Anti-invasive activities of anthocyanins through modulation of tight junctions and suppression of matrix metalloproteinase activities in HCT-116 human colon carcinoma cells

Oncology Reports

Volumn 25, Issue 2, 2011, Pages 567-572

  Shin, Dong Yeok ^a,c   Lu, Jing Nan ^d   Kim, Gi Young ^e   Jung, Jin Myung ^d   Kang, Ho Sung ^c   Lee, Won Sup ^d   Choi, Yung Hyun ^a,b,f  

^a Research Institute of Oriental Medicine   (South Korea)

^b Dong Eui University   (South Korea)

^c Pusan National University   (South Korea)

^d Gyeongsang National University School of Medicine   (South Korea)

^e Jeju National University   (South Korea)

^f Dong Eui University   (South Korea)

Author keywords

Anthocyanins; Claudins; Invasion; Matrix metalloproteinases; Tight junctions

Indexed keywords

ANTHOCYANIN; CLAUDIN; GELATINASE A; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ARTICLE; CANCER INVASION; CARCINOMA CELL; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; COLON CARCINOMA; CONCENTRATION RESPONSE; DOWN REGULATION; DRUG MECHANISM; ELECTRIC RESISTANCE; ENZYME INACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIGHT JUNCTION;

ANTHOCYANINS; ANTINEOPLASTIC AGENTS; CARCINOMA; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ELECTRIC IMPEDANCE; HCT116 CELLS; HUMANS; MATRIX METALLOPROTEINASES; NEOPLASM INVASIVENESS; PLANT EXTRACTS; TIGHT JUNCTIONS; VITIS;

EID: 78651378616     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2010.1104     Document Type: Article

References (27)

