NPD1 induction of retinal pigment epithelial cell survival involves PI3K/Akt phosphorylation signaling

Neurochemical Research

Volumn 35, Issue 12, 2010, Pages 1944-1947

  Halapin, Natalie A ^a   Bazan, Nicolas G ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Age related macular degeneration; Cell survival; DHA; Omega 3 fatty acid; Oxidative stress

Indexed keywords

DOCOSAHEXAENOIC ACID; MAMMALIAN TARGET OF RAPAMYCIN; NEUROPROTECTIN D1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL SURVIVAL; CONCENTRATION (PARAMETERS); HUMAN; MOLECULAR MECHANICS; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CELL LINE; CELL SURVIVAL; DOCOSAHEXAENOIC ACIDS; HUMANS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RETINAL PIGMENT EPITHELIUM; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 78651330802     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-010-0351-8     Document Type: Article

References (31)

1. M Akbar F Calderon Z Wen, et al. 2005 Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival Proc Natl Acad Sci USA 102 10858 10863 1:CAS:528:DC%2BD2MXnvVWjtro%3D 10.1073/pnas.0502903102 16040805
2. L in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival J Biol Chem 285 18301 18308 1:CAS:528:DC%2BC3cXmvFaru7g%3D 10.1074/jbc.M109.095232 20363734
3. NG Bazan 2006 Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors Trends Neurosci 29 263 271 1:CAS:528:DC%2BD28XktVehtb4%3D 10.1016/j.tins.2006.03.005 16580739
4. NG Bazan 2007 Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid Invest Opthalmol Vis Sci 48 4866 4881 10.1167/iovs.07-0918
5. D Bok 1993 The retinal pigment epithelium: a versatile partner in vision J Cell Sci Suppl 17 189 195 1:CAS:528:DyaK2cXktVGltrg%3D 8144697
6. LC Cantley 2002 The phosphoinositide 3-kinase pathway Science 296 1655 1657 1:CAS:528:DC%2BD38XktlChu7s%3D 10.1126/science.296.5573.1655 12040186
7. JQ Chen DA Altomare MA Klein, et al. 1997 Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis Oncogene 14 2793 2801 10.1038/sj.onc.1201121
8. Z Faghiri NG Bazan 2010 PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative-stress induced apoptosis Exp Eye Res 90 718 725 1:CAS:528: DC%2BC3cXmtFCgsr4%3D 10.1016/j.exer.2010.03.002 20230819
9. SJ Fliesler RE Anderson 1983 Chemistry and metabolism of lipids in the vertebrate retina Prog Lipid Res 22 79 131 1:CAS:528:DyaL3sXkt1Sjsbw%3D 10.1016/0163-7827(83)90004-8 6348799
10. AC Gingras SG Kennedy MA O'Leary, et al. 1998 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway Genes Deve 12 502 513 1:CAS:528:DyaK1cXhtlSgsbk%3D 10.1101/gad.12.4.502
11. TC Grammer L Cheatham MM Chou, et al. 1996 The p70S6K signaling pathway: a novel signaling system involved in growth regulation Cancer Surv 27 271 292 1:CAS:528:DyaK28XntlSnsLs%3D 8909805
12. K Hara K Yonezawa QP Weng, et al. 1998 Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism J Biol Chem 273 14484 14494 1:CAS:528:DyaK1cXjs1Oqs74%3D 10.1074/jbc.273.23.14484 9603962
13. H Harada JS Andersen M Mann, et al. 2001 p70S6K kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD Proc Natl Acad Sci USA 98 9666 9670 1:CAS:528:DC%2BD3MXmtlCnu7o%3D 10.1073/pnas.171301998 11493700
