Myocardial NOS activity and connexin-43 expression in untreated and omega-3 fatty acids-treated spontaneously hypertensive and hereditary hypertriglyceridemic rats

Molecular and Cellular Biochemistry

Volumn 347, Issue 1-2, 2011, Pages 163-173

  Radosinska, Jana ^a,b   Bacova, Barbara ^a   Bernatova, Iveta ^a   Navarova, Jana ^c   Zhukovska, Anna ^d   Shysh, Angela ^d   Okruhlicova, Ludmila ^a   Tribulova, Narcis ^a  

^a INSTITUTE OF CHEMISTRY   (Slovakia)

^b Physics and Informatics   (Slovakia)

^c INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^d BOGOMOLETZ INSTITUTE OF PHYSIOLOGY   (Ukraine)

Author keywords

Connexin 43; Heart; Hereditary hypertriglyceridemic rats; Nitric oxide synthase; Omega 3 polyunsaturated fatty acids; Spontaneously hypertensive rats

Indexed keywords

CONNEXIN 43; NITRIC OXIDE SYNTHASE; OMEGA 3 FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ESSENTIAL HYPERTENSION; HEART MUSCLE; HYPERTRIGLYCERIDEMIA; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR UPREGULATION; SPONTANEOUSLY HYPERTENSIVE RAT; SUPPLEMENTATION; SYSTOLIC BLOOD PRESSURE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CONNEXIN 43; DENSITOMETRY; FATTY ACIDS, OMEGA-3; FLUORESCENT ANTIBODY TECHNIQUE; HEART VENTRICLES; HYPERTRIGLYCERIDEMIA; MYOCARDIUM; NITRIC OXIDE SYNTHASE; RATS; RATS, INBRED SHR;

RATTUS;

EID: 78651311624     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0625-0     Document Type: Article

References (48)

