Determining cell fate transition probabilities to VEGF/Ang 1 levels: Relating computational modeling to microfluidic angiogenesis studies

Cellular and Molecular Bioengineering

Volumn 3, Issue 4, 2010, Pages 345-360

  Das, Anusuya ^a   Lauffenburger, Doug ^a   Asada, Harry ^a   Kamm, Roger ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Angiogenesis; Capillary characteristics; Microfluidics

Indexed keywords

ANGIOPOIETIN 1; THROMBOCYTE FACTOR 4; VASCULOTROPIN;

ANGIOGENESIS; CELL FATE; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; CONTROLLED STUDY; DECISION TREE; HUMAN; HUMAN CELL; IN VITRO STUDY; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MICROENVIRONMENT; MICROFLUIDIC ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROCESS MODEL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SPROUT; THREE DIMENSIONAL IMAGING;

EID: 78651391837     PISSN: 18655025     EISSN: 18655033     Source Type: Journal    
DOI: 10.1007/s12195-010-0146-7     Document Type: Conference Paper

References (40)

1. Adams, R. H., and K. Alitalo. Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 8:464-478, 2007.
2. Bogdanovic, E., V. Nguyen, and D. J. Dumont. Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization. J. Cell Sci. 119:3551-3560, 2006.
3. Brekken, R. A., and P. E. Thorpe. Vascular endothelial growth factor and vascular targeting of solid tumors. Anticancer Res. 21 (6 B): 4221-4229, 2001.
4. Cebe Suarez, S., M. Pieren, L. Cariolato, S. Arn, U. Hoffmann, A. Bogucki, C. Manlius, J. Wood, and K. Ballmer-Hofer. A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2. Cell. Mol. Life Sci. 63(17):2067-2077, 2006.
5. Chung, B., L. Flanagan, S. Rhee, P. Schwarz, A. Lee, E. Monuki, and N. Jeon. Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab. Chip. 5(4):401-406, 2005.
6. Chung, S., R. Sudo, P. J. Mack, C. R. Wan, V. Vickerman, and R. D. Kamm. Cell migration into scaffolds under co-culture conditions in a microfluidic platform. Lab. Chip. 9(2):269-275, 2009.
7. Das, A., H. Asada, D. Lauffenburger, and R. D. Kamm. A hybrid continuum-discrete modelling approach to predict and control angiogenesis: analysis of combinatorial growth factor and matrix effects on vessel-sprouting morphology. Philos. Trans. A Math. Phys. Eng. Sci. 368(1921):2937-2960, 2010.
8. Davis, S., T. H. Aldrich, P. F. Jones, A. Acheson, D. L. Compton, V. Jain, T. E. Ryan, J. Bruno, C. Radziejewski, P. C. Maisonpierre, and G. D. Yancopoulos. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87(7):1161-1169, 1996.
9. Folkman, J., and Y. Shing. Angiogenesis. J. Biol. Chem. 267(16):10931-10934, 1992.
10. Frisk, T., S. Rydholm, T. Liebmann, H. Svahn, G. Stemme, and H. Brismar. A microfluidic device for parallel 3-D cell cultures in asymmetric environments. Electrophoresis 28:4705-4712, 2007.
11. Garcia-Cardeña, G., J. Comander, K. R. Anderson, B. R. Blackman, and M. A. Gimbrone. Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc. Natl Acad. Sci. U. S. A. 98:4478-4485, 2001.
12. Gavard, J., V. Patel, and J. S. Gutkind. Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev. Cell 14:25-36, 2008.
13. Gengrinovitch, S., S. M. Greenberg, T. Cohen, et al. Platelet factor-4 inhibits the mitogenic activity of VEGF121 and VEGF165 using several concurrent mechanisms. J. Biol. Chem. 270:15059-15065, 1995.
14. Gomez-Sjoberg, R., A. Leyrat, D. Pirone, C. Chen, and S. Quake. Versatile, fully automated, microfluidic cell culture system. Anal Chem. 79:8557-8563, 2007.
15. Gu, W., X. Zhu, N. Futai, B. Cho, and S. Takayama. Computerized microfluidic cell culture using elastomeric channels and Braille displays. Proc. Natl Acad. Sci. U. S. A. 101(45):15861-15866, 2004.
16. Hayes, A. J., W. Q. Huang, J. Mallah, D. Yang, M. E. Lippman, and L. Y. Li. Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells. Microvasc. Res. 58(3):224-237, 1999.
17. Helm, C. L., M. E. Fleury, A. H. Zisch, F. Boschetti, and M. A. Swartz. Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism. Proc. Natl Acad. Sci. U. S. A. 102(44):15779-15784, 2005.
18. Hernández Vera, R., E. Genové, L. Alvarez, S. Borrós, R. Kamm, D. Lauffenburger, and C. E. Semino. Interstitial fluid flow intensity modulates endothelial sprouting in restricted Src-activated cell clusters during capillary morphogenesis. Tissue Eng. Part A 15(1):175-185, 2009.