14. J Huang BD Manning 2009 A complex interplay between Akt, TSC2 and the two mTOR complexes Biochem Soc Trans 37 217 222 1:CAS:528:DC%2BD1MXotVWlsg%3D%3D 10.1042/BST0370217 19143635
15. K Inoki Y Li T Zhu, et al. 2002 TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nat Cell Biol 4 648 657 1:CAS:528: DC%2BD38Xms1ahtL4%3D 10.1038/ncb839 12172553
16. KH Kang G Lemke JW Kim 2009 The PI3K-PTEN tug-of-war, oxidative stress and retinal degeneration Trends Mol Med 15 191 198 1:CAS:528: DC%2BD1MXmtVWnt7o%3D 10.1016/j.molmed.2009.03.005 19380252
17. JW Kim KH Kang P Burrola, et al. 2008 Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium Genes Dev 22 3147 3157 1:CAS:528:DC%2BD1cXhsVKhs7%2FJ 10.1101/gad.1700108 18997061
18. 2 in the human eye: involvement in phagocytosis of photoreceptor outer segments Invest Ophthalmol Vis Sci 48 1401 1409 10.1167/iovs.06-0865 17325189
19. MM LaVail 1980 Circadian nature of rod outer segment disc shedding in the rat Invest Ophthalmol Vis Sci 19 407 411 1:STN:280:DyaL3c7js1KktA%3D%3D 7358492
20. NR Leslie D Bennett YE Lindsay, et al. 2003 Redox regulation of PI 3-kinase signaling via inactivation of PTEN EMBO J 22 5501 5510 1:CAS:528:DC%2BD3sXot1Crtrw%3D 10.1093/emboj/cdg513 14532122
21. EK Lobenhofer G Huper JD Iglehart, et al. 2000 Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis Cell Growth Differ 11 99 110 1:CAS:528:DC%2BD3cXhslSiu7g%3D 10714766
22. T Maehama JE Dixon 1998 The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate J Biol Chem 273 13375 13378 1:CAS:528:DyaK1cXjvVejsLk%3D 10.1074/jbc.273.22.13375 9593664
23. BD Manning AR Tee MN Logsdon 2002 Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway Mol Cell 10 151 162 1:CAS:528: DC%2BD38XmtFaktbg%3D 10.1016/S1097-2765(02)00568-3 12150915
24. PK Mukherjee VL Marcheselli CN Serhan NG Bazan 2004 Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress Proc Natl Acad Sci USA 101 8491 8496 1:CAS:528:DC%2BD2cXkvFOmt74%3D 10.1073/pnas.0402531101 15152078
25. PK Mukherjee VL Marcheselli S Barreiro, et al. 2007 Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling Proc Natl Acad Sci USA 104 32 13152 13157 1:CAS:528:DC%2BD2sXpt1GntbY%3D 10.1073/pnas.0705949104 17670936
26. PK Mukherjee VL Marcheselli JC de Rivero Vaccari, et al. 2007 Photoreceptor out segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis Proc Natl Acad Sci USA 104 13158 13163 1:CAS:528:DC%2BD2sXpt1Gnurw%3D 10.1073/pnas.0705963104 17670935
27. V Stambolic A Suzuki JL de la Pompa, et al. 1998 Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN Cell 95 29 39 1:CAS:528:DyaK1cXmslWlsr0%3D 10.1016/S0092-8674(00)81780-8 9778245
28. O Strauss 2005 The retinal pigment epithelium in visual function Physiol Rev 85 845 881 1:CAS:528:DC%2BD2MXmsFymu7Y%3D 10.1152/physrev.00021.2004 15987797
29. G Thomas MN Hall 1997 TOR signaling and control of cell growth Curr Opin Cell Biol 9 782 787 1:CAS:528:DyaK2sXnvFGjsL0%3D 10.1016/S0955-0674(97)80078-6 9425342
30. L Weng J Brown C Eng 2001 PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and-independent pathways Hum Mol Genet 10 237 242 1:CAS:528:DC%2BD3MXht1Sktbk%3D 10.1093/hmg/10.3.237 11159942
31. P Yang JJ Peairs R Tano, et al. 2006 Oxidant-mediated Akt activation in human RPE cells Invest Opthalmol Vis Sci 47 4598 4606 10.1167/iovs.06-0140