1. A Salameh S Dhein 2005 Pharmacology of gap junctions. new pharmacological targets for treatment of arrhythmia, seizure and cancer? Biochim Biophys Acta 1719 36 58 1:CAS:528:DC%2BD2MXhtlaisLvO 10.1016/j.bbamem.2005.09.007 16216217 (Pubitemid 41785635)
2. NJ Severs E Dupont SR Coppen D Halliday E Inett D Baylis S Rothery 2004 Remodelling of gap junctions and connexin expression in heart disease Biochim Biophys Acta 1662 138 148 1:CAS:528:DC%2BD2cXisVKlt7c%3D 10.1016/j.bbamem.2003. 10.019 15033584 (Pubitemid 38366518)
3. N Tribulova V Knezl L Okruhlicova J Slezak 2008 Myocardial gap junctions: targets for novel approaches in the prevention of life-threatening cardiac arrhythmias Physiol Res 57 S1 S13 1:CAS:528:DC%2BD1cXhtVSktbzE 18373398
4. N Tribulova V Knezl A Shainberg S Seki T Soukup 2009 Thyroid hormones and cardiac arrhythmias Vascul Pharmacol 52 102 112 10.1016/j.vph.2009.10.001 19850152
5. J Kunes S Hojna M Kadlecova 2004 Altered balance of vasoactive systems in experimental hypertension: the role of relative NO deficiency Physiol Res 53 23 34
6. J Kopincova A Puzserova I Bernatova 2008 Chronic low-dose L-NAME treatment effect on cardiovascular system of borderline hypertensive rats: feedback regulation? Neuro Endocrinol Lett 29 784 789 1:CAS:528: DC%2BD1MXht1Wnsro%3D 18987608
7. U Förstermann J Boissel H Kleinert 1998 Expressional control of the constitutive' isoforms of nitric oxide synthase (NOS I and NOS III) FASEB J 12 773 790 9657518
8. M Maes I Mihaylova M Kubera E Bosmans 2007 Not in the mind but in the cell: increased production of cyclo- oxygenase 2 and inducible NO synthase in chronic fatigue syndrome Neuro Endocrinol Lett 28 463 469 1:CAS:528: DC%2BD2sXht12rt7vN 17693978 (Pubitemid 47577727)
9. A Hoffmann T Gloe U Pohl S Zahler 2003 Nitric oxide enhances de novo formation of endothelial gap junctions Cardiovasc Res 60 421 430 1:CAS:528:DC%2BD3sXovVGhu7s%3D 10.1016/j.cardiores.2003.04.001 14613872 (Pubitemid 37412376)
10. CR Roh JH Heo SH Yang DS Bae 2002 Regulation of connexin 43 by nitric oxide in primary uterine myocytes from term pregnant women Am J Obstet Gynecol 187 434 440 1:CAS:528:DC%2BD38Xntleis78%3D 10.1067/mob.2002.123600 12193939 (Pubitemid 34925584)
11. E Miyachi M Murakami T Nakaki 1990 Arginine blocks gap junctions between retinal horizontal cells Neuroreport 1 107 110 1:CAS:528:DyaK38Xlt1yntbw%3D 10.1097/00001756-199010000-00006 2129864
12. I Bernatova MV Conde J Kopincova MC Gonzalez A Puzserova SM Arribas 2009 Endothelial dysfunction in spontaneously hypertensive rats focus on methodological aspects J Hypertens 27 27 31 10.1097/01.hjh.0000358834.18311.fc
13. L Zicha O Pechanova S Cacanyiova M Cebova F Kristek J Torok F Simko Z Dobesova J Kunes 2006 Hereditary hypertriglyceridemic rat: A suitable model of cardiovascular disease and metabolic syndrome? Physiol Res 55 49 63
14. S Grunfeld CA Hamilton S Mesaros SW McClain AF Dominiczak DF Bohr T Malinsky 1995 Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats Hypertension 26 854 857 1:CAS:528:DyaK28XmvFSjtg%3D%3D 7490139
15. NS Dhalla RM Temsah T Netticadan 2000 Role of oxidative stress in cardiovascular diseases J Hypertens 18 655 673 1:CAS:528:DC%2BD3cXksFWrur4%3D 10.1097/00004872-200018060-00002 10872549
16. G Ambrozova M Pekarova A Lojek 2010 Effect of polyunsaturated fatty acids on the reactive oxygen and nitrogen species production by raw 264.7 macrophages Eur J Nutr 49 133 139 1:CAS:528:DC%2BC3cXjtlagu7o%3D 10.1007/s00394-009-0057-3 19784538
17. J Ren SH Chung 2007 Anti-inflammatory effect of alpha-linolenic acid and its mode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF-kappaB and mitogen-activated protein kinase pathways J Agric Food Chem 55 5073 5080 1:CAS:528:DC%2BD2sXlvFKjtb4%3D 10.1021/jf0702693 17542608 (Pubitemid 47056059)
