Plausible mechanism of antioxidant action of fagonia cretica linn, rubia cordifolia and tinospora cordifolia during ischemic reperfusion injury in rat hippocampus

International Journal of Applied Research in Natural Products

Volumn 1, Issue 2, 2008, Pages 16-25

  Rawal, A K ^a   Nath, D K ^a   Biswas, S K ^a  

^a Dr Ambedkar College   (India)

Author keywords

Antioxidants; Free radicals; Ischemic reperfusion injury; Stroke

Indexed keywords

EID: 80055026776     PISSN: None     EISSN: 19406223     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Albers GW, Atkinson RP, Kelley R, Roseabaum MD. 1995. Safety tolerability and pharmacokinetics of the NMDA antagonist dextrorphan in patients with acute stroke. Stroke. 26, 254-258.
2. Baker K, Marcus, CB, Huffman K, Kruk H, Malfroy B, Doctrow SR. 1998. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J Pharmacol. Exp. Ther. 284, 215- 221.
3. Beal MF. 1997. Oxidative damage in neurodegenerative diseases. Neuroscientist 3, 327-333.
4. Beckman JS, Ischiropolous H, Zhu L, Woerd M, Smith C, Chen J, Harrison J, Martin JC, Tsai M. 1992. Kinetics of superoxide dismutase and iron catalysed nitration of phenolics by peroxynitrite. Arch. Biochem. Biophys., 298, 438- 445.
5. Beyer WF, Jr. Fridovich I, Mullenbach GT, Halliwell RJ. 1987. Examination of the role of arginine-143 in the human copper and zinc superoxide dismutase by site-specific mutagenesis. J.Biol Chem. 262, 11182-11187.
6. Bhavmishra.1929. Sarth Bhavaprakasha., Raghuwanshi Prakashan.
7. Bishayi B, Roychowdhury S, Ghosh S, Sengupta M. 2002. Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats. J Toxicol. Sci. 27, 139-46.
8. Chan PH. 1996. Role of oxidants in ischemic brain damage. Stroke 27, 1124-1129.
9. Chan PH. 2001. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab. 21, 2-14.
10. Crack PJ, Taylor JM, de Haan JB, Kola I, Hertzog P, Iannello R C. 2003. Glutathione peroxidase-1 contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic mouse in response to ischemia/reperfusion injury. J Cereb. Blood Flow Metab. 23, 19-22.
11. Ebadi M, Srinivasan SK, Baxi MD. 1996. Oxidative stress and antioxidant therapy in Parkinson's disease. Prog. Neurobiol. 48, 1-19.
12. Edwards K. 1997. Crestat in the treatment of acute ischemic stroke: results of phase II trials. Neurology 46, A-424.
13. Eliasson MJL, Huang Z, Ferrante RJ, Sasamata M, Molliver ME, Snyder SH, Moskowitz MA. 1999. Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage. J Neurosci.19, 5910-5918.
14. Eskandari M, et al. 1999. Am. J. Physiol. 277, G478.
15. Ernster L, Nordenbrand K. 1967. Methods in Enzymology: X, 574 Academic Press, New York.
16. Gilani AH, Janbaz KH, Zaman M, Lateet A, Suria, A, Ahmed HR.1994. Possible presence of calcium channel blocker(s) in Rubia cordifolia: an indigenous medicinal plant. J of Pak Med Assoc. 44, 182-185.
17. Goel HC, Prem Kumar I, Rana SV. 2002. Free radical scavenging and metal chelation by Tinospora cordifolia, a possible role in radioprotection. Indian J Exp. Biol. 40, 727-734.
18. Green LC, Wagner DA, Glogowaski J, Skipper PL, Wishnok JS, Tannenbum SR. 1982. Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Analytical Biochemistry 126, 131-138.
19. Haley EC. 1998. A randomized trial of tirilazad mesylate in patients with acute stroke: High dose tirilazad for acute stroke. Stroke. 29, 112-118.
20. Ischiropoulos H, Zhu L, Smith C, Chen J, Martin JC, Tsai M, Beckman JS. 1992. Peroxynitrite Mediated tyrosine nitration catalyzed by superoxide dismutase. Arch. Biochem. Biophys. 298, 431-437.
