIVERSITY   (India)

Author keywords

COX2; Fagonia cretica linn; Hippocampus; Inflammation; Ischemia; Platelet aggregation; Rubia cordifolia; Tinospora coridfolia; VCAM; VEGF

Indexed keywords

FAGONIA CRETICA; RATTUS; RUBIA CORDIFOLIA; TINOSPORA; TINOSPORA CORDIFOLIA;

EID: 78651436324     PISSN: None     EISSN: 19406223     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Abrams C, Shattil SJ. 1991. Immunological detection of activated platelets in clinical disorders, Thromb. Haemostasis 65, 467-473.
2. Blann A, Kumar P, Krupinski J, McCollum C, Beevers DG, Lip GY. 1999. Soluble intercellular adhesion molecule-1, E-selectin, vascular cell adhesion molecule-1 and von Willebrand factor in stroke, Blood Coagul. Fibrinolysis. 10, 277-284.
3. Bombeli TR, Barbara et al.. 1998. Adhesion of Activated Platelets to Endothelial Cells: Evidence for a GPIIbIIIa-dependent Bridging Mechanism and Novel Roles for Endothelial Intercellular Adhesion Molecule 1 (ICAM-1), αvβ3 Integrin, and GPIbα,. J. Exp. Med. 187, 329-339.
4. Chamorro A, Hallenbeck J. 2006. The harms and benefits of inflammatory and immune responses in vascular disease. Stroke. 37, 291-293.
5. Clark WM, Madden KP, Rothlein R, Zivin JA. 1991. Reduction of central nervous system ischemic injury by monoclonal antibody to intracellular adhesion molecule, J. Neurosurg. 75, 623-627.
6. Clemetson KJ, Clemetson JM. 2001. Platelet collagen receptors Thrombosis And Haemostasis. 86, 189-197.
7. Dore S, Otsuka T, Mito TT, Sugo N, Hand T, Wu L, Hurn PD, Traystman RJ, Andreasson K. 2003. Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction, Ann Neurol. 54,155-162.
8. 2. radicals during reperfusion after prolonged myocardial ischemia, Am J Physiol Heart Circ Physiol. 280, H2649-57
9. Fassbender K, Mossner R, Motsch L, Kischka U, Grau A, Hennerici M. 1995.Circulating selectin- and immunoglobulin-type adhesion molecules in acute ischemic stroke, Stroke. 269,1361-1364.
10. Frijns CJM, Kappelle LJ, Gijn J, Nieuwenhuis HK, Sixma JJ, Fijinheer R. 1997. Soluble adhesion molecules reflect endothelial cell activation in ischemic stroke and in carotid atherosclerosis, Stroke. 28, 2214-2218.
11. Frijns CJM, Kappelle LJ. 2002. Inflammatory Cell Adhesion Molecules in Ischemic Cerebrovascular Disease, Stroke. 33, 2115-2122.
12. Gearing AJH, Hemingway I, Pigott R, Hughes J, Ross AJ, Cashman SJ. 1992. Soluble form of vascular adhesion molecules, E-selectin, ICAM-1, and VCAM-1: pathological significance, Ann. New York Acad. Sci. 667, 324-331.
13. Gumina RJ, Newman PJ, Kenny D, Warltier DC, Gross CJ. 1997. The leukocyte cell adhesion cascade and its role in myocardial ischemia-reperfusion injury, Basic Res Cardiol. 92, 201-13.
14. Hamberg MJ, Svensson J, Samuelsson B. 1975. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides, Proc. Natl. Acad. Sci. USA. 72, 2994-2998.
15. Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S, Ross SE. 2001. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice, Proc Natl Acad Sci USA. 98, 1294-1299.
16. Inoue H, Nanayama T, Hara S, Yokoyama C, Tanabe T. 1994. The cyclic AMP response element plays an essential role in the expression of the human prostaglandin-endoperoxide synthase 2 gene in differentiated U937 monocytic cells, FEBS Letters. 350, 51-54.
17. Ishizuka T, Kawakami M, Hidaka T, Matsuki Y, Takamizawa M, Suzuki K, Kurita A, Nakamura H. 1998. Stimulation with thromboxane A2 (TXA2) receptor agonist enhances ICAM-1, VCAM-1 or ELAM-1 expression by human vascular endothelial cells, Clin. Exp. Immunol. 112, 464-470.
18. Keck PJ et al. 1989. Vascular permeability factor, an endothelial cell mitogen related to PDGF, Science. 246, 1309-1312.
19. Kochanek PM, Hallenbeck JM. 1992. Polymorph nuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke, Stroke. 23, 1367-1379.
20. Kovàcs Z, Ikezaki K, Samoto K, Inamura T, Fukui M. 1996. VEGF and flt: expression time kinetics in rat brain infarct, Stroke. 27, 1865-1873.
21. Kraemer SA, Meade EA, DeWitt DL. 1992. Prostaglandin endoperoxide synthase gene structure: identification of the transcriptional start site and 5'-flanking regulatory sequences, Arch Biochem Biophys. 293, 391-400.
22. Kramer RM, Roberts EF, Strifler BA, Johnstone EM. 1995. Thrombin induces activation of p38 MAP kinase in human platelets, J. Biol. Chem. 270, 27395-27398.
23. Krum JM, Mani N, Rosenstein JM. 2002. Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain, Neuroscience. 110, 589-604.
24. Lancet. 1995. Multicentre Acute Stroke Trial-Italy Group (MAST-I). Randomized controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke [see comment]. 346,1509-1514.
25. Lancet. 1997a. International Stroke Trial Collaborative Group (IST). A randomized trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke.. 349,1569-1581.
26. Lancet. 1997b. Chinese Acute Stroke Trial Collaborative Group (CAST). Randomized placebo-controlled trial of early aspirin use in 20,000 patients with acute ischemic stroke. 349,1641-1649.
27. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. 1989. Vascular endothelial growth factor is a secreted angiogenic mitogen, Science. 246,1306-1309.
28. Li N, Hu H, Lindquist M, et al. 2000. Platelet-Leukocyte Cross Talk in Whole Blood, Arteriosclerosis, Thrombosis, and Vascular Biology. 20, 2702-2708.
29. Lipton P. 1999. Ischemic cell death in cerebral neurons. Am. J Physio. 79,1432- 1568.
30. Manabe Y, Anrather J, Kawano T, Niwa K, Zhou P, Ross ME, Iadecola C. 2004. Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity, Ann Neurol. 55, 668-675.
31. Marcus AJ. 1999. Platelets: their role in hemostasis, thrombosis, and inflammation. In Inflammation. Basic Principles and Clinical Correlates. Gallin GI and. Synderman R, eds. Lippincott, Philadelphia. Pg- 77.
32. Marti HJH, Bernaudin M, Bellail A et al. 2002. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia, Am J Pathol. 156, 965-976.
33. Nogawa SF, Zhang ME, Iadecola C. 1997. Cyclooxygenase-2 gene expression in neurons contributes to ischemic brain damage, J. Neurosci. 17, 2746-2755.
34. Ogunshola OO et al. 2000. Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain, Brain Res. Dev. Brain Res. 119, 139-153.
35. Perkins DJ, Kniss DA. 1997. Tumor necrosis factor-alpha promotes sustained cyclooxygenase-2 expression: attenuation by dexamethasone and NSAIDs, Prostaglandins. 54, 727-43.
36. Pichiule P, Agani F, Chavez JC, Xu K, LaManna JC. 2003. HIF-1 alpha and VEGF expression after transient global cerebral ischemia, Adv Exp Med Biol. 530, 611-617.
37. Qing W, Xian NT, Midori AY. 2007. The Inflammatory response in Stroke, J Neuroimmunol. 184, 53-68.
38. Rabb H, Martin JG. 1997. An emerging paradigm shift on the role of leukocyte adhesion molecules. J Clin Invest. 100, 2937-2938.
39. Rawal AK, Muddeshwar MG, Biswas SK. 2004. Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen glucose deprivation, BMC Complement Altern Med. 4, 11-19.
40. Rawal AK, Nath DK, Biswas SK. 2008. Plausible mechanism of antioxidant action of Fagonia cretica linn, Rubia cordifolia and Tinospora cordifolia during ischemic reperfusion injury in rat hippocampus, Int J of Applied Res in Natural Products. 1,16-25.
41. Raychowdhury MK, Yukawa M, Collins LJ, McGrail SH, Kent KC, Ware JA. 1994. Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor, J. Biol. Chem. 269, 19256-19261.
42. Rosenblum WI, Nelson GH, Wormley B, Werner P, Wang J, Shih CCY. 1996. Role of platelet-endothelial cell adhesion molecule (PECAM) in platelet adhesion/aggregation over injured but not denuded endothelium in vivo and ex vivo, Stroke. 27, 709-711.
43. Rosenstein JM, Mani N, Silverman WF, Krum JM. 1998. Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo, Proc. Natl. Acad. Sci. USA. 95, 7086-7091.
44. Ruggeri ZM. 1997. von Willerbrand factor, J. Clin. Invest. 99, 559-564.
45. Saklatvala J, Rawlinson L, Waller RJ, Sarsfield S, Lee JC, Morton LF, Barnes MJ, Farndale RW. 1996. Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue, J. Biol. Chem. 271, 6586-6589.
46. Samson Y, Lapergue B, Hosseini H. 2005. Inflammation and ischaemic stroke: current status and future perspectives, Rev Neurol (Paris). 1611177-1182.
47. Sanchez-Moreno C, Dashe JF, Scott T, Thaler D, Folstein MF, Martin A. 2004.Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke, Stroke. 35,163-168.
48. Schoch HJ, Fischer S, Marti HJH. 2002. Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain, Brain. 125, 2549-2557.
49. Schwab JM, Beschorner R, Meyermann R, Gozalan F, Schluesener HJ. 2002. Persistent accumulation of cyclooxygenase-1-expressing microglial cells and macrophages and transient upregulation by endothelium in human brain injury, J Neurosurg. 96, 892-899.
50. Shweiki D, Itin A, Soffer D, Keshet E. 1992. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis, Nature. 359, 843-845.
51. Siess W. 1989 Molecular mechanisms of platelet activation, Physiol. Rev. 69, 58-178.
52. Taylor CP, Weber ML. 1993. Effect of temperature on synaptic function after reduced oxygen and glucose in hippocampal slices, Neuroscience. 52, 555-562.
53. Verstraete M. 1991. Risk factors, interventions and therapeutic agents in the prevention of atherosclerosis-related ischaemic diseases, Drugs. 42, 22-38.
54. Wick A, Wick W, Waltenberger J, Weller M, Dichgans J, Schulz JB. 2002. Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt, J Neurosci. 22, 6401-6407.
55. Yang ZJ, Bao WL, Qiu MH, Zhang LM, Lu SD, Huang YL, Sun FY. 2002. Role of vascular endothelial growth factor in neuronal DNA damage and repair in rat brain following a transient cerebral ischemia, J Neurosci Res. 70, 140-149.
56. Zhang RL, Chopp M, Jiang N. 1995. Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat, Stroke. 26, 1438-1443.
57. Zuker MB. 1980. The functioning of blood platelets, Sci. Am. 242, 86-103.