18. G Champeil-Potokar C Chaumontet P Guesnet M Lavialle I Denis 2006 Docosahexaenoic acid (22:6n-3) enrichment of membrane phospholipids increases gap junction coupling capacity in cultured astrocytes Eur J Neurosci 24 3084 3090 10.1111/j.1460-9568.2006.05185.x 17156369 (Pubitemid 44952640)
19. K Dlugosova L Okruhlicova M Mitasikova R Sotnikova I Bernatova P Weismann J Slezak N Tribulova 2009 Modulation of connexin-43 by omega-3 fatty acids in the aorta of old spontaneously hypertensive rats J Physiol Pharmacol 60 63 69 1:CAS:528:DC%2BD1MXhsVeht7bK 19826183
20. M Mitasikova S Smidova A Macsaliova V Knezl K Dlugosova L Okruhlicova P Weismass N Tribulova 2008 Aged male and female spontaneously hypertensive rats benefit from n-3 polyunsaturated fatty acids supplementation Physiol Res 57 39 48
21. A Leaf JX Kang YF Xiao GE Billman 2003 Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils Circulation 107 2646 2652 10.1161/01.CIR. 0000069566.78305.33 12782616
22. Sharma R, Raghuram TC, Rao UB, Moffatt RJ, Krishnaswamy K (2010) The effect of fat intake and antihypertensive drug therapy on serum lipid profile: a cross-sectional survey of serum lipids in male and female hypertensives. Mol Cell Biochem http://www.springerlink.com/content/qv726tkv5t237q75/fulltext.html. Accessed 4 June 2010
23. R Marchioli RM Marfisi G Borrelli C Chieffo MG Franzosi G Levantesi AP Maggioni GL Nicolosi M Scarano MG Silletta C Schweiger L Tavazzi G Tognoni 2007 Efficacy of n-3 polyunsaturated fatty acids according to clinical characteristics of patients with recent myocardial infarction: insights from the GISSI-prevenzione trial J Cardiovasc Med (Hagerstown) 8 Suppl 1 34 37 10.2459/01.JCM.0000289271.80180.b6 (Pubitemid 47429080)
24. GE Billman JX Kang A Leaf 1999 Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs Circulation 99 2452 2457 1:CAS:528:DyaK1MXjsFartro%3D 10318669
25. OH Bing WW Brooks KG Robinson MT Slawsky JA Hayes SE Litwin S Sen Conrad Ch 1995 The spontaneously hypertensive rat as a model of the transition from compensated left ventricular hypertrophy to failure J Mol Cell Cardiol 27 383 396 1:CAS:528:DyaK2MXjvVyisrc%3D 10.1016/S0022-2828(08)80035-1 7760360
26. I Bernatova J Kopincova A Puzserova P Janega P Babal 2007 Chronic low-dose L-NAME treatment increases nitric oxide production and vasorelaxation in normotensive rats Physiol Res 56 Suppl 2 S17 S24 1:CAS:528: DC%2BD1cXitV2qsLg%3D 17824811
27. N Tribulova L Okruhlicova S Novakova D Pancza I Bernatova O Pechanova P Weismann M Manoach S Seki S Mochizuki 2002 Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart Exp Physiol 87 195 205 1:CAS:528:DC%2BD38Xjt1ymsbg%3D 10.1113/eph8702336 11856964 (Pubitemid 34257034)
28. N Tribulova L Okruhlicova I Imanaga N Hirosawa K Ogawa P Weismann 2003 Factors involved in the susceptibility of spontaneously hypertensive rats to low K+-induced arrhythmias Gen Physiol Biophys 22 369 382 1:CAS:528: DC%2BD2cXhsVGhtLg%3D 14986887
29. N Tribulova E Dupont T Soukup L Okruhlicova NJ Severs 2005 Sex differences in connexin-43 expression in left ventricles of aging rats Physiol Res 54 705 708 1:CAS:528:DC%2BD28Xpt1Wjuw%3D%3D 16351499
30. S Dhein 1998 Gap junctional channels in cardiovascular system: pharmacological and physiological modulation Trends Pharmacol Sci 19 229 241 1:CAS:528:DyaK1cXktlWrsLs%3D 10.1016/S0165-6147(98)01192-4 9666714 (Pubitemid 28312168)
31. AJ Hobbs A Higgs S Moncada 1999 Inhibition of nitric oxide synthase as a potential therapeutic target Annu Rev Pharmacol Toxicol 39 191 220 1:CAS:528:DyaK1MXjtVejt7k%3D 10.1146/annurev.pharmtox.39.1.191 10331082 (Pubitemid 29222557)
32. ND Vaziri Z Ni F Oveisi DL Trnavsky-Hobbs 2000 Effect of antioxidant therapy on blood pressure and NO synthase expression in hypertensive rats Hypertension 36 957 964 1:CAS:528:DC%2BD3MXitlSiuw%3D%3D 11116107
