Recruitment of mycobacterium tuberculosis specific CD4+ T cells to the site of infection for diagnosis of active tuberculosis

Journal of Internal Medicine

Volumn 265, Issue 1, 2009, Pages 163-168

  Nemeth, J ^a,b   Winkler, H M ^b   Zwick, R H ^c   Rumetshofer, R ^c   Schenk, P ^a   Burghuber, O C ^c   Graninger, W ^a   Ramharter, M ^a   Winkler, S ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c OTTO WAGNER HOSPITAL   (Austria)

Author keywords

ESAT 6; IFN ; T cell; Tuberculosis

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FEMALE; HUMAN; HUMAN CELL; LUNG LAVAGE; MALE; MYCOBACTERIUM TUBERCULOSIS; PATIENT ASSESSMENT; PLEURA FLUID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUBERCULOSIS;

ACUTE DISEASE; ADOLESCENT; ADULT; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNITY, CELLULAR; INTERFERON-GAMMA; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; SENSITIVITY AND SPECIFICITY; TUBERCULOSIS; YOUNG ADULT;

EID: 57449083601     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2008.02012.x     Document Type: Article

References (12)

1. World Health Organization (WHO). Tuberculosis facts 2007. Available at http://www.who.int/tb/en/, accessed 18 August 2008.
2. Light RW. Pleural effusion. N Engl J Med 2002 346 : 1971.
3. Thwaites GE, Tran TH. Tuberculous meningitis: many questions, too few answers. Lancet Neurol 2005 4 : 160 70.
4. Barnes PF, Mistry SD, Cooper CL et al. Compartmentalization of a CD4+ T lymphocyte subpopulation in tuberculous pleuritis. J Immunol 1989 142 : 1114 9.
5. Schwander SK, Torres M, Sada E et al. Enhanced responses to Mycobacterium tuberculosis antigens by human alveolar lymphocytes during active pulmonary tuberculosis. J Infect Dis 1998 178 : 1434 45.
6. Lalvani A, Pathan AA, Durkan H et al. Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells. Lancet 2001 357 : 2017 21.
7. Menzies D, Pai M, Comstock G. Meta-analysis: new tests for diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann Intern Med 2007 146 : 340 54.
8. Dewan PK, Grinsdale J, Kawamura LM. Low sensitivity of a whole-blood interferon-gamma release assay for detection of active tuberculosis. Clin Infect Dis 2007 44 : 69 73.
9. Lalvani A, Pathan AA, McShane H et al. Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells. Am J Respir Crit Care Med 2001 163 : 824 8.
10. Jafari C, Ernst M, Kalsdorf B et al. Rapid diagnosis of smear-negative tuberculosis by bronchoalveolar lavage enzyme-linked immunospot. Am J Respir Crit Care Med 2006 174 : 1048 54.
11. Wilkinson KA, Wilkinson RJ, Pathan A et al. Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. Clin Infect Dis 2005 40 : 184 7.
12. Losi M, Bossink A, Codecasa L et al. European Tuberculosis Network (TBNET). Use of a T-cell interferon-gamma release assay for the diagnosis of tuberculous pleurisy. Eur Respir J 2007 30 : 1173 9.