19. Hua, F., S. Hautaniemi, R. Yokoo, D. A. Lauffenburger. Integrated mechanistic and data-driven modelling for multivariate analysis of signaling pathways. J. R. Soc. Interface 3(9):515-526, 2006.
20. Huang, S., and D. Ingber. Shape-dependent control of cell growth, differentiation, apoptosis: switching between attractors in cell regulatory networks. Exp. Cell Res. 261:91-103, 2000.
21. Jeon, N. L., H. Baskaran, S. K. W. Dertinger, G. M. Whitesides, L. Van de Water, and M. Toner. Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nat. Biotechnol. 20(8):826-830, 2002.
22. Jones, M. K., M. Tomikawa, B. Mohajer, and A. S. Tarnawski. Gastrointestinal mucosal regeneration: role of growth factors. Front Biosci. 15(4):D303-D309, 1999.
23. Jośko, J., B. Gwóźdź, H. Jedrzejowska- Szypuka, and S. Hendryk. Vascular endothelial growth factor (VEGF) and its effect on angiogenesis. Med. Sci. Monit. 6(5):1047-1052, 2000.
24. Koblizek, T. I., C. Weiss, G. D. Yancopoulos, U. Deutsch, and W. Risau. Angiopoietin-1 induces sprouting angiogenesis in vitro. Curr. Biol. 8(9):529-532, 1998.
25. Kothapalli, C. R., S. de Valence, J. E. Van Veen, S. Chung, F. B. Gertler, and R. D. Kamm. A high-throughput microfluidic assay to study axonal response to growth factor gradients. Lab. Chip. (in review).
26. Kwak, H. J., J. N. So, S. J. Lee, I. Kim, and G. Y. Koh. Angiopoietin-1 is an apoptosis survival factor for endothelial cells. FEBS Lett. 448 (2-3): 249-253, 1999.
27. Li, X., M. Stankovic, C. S. Bonder, et al. Basal and angiopoietin-1- mediated endothelial permeability is regulated by sphingosine kinase-1. Blood 111:3489-3497, 2008.
28. Maione, T. E., G. S. Gray, and J. Petro. Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. Science 247:77-79, 1990.
29. Nakatsu, M., C. A. R. Sainson, J. N. Aoto, K. L. Taylor, M. Aitkenhead, S. Pérez-del-Pulgar, P. M. Carpenter, and C. C. W. Hughesa. Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvasc. Res. 66:102-112, 2003.
30. Saadi, W., S. Rhee, F. Lin, B. Vahidi, B. Chung, and N. Jeon. Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber. Biomed. Microdevices 9(5):627-635, 2007.
31. Slungaard, A. Platelet factor 4: a chemokine enigma. Int. J. Biochem. Cell Biol. 37(6):1162-1167, 2005.
32. Sudo, R., S. Chung, I. K. Zervantonakis, V. Vickerman, Y. Toshimitsu, L. G. Griffith, and R. D. Kamm. Transport-mediated angiogenesis in 3D epithelial coculture. FASEB J. 23(7):2155-2164, 2009.
33. Teichert-Kuliszewska, K., P. C. Maisonpierre, N. Jones, A. I. Campbell, Z. Master, M. P. Bendeck, K. Alitalo, D. J. Dumont, G. D. Yancopoulos, and D. J. Stewart. Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2. Cardiovasc. Res. 49(3):659-670, 2001.
34. Thomas, M., and H. G. Augustin. The role of the Angiopoietins in vascular morphogenesis. Angiogenesis 12(2):125-37, 2009. Epub 2009 May 16.
35. Tourovskaia, A., X. Figueroa-Masot, and A. Folch. Differentiation-on-a- chip: a microfluidic platform for long-term cell culture studies. Lab Chip. 5(1):14-19, 2005.
36. Vickerman, V., J. Blundo, S. Chung, and R. Kamm. Design, fabrication and implementation of a novel multiparameter control microfluidic platform for three-dimensional cell culture and real-time imaging. Lab. Chip. 8(9):1468-1477, 2008.
37. von Hundelshausen, P., F. Petersen, and E. Brandt. Platelet-derived chemokines in vascular biology. Thromb. Haemost. 97:704-713, 2007.
38. Witzenbichler, B., P. C. Maisonpierre, P. Jones, G. D. Yancopoulos, and J. M. Isner. Chemotactic properties of angiopoietin-1 and-2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. J. Biol. Chem. 273(29):18514-18521, 1998.
39. Yamamura, N., R. Sudo, M. Ikeda, and K. Tanishita. Effects of the mechanical properties of collagen gel on the in vitro formation of microvessel networks by endothelial cells. Tissue Eng. 13(7):1443-1453, 2007.
40. Zhu, W. H., A. MacIntyre, and R. F. Nicosia. Regulation of angiogenesis by vascular endothelial growth factor and angiopoietin-1 in the rat aorta model: distinct temporal patterns of intracellular signaling correlate with induction of angiogenic sprouting. Am. J. Pathol. 161(3):823-830, 2002.