1. Schneeberger EE and Lynch RD: The tight junction: a multifunctional complex. Am J Physiol Cell Physiol 286: C1213-C1228, 2004.
2. Soler AP, Miller RD, Laughlin KV, Carp NZ, Klurfeld DM and Mullin JM: Increased tight junctional permeability is associated with the development of colon cancer. Carcinogenesis 20: 1425-1431, 1999.
3. Ruffer C and Gerke V: The C-terminal cytoplasmic tail of claudins 1 and 5 but not its PDZ-binding motif is required for apical localization at epithelial and endothelial tight junctions. Eur J Cell Biol 83: 135-144, 2004. (Pubitemid 39010858)
4. Mees ST, Mennigen R, Spieker T, Rijcken E, Senninger N, Haier J and Bruewer M: Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin-1, claudin-3, claudin-4 and beta-catenin. Int J Colorectal Dis 24: 361-368, 2009.
5. Morin PJ: Claudin proteins in human cancer: promising new targets for diagnosis and therapy. Cancer Res 65: 9603-9606, 2005.
6. Rangel LB, Agarwal R, D'Souza T, Pizer ES, Alo PL, Lancaster WD, Gregoire L, Schwartz DR, Cho KR and Morin PJ: Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. Clin Cancer Res 9: 2567-2575, 2003. (Pubitemid 36842098)
7. Agarwal R, D'Souza T and Morin PJ: Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity. Cancer Res 65: 7378-7385, 2005. (Pubitemid 41161271)
8. Roeb E, Dietrich CG, Winograd R, Arndt M, Breuer B, Fass J, Schumpelick V and Matern S: Activity and cellular origin of gelatinases in patients with colon and rectal carcinoma differential activity of matrix metalloproteinase-9. Cancer 92: 2680-2691, 2001. (Pubitemid 33049453)
9. Sundov Z, Tomic S, Vilovic K, Kunac N, Kalebic M and Bezic J: Immunohistochemically detected high expression of matrix metalloproteinase-2 as predictor of poor prognosis in Dukes' B colon cancer. Croat Med J 49: 636-642, 2008.
10. Ding M, Feng R, Wang SY, Bowman L, Lu Y, Qian Y, Castranova V, Jiang BH and Shi X: Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. J Biol Chem 281: 17359-17368, 2006. (Pubitemid 43909544)
11. Syed DN, Afaq F, Sarfaraz S, Khan N, Kedlaya R, Setaluri V and Mukhtar H: Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation. Toxicol Appl Pharmacol 231: 52-60, 2008.
12. Favot L, Martin S, Keravis T, Andriantsitohaina R and Lugnier C: Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis. Cardiovasc Res 59: 479-487, 2003. (Pubitemid 37272042)
13. Yun JW, Lee WS, Kim MJ, Lu JN, Kang MH, Kim HG, Kim DC, Choi EJ, Choi JY, Lee YK, Ryu CH, Kim G, Choi YH, Park OJ and Shin SC: Characterization of a profile of the anthocyanins isolated from Vitis coignetiae Pulliat and their anti-invasive activity on HT-29 human colon cancer cells. Food Chem Toxicol 48: 903-909, 2010.
14. Lee EJ, Choi EM, Kim SR, Park JH, Kim H, Ha KS, Kim YM, Kim SS, Choe M, Kim JI and Han JA: Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. Exp Mol Med 39: 469-476, 2007. (Pubitemid 47443860)
15. Choi YH, Choi WY, Hong SH, Kim SO, Kim GY, Lee WH and Yoo YH: Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells. Chem Biol Interact 179: 185-191, 2009.
16. Lee YR, Noh EM, Jeong EY, Yun SK, Jeong YJ, Kim JH, Kwon KB, Kim BS, Lee SH, Park CS and Kim JS: Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-kappaB pathway in human dermal fibroblasts. Exp Mol Med 41: 548-554, 2009.
17. Cereijido M, Robbins ES, Dolan WJ, Rotunno CA and Sabatini DD: Polarized monolayers formed by epithelial cells on a permeable and translucent support. J Cell Biol 77: 853-880, 1978. (Pubitemid 8347746)
18. Kominsky SL: Claudins: emerging targets for cancer therapy. Expert Rev Mol Med 8: 1-11, 2006. (Pubitemid 44184255)
19. Shin DY, Lee WS, Lu JN, Kang MH, Ryu CH, Kim GY, Kang HS, Shin SC and Choi YH: Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK. Int J Oncol 35: 1499-1504, 2009.
20. Bogenrieder T and Herlyn M: Axis of evil: molecular mechanisms of cancer metastasis. Oncogene 22: 6524-6536, 2003. (Pubitemid 37372332)
21. Davies B, Waxman J, Wasan H, Abel P, Williams G, Krausz T, Neal D, Thomas D, Hanby A and Balkwill F: Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion. Cancer Res 53: 5365-5369, 1993. (Pubitemid 23342150)
22. Garbisa S, Scagliotti G, Masiero L, Di Francesco C, Caenazzo C, Onisto M, Micela M, Stetler-Stevenson WG and Liotta LA: Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy. Cancer Res 52: 4548-4549, 1992.
23. Vihinen P and Kahari VM: Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. Int J Cancer 99: 157-166, 2002. (Pubitemid 34309470)
24. Chen PN, Chu SC, Chiou HL, Kuo WH, Chiang CL and Hsieh YS: Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer Lett 235: 248-259, 2006.
25. Chen PN, Kuo WH, Chiang CL, Chiou HL, Hsieh YS and Chu SC: Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. Chem Biol Interact 163: 218-229, 2006.
26. Chu KC, Tarone RE, Chow WH, Hankey BF and Ries LA: Temporal patterns in colorectal cancer incidence, survival, and mortality from 1950 through 1990. J Natl Cancer Inst 86: 997-1006, 1994.
27. Kim HJ, Tsoy I, Park JM, Chung JI, Shin SC and Chang KC: Anthocyanins from soybean seed coat inhibit the expression of TNF-alpha-induced genes associated with ischemia/reperfusion in endothelial cell by NF-kappaB-dependent pathway and reduce rat myocardial damages incurred by ischemia and reperfusion in vivo. FEBS Lett 580: 1391-1397, 2006. (Pubitemid 43222006)