Rational design of a selective covalent modifier of G protein βγ subunits

Molecular Pharmacology

Volumn 79, Issue 1, 2011, Pages 24-33

  Dessal, Axel L ^a   Prades, Roger ^b   Giralt, Ernest ^b,c   Smrcka, Alan V ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEAMINE DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; PROTEIN INHIBITOR; SELENIUM DERIVATIVE; SELENOCYSTAMINE; SERYLISOLEUCYLGLYCYLCYSTEINYLALANYLPHENYLALANYLLYSYLISOLEUCYLLEUCYLGLYCYLTYROSYLCYSTEAMINE; SERYLISOLEUCYLGLYCYLCYSTEINYLCYSTEAMINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; DRUG BINDING SITE; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; MASS SPECTROMETRY; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CYSTAMINE; DRUG DESIGN; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; ORGANOSELENIUM COMPOUNDS; OXIDATION-REDUCTION; PROTEIN BINDING;

EID: 78651329645     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.068155     Document Type: Article

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