21. Kasture SB, Kasture VS, Chopde CT. 2001. Anti-inflammatory activity of Rubia cordifolia roots. J of Natural Remedies. 1, 111-115.
22. Kuroda S, Siesjo BK. 1996. Postischemic administration of FK506 reduces infarct volume following transient focal brain ischemia. Neurosci. Res. Commun. 19, 83-90.
23. Lipton P. 1999. Ischemic cell death in cerebral neurons. Am. J Physiol. 79, 1432-1568.
24. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J.Biol.Chem.193, 265.275.
25. Maslova GT, Boboriko TL.1990. Effect of antioxidants on the status of the antioxidative system in cerebral ischemia and reperfusion injury. Ukr. Biokhim. Zh. 62, 101-105.
26. Pandey S, Sharma M, Chaturvedi P, Tripathi YB. 1994. Protective effect of Rubia cordifolia on lipid peroxide formation in isolated rat liver homogenate. Indian J of Exp. Biol. 32, 180-183.
27. Pick ED, Mizel D. 1981. Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader. J. Immunol. Meth. 46, 211-226.
28. Rawal AK, Muddeshwar MG, Biswas SK. 2004a. Effect of Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia on nitric oxide, peroxynitrite and lipid peroxidation during oxygen glucose deprivation in rat hippocampal slices. BMC Alternative and Complementary Medicine. 4, 11.
29. Rawal, A. K., Muddeshwar, M. G. and Biswas, S. K. 2004b. Effect of Rubia cordifolia, Fagonia cretica linn and Tinospora cordifolia on free radical generation and lipid peroxidation during oxygen glucose deprivation in rat hippocampal slices. Biochem. Biophys. Res. Comm. 324(2), 588-596.
30. Sarchielli P, Galli F, Floridi AR, Floridi AL, V Gallai V. 2003. Relevance of protein nitration in brain injury: a key pathophysiological mechanism in neurodegenerative, autoimmune, or inflammatory CNS diseases and stroke. Amino Acids. Springer-Verlag, Wien.
31. Siesjo BK, Zhao Q, Pahlmark K, Sisejo P., Katsura KI, Folbergova J. 1995. Glutamate, calcium and free radicals as mediators of ischemic brain damage. Ann. Thorac. Surg. 59, 1316-1320.
32. Sheng H, Batinc-Haberle I. and Warner DS. 2002. Catalytic Antioxidants as Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury. Drug News Perspect. 15, 654-665.
33. Subramanian M, Chintalwar GJ, Chattopadhyay S. 2002. Antioxidant properties of a Tinospora cordifolia polysaccharide against iron-mediated lipid damage and gamma-ray induced protein damage. Redox Rep. 7, 137-143.
34. Stanel Mainzen PP, Menon VP. 2001. Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats., Phytother Res. 15, 213-218.
35. Taylor CP, Weber ML. 1993. Effect of temperature on synaptic function after reduced oxygen and glucose in hippocampal slices., Neuroscience. 52, 555-562.
36. Teitz F. 1969-. Enzymic method for quantitative determination of nanogram amounts of total and oxidised glutathione: Applications to mammalian blood and other tissues. Anal.Biochem. 27, 502-522.
37. Tezuka Y, Irikawa S, Kaneko T, Banskota AH, Nagaoka T, Xiong Q, Hase K, Kadota S. 2001. Screening of Chinese herbal drug extract for inhibitory activity on nitric oxide production and identification of an active compound of Zanthoxylum bungeanum. J Ethnopharmacology. 77, 209-217.
38. Tripathi YB, Sharma M, Manickam M. 1997. Rubiadin, a new antioxidant from Rubia cordifolia. Indian J. Biochem. Biophys.34, 302-306.
39. Turnbull CM, McClure D, Rossi AD, Megson IL. 2006. A novel electron paramagnetic resonance-based assay for prostaglandin H synthase-1 activity. J Inflamm (Lond). 3, 12.