Activation of nitric oxide/cGMP/PKG signaling cascade mediates antihypertensive effects of Muntingia calabura in anesthetized spontaneously hypertensive rats

American Journal of Chinese Medicine

Volumn 37, Issue 6, 2009, Pages 1045-1058

  Shih, Cheng Dean ^a  

^a TAJEN UNIVERSITY   (Taiwan)

Author keywords

Antihypertensive Action; Muntingia calabura; Nitric Oxide; Nitric Oxide Synthase; Tiliaceae

Indexed keywords

ANTIHYPERTENSIVE AGENT; BUTANOL; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; METHANOL; MUNTINGIA CALABURA EXTRACT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTERIAL PRESSURE; ARTICLE; ATTENUATION; BRADYCARDIA; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG SOLUBILITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SYNTHESIS; ESSENTIAL HYPERTENSION; FRACTIONATION; HEART RATE; MALE; MEDICINAL PLANT; MUNTINGIA CALABURA; NONHUMAN; PLANT LEAF; RAT; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SPONTANEOUSLY HYPERTENSIVE RAT; STRAIN DIFFERENCE; WISTAR KYOTO RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BRADYCARDIA; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HYPERTENSION; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SIGNAL TRANSDUCTION; TILIACEAE;

EID: 76449109161     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X0900748X     Document Type: Article

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