33. PY Cheng JJ Chen MH Yen 2004 The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats Am J Hypertens 17 1127 1134 1:CAS:528:DC%2BD2cXhtVyqsrjE 10.1016/j.amjhyper.2004.07.018 15607619 (Pubitemid 40029410)
34. M Kimura I Ushijima M Hiraki M Kimura N Ono 2009 Enhancement of caffeine induced locomotor hyperactivity produced by the combination with l arginine or taurine in mice: possible involvement of nitric oxide Methods Find Exp Clin Pharmacol 31 585 589 1:CAS:528:DC%2BC3cXjtlGksLc%3D 20094641
35. SW Kim KH Moon SC Lee NH Kim DG Kang JU Lee KC Choi YJ Kang 1999 Altered renal expression of nitric oxide synthase isozymes in spontaneously hypertensive rats Korean J Intern Med 14 21 26 1:STN:280:DyaK1M7mt1OqtQ%3D%3D 10063310
36. HJ Hong SH Loh MH Yen 2000 Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase Br J Clin Pharmacol 131 631 637 1:CAS:528:DC%2BD3cXnsVygur4%3D
37. PEM Jackson QP Feng DL Jones 2008 Nitric oxide depresses connexin 43 after myocardial infarction in mice Acta Physiol 194 23 33 1:CAS:528: DC%2BD1cXhtVCrtb%2FE 10.1111/j.1748-1716.2008.01858.x
38. O Moibenko A Shysh T Kukoba A Kotsjuruba O Kharchenko 2007 N-3 polyunsaturated fatty acids and nitric oxide synthases activity J Mol Cell Cardiol 42 S207 10.1016/j.yjmcc.2007.03.626
39. WS Harris GS Rainbjør SL Windsor D Diederich 1997 N-3 Fatty acids and urinary excretion of nitric oxide metabolites in humans Am J Clin Nutr 65 459 464 1:CAS:528:DyaK2sXpvVWitw%3D%3D 9022531
40. PL Huang 2009 eNOS, metabolic syndrome and cardiovascular disease Trends Endocrinol Metab 20 295 302 1:CAS:528:DC%2BD1MXps1Sqsrk%3D 10.1016/j.tem.2009. 03.005 19647446
41. T Kishi Y Hirooko Y Mukai H Shimokawa A Takeshita 2003 Atorvastatin causes depressor and sympatho-inhibitory effects with upregulation of nitric oxide synthases in stroke-prone spontaneously hypertensive rats J Hypertens 21 379 386 1:CAS:528:DC%2BD3sXptFOisw%3D%3D 10.1097/00004872-200302000-00030 12569269 (Pubitemid 36269710)
42. CD Shih 2009 Activation of nitric oxide/cGMP/PKG signaling cascade mediates antihypertensive effects of Muntingia calabura in anesthetized spontaneously hypertensive rats Am J Chin Med 37 1045 1058 10.1142/ S0192415X0900748X 19938215
43. P Kameritsch N Khandoga W Nagel C Hundhausen D Lidington U Pohl 2005 Nitric oxide specifically reduces the permeability of Cx37-containing gap junctions to small molecules J Cell Physiol 203 233 242 1:CAS:528: DC%2BD2MXit1SqurY%3D 10.1002/jcp.20218 15481066 (Pubitemid 40328190)
44. J Radosinska B Bacova V Knezl M Barancik P Weismann N Tribulova 2010 Up-regulation of myocardial connexin-43 and PKCe is most likely involved in cardioprotective-antiarrhythmic effects of omega-3 fatty acids in old hypertensive rats J Hypertens 28 e498
45. N Tribulova B Bacova J Radosinska V Knezl M Barancik J Slezak 2010 Chronic and acute treatment with atorvastatin and omega-3 fatty acids protects against malignant arrhythmias. Are intercellular connexin channels implicated? Eur Heart J 3 545
46. M Gönczi R Papp M Kovács G Seprényi A Végh 2009 Modulation of gap junctions by nitric oxide contributes to the anti-arrhythmic effect of sodium nitroprusside? Br J Pharmacol 156 786 793 10.1111/j.1476-5381. 2008.00089.x 19239476
47. O Rickover T Zinman D Kaplan A Shainberg 2007 Exogenous nitric oxide triggers classic ischemic preconditioning by preventing intracellular Ca2+ overload in cardiomyocytes Cell Calcium 43 324 333 10.1016/j.ceca.2007.06.003 17692373
48. N Tribulova S Seki J Radosinska P Kaplan E Babusikova V Knezl S Mochizuki 2009 Myocardial Ca2+ handling and cell-to-cell coupling, key factors in prevention of sudden cardiac death Can J Physiol Pharmacol 87 1120 1129 1:CAS:528:DC%2BD1MXhsFymtLnF 10.1139/Y09-106 20029549